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Conserved domains on  [gi|1063715661|ref|NP_001326333|]
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xyloglucan endotransglucosylase/hydrolase 11 [Arabidopsis thaliana]

Protein Classification

LamG domain-containing protein( domain architecture ID 366259)

LamG (Laminin G) domain-containing protein may serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 4-214 6.31e-79

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member cd02176:

Pssm-ID: 473984 [Multi-domain]  Cd Length: 263  Bit Score: 237.10  E-value: 6.31e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661   4 TGSGFESQLIYGSGYFNVRIKAPQTTSTGVITSFYLISR-SSRHDELCFQILG-KNGPPYLLNTNMYLYGEGGKDQRFRL 81
Cdd:cd02176    36 SGSGFKSKNKYLFGFFSMRIKLPPGDSAGTVTAFYLSSQgPDNHDEIDFEFLGnVTGQPYTLQTNVFANGVGGREQRIYL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661  82 WFDPTKDYHSYSFLWNPNQLVFYVDDTPIRVYSKN--PDVYYPSVQTMFLMGSVQNGSI---------IDPKQMPYIAKF 150
Cdd:cd02176   116 WFDPTADFHTYSILWNPHQIVFYVDDVPIRVFKNNeaLGVPYPSSQPMGVYASIWDGSDwatqggrvkIDWSYAPFVASY 195

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661 151 QASKIEGCKTEfmGIDK---CTDPKFWWNRK---QLSSKEKTLYLNARKTYLDYDYCSDRQRYPKVPQEC 214
Cdd:cd02176   196 RDFKLDGCVVD--PGDSfssCSCTEDWWNGStyqQLSANQQRAMEWVRRNYMVYDYCDDRKRYPVPPPEC 263
 
Name Accession Description Interval E-value
GH16_XET cd02176
Xyloglucan endotransglycosylase, member of glycosyl hydrolase family 16; Xyloglucan ...
 4-214 6.31e-79

Xyloglucan endotransglycosylase, member of glycosyl hydrolase family 16; Xyloglucan endotransglycosylases (XETs) cleave and religate xyloglucan polymers in plant cell walls via a transglycosylation mechanism. Xyloglucan is a soluble hemicellulose with a backbone of beta-1,4-linked glucose units, partially substituted with alpha-1,6-linked xylopyranose branches. It binds noncovalently to cellulose, cross-linking the adjacent cellulose microfibrils, giving it a key structural role as a matrix polymer. Therefore, XET plays an important role in all plant processes that require cell wall remodeling.


Pssm-ID: 185685 [Multi-domain]  Cd Length: 263  Bit Score: 237.10  E-value: 6.31e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661   4 TGSGFESQLIYGSGYFNVRIKAPQTTSTGVITSFYLISR-SSRHDELCFQILG-KNGPPYLLNTNMYLYGEGGKDQRFRL 81
Cdd:cd02176    36 SGSGFKSKNKYLFGFFSMRIKLPPGDSAGTVTAFYLSSQgPDNHDEIDFEFLGnVTGQPYTLQTNVFANGVGGREQRIYL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661  82 WFDPTKDYHSYSFLWNPNQLVFYVDDTPIRVYSKN--PDVYYPSVQTMFLMGSVQNGSI---------IDPKQMPYIAKF 150
Cdd:cd02176   116 WFDPTADFHTYSILWNPHQIVFYVDDVPIRVFKNNeaLGVPYPSSQPMGVYASIWDGSDwatqggrvkIDWSYAPFVASY 195

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661 151 QASKIEGCKTEfmGIDK---CTDPKFWWNRK---QLSSKEKTLYLNARKTYLDYDYCSDRQRYPKVPQEC 214
Cdd:cd02176   196 RDFKLDGCVVD--PGDSfssCSCTEDWWNGStyqQLSANQQRAMEWVRRNYMVYDYCDDRKRYPVPPPEC 263
PLN03161 PLN03161
Probable xyloglucan endotransglucosylase/hydrolase protein; Provisional
 4-214 9.73e-45

