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Conserved domains on  [gi|1344537288|ref|NP_001347838|]
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elongator complex protein 2 isoform 2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-371 1.16e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 134.00  E-value: 1.16e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288  54 LNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLKsvRLQGHEGPVCAVHAIYQSGpsegeqhaLIAS 132
Cdd:cd00200     5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLR--TLKGHTGPVRDVAASADGT--------YLAS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 133 AASDSTVRIWSKKGSEVkyLQTLSFRDGFVLsvCLAILPgtNVPVLACGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRG 212
Cdd:cd00200    69 GSSDKTIRLWDLETGEC--VRTLTGHTSYVS--SVAFSP--DGRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNS 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 213 VEWATFGRdlFLASCSQDCLIRIWRL-YMKP-ASFETKDG---SLRLKENTFTIKDGGVRTTVAV------TLETVLAGH 281
Cdd:cd00200   141 VAFSPDGT--FVASSSQDGTIKLWDLrTGKCvATLTGHTGevnSVAFSPDGEKLLSSSSDGTIKLwdlstgKCLGTLRGH 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 282 ENWVNAVHWQPsfykDGVLqqpvrLLSASMDKTMILWapDEESGVwleqrqwaPEIVISGHFDGVQDLMWDPEGEFIITT 361
Cdd:cd00200   219 ENGVNSVAFSP----DGYL-----LASGSEDGTIRVW--DLRTGE--------CVQTLSGHTNSVTSLAWSPDGKRLASG 279

                         330
                  ....*....|
gi 1344537288 362 STDQTTRLFA 371
Cdd:cd00200   280 SADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
194-652 4.87e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 4.87e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 194 DDQFQKALSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLymkpasfetkdgslrlkentftikDGGvrttvavT 273
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSPDGR--LLASASADGTVRLWDL------------------------ATG-------L 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 274 LETVLAGHENWVNAVHWQPsfykDGVlqqpvRLLSASMDKTMILWapDEESGVWLEqrqwapeiVISGHFDGVQDLMWDP 353
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSP----DGK-----TLASGSADGTVRLW--DLATGKLLR--------TLTGHSGAVTSVAFSP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 354 EGEFIITTSTDQTTRLfapWKKKDQKdrsqvtwhEIARPQIHGYNIKCLAMI-DRFQFVSGADEKVLRVFSAPRNFVenf 432
Cdd:COG2319   173 DGKLLASGSDDGTVRL---WDLATGK--------LLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKL--- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 433 svisRQSLSHmlcddqdlpEGATVPALGLSNkalfQGDIAsqpfeedelispAFGSpqvtfqpavlnepptEDHLLQntL 512
Cdd:COG2319   239 ----LRTLTG---------HSGSVRSVAFSP----DGRLL------------ASGS---------------ADGTVR--L 272

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 513 W-----PEIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLA 587
Cdd:COG2319   273 WdlatgELLRTLTGHSGGVNSVAFSPDGKLLASGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1344537288 588 VSRDRTWSLWKRQDATssefdpffSLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 652
Cdd:COG2319   348 GSDDGTVRLWDLATGE--------LLRTLTG-----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
544-787 5.41e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 5.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 544 ASQKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWkrqDATSSEFDPFFSLfaftnkitsv 623
Cdd:COG2319    52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG---------- 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 624 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksSHNPMEHPirpcssildvgSSVTAVSVcpvlNPAQRYIVAiG 699
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWdlatGKL--LRTLTGHS-----------GAVTSVAF----SPDGKLLAS-G 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 700 LESGKICIYSWnKTNQEINDWTscvetnpsqSHSLGIRRLCWkscsddddddddddteqSEEGpEWLhfASCGEDHTVKI 779
Cdd:COG2319   181 SDDGTVRLWDL-ATGKLLRTLT---------GHTGAVRSVAF-----------------SPDG-KLL--ASGSADGTVRL 230


