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Conserved domains on  [gi|1209857061|ref|NP_001339894|]
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DENN domain-containing protein 1A isoform 4 [Homo sapiens]

Protein Classification

DENN domain-containing protein( domain architecture ID 10655395)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  1.10.287.2550|3.40.50.11500|3.30.450.200
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 63-241 4.24e-64

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214823  Cd Length: 183  Bit Score: 214.37  E-value: 4.24e-64
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061    63 SCFCILSYLPWFEVFYKLLNILADYTTKRQENQwNELLETLHKLPIPDPG-----VSVHLSVHSYFTVPDTRELPSIPen 137
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061   138 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 217
Cdd:smart00799   80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                           170       180
                    ....*....|....*....|....
gi 1209857061   218 HLSLMEKVRNMALDDVVILNVDTN 241
Cdd:smart00799  160 HSSYFEEVKELPDEDVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 273-339 4.99e-17

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 76.17  E-value: 4.99e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061   273 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGR 339
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 10-59 2.37e-14

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 69.29  E-value: 2.37e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1209857061    10 QDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 59
Cdd:smart00800   38 EDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 655-1006 7.90e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.89  E-value: 7.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  655 DDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilnpsdkeevptPTLGSITIPRPQGRKTPELGIVPPPPIPRPAK 734
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD------------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  735 LQAAGAALGDVSErlqtdrdrraALSPGLLPGVVPQgPTELLQPLSPGPGAAGTSSDALLALLDPLSTAwSGSTLPSRPA 814
Cdd:PHA03247  2688 ARPTVGSLTSLAD----------PPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPA 2755

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  815 TPNV-ATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPfgaPPASLGPAFASGLLLSSAGFCAPHR 893
Cdd:PHA03247  2756 RPARpPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP---PAAVLAPAAALPPAASPAGPLPPPT 2832

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  894 S-QPNLSALSMPNLFGQMPMGTHTSPLQPL---GPPAVAPSRI--RTLPLARSSARAA--ETKQGLALRPGDPPLLPprp 965
Cdd:PHA03247  2833 SaQPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPaaPARPPVRRLARPAvsRSTESFALPPDQPERPP--- 2909

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1209857061  966 pqgleptlQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAP 1006
Cdd:PHA03247  2910 --------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 63-241 4.24e-64

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 214.37  E-value: 4.24e-64
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061    63 SCFCILSYLPWFEVFYKLLNILADYTTKRQENQwNELLETLHKLPIPDPG-----VSVHLSVHSYFTVPDTRELPSIPen 137
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061   138 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 217
Cdd:smart00799   80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                           170       180
                    ....*....|....*....|....
gi 1209857061   218 HLSLMEKVRNMALDDVVILNVDTN 241
Cdd:smart00799  160 HSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 64-241 2.81e-44

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 158.51  E-value: 2.81e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061   64 CFCILSYLPWFEVFYKLLNILAdytTKRQENQWNELLET-----LHKLPIPDPGVSVHLSVHS-----YFTVPDTRELPS 133
Cdd:pfam02141    5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  134 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 213
Cdd:pfam02141   82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159

                          170       180
                   ....*....|....*....|....*...
gi 1209857061  214 LIGIHLSLMEKVRNmALDDVVILNVDTN 241
Cdd:pfam02141  160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 273-339 4.99e-17

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 76.17  E-value: 4.99e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061   273 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGR 339
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 10-59 2.37e-14

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 69.29  E-value: 2.37e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1209857061    10 QDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 59
Cdd:smart00800   38 EDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
PHA03247 PHA03247
large tegument protein UL36; Provisional
 655-1006 7.90e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.89  E-value: 7.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  655 DDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilnpsdkeevptPTLGSITIPRPQGRKTPELGIVPPPPIPRPAK 734
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD------------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  735 LQAAGAALGDVSErlqtdrdrraALSPGLLPGVVPQgPTELLQPLSPGPGAAGTSSDALLALLDPLSTAwSGSTLPSRPA 814
Cdd:PHA03247  2688 ARPTVGSLTSLAD----------PPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPA 2755

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  815 TPNV-ATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPfgaPPASLGPAFASGLLLSSAGFCAPHR 893
Cdd:PHA03247  2756 RPARpPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP---PAAVLAPAAALPPAASPAGPLPPPT 2832

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  894 S-QPNLSALSMPNLFGQMPMGTHTSPLQPL---GPPAVAPSRI--RTLPLARSSARAA--ETKQGLALRPGDPPLLPprp 965
Cdd:PHA03247  2833 SaQPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPaaPARPPVRRLARPAvsRSTESFALPPDQPERPP--- 2909

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1209857061  966 pqgleptlQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAP 1006
Cdd:PHA03247  2910 --------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 305-356 1.34e-07

