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Conserved domains on  [gi|1063732473|ref|NP_001331467|]
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disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03210 super family cl33662
Resistant to P. syringae 6; Provisional
 16-869 0e+00

Resistant to P. syringae 6; Provisional


The actual alignment was detected with superfamily member PLN03210:

Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 727.05  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473   16 WKTDVFVSFRGEDVRKTFVSHLFCEFDRMGIKAFRDDlDLQRGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLK 95
Cdd:PLN03210    11 WVYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDN-EIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNELLE 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473   96 IMECNKD---TIVPIFYEVDPSDVRRQRGSFGEDVES--HSDKEKVGK-WKEALKKLAAISGEDSRNWRDDSKLIKKIVK 169
Cdd:PLN03210    90 IVRCKEElgqLVIPVFYGLDPSHVRKQTGDFGEAFEKtcQNKTEDEKIqWKQALTDVANILGYHSQNWPNEAKMIEEIAN 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  170 DISDKLVSTSWDDSKGLIGMSSHMDFLQSMISIVDKDVRMLGIWGMGGVGKTTIAKYLYNQLSGQFQVHCFMENV----- 244
Cdd:PLN03210   170 DVLGKLNLTPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAfisks 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  245 KEVCNR-----YGVR-RLQVEFLCRMFQERDKEawssVSCCNIIKERFRHKMVFIVLDDVDRSEQLNELVKETGWFGPGS 318
Cdd:PLN03210   250 MEIYSSanpddYNMKlHLQRAFLSEILDKKDIK----IYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGS 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  319 RIIVTTRDRHLLLSHGINLVYKVkCLPKKE-ALQLFCNYAFREEIIlPHGFEELSVQAVNYASGLPLALRVLGSFLYRRS 397
Cdd:PLN03210   326 RIIVITKDKHFLRAHGIDHIYEV-CLPSNElALEMFCRSAFKKNSP-PDGFMELASEVALRAGNLPLGLNVLGSYLRGRD 403

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  398 QIEWESTLARLKTYPHSDIMEVLRVSYDGL-DEQEKAIFLYISCFYNMKQVDYVRKLLDLCGYAAEIGITILTEKSLIVE 476
Cdd:PLN03210   404 KEDWMDMLPRLRNGLDGKIEKTLRVSYDGLnNKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLIHV 483

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  477 SNGCVKIHDLLEQMGRELVRQQAvNNPAQRLLLWDPEDICHLLSENSGTQLVEGISLNLSEISEVFASDRAFEGLSNLKL 556
Cdd:PLN03210   484 REDIVEMHSLLQEMGKEIVRAQS-NEPGEREFLVDAKDICDVLEDNTGTKKVLGITLDIDEIDELHIHENAFKGMRNLLF 562

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  557 LNFYDLSFD--GETRVHLPNGLSYLPRKLRYLRWDGYPLKTMPSRFFPEFLVELCMSNSNLEKLWDGIQPLRNLKKMDLS 634
Cdd:PLN03210   563 LKFYTKKWDqkKEVRWHLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLR 642

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  635 RCKYLVEVPDLSKATNLEELNLSYCQSLVEVTPSIKNLKGLSCFYLTNCIQLKDIPIGIILKSLETVGMSGCSSLKHFPE 714
Cdd:PLN03210   643 GSKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEILPTGINLKSLYRLNLSGCSRLKSFPD 722

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  715 ISWNTRRLYLSSTKIEELPSSIsRLSCLVKLDM-------------------------------SDCQRLRTLPSYLGHL 763
Cdd:PLN03210   723 ISTNISWLDLDETAIEEFPSNL-RLENLDELILcemkseklwervqpltplmtmlspsltrlflSDIPSLVELPSSIQNL 801

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  764 VSLKSLNLDGCRRLENLPdTLQNLTSLETLEVSGCLNVNEFPRVSTSIEVLRISETSIEEIPARICNLSQLRSLDISENK 843
Cdd:PLN03210   802 HKLEHLEIENCINLETLP-TGINLESLESLDLSGCSRLRTFPDISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGCN 880

                          890       900
                   ....*....|....*....|....*.
gi 1063732473  844 RLASLPVSISELRSLEKLKLSGCSVL 869
Cdd:PLN03210   881 NLQRVSLNISKLKHLETVDFSDCGAL 906
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
763-1040 1.92e-32

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.59  E-value: 1.92e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  763 LVSLKSLNLDGCRRLENLPDTLQNLTSLETLEVSGCLNVNEFprvsTSIEVLRISETSIEEIPARICNLSQLRSLDISEN 842
Cdd:COG4886     71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNN 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  843 KrLASLPVSISELRSLEKLKLSGCSvLESFPLEICQtMSCLRWFDLDRTSIKELPENIGNLVALEVLQASRTVIRRAPWS 922
Cdd:COG4886    147 Q-LTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGN-LTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP 223

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  923 IARLTRLQVLAIGNSFFTPegllhslCPPLSRFDDLRALSLSNMNMTEIPNSiGNLWNLLELDLSGNNFEFIpaSIKRLT 1002
Cdd:COG4886    224 LANLTNLETLDLSNNQLTD-------LPELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDL--KLKELE 293

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1063732473 1003 RLNRLNLNNCQRLQALPDELPRGLLYIYIHSCTSLVSI 1040
Cdd:COG4886    294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
C-JID super family cl45530
C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron ...
 1084-1219 1.51e-09

C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron microscopy (cryoEM) structures of plant intracellular immune receptors containing Toll/interleukin-1 receptor (TIR, PF01582), nucleotide-binding (NB-ARC, PF00931) and leucine-rich repeat (LRR) domains (TIR-NLRs). Structurally, the C-JID core is represented by a beta-sandwich made up of 8 to 9 beta-strands. C-JID matches the so-called post LRR domain originally detected via a set of MEME motifs. The domain showed a strong distribution bias towards TIR-NLRs of dicotyledonous plant species despite broader taxonomic distribution of TIR-NLR in plant groups. Structure-function analyses of cryoEM structures suggest that C-JID domains play a role in substrate-recognition, such as binding to effector proteins from pathogens, and thus are involved in the initiation of signaling by TIR-NLR receptors. Presence of C-JID (or post-LRR) and its importance for the function of Arabidopsis TIR-NLR RPS4 that partners with RRS1 for effector recognition suggest that C-JID has additional functions.


