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Conserved domains on  [gi|1063703976|ref|NP_001324491|]
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disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03210 super family cl33662
Resistant to P. syringae 6; Provisional
 7-724 2.93e-93

Resistant to P. syringae 6; Provisional


The actual alignment was detected with superfamily member PLN03210:

Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 327.60  E-value: 2.93e-93
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976    7 ELVEDIARDMYEKI--FPTKR----IGIYRKMLKLEKIVYKQLWGIRSIGIWGMPGIGKTTLAEAAFDQFSGDYEASCII 80
Cdd:PLN03210   162 KMIEEIANDVLGKLnlTPSNDfedfVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFI 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976   81 kdfDKEFLAKGL--------------YHLWNEYLGE-----NINNSFIKSGQKRL-----LIVLDNVLKPLDADAFLNGF 136
Cdd:PLN03210   242 ---DRAFISKSMeiyssanpddynmkLHLQRAFLSEildkkDIKIYHLGAMEERLkhrkvLIFIDDLDDQDVLDALAGQT 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  137 DWFGPGSLIIITSRDKQVLVQCGVNQIYEVEGLNKDEAKQLLHGCAFgidwRKQSGLETLAPYYISVKYFSGN-PLALSL 215
Cdd:PLN03210   319 QWFGSGSRIIVITKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAF----KKNSPPDGFMELASEVALRAGNlPLGLNV 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  216 YEEMLSHM-KSDKMEVKLLKLNHPPPQIMEVFKSNYNALN-ENEKSMFLDIACFFRGEKADYVMQLFEGCGFFPHVGIYV 293
Cdd:PLN03210   395 LGSYLRGRdKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNnKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKN 474

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  294 LVDKCLVTIVKRKMEMHNLIQIVGKAISNEGTVELDRHVRLWDTSIIQPLLEDeetklkgeSKGTtEDIEVIFLDMSNL- 372
Cdd:PLN03210   475 LVDKSLIHVREDIVEMHSLLQEMGKEIVRAQSNEPGEREFLVDAKDICDVLED--------NTGT-KKVLGITLDIDEId 545

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  373 KFFVKPDAFKSMHNLRFLKIYSSNPGKHQRIRFR--EALQSLPNELRLLHWEDYPLQSLPQHFDPTHLVELNMPYSKLQK 450
Cdd:PLN03210   546 ELHIHENAFKGMRNLLFLKFYTKKWDQKKEVRWHlpEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEK 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  451 LWGGTKNLEMLKMVRLSHSQDLVEIEELIKSKNIEVIDL------------------------QGCTKIQSFPATRHLQH 506
Cdd:PLN03210   626 LWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLsdcsslvelpssiqylnkledldmSRCENLEILPTGINLKS 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  507 LRVINLSGCVEIKStqleeFQGFPRNLKELYLSGTGIREVTSSIHLSSLEVLDLSNCKRlQNLPMGKGNLASLIKLmlsg 586
Cdd:PLN03210   706 LYRLNLSGCSRLKS-----FPDISTNISWLDLDETAIEEFPSNLRLENLDELILCEMKS-EKLWERVQPLTPLMTM---- 775

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  587 csklqniqdLPTNLKELYLAGT-SIREVPSSICHLTQLVVFDAENCKKLQDLPMGMgNLISLTMLILSGCSELRSIPDLP 665
Cdd:PLN03210   776 ---------LSPSLTRLFLSDIpSLVELPSSIQNLHKLEHLEIENCINLETLPTGI-NLESLESLDLSGCSRLRTFPDIS 845

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063703976  666 RNLRHLNLAETPIKKLPSSFEDLTKLVSLDLNHCERLQ--HLQMESFESVVRVDLSGCLEL 724
Cdd:PLN03210   846 TNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGCNNLQrvSLNISKLKHLETVDFSDCGAL 906
TIR smart00255
Toll - interleukin 1 - resistance;
1156-1293 1.44e-34

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 129.37  E-value: 1.44e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  1156 HQVFLSFS--EDVPRYFVSYLIKKLKWIGITVVYSGFMGGKSMsRPEVTQAIEESSISVVILSKDYVSSSKCLDELVEII 1233
Cdd:smart00255    2 YDVFISYSgkEDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGD-LEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAAL 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  1234 RWREENLGNRVMPIYYEMGTSDVMKQAKTIGNRLVETYLGKVVEKPELRWMRALAYIVNI 1293
Cdd:smart00255   81 ENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQFWKKALYAVPSK 140
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
807-897 1.20e-06

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 1.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  807 SLFLSKAYLLDIhiPQEICNLLSLKTLDLSGNNFGKLPESIKQFRNLESLILCHCKnLESLPEL---PQSLEFLNAHGCv 883
Cdd:COG4886    140 ELDLSNNQLTDL--PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPlgnLTNLEELDLSGN- 215

                           90
                   ....*....|....
gi 1063703976  884 CLKNIHRSFQQFPR 897
Cdd:COG4886    216 QLTDLPEPLANLTN 229
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 7-724 2.93e-93