Probable xyloglucan endotransglucosylase/hydrolase protein; Provisional


Pssm-ID: 178706 [Multi-domain]  Cd Length: 291  Bit Score: 150.82  E-value: 9.73e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661   4 TGSGFESQLIYGSGYFNVRIKAPQTTSTGVITSFYLISRSSRHDELCFQILGK-NGPPYLLNTNMYLYGEGGKDQRFRLW 82
Cdd:PLN03161   57 SGSGIKSKRAFLFGSIEMLIKLVPGNSAGTVTAYYLSSTGSRHDEIDFEFLGNvSGQPYTIHTNIYTQGNGSREQQFRPW 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661  83 FDPTKDYHSYSFLWNPNQLVFYVDDTPIRVYS--KNPDVYYPSVQTMFLMGSVQNGS---------IIDPKQMPYIAKFQ 151
Cdd:PLN03161  137 FDPTADFHNYTIHWNPSEVVWYVDGTPIRVFRnyENEGIAYPNKQGMRVYSSLWNADnwatqggrvKIDWTLAPFVARGR 216

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661 152 ASKIEGCKTE-FMGIDKCTD--PKFWWNR---KQLSSKEKTLYLNARKTYLDYDYCSDRQRYP-KVPQEC 214
Cdd:PLN03161  217 RFRARACKWNgPVSIKQCADptPSNWWTSpsySQLTNAQLTQMKKVRDNFMIYDYCKDTKRFNgVMPPEC 286
Glyco_hydro_16 pfam00722
Glycosyl hydrolases family 16;
4-137 3.41e-38

Glycosyl hydrolases family 16;


Pssm-ID: 395585 [Multi-domain]  Cd Length: 168  Bit Score: 130.02  E-value: 3.41e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661   4 TGSGFESQLIYGSGYFNVRIKAPqtTSTGVITSFYLISRS-SRHDELCFQILGKNgpPYLLNTNMYLYGEGGKD-QRFRL 81
Cdd:pfam00722  21 TGSGFQSKFYYLYGKVEARIKAA--RGAGVVTAFYLSSEDwDDHDEIDFEFLGND--TGQVQTNVYGNGKGNRGeQRFSL 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063715661  82 WFDPTKDYHSYSFLWNPNQLVFYVDDTPIRVYSKNPD--VYYPSvQTMFLMGSVQNGS 137
Cdd:pfam00722  97 WFDPTADFHTYSILWNPDKITWYVDGVPVRTLKNNDAggVPYPQ-TPMRLYVSLWPGG 153
BglS COG2273
Beta-glucanase, GH16 family [Carbohydrate transport and metabolism];
17-130 5.03e-11

Beta-glucanase, GH16 family [Carbohydrate transport and metabolism];


Pssm-ID: 441874 [Multi-domain]  Cd Length: 259  Bit Score: 60.39  E-value: 5.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661  17 GYFNVRIKAPQTTstGVITSFYLISRSS-----RHDELCFQ-ILGKNgpPYLLNTNMYLYGEGGKDQR---FRLWFDPTK 87
Cdd:COG2273   108 GRFEARAKLPKGQ--GLWPAFWMLGGDIdggwpASGEIDIMeFVGKD--PNKVHGNVHYGGYNGGEGIgasYDLPFDASD 183

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1063715661  88 DYHSYSFLWNPNQLVFYVDDTPIRVYSkNPDVYYPSV--QTMFLM 130
Cdd:COG2273   184 DFHTYAVEWTPDSIRWYVDGVLVHTVT-PADVGGPWPfdQPFYLI 227
 
Name Accession Description Interval E-value
GH16_XET cd02176
Xyloglucan endotransglycosylase, member of glycosyl hydrolase family 16; Xyloglucan ...
 4-214 6.31e-79

Xyloglucan endotransglycosylase, member of glycosyl hydrolase family 16; Xyloglucan endotransglycosylases (XETs) cleave and religate xyloglucan polymers in plant cell walls via a transglycosylation mechanism. Xyloglucan is a soluble hemicellulose with a backbone of beta-1,4-linked glucose units, partially substituted with alpha-1,6-linked xylopyranose branches. It binds noncovalently to cellulose, cross-linking the adjacent cellulose microfibrils, giving it a key structural role as a matrix polymer. Therefore, XET plays an important role in all plant processes that require cell wall remodeling.