                  ....*...
gi 1344537288 780 YRVNRRAL 787
Cdd:COG2319   231 WDLATGKL 238
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-371 1.16e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.00  E-value: 1.16e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288  54 LNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLKsvRLQGHEGPVCAVHAIYQSGpsegeqhaLIAS 132
Cdd:cd00200     5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLR--TLKGHTGPVRDVAASADGT--------YLAS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 133 AASDSTVRIWSKKGSEVkyLQTLSFRDGFVLsvCLAILPgtNVPVLACGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRG 212
Cdd:cd00200    69 GSSDKTIRLWDLETGEC--VRTLTGHTSYVS--SVAFSP--DGRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNS 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 213 VEWATFGRdlFLASCSQDCLIRIWRL-YMKP-ASFETKDG---SLRLKENTFTIKDGGVRTTVAV------TLETVLAGH 281
Cdd:cd00200   141 VAFSPDGT--FVASSSQDGTIKLWDLrTGKCvATLTGHTGevnSVAFSPDGEKLLSSSSDGTIKLwdlstgKCLGTLRGH 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 282 ENWVNAVHWQPsfykDGVLqqpvrLLSASMDKTMILWapDEESGVwleqrqwaPEIVISGHFDGVQDLMWDPEGEFIITT 361
Cdd:cd00200   219 ENGVNSVAFSP----DGYL-----LASGSEDGTIRVW--DLRTGE--------CVQTLSGHTNSVTSLAWSPDGKRLASG 279

                         330
                  ....*....|
gi 1344537288 362 STDQTTRLFA 371
Cdd:cd00200   280 SADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
29-369 1.52e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.72  E-value: 1.52e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288  29 GGLLAFGTS-CSVVLYDPQKKVVITNLNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLKSvrLQGH 106
Cdd:COG2319   132 GKTLASGSAdGTVRLWDLATGKLLRTLTGHSGAVTSVAF------SPDGKlLASGSDDGTVRLWDLATGKLLRT--LTGH 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 107 EGPVCAVhAIYQSGpsegeqhALIASAASDSTVRIWSKKGSEVkyLQTLSFRDGFVLSVclAILP-GTnvpVLACGDDDC 185
Cdd:COG2319   204 TGAVRSV-AFSPDG-------KLLASGSADGTVRLWDLATGKL--LRTLTGHSGSVRSV--AFSPdGR---LLASGSADG 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 186 RIHLYIQQDDQFQKALSlcGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLymkpasfetKDGSLRlkentftikdgg 265
Cdd:COG2319   269 TVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGK--LLASGSDDGTVRLWDL---------ATGKLL------------ 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 266 vrttvavtleTVLAGHENWVNAVHWQPsfykDGVlqqpvRLLSASMDKTMILWAPDeesgvwleqrQWAPEIVISGHFDG 345
Cdd:COG2319   324 ----------RTLTGHTGAVRSVAFSP----DGK-----TLASGSDDGTVRLWDLA----------TGELLRTLTGHTGA 374

                         330       340
                  ....*....|....*....|....
gi 1344537288 346 VQDLMWDPEGEFIITTSTDQTTRL 369
Cdd:COG2319   375 VTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
194-652 4.87e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 4.87e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 194 DDQFQKALSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLymkpasfetkdgslrlkentftikDGGvrttvavT 273
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSPDGR--LLASASADGTVRLWDL------------------------ATG-------L 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 274 LETVLAGHENWVNAVHWQPsfykDGVlqqpvRLLSASMDKTMILWapDEESGVWLEqrqwapeiVISGHFDGVQDLMWDP 353
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSP----DGK-----TLASGSADGTVRLW--DLATGKLLR--------TLTGHSGAVTSVAFSP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 354 EGEFIITTSTDQTTRLfapWKKKDQKdrsqvtwhEIARPQIHGYNIKCLAMI-DRFQFVSGADEKVLRVFSAPRNFVenf 432
Cdd:COG2319   173 DGKLLASGSDDGTVRL---WDLATGK--------LLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKL--- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 433 svisRQSLSHmlcddqdlpEGATVPALGLSNkalfQGDIAsqpfeedelispAFGSpqvtfqpavlnepptEDHLLQntL 512
Cdd:COG2319   239 ----LRTLTG---------HSGSVRSVAFSP----DGRLL------------ASGS---------------ADGTVR--L 272