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 327.60  E-value: 2.93e-93
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976    7 ELVEDIARDMYEKI--FPTKR----IGIYRKMLKLEKIVYKQLWGIRSIGIWGMPGIGKTTLAEAAFDQFSGDYEASCII 80
Cdd:PLN03210   162 KMIEEIANDVLGKLnlTPSNDfedfVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFI 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976   81 kdfDKEFLAKGL--------------YHLWNEYLGE-----NINNSFIKSGQKRL-----LIVLDNVLKPLDADAFLNGF 136
Cdd:PLN03210   242 ---DRAFISKSMeiyssanpddynmkLHLQRAFLSEildkkDIKIYHLGAMEERLkhrkvLIFIDDLDDQDVLDALAGQT 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  137 DWFGPGSLIIITSRDKQVLVQCGVNQIYEVEGLNKDEAKQLLHGCAFgidwRKQSGLETLAPYYISVKYFSGN-PLALSL 215
Cdd:PLN03210   319 QWFGSGSRIIVITKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAF----KKNSPPDGFMELASEVALRAGNlPLGLNV 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  216 YEEMLSHM-KSDKMEVKLLKLNHPPPQIMEVFKSNYNALN-ENEKSMFLDIACFFRGEKADYVMQLFEGCGFFPHVGIYV 293
Cdd:PLN03210   395 LGSYLRGRdKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNnKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKN 474

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  294 LVDKCLVTIVKRKMEMHNLIQIVGKAISNEGTVELDRHVRLWDTSIIQPLLEDeetklkgeSKGTtEDIEVIFLDMSNL- 372
Cdd:PLN03210   475 LVDKSLIHVREDIVEMHSLLQEMGKEIVRAQSNEPGEREFLVDAKDICDVLED--------NTGT-KKVLGITLDIDEId 545

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  373 KFFVKPDAFKSMHNLRFLKIYSSNPGKHQRIRFR--EALQSLPNELRLLHWEDYPLQSLPQHFDPTHLVELNMPYSKLQK 450
Cdd:PLN03210   546 ELHIHENAFKGMRNLLFLKFYTKKWDQKKEVRWHlpEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEK 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  451 LWGGTKNLEMLKMVRLSHSQDLVEIEELIKSKNIEVIDL------------------------QGCTKIQSFPATRHLQH 506
Cdd:PLN03210   626 LWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLsdcsslvelpssiqylnkledldmSRCENLEILPTGINLKS 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  507 LRVINLSGCVEIKStqleeFQGFPRNLKELYLSGTGIREVTSSIHLSSLEVLDLSNCKRlQNLPMGKGNLASLIKLmlsg 586
Cdd:PLN03210   706 LYRLNLSGCSRLKS-----FPDISTNISWLDLDETAIEEFPSNLRLENLDELILCEMKS-EKLWERVQPLTPLMTM---- 775

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  587 csklqniqdLPTNLKELYLAGT-SIREVPSSICHLTQLVVFDAENCKKLQDLPMGMgNLISLTMLILSGCSELRSIPDLP 665
Cdd:PLN03210   776 ---------LSPSLTRLFLSDIpSLVELPSSIQNLHKLEHLEIENCINLETLPTGI-NLESLESLDLSGCSRLRTFPDIS 845

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063703976  666 RNLRHLNLAETPIKKLPSSFEDLTKLVSLDLNHCERLQ--HLQMESFESVVRVDLSGCLEL 724
Cdd:PLN03210   846 TNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGCNNLQrvSLNISKLKHLETVDFSDCGAL 906
TIR smart00255
Toll - interleukin 1 - resistance;
1156-1293 1.44e-34

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 129.37  E-value: 1.44e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  1156 HQVFLSFS--EDVPRYFVSYLIKKLKWIGITVVYSGFMGGKSMsRPEVTQAIEESSISVVILSKDYVSSSKCLDELVEII 1233
Cdd:smart00255    2 YDVFISYSgkEDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGD-LEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAAL 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  1234 RWREENLGNRVMPIYYEMGTSDVMKQAKTIGNRLVETYLGKVVEKPELRWMRALAYIVNI 1293
Cdd:smart00255   81 ENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQFWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 1156-1320 7.73e-29

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 114.00  E-value: 7.73e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976 1156 HQVFLSFS-EDVPRYFVSYLIKKLKWIGIT--VVYSGFMGGKSMSrPEVTQAIEESSISVVILSKDYVSSSKCLDELVEI 1232
Cdd:pfam01582    1 YDVFLSFRgSDTREWFVSHLLKELKQKGIKlfIDDRDLEPGEAIA-PELLSAIEKSRRSVVVLSPNYASSGWCLDELVKI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976 1233 IRWREENlGNRVMPIYYEMGTSDVMKQAKTIGNRLVETYLGKvVEKPELRWMRALAYIVNIvgESSQYWVDKAKMIEKTV 1312
Cdd:pfam01582   80 LECALDL-GQKVIPIFYEVDPSDVRKQTGSFGKAFKKHKKVL-TEEKVLKWRGALNEVANI--WHSKSVSDESKFWKKIA 155