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 48.73  E-value: 1.34e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1209857061  305 FCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGRLDLLNsgeGFSDVFEEE 356
Cdd:pfam03455    1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 11-57 1.22e-06

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 46.45  E-value: 1.22e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1209857061   11 DQEVLQTLTKFCFPFYVDSLtVSQVGQNFTFVLTDIDSKQRFGFCRL 57
Cdd:pfam03456   14 DPPLPDGIPMFCFPEGLETL-SSREPTFFSFVLTDEDGSRLYGACLT 59
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 652-1008 1.96e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 1.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  652 LGQDDMAIPSKPPAASPEKPSALLGNSLALPRRPqnrdsilnPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPR 731
Cdd:pfam03154  167 LQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPT--------PSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLH 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  732 PAKLQAAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPtellQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPS 811
Cdd:pfam03154  239 PQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMP----HSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPS 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  812 rpatPNVATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTL-PLVSTPAGPFGAPPASLGPAFASGlllsSAGFCA 890
Cdd:pfam03154  315 ----PAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIkPPPTTPIPQLPNPQSHKHPPHLSG----PSPFQM 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  891 PHRSQPNLSALSMPNLFGQMPMGTHTSPLQ------PLGPPAVAPSRIRTLPLARSSARAAETKQGLALRPGDPPLLPPR 964
Cdd:pfam03154  387 NSNLPPPPALKPLSSLSTHHPPSAHPPPLQlmpqsqQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHP 466

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 1209857061  965 PPQGLEPT-LQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDS 1008
Cdd:pfam03154  467 FVPGGPPPiTPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVS 511
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
765-871 3.51e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 41.28  E-value: 3.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  765 PGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVATPFTPQFSFPPAGTPTPFPQPPLNP 844
Cdd:COG3469    108 GTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATA 187

                           90       100
                   ....*....|....*....|....*..
gi 1209857061  845 FVPSMPAAPPTLPLVSTPAGPFGAPPA 871
Cdd:COG3469    188 TTASGATTPSATTTATTTGPPTPGLPK 214
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 63-241 4.24e-64

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 214.37  E-value: 4.24e-64
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061    63 SCFCILSYLPWFEVFYKLLNILADYTTKRQENQwNELLETLHKLPIPDPG-----VSVHLSVHSYFTVPDTRELPSIPen 137
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061   138 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 217
Cdd:smart00799   80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                           170       180
                    ....*....|....*....|....
gi 1209857061   218 HLSLMEKVRNMALDDVVILNVDTN 241
Cdd:smart00799  160 HSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 64-241 2.81e-44

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 158.51  E-value: 2.81e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061   64 CFCILSYLPWFEVFYKLLNILAdytTKRQENQWNELLET-----LHKLPIPDPGVSVHLSVHS-----YFTVPDTRELPS 133
Cdd:pfam02141    5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  134 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 213
Cdd:pfam02141   82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159

                          170       180
                   ....*....|....*....|....*...
gi 1209857061  214 LIGIHLSLMEKVRNmALDDVVILNVDTN 241
Cdd:pfam02141  160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 273-339 4.99e-17

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 76.17  E-value: 4.99e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061   273 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGR 339
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 10-59 2.37e-14

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 69.29  E-value: 2.37e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1209857061    10 QDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 59
Cdd:smart00800   38 EDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
PHA03247 PHA03247
large tegument protein UL36; Provisional
 655-1006 7.90e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.89  E-value: 7.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  655 DDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilnpsdkeevptPTLGSITIPRPQGRKTPELGIVPPPPIPRPAK 734
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD------------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  735 LQAAGAALGDVSErlqtdrdrraALSPGLLPGVVPQgPTELLQPLSPGPGAAGTSSDALLALLDPLSTAwSGSTLPSRPA 814
Cdd:PHA03247  2688 ARPTVGSLTSLAD----------PPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPA 2755

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  815 TPNV-ATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPfgaPPASLGPAFASGLLLSSAGFCAPHR 893
Cdd:PHA03247  2756 RPARpPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP---PAAVLAPAAALPPAASPAGPLPPPT 2832

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  894 S-QPNLSALSMPNLFGQMPMGTHTSPLQPL---GPPAVAPSRI--RTLPLARSSARAA--ETKQGLALRPGDPPLLPprp 965
Cdd:PHA03247  2833 SaQPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPaaPARPPVRRLARPAvsRSTESFALPPDQPERPP--- 2909

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1209857061  966 pqgleptlQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAP 1006
Cdd:PHA03247  2910 --------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 305-356 1.34e-07

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 48.73  E-value: 1.34e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1209857061  305 FCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGRLDLLNsgeGFSDVFEEE 356
Cdd:pfam03455    1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 11-57 1.22e-06