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 513 W-----PEIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLA 587
Cdd:COG2319   273 WdlatgELLRTLTGHSGGVNSVAFSPDGKLLASGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1344537288 588 VSRDRTWSLWKRQDATssefdpffSLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 652
Cdd:COG2319   348 GSDDGTVRLWDLATGE--------LLRTLTG-----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 274-652 3.92e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 3.92e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 274 LETVLAGHENWVNAVHWQPsfykdgvlqQPVRLLSASMDKTMILWapDEESGvwleqrqwAPEIVISGHFDGVQDLMWDP 353
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSP---------DGKLLATGSGDGTIKVW--DLETG--------ELLRTLKGHTGPVRDVAASA 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 354 EGEFIITTSTDQTTRLfapWKKKDQKDRSQVTWHEIArpqihgynIKCLAMIDRFQFVSGA-DEKVLRVFsaprnfvenf 432
Cdd:cd00200    62 DGTYLASGSSDKTIRL---WDLETGECVRTLTGHTSY--------VSSVAFSPDGRILSSSsRDKTIKVW---------- 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 433 svisrqslshmlcddqDLPEGATVPALGlsnkaLFQGDIASQPFEEDELIspAFGSPQvtfqpavlneppteDHLLqnTL 512
Cdd:cd00200   121 ----------------DVETGKCLTTLR-----GHTDWVNSVAFSPDGTF--VASSSQ--------------DGTI--KL 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 513 W-----PEIQKLYGHGYEIVCVACNNSKTLLASACKASQkehaaIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLA 587
Cdd:cd00200   162 WdlrtgKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-----IKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1344537288 588 VSRDRT---WSLWKRQdatssefdpffslfafTNKITSVHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 652
Cdd:cd00200   237 GSEDGTirvWDLRTGE----------------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
544-787 5.41e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 5.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 544 ASQKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWkrqDATSSEFDPFFSLfaftnkitsv 623
Cdd:COG2319    52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG---------- 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 624 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksSHNPMEHPirpcssildvgSSVTAVSVcpvlNPAQRYIVAiG 699
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWdlatGKL--LRTLTGHS-----------GAVTSVAF----SPDGKLLAS-G 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 700 LESGKICIYSWnKTNQEINDWTscvetnpsqSHSLGIRRLCWkscsddddddddddteqSEEGpEWLhfASCGEDHTVKI 779
Cdd:COG2319   181 SDDGTVRLWDL-ATGKLLRTLT---------GHTGAVRSVAF-----------------SPDG-KLL--ASGSADGTVRL 230


                  ....*...
gi 1344537288 780 YRVNRRAL 787
Cdd:COG2319   231 WDLATGKL 238
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 624-652 1.23e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.23e-05
                           10        20
                   ....*....|....*....|....*....
gi 1344537288  624 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW 652
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
624-652 1.85e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.85e-05
                          10        20
                  ....*....|....*....|....*....
gi 1344537288 624 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW 652
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
202-236 1.44e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1344537288 202 SLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIW 236
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 202-236 1.79e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.79e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1344537288  202 SLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIW 236
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 278-393 2.61e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 278 LAGHENWVNAVHWQPSfyKDGVLQqpvrllSASMDKTMILWapDEESGVWLEqrqwapeiVISGHFDGVQDLMWDPEGEF 357
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPS--AMNVLA------SAGADMVVNVW--DVERGKAVE--------VIKCHSDQITSLEWNLDGSL 182

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1344537288 358 IITTSTDQTTRLFAPwkkKDQKDRSQVTWHEIARPQ 393
Cdd:PTZ00421  183 LCTTSKDKKLNIIDP---RDGTIVSSVEAHASAKSQ 215
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-371 1.16e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.00  E-value: 1.16e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288  54 LNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLKsvRLQGHEGPVCAVHAIYQSGpsegeqhaLIAS 132
Cdd:cd00200     5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLR--TLKGHTGPVRDVAASADGT--------YLAS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 133 AASDSTVRIWSKKGSEVkyLQTLSFRDGFVLsvCLAILPgtNVPVLACGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRG 212
Cdd:cd00200    69 GSSDKTIRLWDLETGEC--VRTLTGHTSYVS--SVAFSP--DGRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNS 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 213 VEWATFGRdlFLASCSQDCLIRIWRL-YMKP-ASFETKDG---SLRLKENTFTIKDGGVRTTVAV------TLETVLAGH 281
Cdd:cd00200   141 VAFSPDGT--FVASSSQDGTIKLWDLrTGKCvATLTGHTGevnSVAFSPDGEKLLSSSSDGTIKLwdlstgKCLGTLRGH 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 282 ENWVNAVHWQPsfykDGVLqqpvrLLSASMDKTMILWapDEESGVwleqrqwaPEIVISGHFDGVQDLMWDPEGEFIITT 361
Cdd:cd00200   219 ENGVNSVAFSP----DGYL-----LASGSEDGTIRVW--DLRTGE--------CVQTLSGHTNSVTSLAWSPDGKRLASG 279