                   ....*...
gi 1063703976 1313 VDVSNQMN 1320
Cdd:pfam01582  156 YDISNKLN 163
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 1155-1359 5.75e-26

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 116.51  E-value: 5.75e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976 1155 SHQVFLSFS-EDVPRYFVSYLIKKLKWIGITVVYSGFMGGKSMSRPEVTQAIEESSISVVILSKDYVSSSKCLDELVEII 1233
Cdd:PLN03210    12 VYDVFPSFSgEDVRITFLSHFLKELDRKLIIAFKDNEIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNELLEIV 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976 1234 RWREEnLGNRVMPIYYEMGTSDVMKQAKTIGNRLVETYLGKVVEKpELRWMRALAYIVNIVGESSQYWVDKAKMIEKTVV 1313
Cdd:PLN03210    92 RCKEE-LGQLVIPVFYGLDPSHVRKQTGDFGEAFEKTCQNKTEDE-KIQWKQALTDVANILGYHSQNWPNEAKMIEEIAN 169

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1063703976 1314 DVSNQMNILESNE----AGLlfiyqeEENMENFKRNVYDEMNGVRIIPIW 1359
Cdd:PLN03210   170 DVLGKLNLTPSNDfedfVGI------EDHIAKMSSLLHLESEEVRMVGIW 213
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
532-720 1.63e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 1.63e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  532 NLKELYLSGTGIREVTSSIHLSSLEVLDLSNCKRLqnlpmgkGNLASLIKLMLSGCsklqNIQDLP------TNLKELYL 605
Cdd:COG4886     75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEEL-------SNLTNLESLDLSGN----QLTDLPeelanlTNLKELDL 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  606 AGTSIREVPSSICHLTQLVVFDAENCKkLQDLPMGMGNLISLTMLILSGCsELRSIPD----LPrNLRHLNLAETPIKKL 681
Cdd:COG4886    144 SNNQLTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKELDLSNN-QITDLPEplgnLT-NLEELDLSGNQLTDL 220

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1063703976  682 PSSFEDLTKLVSLDLNHCeRLQHL-QMESFESVVRVDLSG 720
Cdd:COG4886    221 PEPLANLTNLETLDLSNN-QLTDLpELGNLTNLEELDLSN 259
NB-ARC pfam00931
NB-ARC domain;
49-224 1.48e-10

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 63.17  E-value: 1.48e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976   49 IGIWGMPGIGKTTLAEAAFDQF---------------SGDYEASCIIKDFDKEFLAKGlyHLWNEY----LGENINNSFI 109
Cdd:pfam00931   21 VGIHGMGGVGKTTLAAQIFNDFdeveghfdsvawvvvSKTFTISTLQQTILQNLGLSE--DDWDNKeegeLARKIRRALL 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  110 ksgQKRLLIVLDNVLKPLDADAFLNGFDWFGPGSLIIITSRDKQVlvqCG-VNQIY---EVEGLNKDEAKQLLHGCAFGI 185
Cdd:pfam00931   99 ---TKRFLLVLDDVWDEEDWDKIGIPLPDRENGCRVLLTTRSEEV---AGrVGGPSdphEVELLEPDEAWELFENKVFPK 172

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1063703976  186 DWRKQSGLETLApyYISVKYFSGNPLALSLYEEMLSHMK 224
Cdd:pfam00931  173 TLGECELLEDVA--KEIVEKCRGLPLALKVLGGLLSCKK 209
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 536-726 3.68e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.34  E-value: 3.68e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  536 LYLSGTGIREVTSSIHLSSLEVLDL-SNC-KRLQNLpmgkGNLASLIKLMLSG--CSKLQNIQDLPtNLKELYLAGTSIR 611
Cdd:cd21340      7 LYLNDKNITKIDNLSLCKNLKVLYLyDNKiTKIENL----EFLTNLTHLYLQNnqIEKIENLENLV-NLKKLYLGGNRIS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  612 EVpssiCHLtqlvvfdaENCKKL-------QDLPMGMGnLI-----------SLTMLILSGCSeLRSIPDLP--RNLRHL 671
Cdd:cd21340     82 VV----EGL--------ENLTNLeelhienQRLPPGEK-LTfdprslaalsnSLRVLNISGNN-IDSLEPLAplRNLEQL 147

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063703976  672 NLAETPIkklpSSFEDLTKLVSldlnHCERLQHLqmesfesvvrvDLSG---CLELKY 726
Cdd:cd21340    148 DASNNQI----SDLEELLDLLS----SWPSLREL-----------DLTGnpvCKKPKY 186
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
807-897 1.20e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 1.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  807 SLFLSKAYLLDIhiPQEICNLLSLKTLDLSGNNFGKLPESIKQFRNLESLILCHCKnLESLPEL---PQSLEFLNAHGCv 883
Cdd:COG4886    140 ELDLSNNQLTDL--PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPlgnLTNLEELDLSGN- 215

                           90
                   ....*....|....
gi 1063703976  884 CLKNIHRSFQQFPR 897
Cdd:COG4886    216 QLTDLPEPLANLTN 229
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 829-872 1.51e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 1.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1063703976  829 SLKTLDLSGNNFGKLPeSIKQFRNLESLILCHCKNLESLPELPQ 872
Cdd:pfam12799    2 NLEVLDLSNNQITDIP-PLAKLPNLETLDLSGNNKITDLSDLAN 44
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 7-724 2.93e-93

