Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion ...
129-1042
0e+00
Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).
The actual alignment was detected with superfamily member TIGR00834:
Pssm-ID: 452680 [Multi-domain] Cd Length: 900 Bit Score: 1133.72 E-value: 0e+00
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
129-1042
0e+00
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]
Pssm-ID: 273290 [Multi-domain] Cd Length: 900 Bit Score: 1133.72 E-value: 0e+00
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
462-970
0e+00
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.
Pssm-ID: 460009 Cd Length: 497 Bit Score: 916.53 E-value: 0e+00
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ...
832-985
9.25e-04
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 42.98 E-value: 9.25e-04
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
129-1042
0e+00
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]
Pssm-ID: 273290 [Multi-domain] Cd Length: 900 Bit Score: 1133.72 E-value: 0e+00
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
462-970
0e+00
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.
Pssm-ID: 460009 Cd Length: 497 Bit Score: 916.53 E-value: 0e+00
Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion ...
157-409
1.10e-127
Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).
Pssm-ID: 429542 Cd Length: 255 Bit Score: 389.77 E-value: 1.10e-127
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ...
832-985
9.25e-04
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 42.98 E-value: 9.25e-04
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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