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 46.45  E-value: 1.22e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1209857061   11 DQEVLQTLTKFCFPFYVDSLtVSQVGQNFTFVLTDIDSKQRFGFCRL 57
Cdd:pfam03456   14 DPPLPDGIPMFCFPEGLETL-SSREPTFFSFVLTDEDGSRLYGACLT 59
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
805-1006 1.22e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.02  E-value: 1.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  805 SGSTLPSRPATPNVATPfTPQFSFPPAGTPTPfpqpplnpfvPSMPAAPPTLPLVSTPAGPFGAPPASLGPAFASGLLLS 884
Cdd:PRK12323   369 GGGAGPATAAAAPVAQP-APAAAAPAAAAPAP----------AAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAAR 437

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  885 SAGFCAP-HRSQPNLSALSMPnlfgqmPMGTHTSPLQPLGPPAVAPSRIRTLPLARSSARAA------ETKQGLALRPGD 957
Cdd:PRK12323   438 QASARGPgGAPAPAPAPAAAP------AAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADddpppwEELPPEFASPAP 511

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1209857061  958 PPLLPPRPPQGLEPTLQPsAPQQARDPFEDLLQKTKQDVSPSPALAPAP 1006
Cdd:PRK12323   512 AQPDAAPAGWVAESIPDP-ATADPDDAFETLAPAPAAAPAPRAAAATEP 559
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 507-893 1.36e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 1.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  507 SEDSSDDECQREEGPSSGFTESfffSAPFEWPQPYRTLRESDSAEGDEAESPEQQVRKSTGPVPAPPDRAASI-DLLEDV 585
Cdd:PHA03307    58 GAAACDRFEPPTGPPPGPGTEA---PANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPpSPAPDL 134

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  586 FSNLDMEAALQPLGQAKSLEDLRAPKDLREQPGTFDYQRLDLGGSERSRGVTVALKLTHPYNKLWSLGQDDMAIPSKPPA 665
Cdd:PHA03307   135 SEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPIS 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  666 ASPEKPSALLGNSLALPRRPQNRDSILNPS------DKEEVPTPTLGSITIPRPQGRKTPelgivppppiprpAKLQAAG 739
Cdd:PHA03307   215 ASASSPAPAPGRSAADDAGASSSDSSSSESsgcgwgPENECPLPRPAPITLPTRIWEASG-------------WNGPSSR 281

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  740 AalGDVSERlQTDRDRRAALSPG--LLPGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPN 817
Cdd:PHA03307   282 P--GPASSS-SSPRERSPSPSPSspGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPP 358

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1209857061  818 VATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPFGAPPASLGPAFASGlllSSAGFCAPHR 893
Cdd:PHA03307   359 PADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGA---ASGAFYARYP 431
PHA03247 PHA03247
large tegument protein UL36; Provisional
 660-878 1.48e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  660 PSKPPAASPEKPSALLGNSLALPRRPQNRDSILNPSDKEE-VPTPTLGsitiPRPQGRKTPELGIVPPPPIPRPAKLQAA 738
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPErPPQPQAP----PPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  739 GAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNV 818
Cdd:PHA03247  2943 LAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPV 3022

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1209857061  819 A---TPFTPQ-----------FSFPP---AGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPFGAPPASLGPAFA 878
Cdd:PHA03247  3023 SlkqTLWPPDdtedsdadslfDSDSErsdLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSANAALS 3099
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 652-1008 1.96e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 1.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  652 LGQDDMAIPSKPPAASPEKPSALLGNSLALPRRPqnrdsilnPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPR 731
Cdd:pfam03154  167 LQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPT--------PSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLH 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  732 PAKLQAAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPtellQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPS 811
Cdd:pfam03154  239 PQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMP----HSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPS 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  812 rpatPNVATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTL-PLVSTPAGPFGAPPASLGPAFASGlllsSAGFCA 890
Cdd:pfam03154  315 ----PAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIkPPPTTPIPQLPNPQSHKHPPHLSG----PSPFQM 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  891 PHRSQPNLSALSMPNLFGQMPMGTHTSPLQ------PLGPPAVAPSRIRTLPLARSSARAAETKQGLALRPGDPPLLPPR 964
Cdd:pfam03154  387 NSNLPPPPALKPLSSLSTHHPPSAHPPPLQlmpqsqQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHP 466

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 1209857061  965 PPQGLEPT-LQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDS 1008
Cdd:pfam03154  467 FVPGGPPPiTPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVS 511
PHA03247 PHA03247
large tegument protein UL36; Provisional
 658-945 2.08e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  658 AIPSKPPAASPEKPSAL-LGNSLA----LPRRPQNRDSILNPSDKEEVPTPTLgsitiPRPQGRKTPElgivppppiprp 732
Cdd:PHA03247  2834 AQPTAPPPPPGPPPPSLpLGGSVApggdVRRRPPSRSPAAKPAAPARPPVRRL-----ARPAVSRSTE------------ 2896

