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Conserved domains on  [gi|1063715450|ref|NP_001327111|]
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HNH endonuclease [Arabidopsis thaliana]

Protein Classification

HNH endonuclease signature motif containing protein( domain architecture ID 10052677)

HNH endonuclease signature motif containing protein which may catalyze the hydrolysis of DNA

EC:  3.-.-.-
Gene Ontology:  GO:0004519|GO:0003676|GO:0008270

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
162-203 3.38e-04

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


:

Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 37.45  E-value: 3.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1063715450 162 IVFRKLVGCPGCLCH------DYDHIVPYSKGGKSTLENCQVLqvCSH 203
Cdd:cd00085     6 VLLARDGLCPYCGKPggteglEVDHIIPLSDGGNNDLDNLVLL--CRK 51
 
Name Accession Description Interval E-value
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
162-203 3.38e-04

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 37.45  E-value: 3.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1063715450 162 IVFRKLVGCPGCLCH------DYDHIVPYSKGGKSTLENCQVLqvCSH 203
Cdd:cd00085     6 VLLARDGLCPYCGKPggteglEVDHIIPLSDGGNNDLDNLVLL--CRK 51
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
176-203 5.20e-04

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 37.27  E-value: 5.20e-04
                          10        20
                  ....*....|....*....|....*...
gi 1063715450 176 HDYDHIVPYSKGGKSTLENCQVLqvCSH 203
Cdd:COG1403    34 LEVDHIIPRSRGGTDTWENLVLL--CRR 59
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
170-203 1.81e-03

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 35.02  E-value: 1.81e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1063715450 170 CPGCLCHDY-------DHIVPYSKGGKSTLENCQVLqvCSH 203
Cdd:pfam01844   1 CQYCGRPFHisdaltvDHIIPLSDGGADDIENLILL--CPS 39
HNHc smart00507
HNH nucleases;
161-198 2.36e-03

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 35.13  E-value: 2.36e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1063715450  161 NIVFRKLVGCPGCLCH-----DYDHIVPYSKGGKSTLENCQVL 198
Cdd:smart00507   4 RLLLHRDGVCAYCGKPaseglEVDHIIPLSDGGNDDLDNLVLL 46
 
Name Accession Description Interval E-value
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
162-203 3.38e-04

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 37.45  E-value: 3.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1063715450 162 IVFRKLVGCPGCLCH------DYDHIVPYSKGGKSTLENCQVLqvCSH 203
Cdd:cd00085     6 VLLARDGLCPYCGKPggteglEVDHIIPLSDGGNNDLDNLVLL--CRK 51
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
176-203 5.20e-04

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 37.27  E-value: 5.20e-04
                          10        20
                  ....*....|....*....|....*...
gi 1063715450 176 HDYDHIVPYSKGGKSTLENCQVLqvCSH 203
Cdd:COG1403    34 LEVDHIIPRSRGGTDTWENLVLL--CRR 59
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
170-203 1.81e-03

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 35.02  E-value: 1.81e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1063715450 170 CPGCLCHDY-------DHIVPYSKGGKSTLENCQVLqvCSH 203
Cdd:pfam01844   1 CQYCGRPFHisdaltvDHIIPLSDGGADDIENLILL--CPS 39
HNHc smart00507
HNH nucleases;
161-198 2.36e-03

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 35.13  E-value: 2.36e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1063715450  161 NIVFRKLVGCPGCLCH-----DYDHIVPYSKGGKSTLENCQVL 198
Cdd:smart00507   4 RLLLHRDGVCAYCGKPaseglEVDHIIPLSDGGNDDLDNLVLL 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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