Pssm-ID: 185685 [Multi-domain]  Cd Length: 263  Bit Score: 237.10  E-value: 6.31e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661   4 TGSGFESQLIYGSGYFNVRIKAPQTTSTGVITSFYLISR-SSRHDELCFQILG-KNGPPYLLNTNMYLYGEGGKDQRFRL 81
Cdd:cd02176    36 SGSGFKSKNKYLFGFFSMRIKLPPGDSAGTVTAFYLSSQgPDNHDEIDFEFLGnVTGQPYTLQTNVFANGVGGREQRIYL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661  82 WFDPTKDYHSYSFLWNPNQLVFYVDDTPIRVYSKN--PDVYYPSVQTMFLMGSVQNGSI---------IDPKQMPYIAKF 150
Cdd:cd02176   116 WFDPTADFHTYSILWNPHQIVFYVDDVPIRVFKNNeaLGVPYPSSQPMGVYASIWDGSDwatqggrvkIDWSYAPFVASY 195

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661 151 QASKIEGCKTEfmGIDK---CTDPKFWWNRK---QLSSKEKTLYLNARKTYLDYDYCSDRQRYPKVPQEC 214
Cdd:cd02176   196 RDFKLDGCVVD--PGDSfssCSCTEDWWNGStyqQLSANQQRAMEWVRRNYMVYDYCDDRKRYPVPPPEC 263
PLN03161 PLN03161
Probable xyloglucan endotransglucosylase/hydrolase protein; Provisional
 4-214 9.73e-45

Probable xyloglucan endotransglucosylase/hydrolase protein; Provisional


Pssm-ID: 178706 [Multi-domain]  Cd Length: 291  Bit Score: 150.82  E-value: 9.73e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661   4 TGSGFESQLIYGSGYFNVRIKAPQTTSTGVITSFYLISRSSRHDELCFQILGK-NGPPYLLNTNMYLYGEGGKDQRFRLW 82
Cdd:PLN03161   57 SGSGIKSKRAFLFGSIEMLIKLVPGNSAGTVTAYYLSSTGSRHDEIDFEFLGNvSGQPYTIHTNIYTQGNGSREQQFRPW 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661  83 FDPTKDYHSYSFLWNPNQLVFYVDDTPIRVYS--KNPDVYYPSVQTMFLMGSVQNGS---------IIDPKQMPYIAKFQ 151
Cdd:PLN03161  137 FDPTADFHNYTIHWNPSEVVWYVDGTPIRVFRnyENEGIAYPNKQGMRVYSSLWNADnwatqggrvKIDWTLAPFVARGR 216

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661 152 ASKIEGCKTE-FMGIDKCTD--PKFWWNR---KQLSSKEKTLYLNARKTYLDYDYCSDRQRYP-KVPQEC 214
Cdd:PLN03161  217 RFRARACKWNgPVSIKQCADptPSNWWTSpsySQLTNAQLTQMKKVRDNFMIYDYCKDTKRFNgVMPPEC 286
Glyco_hydro_16 pfam00722
Glycosyl hydrolases family 16;
4-137 3.41e-38

Glycosyl hydrolases family 16;


Pssm-ID: 395585 [Multi-domain]  Cd Length: 168  Bit Score: 130.02  E-value: 3.41e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661   4 TGSGFESQLIYGSGYFNVRIKAPqtTSTGVITSFYLISRS-SRHDELCFQILGKNgpPYLLNTNMYLYGEGGKD-QRFRL 81
Cdd:pfam00722  21 TGSGFQSKFYYLYGKVEARIKAA--RGAGVVTAFYLSSEDwDDHDEIDFEFLGND--TGQVQTNVYGNGKGNRGeQRFSL 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063715661  82 WFDPTKDYHSYSFLWNPNQLVFYVDDTPIRVYSKNPD--VYYPSvQTMFLMGSVQNGS 137
Cdd:pfam00722  97 WFDPTADFHTYSILWNPDKITWYVDGVPVRTLKNNDAggVPYPQ-TPMRLYVSLWPGG 153
Glyco_hydrolase_16 cd00413
glycosyl hydrolase family 16; The O-Glycosyl hydrolases are a widespread group of enzymes that ...
 4-127 5.55e-18

glycosyl hydrolase family 16; The O-Glycosyl hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A glycosyl hydrolase classification system based on sequence similarity has led to the definition of more than 95 different families inlcuding glycosyl hydrolase family 16. Family 16 includes lichenase, xyloglucan endotransglycosylase (XET), beta-agarase, kappa-carrageenase, endo-beta-1,3-glucanase, endo-beta-1,3-1,4-glucanase, and endo-beta-galactosidase, all of which have a conserved jelly roll fold with a deep active site channel harboring the catalytic residues.