                         330
                  ....*....|
gi 1344537288 362 STDQTTRLFA 371
Cdd:cd00200   280 SADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
29-369 1.52e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.72  E-value: 1.52e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288  29 GGLLAFGTS-CSVVLYDPQKKVVITNLNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLKSvrLQGH 106
Cdd:COG2319   132 GKTLASGSAdGTVRLWDLATGKLLRTLTGHSGAVTSVAF------SPDGKlLASGSDDGTVRLWDLATGKLLRT--LTGH 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 107 EGPVCAVhAIYQSGpsegeqhALIASAASDSTVRIWSKKGSEVkyLQTLSFRDGFVLSVclAILP-GTnvpVLACGDDDC 185
Cdd:COG2319   204 TGAVRSV-AFSPDG-------KLLASGSADGTVRLWDLATGKL--LRTLTGHSGSVRSV--AFSPdGR---LLASGSADG 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 186 RIHLYIQQDDQFQKALSlcGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLymkpasfetKDGSLRlkentftikdgg 265
Cdd:COG2319   269 TVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGK--LLASGSDDGTVRLWDL---------ATGKLL------------ 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 266 vrttvavtleTVLAGHENWVNAVHWQPsfykDGVlqqpvRLLSASMDKTMILWAPDeesgvwleqrQWAPEIVISGHFDG 345
Cdd:COG2319   324 ----------RTLTGHTGAVRSVAFSP----DGK-----TLASGSDDGTVRLWDLA----------TGELLRTLTGHTGA 374

                         330       340
                  ....*....|....*....|....
gi 1344537288 346 VQDLMWDPEGEFIITTSTDQTTRL 369
Cdd:COG2319   375 VTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
21-424 1.79e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.78  E-value: 1.79e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288  21 ALSWNTGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLQWIrtedgSPSNELVSGGSDNRVIHWELENNQVLks 100
Cdd:COG2319    41 SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-----PDGRLLASASADGTVRLWDLATGLLL-- 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 101 VRLQGHEGPVCAVhAIYQSGpsegeqhALIASAASDSTVRIWSKKGSEVkyLQTLSFRDGFVLSVclAILP-GTnvpVLA 179
Cdd:COG2319   114 RTLTGHTGAVRSV-AFSPDG-------KTLASGSADGTVRLWDLATGKL--LRTLTGHSGAVTSV--AFSPdGK---LLA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 180 CGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLymkpasfetkdgslrlkentf 259
Cdd:COG2319   179 SGSDDGTVRLWDLATGKLLRTLT--GHTGAVRSVAFSPDGK--LLASGSADGTVRLWDL--------------------- 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 260 tikDGGvrttvavTLETVLAGHENWVNAVHWQPsfykDGVlqqpvRLLSASMDKTMILWAPDEESGVWLeqrqwapeivI 339
Cdd:COG2319   234 ---ATG-------KLLRTLTGHSGSVRSVAFSP----DGR-----LLASGSADGTVRLWDLATGELLRT----------L 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 340 SGHFDGVQDLMWDPEGEFIITTSTDQTTRLFapwkkkdqkDRSqvTWHEIARPQIHGYNIKCLAMI-DRFQFVSGADEKV 418
Cdd:COG2319   285 TGHSGGVNSVAFSPDGKLLASGSDDGTVRLW---------DLA--TGKLLRTLTGHTGAVRSVAFSpDGKTLASGSDDGT 353