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 327.60  E-value: 2.93e-93
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976    7 ELVEDIARDMYEKI--FPTKR----IGIYRKMLKLEKIVYKQLWGIRSIGIWGMPGIGKTTLAEAAFDQFSGDYEASCII 80
Cdd:PLN03210   162 KMIEEIANDVLGKLnlTPSNDfedfVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFI 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976   81 kdfDKEFLAKGL--------------YHLWNEYLGE-----NINNSFIKSGQKRL-----LIVLDNVLKPLDADAFLNGF 136
Cdd:PLN03210   242 ---DRAFISKSMeiyssanpddynmkLHLQRAFLSEildkkDIKIYHLGAMEERLkhrkvLIFIDDLDDQDVLDALAGQT 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  137 DWFGPGSLIIITSRDKQVLVQCGVNQIYEVEGLNKDEAKQLLHGCAFgidwRKQSGLETLAPYYISVKYFSGN-PLALSL 215
Cdd:PLN03210   319 QWFGSGSRIIVITKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAF----KKNSPPDGFMELASEVALRAGNlPLGLNV 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  216 YEEMLSHM-KSDKMEVKLLKLNHPPPQIMEVFKSNYNALN-ENEKSMFLDIACFFRGEKADYVMQLFEGCGFFPHVGIYV 293
Cdd:PLN03210   395 LGSYLRGRdKEDWMDMLPRLRNGLDGKIEKTLRVSYDGLNnKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKN 474

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  294 LVDKCLVTIVKRKMEMHNLIQIVGKAISNEGTVELDRHVRLWDTSIIQPLLEDeetklkgeSKGTtEDIEVIFLDMSNL- 372
Cdd:PLN03210   475 LVDKSLIHVREDIVEMHSLLQEMGKEIVRAQSNEPGEREFLVDAKDICDVLED--------NTGT-KKVLGITLDIDEId 545

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  373 KFFVKPDAFKSMHNLRFLKIYSSNPGKHQRIRFR--EALQSLPNELRLLHWEDYPLQSLPQHFDPTHLVELNMPYSKLQK 450
Cdd:PLN03210   546 ELHIHENAFKGMRNLLFLKFYTKKWDQKKEVRWHlpEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEK 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  451 LWGGTKNLEMLKMVRLSHSQDLVEIEELIKSKNIEVIDL------------------------QGCTKIQSFPATRHLQH 506
Cdd:PLN03210   626 LWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLsdcsslvelpssiqylnkledldmSRCENLEILPTGINLKS 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  507 LRVINLSGCVEIKStqleeFQGFPRNLKELYLSGTGIREVTSSIHLSSLEVLDLSNCKRlQNLPMGKGNLASLIKLmlsg 586
Cdd:PLN03210   706 LYRLNLSGCSRLKS-----FPDISTNISWLDLDETAIEEFPSNLRLENLDELILCEMKS-EKLWERVQPLTPLMTM---- 775

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  587 csklqniqdLPTNLKELYLAGT-SIREVPSSICHLTQLVVFDAENCKKLQDLPMGMgNLISLTMLILSGCSELRSIPDLP 665
Cdd:PLN03210   776 ---------LSPSLTRLFLSDIpSLVELPSSIQNLHKLEHLEIENCINLETLPTGI-NLESLESLDLSGCSRLRTFPDIS 845

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063703976  666 RNLRHLNLAETPIKKLPSSFEDLTKLVSLDLNHCERLQ--HLQMESFESVVRVDLSGCLEL 724
Cdd:PLN03210   846 TNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGCNNLQrvSLNISKLKHLETVDFSDCGAL 906
TIR smart00255
Toll - interleukin 1 - resistance;
1156-1293 1.44e-34

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 129.37  E-value: 1.44e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  1156 HQVFLSFS--EDVPRYFVSYLIKKLKWIGITVVYSGFMGGKSMsRPEVTQAIEESSISVVILSKDYVSSSKCLDELVEII 1233
Cdd:smart00255    2 YDVFISYSgkEDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGD-LEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAAL 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  1234 RWREENLGNRVMPIYYEMGTSDVMKQAKTIGNRLVETYLGKVVEKPELRWMRALAYIVNI 1293
Cdd:smart00255   81 ENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQFWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 1156-1320 7.73e-29

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 114.00  E-value: 7.73e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976 1156 HQVFLSFS-EDVPRYFVSYLIKKLKWIGIT--VVYSGFMGGKSMSrPEVTQAIEESSISVVILSKDYVSSSKCLDELVEI 1232
Cdd:pfam01582    1 YDVFLSFRgSDTREWFVSHLLKELKQKGIKlfIDDRDLEPGEAIA-PELLSAIEKSRRSVVVLSPNYASSGWCLDELVKI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976 1233 IRWREENlGNRVMPIYYEMGTSDVMKQAKTIGNRLVETYLGKvVEKPELRWMRALAYIVNIvgESSQYWVDKAKMIEKTV 1312
Cdd:pfam01582   80 LECALDL-GQKVIPIFYEVDPSDVRKQTGSFGKAFKKHKKVL-TEEKVLKWRGALNEVANI--WHSKSVSDESKFWKKIA 155