The actual alignment was detected with superfamily member pfam20160:

Pssm-ID: 466313  Cd Length: 108  Bit Score: 56.69  E-value: 1.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473 1084 FPGSDIPTCFNHQVMGPSLNIQLPQSESSSDILGFSACIMIGvdgqyPMNNLKIHCSCIlkdadaCELVVMDEVWYPDPK 1163
Cdd:pfam20160    1 LPGSQIPEWFNHQSTGSSISIKLPENWYNDNFLGFAVCAVGS-----LIPSLHNFLGYI------HFFLIPLVSLWDTSK 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063732473 1164 AftNMYFGSDHLLLfsrtctsmeaysEALFEFSventegdsfSPLGEVKKCAVHLI 1219
Cdd:pfam20160   70 A--NGKTPNDYGRI------------EASFEFP---------SDLHEIKQCGVRLI 102
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 16-869 0e+00

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 727.05  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473   16 WKTDVFVSFRGEDVRKTFVSHLFCEFDRMGIKAFRDDlDLQRGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLK 95
Cdd:PLN03210    11 WVYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDN-EIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNELLE 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473   96 IMECNKD---TIVPIFYEVDPSDVRRQRGSFGEDVES--HSDKEKVGK-WKEALKKLAAISGEDSRNWRDDSKLIKKIVK 169
Cdd:PLN03210    90 IVRCKEElgqLVIPVFYGLDPSHVRKQTGDFGEAFEKtcQNKTEDEKIqWKQALTDVANILGYHSQNWPNEAKMIEEIAN 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  170 DISDKLVSTSWDDSKGLIGMSSHMDFLQSMISIVDKDVRMLGIWGMGGVGKTTIAKYLYNQLSGQFQVHCFMENV----- 244
Cdd:PLN03210   170 DVLGKLNLTPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAfisks 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  245 KEVCNR-----YGVR-RLQVEFLCRMFQERDKEawssVSCCNIIKERFRHKMVFIVLDDVDRSEQLNELVKETGWFGPGS 318
Cdd:PLN03210   250 MEIYSSanpddYNMKlHLQRAFLSEILDKKDIK----IYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGS 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  319 RIIVTTRDRHLLLSHGINLVYKVkCLPKKE-ALQLFCNYAFREEIIlPHGFEELSVQAVNYASGLPLALRVLGSFLYRRS 397
Cdd:PLN03210   326 RIIVITKDKHFLRAHGIDHIYEV-CLPSNElALEMFCRSAFKKNSP-PDGFMELASEVALRAGNLPLGLNVLGSYLRGRD 403

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  398 QIEWESTLARLKTYPHSDIMEVLRVSYDGL-DEQEKAIFLYISCFYNMKQVDYVRKLLDLCGYAAEIGITILTEKSLIVE 476
Cdd:PLN03210   404 KEDWMDMLPRLRNGLDGKIEKTLRVSYDGLnNKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLIHV 483

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  477 SNGCVKIHDLLEQMGRELVRQQAvNNPAQRLLLWDPEDICHLLSENSGTQLVEGISLNLSEISEVFASDRAFEGLSNLKL 556
Cdd:PLN03210   484 REDIVEMHSLLQEMGKEIVRAQS-NEPGEREFLVDAKDICDVLEDNTGTKKVLGITLDIDEIDELHIHENAFKGMRNLLF 562

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  557 LNFYDLSFD--GETRVHLPNGLSYLPRKLRYLRWDGYPLKTMPSRFFPEFLVELCMSNSNLEKLWDGIQPLRNLKKMDLS 634
Cdd:PLN03210   563 LKFYTKKWDqkKEVRWHLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLR 642

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  635 RCKYLVEVPDLSKATNLEELNLSYCQSLVEVTPSIKNLKGLSCFYLTNCIQLKDIPIGIILKSLETVGMSGCSSLKHFPE 714
Cdd:PLN03210   643 GSKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEILPTGINLKSLYRLNLSGCSRLKSFPD 722

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  715 ISWNTRRLYLSSTKIEELPSSIsRLSCLVKLDM-------------------------------SDCQRLRTLPSYLGHL 763
Cdd:PLN03210   723 ISTNISWLDLDETAIEEFPSNL-RLENLDELILcemkseklwervqpltplmtmlspsltrlflSDIPSLVELPSSIQNL 801

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  764 VSLKSLNLDGCRRLENLPdTLQNLTSLETLEVSGCLNVNEFPRVSTSIEVLRISETSIEEIPARICNLSQLRSLDISENK 843
Cdd:PLN03210   802 HKLEHLEIENCINLETLP-TGINLESLESLDLSGCSRLRTFPDISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGCN 880

                          890       900
                   ....*....|....*....|....*.
gi 1063732473  844 RLASLPVSISELRSLEKLKLSGCSVL 869
Cdd:PLN03210   881 NLQRVSLNISKLKHLETVDFSDCGAL 906
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 19-178 9.07e-62

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 207.99  E-value: 9.07e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473   19 DVFVSFRGEDVRKTFVSHLFCEFDRMGIKAFRDDLDLQRGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLKIME 98
Cdd:pfam01582    2 DVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKILE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473   99 CNKD---TIVPIFYEVDPSDVRRQRGSFGEDVESHS---DKEKVGKWKEALKKLAAIsgEDSRNWRDDSKLIKKIVKDIS 172
Cdd:pfam01582   82 CALDlgqKVIPIFYEVDPSDVRKQTGSFGKAFKKHKkvlTEEKVLKWRGALNEVANI--WHSKSVSDESKFWKKIAYDIS 159


                   ....*.
gi 1063732473  173 DKLVST 178
Cdd:pfam01582  160 NKLNGT 165
TIR smart00255
Toll - interleukin 1 - resistance;
19-149 1.12e-34

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 129.37  E-value: 1.12e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473    19 DVFVSFRG-EDVRKTFVSHLFCEFDRMGIKAFRDDLDLqrGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLKIM 97
Cdd:smart00255    3 DVFISYSGkEDVRNEFLSHLLEKLRGYGLCVFIDDFEP--GGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAAL 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473    98 EC----NKDTIVPIFYEVDPSDVRRQRGSFGEDVESH----SDKEKVGKWKEALKKLAAI 149
Cdd:smart00255   81 ENaleeGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNylkwPEDEKEQFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
763-1040 1.92e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.59  E-value: 1.92e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  763 LVSLKSLNLDGCRRLENLPDTLQNLTSLETLEVSGCLNVNEFprvsTSIEVLRISETSIEEIPARICNLSQLRSLDISEN 842
Cdd:COG4886     71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNN 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  843 KrLASLPVSISELRSLEKLKLSGCSvLESFPLEICQtMSCLRWFDLDRTSIKELPENIGNLVALEVLQASRTVIRRAPWS 922
Cdd:COG4886    147 Q-LTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGN-LTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP 223

