COMPLEX 1 LYR-like protein [Arabidopsis thaliana]
Protein Classification
LYR motif-containing protein( domain architecture ID 14448712)
LYR (leucine-tyrosine-arginine) motif-containing protein may play a key role in the assembly and function of complexes I, II, and III; LYR motifs are molecular signatures of specific recipient Fe-S proteins or accessory factors that assist Fe-S cluster delivery
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Complex1_LYR_SF | cd20251 | LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The ... |
16-73 | 6.18e-18 | ||
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism. : Pssm-ID: 380755 Cd Length: 57 Bit Score: 70.27 E-value: 6.18e-18
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| Name | Accession | Description | Interval | E-value | ||
| Complex1_LYR_SF | cd20251 | LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The ... |
16-73 | 6.18e-18 | ||
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism. Pssm-ID: 380755 Cd Length: 57 Bit Score: 70.27 E-value: 6.18e-18
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| Complex1_LYR | pfam05347 | Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ... |
16-71 | 3.35e-07 | ||
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins. Pssm-ID: 428432 Cd Length: 59 Bit Score: 42.95 E-value: 3.35e-07
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| Name | Accession | Description | Interval | E-value | ||
| Complex1_LYR_SF | cd20251 | LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The ... |
16-73 | 6.18e-18 | ||
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism. Pssm-ID: 380755 Cd Length: 57 Bit Score: 70.27 E-value: 6.18e-18
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| Complex1_LYR | pfam05347 | Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ... |
16-71 | 3.35e-07 | ||
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins. Pssm-ID: 428432 Cd Length: 59 Bit Score: 42.95 E-value: 3.35e-07
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| Complex1_LYR_LYRM1 | cd20261 | LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and ... |
16-67 | 5.83e-06 | ||
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins; LYR motif-containing protein 1 (LYRM1) may promote cell proliferation and inhibition of apoptosis of preadipocytes. Overexpression of the human LYRM1 causes mitochondrial dysfunction and induces insulin resistance in 3T3-L1 adipocytes. LYRM1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380756 Cd Length: 70 Bit Score: 40.30 E-value: 5.83e-06
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| Complex1_LYR_LYRM9 | cd20269 | LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 9 (LYRM9) and ... |
16-63 | 3.18e-05 | ||
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 9 (LYRM9) and similar proteins; LYRM9 is an uncharacterized LYR motif-containing protein that belongs to the Complex1_LYR-like superfamily which consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380764 Cd Length: 60 Bit Score: 37.99 E-value: 3.18e-05
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| Complex1_LYR_LYRM2 | cd20262 | LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 2 (LYRM2) and ... |
16-61 | 5.67e-05 | ||
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 2 (LYRM2) and similar proteins; LYRM2 is an uncharacterized LYR motif-containing protein that belongs to the Complex1_LYR-like superfamily which consists of proteins of diverse functions that are exclusively found in eukaryotes; these proteins contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380757 Cd Length: 63 Bit Score: 37.52 E-value: 5.67e-05
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| Complex1_LYR_LYRM7 | cd20267 | LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and ... |
16-63 | 2.43e-04 | ||
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and similar proteins; LYRM7 is an assembly factor required for Rieske iron sulfur (Fe-S) protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. It functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. LYRM7 mutations cause a multifocal cavitating leukoencephalopathy with a distinct and recognizable magnetic resonance imaging (MRI) pattern. LYRM7 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380762 Cd Length: 72 Bit Score: 36.00 E-value: 2.43e-04
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| Complex1_LYR_NDUFB9_LYRM3 | cd20263 | LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta ... |
16-67 | 4.68e-04 | ||
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) and similar proteins; NDUFB9, also called LYR motif-containing protein 3 (LYRM3), or Complex I-B22 (CI-B22), or NADH-ubiquinone oxidoreductase B22 subunit (UQOR22), is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFB9 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380758 Cd Length: 77 Bit Score: 35.23 E-value: 4.68e-04
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| Complex1_LYR_MIEF1-MP | cd20272 | LYR (leucine-tyrosine-arginine) motif found in mitochondrial elongation factor 1 microprotein ... |
16-63 | 5.20e-04 | ||
LYR (leucine-tyrosine-arginine) motif found in mitochondrial elongation factor 1 microprotein (MIEF1-MP) and similar proteins; MIEF1-MP, also called alternative mitochondrial elongation factor 1 (MIEF1) protein (AltMIEF1), or MIEF1 upstream open reading frame protein, is involved in the regulation of mitochondrial fission mediated by dynamin-1-like protein (DNM1L). It positively regulates mitochondrial translation. MIEF1-MP belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380767 Cd Length: 58 Bit Score: 34.94 E-value: 5.20e-04
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| Complex1_LYR_LYRM4 | cd20264 | LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and ... |
16-67 | 7.09e-03 | ||
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and similar proteins; LYRM4, also called ISD11, is a eukaryote-specific component of the mitochondrial biogenesis of Fe-S clusters which are essential cofactors in multiple processes, including oxidative phosphorylation. It is required for nuclear and mitochondrial iron-sulfur protein biosynthesis by forming a complex with, and stabilizing, the sulfur donor NFS1. LYRM4 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380759 Cd Length: 69 Bit Score: 32.11 E-value: 7.09e-03
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