                   ....*...
gi 1063703976 1313 VDVSNQMN 1320
Cdd:pfam01582  156 YDISNKLN 163
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 1155-1359 5.75e-26

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 116.51  E-value: 5.75e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976 1155 SHQVFLSFS-EDVPRYFVSYLIKKLKWIGITVVYSGFMGGKSMSRPEVTQAIEESSISVVILSKDYVSSSKCLDELVEII 1233
Cdd:PLN03210    12 VYDVFPSFSgEDVRITFLSHFLKELDRKLIIAFKDNEIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNELLEIV 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976 1234 RWREEnLGNRVMPIYYEMGTSDVMKQAKTIGNRLVETYLGKVVEKpELRWMRALAYIVNIVGESSQYWVDKAKMIEKTVV 1313
Cdd:PLN03210    92 RCKEE-LGQLVIPVFYGLDPSHVRKQTGDFGEAFEKTCQNKTEDE-KIQWKQALTDVANILGYHSQNWPNEAKMIEEIAN 169

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1063703976 1314 DVSNQMNILESNE----AGLlfiyqeEENMENFKRNVYDEMNGVRIIPIW 1359
Cdd:PLN03210   170 DVLGKLNLTPSNDfedfVGI------EDHIAKMSSLLHLESEEVRMVGIW 213
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
532-720 1.63e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 1.63e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  532 NLKELYLSGTGIREVTSSIHLSSLEVLDLSNCKRLqnlpmgkGNLASLIKLMLSGCsklqNIQDLP------TNLKELYL 605
Cdd:COG4886     75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEEL-------SNLTNLESLDLSGN----QLTDLPeelanlTNLKELDL 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  606 AGTSIREVPSSICHLTQLVVFDAENCKkLQDLPMGMGNLISLTMLILSGCsELRSIPD----LPrNLRHLNLAETPIKKL 681
Cdd:COG4886    144 SNNQLTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKELDLSNN-QITDLPEplgnLT-NLEELDLSGNQLTDL 220

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1063703976  682 PSSFEDLTKLVSLDLNHCeRLQHL-QMESFESVVRVDLSG 720
Cdd:COG4886    221 PEPLANLTNLETLDLSNN-QLTDLpELGNLTNLEELDLSN 259
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
337-759 1.72e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 1.72e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  337 TSIIQPLLEDEETKLKGESKGTTEDIEVIFLDMSNLKFFVKPDAFKSMHNLRFLKIYSSNPGKHQRIRFREALQSLPNEL 416
Cdd:COG4886     20 LLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  417 RLLHWEDYPLQSLpqhfdpTHLVELNMPYSKLQKLWGGTKNLEMLKMVRLSHSQdLVEIEELIKS-KNIEVIDLQGCtKI 495
Cdd:COG4886    100 ELDLSGNEELSNL------TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQ-LTDLPEPLGNlTNLKSLDLSNN-QL 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  496 QSFPatrhlqhlrvinlsgcveikstqlEEFQGFPrNLKELYLSGTGIREVTSSI-HLSSLEVLDLSNCKrLQNLPMGKG 574
Cdd:COG4886    172 TDLP------------------------EELGNLT-NLKELDLSNNQITDLPEPLgNLTNLEELDLSGNQ-LTDLPEPLA 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  575 NLASLIKLMLSGCsklqNIQDLP-----TNLKELYLAGTSIREVPSSiCHLTQLVVFDAENCK----KLQDLPMGMGNLI 645
Cdd:COG4886    226 NLTNLETLDLSNN----QLTDLPelgnlTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQltdlKLKELELLLGLNS 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  646 SLTMLILSGCSELRSIPDLPRNLRHLNLAETPIKKLPSSFEDLTKLVSLDLNHCERLQHLQMESFESVVRVDLSGCLELK 725
Cdd:COG4886    301 LLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1063703976  726 YILGFSLQDITQLHEDGTDKVMLHGTPPCNVTLI 759
Cdd:COG4886    381 TLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
518-881 3.98e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 3.98e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  518 IKSTQLEEFQGFPRNLKELYLSGTGIREVTSSIHLSSLEVLDLSNCKRLQNLPMGKGNLASLIKLMLSGCSKLQNIqdlp 597
Cdd:COG4886     37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL---- 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  598 TNLKELYLAGTSIREVPSSICHLTQLVVFDAENCKkLQDLPMGMGNLisltmlilsgcselrsipdlpRNLRHLNLAETP 677
Cdd:COG4886    113 TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQ-LTDLPEPLGNL---------------------TNLKSLDLSNNQ 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  678 IKKLPSSFEDLTKLVSLDLNHcerlqhlqmesfesvvrvdlsgclelkyilgfslqdiTQLHEdgtdkvmlhgtppcnvt 757
Cdd:COG4886    171 LTDLPEELGNLTNLKELDLSN-------------------------------------NQITD----------------- 196