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  923 IARLTRLQVLAIGNSFFTPegllhslCPPLSRFDDLRALSLSNMNMTEIPNSiGNLWNLLELDLSGNNFEFIpaSIKRLT 1002
Cdd:COG4886    224 LANLTNLETLDLSNNQLTD-------LPELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDL--KLKELE 293

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1063732473 1003 RLNRLNLNNCQRLQALPDELPRGLLYIYIHSCTSLVSI 1040
Cdd:COG4886    294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
603-958 4.72e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.66  E-value: 4.72e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  603 EFLVELCMSNSNLEKLWDGIQPLRNLKKMDLSRCKylvevpDLSKATNLEELNLSYCQsLVEVTPSIKNLKGLSCFYLTN 682
Cdd:COG4886     73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQ-LTDLPEELANLTNLKELDLSN 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  683 CiQLKDIPIGIilksletvgmSGCSSLKHfpeiswntrrLYLSSTKIEELPSSISRLSCLVKLDMSDCQrLRTLPSYLGH 762
Cdd:COG4886    146 N-QLTDLPEPL----------GNLTNLKS----------LDLSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGN 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  763 LVSLKSLNLDGCrRLENLPDTLQNLTSLETLEVSGClNVNEFPRVS--TSIEVLRISETSIEEIPArICNLSQLRSLDIS 840
Cdd:COG4886    204 LTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNN-QLTDLPELGnlTNLEELDLSNNQLTDLPP-LANLTNLKTLDLS 280

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  841 ENkrlaslPVSISELRSLEKLKLSGCSVLESFPLEICQTMSCLRWFDLDRTSIKELPENIGNLVALEVLQASRTVIRRAP 920
Cdd:COG4886    281 NN------QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1063732473  921 WSIARLTRLQVLAIGNSFFTPEGLLHSLCPPLSRFDDL 958
Cdd:COG4886    355 LLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 716-1025 3.42e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.13  E-value: 3.42e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  716 SWNTRRLYLSSTKieeLPSSISR--LSCLVKLDMSDCQRLRTLPSYLGHLVSLKSLNLDGCRRLENLPDTLQNLTSLETL 793
Cdd:PLN00113   117 SSSLRYLNLSNNN---FTGSIPRgsIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFL 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  794 EVSGCLNVNEFPRVSTSIEVLRISETSIE----EIPARICNLSQLRSLDISENKRLASLPVSISELRSLEKLKLSGCSVL 869
Cdd:PLN00113   194 TLASNQLVGQIPRELGQMKSLKWIYLGYNnlsgEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS 273

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  870 ESFPLEICqTMSCLRWFDLDRTSIK-ELPENIGNLVALEVLQA-SRTVIRRAPWSIARLTRLQVLAIGNSFFTPEgllhs 947
Cdd:PLN00113   274 GPIPPSIF-SLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLfSNNFTGKIPVALTSLPRLQVLQLWSNKFSGE----- 347

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  948 LCPPLSRFDDLRALSLSNMNMT-EIPNSIGNLWNLLELDLSGNNFEF-IPASIKRLTRLNRLNLNNcqrlQALPDELPRG 1025
Cdd:PLN00113   348 IPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQD----NSFSGELPSE 423
C-JID pfam20160
C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron ...
 1084-1219 1.51e-09

C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron microscopy (cryoEM) structures of plant intracellular immune receptors containing Toll/interleukin-1 receptor (TIR, PF01582), nucleotide-binding (NB-ARC, PF00931) and leucine-rich repeat (LRR) domains (TIR-NLRs). Structurally, the C-JID core is represented by a beta-sandwich made up of 8 to 9 beta-strands. C-JID matches the so-called post LRR domain originally detected via a set of MEME motifs. The domain showed a strong distribution bias towards TIR-NLRs of dicotyledonous plant species despite broader taxonomic distribution of TIR-NLR in plant groups. Structure-function analyses of cryoEM structures suggest that C-JID domains play a role in substrate-recognition, such as binding to effector proteins from pathogens, and thus are involved in the initiation of signaling by TIR-NLR receptors. Presence of C-JID (or post-LRR) and its importance for the function of Arabidopsis TIR-NLR RPS4 that partners with RRS1 for effector recognition suggest that C-JID has additional functions.


Pssm-ID: 466313  Cd Length: 108  Bit Score: 56.69  E-value: 1.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473 1084 FPGSDIPTCFNHQVMGPSLNIQLPQSESSSDILGFSACIMIGvdgqyPMNNLKIHCSCIlkdadaCELVVMDEVWYPDPK 1163
Cdd:pfam20160    1 LPGSQIPEWFNHQSTGSSISIKLPENWYNDNFLGFAVCAVGS-----LIPSLHNFLGYI------HFFLIPLVSLWDTSK 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063732473 1164 AftNMYFGSDHLLLfsrtctsmeaysEALFEFSventegdsfSPLGEVKKCAVHLI 1219
Cdd:pfam20160   70 A--NGKTPNDYGRI------------EASFEFP---------SDLHEIKQCGVRLI 102
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 703-868 3.35e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 3.35e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  703 MSGCSSLKHfpeiswntrrLYLSSTKIeelpSSISRLSCLVKLDMSDCQ--RLRTLPSyLGHLVSLKSLNLDGCR--RLE 778
Cdd:cd21340     20 LSLCKNLKV----------LYLYDNKI----TKIENLEFLTNLTHLYLQnnQIEKIEN-LENLVNLKKLYLGGNRisVVE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  779 NLpdtlQNLTSLETLEVSG-------CLnvnEF-PR----VSTSIEVLRISETSIEEIpARICNLSQLRSLDISENK--R 844
Cdd:cd21340     85 GL----ENLTNLEELHIENqrlppgeKL---TFdPRslaaLSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQisD 156