Pssm-ID: 185683 [Multi-domain]  Cd Length: 210  Bit Score: 78.63  E-value: 5.55e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661   4 TGSGFESQLI-YGSGYFNVRIKAPQttSTGVITSFYLIS---RSSRHDELCFQILGKNGPPYLLNTNMYLYGEGGK---D 76
Cdd:cd00413    54 SSAEIDSQKNnYTYGYYEARAKLAG--GPGAVSAFWTYSdddDPPDGGEIDIEFLGRDPTTVQTNVHWPGYGAGATtgeE 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063715661  77 QRFRLWFDPTKDYHSYSFLWNPNQLVFYVDDTPIRVYSKN-PDvyYPSVQTM 127
Cdd:cd00413   132 KSVHLPFDPADDFHTYRVDWTPGEITFYVDGVLVATITNQvPD--DPMNIIL 181
GH16_lichenase cd02175
lichenase, member of glycosyl hydrolase family 16; Lichenase, also known as 1,3-1, ...
 4-140 3.15e-16

lichenase, member of glycosyl hydrolase family 16; Lichenase, also known as 1,3-1,4-beta-glucanase, is a member of glycosyl hydrolase family 16, that specifically cleaves 1,4-beta-D-glucosidic bonds in mixed-linked beta glucans that also contain 1,3-beta-D-glucosidic linkages. Natural substrates of beta-glucanase are beta-glucans from grain endosperm cell walls or lichenan from the Islandic moss, Cetraria islandica. This protein is found not only in bacteria but also in anaerobic fungi. This domain includes two seven-stranded antiparallel beta-sheets that are adjacent to one another forming a compact, jellyroll beta-sandwich structure.


Pssm-ID: 185684 [Multi-domain]  Cd Length: 212  Bit Score: 73.84  E-value: 3.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661   4 TGSGFESQLIYGSGYFNVRIKAPQttSTGVITSFYLISRSS---RHDELCFQILGKNgpPYLLNTNMYLYGEGGKDQRFR 80
Cdd:cd02175    56 ACGEYRTRGFYGYGRYEVRMKPAK--GSGVVSSFFTYTGPYdgdPHDEIDIEFLGKD--TTKVQFNYYTNGVGGHEKLID 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063715661  81 LWFDPTKDYHSYSFLWNPNQLVFYVDDTPI-RVYSKNPDVyypSVQTMFLMGSVQNGSIID 140
Cdd:cd02175   132 LGFDASEGFHTYAFEWEPDSIRWYVDGELVhEATATDPNI---PDTPGKIMMNLWPGDGVD 189
BglS COG2273
Beta-glucanase, GH16 family [Carbohydrate transport and metabolism];
17-130 5.03e-11

Beta-glucanase, GH16 family [Carbohydrate transport and metabolism];


Pssm-ID: 441874 [Multi-domain]  Cd Length: 259  Bit Score: 60.39  E-value: 5.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661  17 GYFNVRIKAPQTTstGVITSFYLISRSS-----RHDELCFQ-ILGKNgpPYLLNTNMYLYGEGGKDQR---FRLWFDPTK 87
Cdd:COG2273   108 GRFEARAKLPKGQ--GLWPAFWMLGGDIdggwpASGEIDIMeFVGKD--PNKVHGNVHYGGYNGGEGIgasYDLPFDASD 183

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1063715661  88 DYHSYSFLWNPNQLVFYVDDTPIRVYSkNPDVYYPSV--QTMFLM 130
Cdd:COG2273   184 DFHTYAVEWTPDSIRWYVDGVLVHTVT-PADVGGPWPfdQPFYLI 227
XET_C pfam06955
Xyloglucan endo-transglycosylase (XET) C-terminus; This family represents the C-terminus ...
 171-214 1.46e-09

Xyloglucan endo-transglycosylase (XET) C-terminus; This family represents the C-terminus (approximately 60 residues) of plant xyloglucan endo-transglycosylase (XET). Xyloglucan is the predominant hemicellulose in the cell walls of most dicotyledons. With cellulose, it forms a network that strengthens the cell wall. XET catalyzes the splitting of xyloglucan chains and the linking of the newly generated reducing end to the non-reducing end of another xyloglucan chain, thereby loosening the cell wall. Note that all family members contain the pfam00722 domain.