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  758 liletwrtrhvtpmeksgskfylklmpfvttpyrsklqsslvfrmyamvslflskaylldihIPQEICNLLSLKTLDLSG 837
Cdd:COG4886    197 --------------------------------------------------------------LPEPLGNLTNLEELDLSG 214

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1063703976  838 NNFGKLPESIKQFRNLESLILCHCKnLESLPELPQ--SLEFLNAHG 881
Cdd:COG4886    215 NQLTDLPEPLANLTNLETLDLSNNQ-LTDLPELGNltNLEELDLSN 259
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
334-688 1.74e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 1.74e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  334 LWDTSIIQPLLEDEETKLKGESKGTTEDIEVIFLDMSNLKFFVKPDAFKSMHNLRFLKIYSSNPgkhqrirfreaLQSLP 413
Cdd:COG4886     45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-----------LSNLT 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  414 NeLRLLHWEDYPLQSLPQHF-DPTHLVELNMPYSKLQKLWGGTKNLEMLKMVRLSHSQdLVEI-EELIKSKNIEVIDLQG 491
Cdd:COG4886    114 N-LESLDLSGNQLTDLPEELaNLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ-LTDLpEELGNLTNLKELDLSN 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  492 cTKIQSFPAT-RHLQHLRVINLSGCvEIKS---------------------TQLEEFQGFPrNLKELYLSGTGIREVTSS 549
Cdd:COG4886    192 -NQITDLPEPlGNLTNLEELDLSGN-QLTDlpeplanltnletldlsnnqlTDLPELGNLT-NLEELDLSNNQLTDLPPL 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  550 IHLSSLEVLDLSNCK-RLQNLPMGKGNLASLIKLMLSGCSKLQNIQDLPTNLKELYLAGTSIREVPSSICHLTQLVVFDA 628
Cdd:COG4886    269 ANLTNLKTLDLSNNQlTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLA 348

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  629 ENCKKLQDLPMGMGNLISLTMLILSGCSELRSIPDLPRNLRHLNLAETPIKKLPSSFEDL 688
Cdd:COG4886    349 LLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALL 408
NB-ARC pfam00931
NB-ARC domain;
49-224 1.48e-10

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 63.17  E-value: 1.48e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976   49 IGIWGMPGIGKTTLAEAAFDQF---------------SGDYEASCIIKDFDKEFLAKGlyHLWNEY----LGENINNSFI 109
Cdd:pfam00931   21 VGIHGMGGVGKTTLAAQIFNDFdeveghfdsvawvvvSKTFTISTLQQTILQNLGLSE--DDWDNKeegeLARKIRRALL 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  110 ksgQKRLLIVLDNVLKPLDADAFLNGFDWFGPGSLIIITSRDKQVlvqCG-VNQIY---EVEGLNKDEAKQLLHGCAFGI 185
Cdd:pfam00931   99 ---TKRFLLVLDDVWDEEDWDKIGIPLPDRENGCRVLLTTRSEEV---AGrVGGPSdphEVELLEPDEAWELFENKVFPK 172

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1063703976  186 DWRKQSGLETLApyYISVKYFSGNPLALSLYEEMLSHMK 224
Cdd:pfam00931  173 TLGECELLEDVA--KEIVEKCRGLPLALKVLGGLLSCKK 209
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 536-726 3.68e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.34  E-value: 3.68e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  536 LYLSGTGIREVTSSIHLSSLEVLDL-SNC-KRLQNLpmgkGNLASLIKLMLSG--CSKLQNIQDLPtNLKELYLAGTSIR 611
Cdd:cd21340      7 LYLNDKNITKIDNLSLCKNLKVLYLyDNKiTKIENL----EFLTNLTHLYLQNnqIEKIENLENLV-NLKKLYLGGNRIS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  612 EVpssiCHLtqlvvfdaENCKKL-------QDLPMGMGnLI-----------SLTMLILSGCSeLRSIPDLP--RNLRHL 671
Cdd:cd21340     82 VV----EGL--------ENLTNLeelhienQRLPPGEK-LTfdprslaalsnSLRVLNISGNN-IDSLEPLAplRNLEQL 147

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063703976  672 NLAETPIkklpSSFEDLTKLVSldlnHCERLQHLqmesfesvvrvDLSG---CLELKY 726
Cdd:cd21340    148 DASNNQI----SDLEELLDLLS----SWPSLREL-----------DLTGnpvCKKPKY 186
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 1158-1250 2.15e-08

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 53.86  E-value: 2.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976 1158 VFLSFS-EDvpRYFVSYLIKKLKWIGITVVY--SGFMGGKSMSRpEVTQAIEESSISVVILSKDYVSSSKCLDELVEIir 1234
Cdd:pfam13676    1 VFISYAgED--RAWAEWLADALEAAGYRVWLdrWDIRPGDDWVE-EIEEAIENSDRVLVVLSPNYLESPWCRAEWEAA-- 75