                          170       180
                   ....*....|....*....|....
gi 1063732473  845 LASLPVSISELRSLEKLKLSGCSV 868
Cdd:cd21340    157 LEELLDLLSSWPSLRELDLTGNPV 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 855-1012 2.42e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 2.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  855 LRSLEKLKLSGCSvLESFP-LEICQTMSCLRWFDLDRTSIkelpENIGNLVALEVLQASRTVIRRAPwSIARLTRLQVLA 933
Cdd:cd21340      1 LKRITHLYLNDKN-ITKIDnLSLCKNLKVLYLYDNKITKI----ENLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLY 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  934 IG-NSFFTPEGL--------LH----SLCPPLS-RFDD---------LRALSLSNMNMTEIpNSIGNLWNLLELDLSGN- 989
Cdd:cd21340     75 LGgNRISVVEGLenltnleeLHienqRLPPGEKlTFDPrslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNq 153

                          170       180
                   ....*....|....*....|....*
gi 1063732473  990 --NFEFIPASIKRLTRLNRLNLNNC 1012
Cdd:cd21340    154 isDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
958-1013 7.13e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 7.13e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063732473  958 LRALSLSNMNMTEI-PNSIGNLWNLLELDLSGNNFEFI-PASIKRLTRLNRLNLNNCQ 1013
Cdd:pfam13855    3 LRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 16-869 0e+00

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 727.05  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473   16 WKTDVFVSFRGEDVRKTFVSHLFCEFDRMGIKAFRDDlDLQRGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLK 95
Cdd:PLN03210    11 WVYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDN-EIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNELLE 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473   96 IMECNKD---TIVPIFYEVDPSDVRRQRGSFGEDVES--HSDKEKVGK-WKEALKKLAAISGEDSRNWRDDSKLIKKIVK 169
Cdd:PLN03210    90 IVRCKEElgqLVIPVFYGLDPSHVRKQTGDFGEAFEKtcQNKTEDEKIqWKQALTDVANILGYHSQNWPNEAKMIEEIAN 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  170 DISDKLVSTSWDDSKGLIGMSSHMDFLQSMISIVDKDVRMLGIWGMGGVGKTTIAKYLYNQLSGQFQVHCFMENV----- 244
Cdd:PLN03210   170 DVLGKLNLTPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAfisks 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  245 KEVCNR-----YGVR-RLQVEFLCRMFQERDKEawssVSCCNIIKERFRHKMVFIVLDDVDRSEQLNELVKETGWFGPGS 318
Cdd:PLN03210   250 MEIYSSanpddYNMKlHLQRAFLSEILDKKDIK----IYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGS 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  319 RIIVTTRDRHLLLSHGINLVYKVkCLPKKE-ALQLFCNYAFREEIIlPHGFEELSVQAVNYASGLPLALRVLGSFLYRRS 397
Cdd:PLN03210   326 RIIVITKDKHFLRAHGIDHIYEV-CLPSNElALEMFCRSAFKKNSP-PDGFMELASEVALRAGNLPLGLNVLGSYLRGRD 403

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  398 QIEWESTLARLKTYPHSDIMEVLRVSYDGL-DEQEKAIFLYISCFYNMKQVDYVRKLLDLCGYAAEIGITILTEKSLIVE 476
Cdd:PLN03210   404 KEDWMDMLPRLRNGLDGKIEKTLRVSYDGLnNKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLIHV 483

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  477 SNGCVKIHDLLEQMGRELVRQQAvNNPAQRLLLWDPEDICHLLSENSGTQLVEGISLNLSEISEVFASDRAFEGLSNLKL 556
Cdd:PLN03210   484 REDIVEMHSLLQEMGKEIVRAQS-NEPGEREFLVDAKDICDVLEDNTGTKKVLGITLDIDEIDELHIHENAFKGMRNLLF 562

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  557 LNFYDLSFD--GETRVHLPNGLSYLPRKLRYLRWDGYPLKTMPSRFFPEFLVELCMSNSNLEKLWDGIQPLRNLKKMDLS 634
Cdd:PLN03210   563 LKFYTKKWDqkKEVRWHLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLR 642

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  635 RCKYLVEVPDLSKATNLEELNLSYCQSLVEVTPSIKNLKGLSCFYLTNCIQLKDIPIGIILKSLETVGMSGCSSLKHFPE 714
Cdd:PLN03210   643 GSKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEILPTGINLKSLYRLNLSGCSRLKSFPD 722

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  715 ISWNTRRLYLSSTKIEELPSSIsRLSCLVKLDM-------------------------------SDCQRLRTLPSYLGHL 763
Cdd:PLN03210   723 ISTNISWLDLDETAIEEFPSNL-RLENLDELILcemkseklwervqpltplmtmlspsltrlflSDIPSLVELPSSIQNL 801

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  764 VSLKSLNLDGCRRLENLPdTLQNLTSLETLEVSGCLNVNEFPRVSTSIEVLRISETSIEEIPARICNLSQLRSLDISENK 843
Cdd:PLN03210   802 HKLEHLEIENCINLETLP-TGINLESLESLDLSGCSRLRTFPDISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGCN 880

                          890       900
                   ....*....|....*....|....*.
gi 1063732473  844 RLASLPVSISELRSLEKLKLSGCSVL 869
Cdd:PLN03210   881 NLQRVSLNISKLKHLETVDFSDCGAL 906
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 19-178 9.07e-62

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 207.99  E-value: 9.07e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473   19 DVFVSFRGEDVRKTFVSHLFCEFDRMGIKAFRDDLDLQRGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLKIME 98
Cdd:pfam01582    2 DVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKILE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473   99 CNKD---TIVPIFYEVDPSDVRRQRGSFGEDVESHS---DKEKVGKWKEALKKLAAIsgEDSRNWRDDSKLIKKIVKDIS 172
Cdd:pfam01582   82 CALDlgqKVIPIFYEVDPSDVRKQTGSFGKAFKKHKkvlTEEKVLKWRGALNEVANI--WHSKSVSDESKFWKKIAYDIS 159


                   ....*.
gi 1063732473  173 DKLVST 178
Cdd:pfam01582  160 NKLNGT 165
TIR smart00255
Toll - interleukin 1 - resistance;
19-149 1.12e-34