Pssm-ID: 429210 [Multi-domain]  Cd Length: 48  Bit Score: 51.90  E-value: 1.46e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1063715661 171 PKFWWNRK--QLSSKEKTLYLNARKTYLDYDYCSDRQRYPKVPQ-EC 214
Cdd:pfam06955   2 SSSWWNKAyqQLDPEQRRAMKWVRKNYMIYDYCTDTKRFPQGPPpEC 48
GH16_fungal_CRH1_transglycosylase cd02183
glycosylphosphatidylinositol-glucanosyltransferase; Group of fungal GH16 members related to ...
 17-148 9.57e-09

glycosylphosphatidylinositol-glucanosyltransferase; Group of fungal GH16 members related to Saccharomyces cerevisiae Crh1p. Chr1p and Crh2p are transglycosylases that are required for the linkage of chitin to beta(1-3)glucose branches of beta(1-6)glucan, an important step in the assembly of new cell wall. Both have been shown to be glycosylphosphatidylinositol (GPI)-anchored. A third homologous protein, Crr1p, functions in the formation of the spore wall. They belongs to the family 16 of glycosyl hydrolases that includes lichenase, xyloglucan endotransglycosylase (XET), beta-agarase, kappa-carrageenase, endo-beta-1,3-glucanase, endo-beta-1,3-1,4-glucanase, and endo-beta-galactosidase, all of which have a conserved jelly roll fold with a deep active site channel harboring the catalytic residues.


Pssm-ID: 185692 [Multi-domain]  Cd Length: 203  Bit Score: 53.32  E-value: 9.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661  17 GYFNVRIKApqTTSTGVITSFYLISrsSRHDELCFQILGKNgpPYLLNTNMY------LYGEGGKdqrFRLWFDPTKDYH 90
Cdd:cd02183    48 GKVEVTMKA--APGQGIVSSFVLQS--DDLDEIDWEWVGGD--LTQVQTNYFgkgnttTYDRGGY---HPVPNPQTEEFH 118

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063715661  91 SYSFLWNPNQLVFYVDDTPIRVYSKNPDVY---YPsvQT-MFLM------GSVQN--------GSIIDPKQMPYIA 148
Cdd:cd02183   119 TYTIDWTKDRITWYIDGKVVRTLTKADTTGgygYP--QTpMRLQigiwagGDPSNapgtiewaGGETDYDKGPFTM 192
GH16_laminarinase_like cd08023
Laminarinase, member of the glycosyl hydrolase family 16; Laminarinase, also known as glucan ...
 88-117 2.10e-04

Laminarinase, member of the glycosyl hydrolase family 16; Laminarinase, also known as glucan endo-1,3-beta-D-glucosidase, is a glycosyl hydrolase family 16 member that hydrolyzes 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans such as laminarins, curdlans, paramylons, and pachymans, with very limited action on mixed-link (1,3-1,4-)-beta-D-glucans.


Pssm-ID: 185693 [Multi-domain]  Cd Length: 235  Bit Score: 41.07  E-value: 2.10e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1063715661  88 DYHSYSFLWNPNQLVFYVDDTPIRVYSKNP 117
Cdd:cd08023   159 DFHTYAVEWTPDKITFYVDGKLYFTYTNPN 188
GH16_beta_agarase cd02178
Beta-agarase, member of glycosyl hydrolase family 16; Beta-agarase is a glycosyl hydrolase ...
 17-120 9.41e-03

Beta-agarase, member of glycosyl hydrolase family 16; Beta-agarase is a glycosyl hydrolase family 16 (GH16) member that hydrolyzes the internal beta-1,4-linkage of agarose, a hydrophilic polysaccharide found in the cell wall of Rhodophyceaea, marine red algae. Agarose is a linear chain of galactose units linked by alternating L-alpha-1,3- and D-beta-1,4-linkages that are additionally modified by a 3,6-anhydro-bridge. Agarose forms thermo-reversible gels that are widely used in the food industry or as a laboratory medium. While beta-agarases are also found in two other families derived from the sequence-based classification of glycosyl hydrolases (GH50, and GH86) the GH16 members are most abundant. This domain adopts a curved beta-sandwich conformation, with a tunnel-shaped active site cavity, referred to as a jellyroll fold.


Pssm-ID: 185687  Cd Length: 258  Bit Score: 36.17  E-value: 9.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715661  17 GYFNVRIKAPQTTSTgviTSFYLISRSSRH-DEL-CFQILGKNGPPYL---LNTNMYLY-----GEGGKDQRFRLWFDPT 86
Cdd:cd02178    99 GYFEARAKASNLPMS---SAFWLLSDTKDStTEIdILEHYGGDREEWFatrMNSNTHVFirdpeQDYQPKDDGSWYYNPT 175

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1063715661  87 ---KDYHSYSFLWN-PNQLVFYVDDTPIRVySKNPDVY 120
Cdd:cd02178   176 elaDDFHVYGVYWKdPDTIRFYIDGVLVRT-VENSEIT 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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