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  733 aklqaAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSR 812
Cdd:PHA03247  2897 -----SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGR 2971

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  813 PATPNVATPFtpqfSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPL-VSTPAGPFGA-----PPASLGPAFASGLLLSSA 886
Cdd:PHA03247  2972 VAVPRFRVPQ----PAPSREAPASSTPPLTGHSLSRVSSWASSLALhEETDPPPVSLkqtlwPPDDTEDSDADSLFDSDS 3047

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1209857061  887 GFCAPHRSQPN----LSALSMPNLFGQMPMGTHTSPLQPLGPPAVAPSRIRTLPLARSSARAA 945
Cdd:PHA03247  3048 ERSDLEALDPLppepHDPFAHEPDPATPEAGARESPSSQFGPPPLSANAALSRRYVRSTGRSA 3110
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
765-871 3.51e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 41.28  E-value: 3.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  765 PGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVATPFTPQFSFPPAGTPTPFPQPPLNP 844
Cdd:COG3469    108 GTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATA 187

                           90       100
                   ....*....|....*....|....*..
gi 1209857061  845 FVPSMPAAPPTLPLVSTPAGPFGAPPA 871
Cdd:COG3469    188 TTASGATTPSATTTATTTGPPTPGLPK 214
PHA03378 PHA03378
EBNA-3B; Provisional
 534-948 5.76e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 5.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  534 PFEWPQPYRTLRESDSAEGDEA------------ESPEQQVRKSTGPvPAPPD----RAASIDLLEDVFSNLDMEAALQP 597
Cdd:PHA03378   480 PLPHPQVTPVILHQPPAQGVQAhgsmldllekddEDMEQRVMATLLP-PSPPQpragRRAPCVYTEDLDIESDEPASTEP 558

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  598 LgqAKSLEDLRAPKDLREQPGTFDYQRlDLGGSERSRGVTVALKlTHPynklwSLGQDDMAIPSKPPAASpeKPSALLGN 677
Cdd:PHA03378   559 V--HDQLLPAPGLGPLQIQPLTSPTTS-QLASSAPSYAQTPWPV-PHP-----SQTPEPPTTQSHIPETS--APRQWPMP 627

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  678 SLALPRRPQNRDSI-LNPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPRPAKLQAAGAALGDVSERLQTdRDRR 756
Cdd:PHA03378   628 LRPIPMRPLRMQPItFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPT-PMRP 706

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  757 AALSPGllPGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRP--ATPNVATPFTPQFSFPPAGTP 834
Cdd:PHA03378   707 PAAPPG--RAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPgrARPPAAAPGAPTPQPPPQAPP 784

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  835 TPFPQPPLNPFVPSMPAAPPTLPLVSTPagpfgAPPASLGPAFASGLLLSSAGFCAPHRSQPNLSALSMPNLFGQMP--- 911
Cdd:PHA03378   785 APQQRPRGAPTPQPPPQAGPTSMQLMPR-----AAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTPspg 859

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 1209857061  912 --MGTHTSPLQPLGPPAVAPSRI-----RTLPLARSSARAAETK 948
Cdd:PHA03378   860 sgTSDKIVQAPVFYPPVLQPIQVmrqlgSVRAAAASTVTQAPTE 903
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 658-1013 7.16e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 7.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  658 AIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilNPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPRPAKLQA 737
Cdd:PRK07764   427 AAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPA--AAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPA 504

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  738 AGAALGDVSER----LQTDRDRRAALSPGLLPGVV---PQGPTELLQPLSPGPGAA------------------------ 786
Cdd:PRK07764   505 GADDAATLRERwpeiLAAVPKRSRKTWAILLPEATvlgVRGDTLVLGFSTGGLARRfaspgnaevlvtalaeelggdwqv 584

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  787 ----GTSSDALLALLDPLSTAWSGSTLPSRPATPnvATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTP 862
Cdd:PRK07764   585 eavvGPAPGAAGGEGPPAPASSGPPEEAARPAAP--AAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA 662

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857061  863 AGPFGAPPASLGPAFASglllssagfcaphrsqpnlsalsmpnlfGQMPMGTHTSPLQPLG--PPAVAPSRIRTLPLARS 940
Cdd:PRK07764   663 SDGGDGWPAKAGGAAPA----------------------------APPPAPAPAAPAAPAGaaPAQPAPAPAATPPAGQA 714

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1209857061  941 SARAAETKQGLALRPGDPPLLPPRPPQGLEPTLQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDSVEQLR 1013
Cdd:PRK07764   715 DDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAE 787
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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