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 129.37  E-value: 1.12e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473    19 DVFVSFRG-EDVRKTFVSHLFCEFDRMGIKAFRDDLDLqrGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLKIM 97
Cdd:smart00255    3 DVFISYSGkEDVRNEFLSHLLEKLRGYGLCVFIDDFEP--GGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAAL 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473    98 EC----NKDTIVPIFYEVDPSDVRRQRGSFGEDVESH----SDKEKVGKWKEALKKLAAI 149
Cdd:smart00255   81 ENaleeGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNylkwPEDEKEQFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
763-1040 1.92e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.59  E-value: 1.92e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  763 LVSLKSLNLDGCRRLENLPDTLQNLTSLETLEVSGCLNVNEFprvsTSIEVLRISETSIEEIPARICNLSQLRSLDISEN 842
Cdd:COG4886     71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNN 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  843 KrLASLPVSISELRSLEKLKLSGCSvLESFPLEICQtMSCLRWFDLDRTSIKELPENIGNLVALEVLQASRTVIRRAPWS 922
Cdd:COG4886    147 Q-LTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGN-LTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP 223

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  923 IARLTRLQVLAIGNSFFTPegllhslCPPLSRFDDLRALSLSNMNMTEIPNSiGNLWNLLELDLSGNNFEFIpaSIKRLT 1002
Cdd:COG4886    224 LANLTNLETLDLSNNQLTD-------LPELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDL--KLKELE 293

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1063732473 1003 RLNRLNLNNCQRLQALPDELPRGLLYIYIHSCTSLVSI 1040
Cdd:COG4886    294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
603-958 4.72e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.66  E-value: 4.72e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  603 EFLVELCMSNSNLEKLWDGIQPLRNLKKMDLSRCKylvevpDLSKATNLEELNLSYCQsLVEVTPSIKNLKGLSCFYLTN 682
Cdd:COG4886     73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQ-LTDLPEELANLTNLKELDLSN 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  683 CiQLKDIPIGIilksletvgmSGCSSLKHfpeiswntrrLYLSSTKIEELPSSISRLSCLVKLDMSDCQrLRTLPSYLGH 762
Cdd:COG4886    146 N-QLTDLPEPL----------GNLTNLKS----------LDLSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGN 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  763 LVSLKSLNLDGCrRLENLPDTLQNLTSLETLEVSGClNVNEFPRVS--TSIEVLRISETSIEEIPArICNLSQLRSLDIS 840
Cdd:COG4886    204 LTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNN-QLTDLPELGnlTNLEELDLSNNQLTDLPP-LANLTNLKTLDLS 280

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  841 ENkrlaslPVSISELRSLEKLKLSGCSVLESFPLEICQTMSCLRWFDLDRTSIKELPENIGNLVALEVLQASRTVIRRAP 920
Cdd:COG4886    281 NN------QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1063732473  921 WSIARLTRLQVLAIGNSFFTPEGLLHSLCPPLSRFDDL 958
Cdd:COG4886    355 LLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
612-986 3.35e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 121.96  E-value: 3.35e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  612 NSNLEKLWDGIQPLRNLKKMDLSRCKYLVEVPDLSKATNLEELNLSYCQSlvevtpsIKNLKGLSCFYLTNCiQLKDIPI 691
Cdd:COG4886     59 DLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGN-QLTDLPE 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  692 GIilksletvgmSGCSSLKHfpeiswntrrLYLSSTKIEELPSSISRLSCLVKLDMSDCQrLRTLPSYLGHLVSLKSLNL 771
Cdd:COG4886    131 EL----------ANLTNLKE----------LDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKELDL 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  772 DGCrRLENLPDTLQNLTSLETLEVSGClNVNEFPRV---STSIEVLRISETSIEEIPArICNLSQLRSLDISENKrLASL 848
Cdd:COG4886    190 SNN-QITDLPEPLGNLTNLEELDLSGN-QLTDLPEPlanLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQ-LTDL 265

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  849 PvSISELRSLEKLKLSGCSvLESFPLEICQTMSCLRWFDLDRTSIKELPENIGNLVALEVLQASRTVIRRAPWSIARLTR 928
Cdd:COG4886    266 P-PLANLTNLKTLDLSNNQ-LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063732473  929 LQVLAIGNSFFTPEGLLHSLCPPLSRFDDLRALSLSNMNMTEIPNSIGNLWNLLELDL 986
Cdd:COG4886    344 LSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
777-1056 3.55e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.94  E-value: 3.55e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  777 LENLPDTLQNLTSLETLEVSGCLNVNEFPRVSTSIEVLRISETSIEEIPARICNLSQLRSLDISENKRLASLPVSISELR 856
Cdd:COG4886     17 LLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  857 SLEKLKLSGCSVLESFpleicqtmSCLRWFDLDRTSIKELPENIGNLVALEVLQASRTVIRRAPWSIARLTRLQVLAIGN 936
Cdd:COG4886     97 NLTELDLSGNEELSNL--------TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSN 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  937 SfftpegLLHSLCPPLSRFDDLRALSLSNMNMTEIPNSIGNLWNLLELDLSGNNFEFIPASIKRLTRLNRLNLNNCQrLQ 1016
Cdd:COG4886    169 N------QLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQ-LT 241

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 1063732473 1017 ALPD--ELPRgLLYIYIHScTSLVSISGCFNQYCLRKLVASN 1056
Cdd:COG4886    242 DLPElgNLTN-LEELDLSN-NQLTDLPPLANLTNLKTLDLSN 281
NB-ARC pfam00931
NB-ARC domain;
206-425 5.06e-21

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 93.60  E-value: 5.06e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  206 DVRMLGIWGMGGVGKTTIAKYLYN---QLSGQFQVHCFMENVKEvcnrYGVRRLQVEFLCRMFQERDKeaWSSVSCCNI- 281
Cdd:pfam00931   17 EPGIVGIHGMGGVGKTTLAAQIFNdfdEVEGHFDSVAWVVVSKT----FTISTLQQTILQNLGLSEDD--WDNKEEGELa 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  282 --IKERFRHKMVFIVLDDVDRSEQLNELVKETGWFGPGSRIIVTTRDRHLLLSHG-INLVYKVKCLPKKEALQLFCNYAF 358
Cdd:pfam00931   91 rkIRRALLTKRFLLVLDDVWDEEDWDKIGIPLPDRENGCRVLLTTRSEEVAGRVGgPSDPHEVELLEPDEAWELFENKVF 170