                           90
                   ....*....|....*.
gi 1063703976 1235 WREENLGNRVMPIYYE 1250
Cdd:pfam13676   76 LADPEGRKRLIPVRLE 91
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
548-882 2.16e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 2.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  548 SSIHLSSLEVLDLSNCKRLQNLPMGKGNLASLIKLMLSGCSKLQNIQDLPTNLKELYLAGTSIREVPSSICHLTQLVVFD 627
Cdd:COG4886      3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  628 AENCKKLQDLpmgmGNLISLTMLILSGCSELRSIPdlprNLRHLNLAETPIKKLPSSFEDLTKLVSLDLNHCerlqhlQM 707
Cdd:COG4886     83 SLLLLGLTDL----GDLTNLTELDLSGNEELSNLT----NLESLDLSGNQLTDLPEELANLTNLKELDLSNN------QL 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  708 ESFESvvrvDLSGCLELKYiLGFSLQDITQlhedgtdkvmlhgtppcnvtliletwrtrhvtpmeksgskfylklmpfvt 787
Cdd:COG4886    149 TDLPE----PLGNLTNLKS-LDLSNNQLTD-------------------------------------------------- 173

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  788 tpyrsklqsslvfrmyamvslflskaylldihIPQEICNLLSLKTLDLSGNNFGKLPESIKQFRNLESLILCHCKnLESL 867
Cdd:COG4886    174 --------------------------------LPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ-LTDL 220

                          330
                   ....*....|....*...
gi 1063703976  868 P-ELPQ--SLEFLNAHGC 882
Cdd:COG4886    221 PePLANltNLETLDLSNN 238
LRR_3 pfam07725
Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the ...
 437-456 8.71e-07

Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the pfam00560 model.


Pssm-ID: 429621 [Multi-domain]  Cd Length: 20  Bit Score: 46.18  E-value: 8.71e-07
                           10        20
                   ....*....|....*....|
gi 1063703976  437 HLVELNMPYSKLQKLWGGTK 456
Cdd:pfam07725    1 NLVELNMPYSKLEKLWEGVK 20
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
807-897 1.20e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 1.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  807 SLFLSKAYLLDIhiPQEICNLLSLKTLDLSGNNFGKLPESIKQFRNLESLILCHCKnLESLPEL---PQSLEFLNAHGCv 883
Cdd:COG4886    140 ELDLSNNQLTDL--PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPlgnLTNLEELDLSGN- 215

                           90
                   ....*....|....
gi 1063703976  884 CLKNIHRSFQQFPR 897
Cdd:COG4886    216 QLTDLPEPLANLTN 229
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
51-215 9.19e-06

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 50.19  E-value: 9.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976   51 IWGMPGIGKTTLAEAAFDQFSGDY--EASCI-----IKDFDKEF-LAKGLYHLWNEYLGENINN--SFIKSGqkRLLIVL 120
Cdd:COG5635    185 ILGEPGSGKTTLLRYLALELAERYldAEDPIpilieLRDLAEEAsLEDLLAEALEKRGGEPEDAleRLLRNG--RLLLLL 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  121 DN---VLKPLDADAFLNGFDWFG---PGSLIIITSR----DKQVLVQCgvnQIYEVEGLNKDEAKQLLHGCAFGIDWRKQ 190
Cdd:COG5635    263 DGldeVPDEADRDEVLNQLRRFLeryPKARVIITSRpegyDSSELEGF---EVLELAPLSDEQIEEFLKKWFEATERKAE 339

                          170       180
                   ....*....|....*....|....*
gi 1063703976  191 SGLETLAPYYiSVKYFSGNPLALSL 215
Cdd:COG5635    340 RLLEALEENP-ELRELARNPLLLTL 363
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
516-696 1.86e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.39  E-value: 1.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  516 VEIKSTQLEEFQGFPRNLKELYLSGTgirevtssiHLSSLEVLDLSnckrLQNLPMGKGNLASLIKLMLSGC------SK 589
Cdd:PRK15387   267 LSIFSNPLTHLPALPSGLCKLWIFGN---------QLTSLPVLPPG----LQELSVSDNQLASLPALPSELCklwaynNQ 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  590 LQNIQDLPTNLKELYLAGTSIREVPSSICHLTQLVVFDaENCKKLQDLPMGMGNLI--------------SLTMLILSGc 655
Cdd:PRK15387   334 LTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYN-NRLTSLPALPSGLKELIvsgnrltslpvlpsELKELMVSG- 411

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1063703976  656 SELRSIPDLPRNLRHLNLAETPIKKLPSSFEDLTKLVSLDL 696
Cdd:PRK15387   412 NRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNL 452
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 501-740 4.58e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.48  E-value: 4.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  501 TRHLQHLRVINLS---GCVEIKSTQLEEFQGFPRNLKELYLSGTGIREVTSSIHLSSLEVLDL-SNCKRLQNLPMGKGNL 576
Cdd:COG5238    108 TATAVATPPPDLRrimAKTLEDSLILYLALPRRINLIQVLKDPLGGNAVHLLGLAARLGLLAAiSMAKALQNNSVETVYL 187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  577 ASLiKLMLSGCSKLQNIQDLPTNLKELYLAGTSI-----REVPSSICHLTQLVVFDaenckkLQDLPMGMGNLI------ 645
Cdd:COG5238    188 GCN-QIGDEGIEELAEALTQNTTVTTLWLKRNPIgdegaEILAEALKGNKSLTTLD------LSNNQIGDEGVIalaeal 260