                  ....*.
gi 1344537288 419 LRVFSA 424
Cdd:COG2319   354 VRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
194-652 4.87e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 4.87e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 194 DDQFQKALSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLymkpasfetkdgslrlkentftikDGGvrttvavT 273
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSPDGR--LLASASADGTVRLWDL------------------------ATG-------L 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 274 LETVLAGHENWVNAVHWQPsfykDGVlqqpvRLLSASMDKTMILWapDEESGVWLEqrqwapeiVISGHFDGVQDLMWDP 353
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSP----DGK-----TLASGSADGTVRLW--DLATGKLLR--------TLTGHSGAVTSVAFSP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 354 EGEFIITTSTDQTTRLfapWKKKDQKdrsqvtwhEIARPQIHGYNIKCLAMI-DRFQFVSGADEKVLRVFSAPRNFVenf 432
Cdd:COG2319   173 DGKLLASGSDDGTVRL---WDLATGK--------LLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKL--- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 433 svisRQSLSHmlcddqdlpEGATVPALGLSNkalfQGDIAsqpfeedelispAFGSpqvtfqpavlnepptEDHLLQntL 512
Cdd:COG2319   239 ----LRTLTG---------HSGSVRSVAFSP----DGRLL------------ASGS---------------ADGTVR--L 272

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 513 W-----PEIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLA 587
Cdd:COG2319   273 WdlatgELLRTLTGHSGGVNSVAFSPDGKLLASGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1344537288 588 VSRDRTWSLWKRQDATssefdpffSLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 652
Cdd:COG2319   348 GSDDGTVRLWDLATGE--------LLRTLTG-----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
29-238 4.97e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 4.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288  29 GGLLAFGTS-CSVVLYDPQKKVVITNLNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLKsvRLQGH 106
Cdd:COG2319   216 GKLLASGSAdGTVRLWDLATGKLLRTLTGHSGSVRSVAF------SPDGRlLASGSADGTVRLWDLATGELLR--TLTGH 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 107 EGPVCAVhAIYQSGpsegeqhALIASAASDSTVRIWSKKGSEVkyLQTLSFRDGFVLSVclAILPGTNVpvLACGDDDCR 186
Cdd:COG2319   288 SGGVNSV-AFSPDG-------KLLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSV--AFSPDGKT--LASGSDDGT 353

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1344537288 187 IHLYIQQDDQFQKALSlcGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRL 238
Cdd:COG2319   354 VRLWDLATGELLRTLT--GHTGAVTSVAFSPDGR--TLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 274-652 3.92e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 3.92e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 274 LETVLAGHENWVNAVHWQPsfykdgvlqQPVRLLSASMDKTMILWapDEESGvwleqrqwAPEIVISGHFDGVQDLMWDP 353
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSP---------DGKLLATGSGDGTIKVW--DLETG--------ELLRTLKGHTGPVRDVAASA 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 354 EGEFIITTSTDQTTRLfapWKKKDQKDRSQVTWHEIArpqihgynIKCLAMIDRFQFVSGA-DEKVLRVFsaprnfvenf 432
Cdd:cd00200    62 DGTYLASGSSDKTIRL---WDLETGECVRTLTGHTSY--------VSSVAFSPDGRILSSSsRDKTIKVW---------- 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 433 svisrqslshmlcddqDLPEGATVPALGlsnkaLFQGDIASQPFEEDELIspAFGSPQvtfqpavlneppteDHLLqnTL 512
Cdd:cd00200   121 ----------------DVETGKCLTTLR-----GHTDWVNSVAFSPDGTF--VASSSQ--------------DGTI--KL 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 513 W-----PEIQKLYGHGYEIVCVACNNSKTLLASACKASQkehaaIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLA 587
Cdd:cd00200   162 WdlrtgKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-----IKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1344537288 588 VSRDRT---WSLWKRQdatssefdpffslfafTNKITSVHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 652
Cdd:cd00200   237 GSEDGTirvWDLRTGE----------------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
266-783 5.38e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.89  E-value: 5.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 266 VRTTVAVTLETVLAGHENWVNAVHWQPSfykdgvlqqPVRLLSASMDKTMILWapDEESGvwleqrqwAPEIVISGHFDG 345
Cdd:COG2319    62 LLDAAAGALLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATG--------LLLRTLTGHTGA 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 346 VQDLMWDPEGEFIITTSTDQTTRLfapWKKKDQKdrsqvtwhEIARPQIHGYNIKCLAmidrF-----QFVSGADEKVLR 420
Cdd:COG2319   123 VRSVAFSPDGKTLASGSADGTVRL---WDLATGK--------LLRTLTGHSGAVTSVA----FspdgkLLASGSDDGTVR 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 421 VFsaprnfvenfsvisrqslshmlcddqDLPEGAtvpalglsnkalfqgdiasqpfeedelispafgspqvtfqpavlne 500
Cdd:COG2319   188 LW--------------------------DLATGK---------------------------------------------- 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 501 pptedhllqntlwpEIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSP 580
Cdd:COG2319   196 --------------LLRTLTGHTGAVRSVAFSPDGKLLASGS-----ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP 256