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063732473  359 REEIILPHGFEELSVQAVNYASGLPLALRVLGSFLYRRSQI-EWE------STLARLKTYPHSDIMEVLRVSYD 425
Cdd:pfam00931  171 PKTLGECELLEDVAKEIVEKCRGLPLALKVLGGLLSCKKTVeEWKhvydvlQSELKSNSYSLNSVRSILQLSYE 244
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 20-115 2.76e-16

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 76.20  E-value: 2.76e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473   20 VFVSFRGEDvrKTFVSHLFCEFDRMGIKAFRDDLDLQRGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLKIMEC 99
Cdd:pfam13676    1 VFISYAGED--RAWAEWLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALAD 78

                           90
                   ....*....|....*...
gi 1063732473  100 --NKDTIVPIFYEVDPSD 115
Cdd:pfam13676   79 peGRKRLIPVRLECDLEL 96
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 716-1025 3.42e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.13  E-value: 3.42e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  716 SWNTRRLYLSSTKieeLPSSISR--LSCLVKLDMSDCQRLRTLPSYLGHLVSLKSLNLDGCRRLENLPDTLQNLTSLETL 793
Cdd:PLN00113   117 SSSLRYLNLSNNN---FTGSIPRgsIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFL 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  794 EVSGCLNVNEFPRVSTSIEVLRISETSIE----EIPARICNLSQLRSLDISENKRLASLPVSISELRSLEKLKLSGCSVL 869
Cdd:PLN00113   194 TLASNQLVGQIPRELGQMKSLKWIYLGYNnlsgEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS 273

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  870 ESFPLEICqTMSCLRWFDLDRTSIK-ELPENIGNLVALEVLQA-SRTVIRRAPWSIARLTRLQVLAIGNSFFTPEgllhs 947
Cdd:PLN00113   274 GPIPPSIF-SLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLfSNNFTGKIPVALTSLPRLQVLQLWSNKFSGE----- 347

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  948 LCPPLSRFDDLRALSLSNMNMT-EIPNSIGNLWNLLELDLSGNNFEF-IPASIKRLTRLNRLNLNNcqrlQALPDELPRG 1025
Cdd:PLN00113   348 IPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQD----NSFSGELPSE 423
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
836-1022 4.37e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 4.37e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  836 SLDISENKRLASLPVSISELRSLEKLKLSGCSVLESFPLEICQTMSCLRWFDLDRTSIKELPENIGNLVALEVLQASRTV 915
Cdd:COG4886      5 LLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSL 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  916 IRRAPWSIARLTRLQVLAIGNsfftpegllhslCPPLSRFDDLRALSLSNMNMTEIPNSIGNLWNLLELDLSGNNFEFIP 995
Cdd:COG4886     85 LLLGLTDLGDLTNLTELDLSG------------NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP 152

                          170       180
                   ....*....|....*....|....*..
gi 1063732473  996 ASIKRLTRLNRLNLNNCQrLQALPDEL 1022
Cdd:COG4886    153 EPLGNLTNLKSLDLSNNQ-LTDLPEEL 178
PLN03194 PLN03194
putative disease resistance protein; Provisional
 19-117 1.88e-13

putative disease resistance protein; Provisional


Pssm-ID: 215626 [Multi-domain]  Cd Length: 187  Bit Score: 70.24  E-value: 1.88e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473   19 DVFVSFRGEDVRKTFVSHLFCEFDRMGIKAFRDDLDLQRGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLKIME 98
Cdd:PLN03194    28 DVFINHRGIDTKRTIATLLYDHLSRLNLRPFLDNKNMKPGDKLFDKINSAIRNCKVGVAVFSPRYCESYFCLHELALIME 107

                           90
                   ....*....|....*....
gi 1063732473   99 cNKDTIVPIFYEVDPSDVR 117
Cdd:PLN03194   108 -SKKRVIPIFCDVKPSQLR 125
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 499-1023 2.81e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 74.88  E-value: 2.81e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  499 AVNNPAQRLLLWDPE-DICH---LLSENSGTqlVEGISLNLSEISEVFASdrAFEGLSNLKLLNFYDLSFDGEtrvhLPN 574
Cdd:PLN00113    40 SINDPLKYLSNWNSSaDVCLwqgITCNNSSR--VVSIDLSGKNISGKISS--AIFRLPYIQTINLSNNQLSGP----IPD 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  575 GLSYLPRKLRYLRWDGYPLK-TMPSRFFPeFLVELCMSNSNLE-KLWDGIQPLRNLKKMDLSRCKYLVEVP-DLSKATNL 651
Cdd:PLN00113   112 DIFTTSSSLRYLNLSNNNFTgSIPRGSIP-NLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIPnSLTNLTSL 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  652 EELNLSYCQSLVEVTPSIKNLKGLSCFYLTNCIQLKDIPIGI----ILKSLETV--GMSGC--SSLKHFPEISWntrrLY 723
Cdd:PLN00113   191 EFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIggltSLNHLDLVynNLTGPipSSLGNLKNLQY----LF 266

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  724 LSSTKIE-ELPSSISRLSCLVKLDMSDCQRLRTLPSYLGHLVSLKSLNLDGCRRLENLPDTLQNLTSLETLEVSGCLNVN 802
Cdd:PLN00113   267 LYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSG 346

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  803 EFPR---VSTSIEVLRISETSIE-EIPARICNLSQLRSLDISENKRLASLPVSISELRSLEKLKLSGCSVLESFPLEICQ 878
Cdd:PLN00113   347 EIPKnlgKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTK 426

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  879 tMSCLRWFDLDRTSIKelpeniGNlvalevlqasrtvIRRAPWSiarLTRLQVLAIG-NSFFtpeGLLhslcPPLSRFDD 957
Cdd:PLN00113   427 -LPLVYFLDISNNNLQ------GR-------------INSRKWD---MPSLQMLSLArNKFF---GGL----PDSFGSKR 476

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063732473  958 LRALSLSNMNMTE-IPNSIGNLWNLLELDLSGNNFE-FIPASIKRLTRLNRLNLNNCQRLQALPD---ELP 1023
Cdd:PLN00113   477 LENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPAsfsEMP 547
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
505-705 7.04e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 7.04e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  505 QRLLLWDPEDICHL-------LSENSGTQLVEGISlNLSEISEVFASD-------RAFEGLSNLKLLNFYDlsfdgetrv 570
Cdd:COG4886     99 TELDLSGNEELSNLtnlesldLSGNQLTDLPEELA-NLTNLKELDLSNnqltdlpEPLGNLTNLKSLDLSN--------- 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  571 hlpNGLSYLPRklrylrwdgyPLKTMPSrffpefLVELCMSNSNLEKLWDGIQPLRNLKKMDLSRCKyLVEVPD-LSKAT 649
Cdd:COG4886    169 ---NQLTDLPE----------ELGNLTN------LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ-LTDLPEpLANLT 228