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  646 ----SLTMLILSG----CSELRSIPDL---PRNLRHLNLAETPI-----KKLPSSFEDLTKLVSLDLNHC-------ERL 702
Cdd:COG5238    261 knntTVETLYLSGnqigAEGAIALAKAlqgNTTLTSLDLSVNRIgdegaIALAEGLQGNKTLHTLNLAYNgigaqgaIAL 340

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1063703976  703 -QHLQMESfeSVVRVDLSGclelKYI-------LGFSLQDITQLHE 740
Cdd:COG5238    341 aKALQENT--TLHSLDLSD----NQIgdegaiaLAKYLEGNTTLRE 380
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 532-570 2.74e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 2.74e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1063703976  532 NLKELYLSGTGIREVTSSIHLSSLEVLDLSNCKRLQNLP 570
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNKITDLS 40
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 829-872 1.51e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 1.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1063703976  829 SLKTLDLSGNNFGKLPeSIKQFRNLESLILCHCKNLESLPELPQ 872
Cdd:pfam12799    2 NLEVLDLSNNQITDIP-PLAKLPNLETLDLSGNNKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 667-706 1.63e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 1.63e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1063703976  667 NLRHLNLAETPIKKLPSsFEDLTKLVSLDLNHCERLQHLQ 706
Cdd:pfam12799    2 NLEVLDLSNNQITDIPP-LAKLPNLETLDLSGNNKITDLS 40
LRR_8 pfam13855
Leucine rich repeat;
646-699 2.30e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 2.30e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  646 SLTMLILSgCSELRSIPD-----LPrNLRHLNLAETPIKKL-PSSFEDLTKLVSLDLNHC 699
Cdd:pfam13855    2 NLRSLDLS-NNRLTSLDDgafkgLS-NLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 481-697 3.00e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 3.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  481 SKNIEVIDLQG---CTKIQSfpATRHLQHLRVINLSgcveikSTQLEefQGFPRN-------LKELYLSGTGIREVTSSI 550
Cdd:PLN00113    68 SSRVVSIDLSGkniSGKISS--AIFRLPYIQTINLS------NNQLS--GPIPDDifttsssLRYLNLSNNNFTGSIPRG 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  551 HLSSLEVLDLSNCKRLQNLPMGKGNLASLIKLMLSGCSKLQNIQDLPTN---LKELYLAGTS-IREVPSSICHLTQL--V 624
Cdd:PLN00113   138 SIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNltsLEFLTLASNQlVGQIPRELGQMKSLkwI 217

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063703976  625 VFDAENCKKlqDLPMGMGNLISLTMLILSGCSELRSIP----DLpRNLRHLNLAETPIK-KLPSSFEDLTKLVSLDLN 697
Cdd:PLN00113   218 YLGYNNLSG--EIPYEIGGLTSLNHLDLVYNNLTGPIPsslgNL-KNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLS 292
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 463-636 4.80e-03

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 40.00  E-value: 4.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  463 MVRLSHSQDlVEIEELIKS--KNIEVIDLQGCTKIQ-SFPATRHLQHLRVINLSGCVEIKSTQLEEFQGFPRNLKELYLs 539
Cdd:cd09293      8 LHKLGQITQ-SNISQLLRIlhSGLEWLELYMCPISDpPLDQLSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDL- 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  540 gtgirevTSSIHLSSLEVLDLS-NCKRLQNLPMGKGNLASLIklmlSGCSkLQNIQDLPTNLKELYLAGT-----SIREV 613
Cdd:cd09293     86 -------RACENITDSGIVALAtNCPKLQTINLGRHRNGHLI----TDVS-LSALGKNCTFLQTVGFAGCdvtdkGVWEL 153

                          170       180
                   ....*....|....*....|...
gi 1063703976  614 PSSICHltQLVVFDAENCKKLQD 636
Cdd:cd09293    154 ASGCSK--SLERLSLNNCRNLTD 174
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 465-593 5.80e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 5.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  465 RLSH----SQDLVEIEELIKSKNIEVIDLQG--CTKIQSFPATRHLQHL-------RVI-NLSGCVEIKS--------TQ 522
Cdd:cd21340      3 RITHlylnDKNITKIDNLSLCKNLKVLYLYDnkITKIENLEFLTNLTHLylqnnqiEKIeNLENLVNLKKlylggnriSV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063703976  523 LEEFQGfPRNLKELYL------------------------------SGTGIREVTSSIHLSSLEVLDLSNCKrLQNLpmg 572
Cdd:cd21340     83 VEGLEN-LTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLRNLEQLDASNNQ-ISDL--- 157

                          170       180
                   ....*....|....*....|.
gi 1063703976  573 kgnlaSLIKLMLSGCSKLQNI 593
Cdd:cd21340    158 -----EELLDLLSSWPSLREL 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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