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063732473  650 NLEELNLSYCQslVEVTPSIKNLKGLSCFYLTNCiQLKDIPIGIILKSLETVGMSG 705
Cdd:COG4886    229 NLETLDLSNNQ--LTDLPELGNLTNLEELDLSNN-QLTDLPPLANLTNLKTLDLSN 281
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
707-923 1.54e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.87  E-value: 1.54e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  707 SSLKHFPE-ISWNTRRLYLSSTKIEELPSSISRLSCLVKLDMSdcqRLRTLPSYLGHlvSLKSLNLdGCRRLENLPDTLQ 785
Cdd:PRK15370   209 NELKSLPEnLQGNIKTLYANSNQLTSIPATLPDTIQEMELSIN---RITELPERLPS--ALQSLDL-FHNKISCLPENLP 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  786 NltSLETLEVSGClNVNEFP-RVSTSIEVLRISETSIEEIPARICnlSQLRSLDISENKrLASLPVSIS-ELRSLEkLKL 863
Cdd:PRK15370   283 E--ELRYLSVYDN-SIRTLPaHLPSGITHLNVQSNSLTALPETLP--PGLKTLEAGENA-LTSLPASLPpELQVLD-VSK 355

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063732473  864 SGCSVL-ESFPLEIcQTMsclrwfDLDRTSIKELPENIGnlVALEVLQASRTVIRRAPWSI 923
Cdd:PRK15370   356 NQITVLpETLPPTI-TTL------DVSRNALTNLPENLP--AALQIMQASRNNLVRLPESL 407
C-JID pfam20160
C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron ...
 1084-1219 1.51e-09

C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron microscopy (cryoEM) structures of plant intracellular immune receptors containing Toll/interleukin-1 receptor (TIR, PF01582), nucleotide-binding (NB-ARC, PF00931) and leucine-rich repeat (LRR) domains (TIR-NLRs). Structurally, the C-JID core is represented by a beta-sandwich made up of 8 to 9 beta-strands. C-JID matches the so-called post LRR domain originally detected via a set of MEME motifs. The domain showed a strong distribution bias towards TIR-NLRs of dicotyledonous plant species despite broader taxonomic distribution of TIR-NLR in plant groups. Structure-function analyses of cryoEM structures suggest that C-JID domains play a role in substrate-recognition, such as binding to effector proteins from pathogens, and thus are involved in the initiation of signaling by TIR-NLR receptors. Presence of C-JID (or post-LRR) and its importance for the function of Arabidopsis TIR-NLR RPS4 that partners with RRS1 for effector recognition suggest that C-JID has additional functions.


Pssm-ID: 466313  Cd Length: 108  Bit Score: 56.69  E-value: 1.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473 1084 FPGSDIPTCFNHQVMGPSLNIQLPQSESSSDILGFSACIMIGvdgqyPMNNLKIHCSCIlkdadaCELVVMDEVWYPDPK 1163
Cdd:pfam20160    1 LPGSQIPEWFNHQSTGSSISIKLPENWYNDNFLGFAVCAVGS-----LIPSLHNFLGYI------HFFLIPLVSLWDTSK 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063732473 1164 AftNMYFGSDHLLLfsrtctsmeaysEALFEFSventegdsfSPLGEVKKCAVHLI 1219
Cdd:pfam20160   70 A--NGKTPNDYGRI------------EASFEFP---------SDLHEIKQCGVRLI 102
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 703-868 3.35e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 3.35e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  703 MSGCSSLKHfpeiswntrrLYLSSTKIeelpSSISRLSCLVKLDMSDCQ--RLRTLPSyLGHLVSLKSLNLDGCR--RLE 778
Cdd:cd21340     20 LSLCKNLKV----------LYLYDNKI----TKIENLEFLTNLTHLYLQnnQIEKIEN-LENLVNLKKLYLGGNRisVVE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  779 NLpdtlQNLTSLETLEVSG-------CLnvnEF-PR----VSTSIEVLRISETSIEEIpARICNLSQLRSLDISENK--R 844
Cdd:cd21340     85 GL----ENLTNLEELHIENqrlppgeKL---TFdPRslaaLSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQisD 156

                          170       180
                   ....*....|....*....|....
gi 1063732473  845 LASLPVSISELRSLEKLKLSGCSV 868
Cdd:cd21340    157 LEELLDLLSSWPSLRELDLTGNPV 180
COG4916 COG4916
Uncharacterized conserved protein [Function unknown];
19-169 5.35e-08

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443944 [Multi-domain]  Cd Length: 236  Bit Score: 55.12  E-value: 5.35e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473   19 DVFVSFRGEDvrKTFVSHLFCEFDRMGIKAFRDDLDLQR--GKSISPELIDAIKG-SRFAIVVVSRNYAASSWCLDELL- 94
Cdd:COG4916      2 DVALSFAGED--REFVERVAEALKARGIKVFYDENEEAElwGKDLDEYLQDIYRSeSRFVVVFLSKDYVEKKWTGLERRa 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063732473   95 ---KIMECNKDTIVPIFY-EVDPSDVRRQRGSFgeDVESHSDKEKVgkwKEALKKLAAisgEDSRNWRDDSKLIKKIVK 169
Cdd:COG4916     80 alaRAMQRKKEYILPIRLdDTEIPGILATIGYI--DLRNRTPEEIA---DLILEKLAK---GRPKPSRALSLAPTETVG 150
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 602-864 8.27e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 8.27e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  602 PEFLVEL-------CMSNSNLEKLWDGIQPLRNLKKMDLSRCKYLVEVP-DLSKATNLEELNLSyCQSLVEVTPsiknlK 673
Cdd:PLN00113   301 PELVIQLqnleilhLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPkNLGKHNNLTVLDLS-TNNLTGEIP-----E 374

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  674 GL-SCFYLTNCIQLKDIPIGIILKSLetvgmSGCSSLkhfpeiswntRRLYLSSTKIE-ELPSSISRLSCLVKLDMSDCQ 751
Cdd:PLN00113   375 GLcSSGNLFKLILFSNSLEGEIPKSL-----GACRSL----------RRVRLQDNSFSgELPSEFTKLPLVYFLDISNNN 439

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  752 RLRTLPSYLGHLVSLKSLNLDGCRRLENLPDTLQNlTSLETLEVSGCLNVNEFPRVSTS---IEVLRISETSIE-EIPAR 827
Cdd:PLN00113   440 LQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSlseLMQLKLSENKLSgEIPDE 518

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1063732473  828 ICNLSQLRSLDISENKRLASLPVSISELRSLEKLKLS 864
Cdd:PLN00113   519 LSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555
PLN03150 PLN03150
hypothetical protein; Provisional
 942-1010 8.85e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 53.28  E-value: 8.85e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063732473  942 EGLLHSLCPPLSRFDDLRALSLSNMNMT-EIPNSIGNLWNLLELDLSGNNFE-FIPASIKRLTRLNRLNLN 1010
Cdd:PLN03150   428 QGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLN 498
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 553-783 3.93e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 3.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  553 NLKLLNFYDLSFDGEtrvhLPNGLSYLpRKLRYLRWDGYPLK-TMPSRFFPEFLVE-LCMSNSNLE-----KLWDgiqpL 625
Cdd:PLN00113   381 NLFKLILFSNSLEGE----IPKSLGAC-RSLRRVRLQDNSFSgELPSEFTKLPLVYfLDISNNNLQgrinsRKWD----M 451

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  626 RNLKKMDLSRCKYLVEVPDLSKATNLEELNLSYCQSLVEVTPSIKNLKGLSCFYLTNCIQLKDIPigiilksletVGMSG 705
Cdd:PLN00113   452 PSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIP----------DELSS 521

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063732473  706 CSSLKHfpeiswntrrLYLSSTKIE-ELPSSISRLSCLVKLDMSDCQRLRTLPSYLGHLVSLKSLNLDGCRRLENLPDT 783
Cdd:PLN00113   522 CKKLVS----------LDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPST 590
LRR_3 pfam07725
Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the ...
 604-623 5.09e-04

Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the pfam00560 model.


Pssm-ID: 429621 [Multi-domain]  Cd Length: 20  Bit Score: 38.47  E-value: 5.09e-04
                           10        20
                   ....*....|....*....|
gi 1063732473  604 FLVELCMSNSNLEKLWDGIQ 623
Cdd:pfam07725    1 NLVELNMPYSKLEKLWEGVK 20
PLN03150 PLN03150
hypothetical protein; Provisional
 811-868 8.58e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 8.58e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063732473  811 IEVLRISETSIE-EIPARICNLSQLRSLDISENKRLASLPVSISELRSLEKLKLSGCSV 868
Cdd:PLN03150   444 LQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 531-849 1.26e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 1.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  531 ISLNLS------EISEVFASdrafegLSNLKLLNFYDLSFDGEtrvhLPNGLSYLPRkLRYLR-WDgyplktmpSRFFPE 603
Cdd:PLN00113   287 ISLDLSdnslsgEIPELVIQ------LQNLEILHLFSNNFTGK----IPVALTSLPR-LQVLQlWS--------NKFSGE 347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  604 FLVELCMSNsnleklwdgiqplrNLKKMDLSRCKYLVEVPD-LSKATNLEELNLsYCQSLV-EVTPSiknlkglscfyLT 681
Cdd:PLN00113   348 IPKNLGKHN--------------NLTVLDLSTNNLTGEIPEgLCSSGNLFKLIL-FSNSLEgEIPKS-----------LG 401

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  682 NCIQLKDIpigiilkSLETVGMSGCSS-------LKHFPEISWNTRRLYLSSTKIE----------------ELPSSiSR 738
Cdd:PLN00113   402 ACRSLRRV-------RLQDNSFSGELPseftklpLVYFLDISNNNLQGRINSRKWDmpslqmlslarnkffgGLPDS-FG 473

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  739 LSCLVKLDMSDCQRLRTLPSYLGHLVSLKSLNLDGCRRLENLPDTLQNLTSLETLEVSGCLNVNEFPRVSTSIEVLRISE 818
Cdd:PLN00113   474 SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLD 553

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 1063732473  819 TSIE----EIPARICNLSQLRSLDISENKRLASLP 849
Cdd:PLN00113   554 LSQNqlsgEIPKNLGNVESLVQVNISHNHLHGSLP 588
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
886-1057 2.00e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 2.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  886 FDLDRTSIKELPENIGNLVALEVLQASRTVIRRAPWSIARLTRLQVLAIGNSFFTPEGLLHSLCPPLSRFDDLRALSLSN 965
Cdd:COG4886      3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  966 MNMTEIPNSIGNLWNLLELD-----------------LSGNNFEFIPASIKRLTRLNRLNLNNCQrLQALPDELPR--GL 1026
Cdd:COG4886     83 SLLLLGLTDLGDLTNLTELDlsgneelsnltnlesldLSGNQLTDLPEELANLTNLKELDLSNNQ-LTDLPEPLGNltNL 161

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1063732473 1027 LYIYIHSC--TSL-VSISGCFNqycLRKLVASNC 1057
Cdd:COG4886    162 KSLDLSNNqlTDLpEELGNLTN---LKELDLSNN 192
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 855-1012 2.42e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 2.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  855 LRSLEKLKLSGCSvLESFP-LEICQTMSCLRWFDLDRTSIkelpENIGNLVALEVLQASRTVIRRAPwSIARLTRLQVLA 933
Cdd:cd21340      1 LKRITHLYLNDKN-ITKIDnLSLCKNLKVLYLYDNKITKI----ENLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLY 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732473  934 IG-NSFFTPEGL--------LH----SLCPPLS-RFDD---------LRALSLSNMNMTEIpNSIGNLWNLLELDLSGN- 989
Cdd:cd21340     75 LGgNRISVVEGLenltnleeLHienqRLPPGEKlTFDPrslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNq 153

                          170       180
                   ....*....|....*....|....*
gi 1063732473  990 --NFEFIPASIKRLTRLNRLNLNNC 1012
Cdd:cd21340    154 isDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
958-1013 7.13e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 7.13e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063732473  958 LRALSLSNMNMTEI-PNSIGNLWNLLELDLSGNNFEFI-PASIKRLTRLNRLNLNNCQ 1013
Cdd:pfam13855    3 LRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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