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 581 DDKFLLAVSRDRTWSLWkrqDATSSEFDPFFslfaftnkitSVHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECK 656
Cdd:COG2319   257 DGRLLASGSADGTVRLW---DLATGELLRTL----------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWdlatGKLL 323

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 657 SSHNPMEHPIRpcssildvgsSVtAVSvcpvlnPAQRYIVAiGLESGKICIysWNKTNQEindwtscvETNPSQSHSLGI 736
Cdd:COG2319   324 RTLTGHTGAVR----------SV-AFS------PDGKTLAS-GSDDGTVRL--WDLATGE--------LLRTLTGHTGAV 375

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1344537288 737 RRLCWkscsddddddddddteqSEEGPewlHFASCGEDHTVKIYRVN 783
Cdd:COG2319   376 TSVAF-----------------SPDGR---TLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
512-787 2.98e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 2.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 512 LW-----PEIQKLYGHGYEIVCVACNNSKTLLASACKASQkehaaIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLL 586
Cdd:COG2319   146 LWdlatgKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 587 AVSRDRTWSLWkrqDATSSEFdpffsLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSShnpM 662
Cdd:COG2319   221 SGSADGTVRLW---DLATGKL-----LRTLTG-----HSGSVRSVAFSPDGRLLASGSADGTVRLWdlatGELLRT---L 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 663 EHPirpcssildvGSSVTAVSVCPvlnpaQRYIVAIGLESGKICIYSWnKTNQEINDWTScvetnpsqsHSLGIRRLCWk 742
Cdd:COG2319   285 TGH----------SGGVNSVAFSP-----DGKLLASGSDDGTVRLWDL-ATGKLLRTLTG---------HTGAVRSVAF- 338

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1344537288 743 scsddddddddddteqSEEGpEWLhfASCGEDHTVKIYRVNRRAL 787
Cdd:COG2319   339 ----------------SPDG-KTL--ASGSDDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 515-781 3.81e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 3.81e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 515 EIQKLYGHGYEIVCVACNNSKTLLASAckasqKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTW 594
Cdd:cd00200    85 CVRTLTGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 595 SLWkrqDATSSEFDPFFSLfaftnkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSSHNPMEHPirpcs 670
Cdd:cd00200   160 KLW---DLRTGKCVATLTG----------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWdlstGKCLGTLRGHENG----- 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 671 sildvgssVTAVSVCPvlnpaQRYIVAIGLESGKICIYswnktnqeinDWTSCVETNPSQSHSLGIRRLCWkscsddddd 750
Cdd:cd00200   222 --------VNSVAFSP-----DGYLLASGSEDGTIRVW----------DLRTGECVQTLSGHTNSVTSLAW--------- 269

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1344537288 751 dddddteqSEEGPewlHFASCGEDHTVKIYR 781
Cdd:cd00200   270 --------SPDGK---RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
515-787 4.27e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.19  E-value: 4.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 515 EIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTW 594
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGS-----ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 595 SLWkrqDATSSEFdpffsLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSshnPMEHPirpcs 670
Cdd:COG2319   187 RLW---DLATGKL-----LRTLTG-----HTGAVRSVAFSPDGKLLASGSADGTVRLWdlatGKLLR---TLTGH----- 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 671 sildvGSSVTAVSVCPvlnpaQRYIVAIGLESGKICIYSWNkTNQEINDWTscvetnpsqSHSLGIRRLCWkscsddddd 750
Cdd:COG2319   246 -----SGSVRSVAFSP-----DGRLLASGSADGTVRLWDLA-TGELLRTLT---------GHSGGVNSVAF--------- 296

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1344537288 751 dddddteqSEEGpEWLhfASCGEDHTVKIYRVNRRAL 787
Cdd:COG2319   297 --------SPDG-KLL--ASGSDDGTVRLWDLATGKL 322
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 515-780 1.04e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.53  E-value: 1.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 515 EIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTW 594
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGS-----GDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 595 SLWKRQdatssefdpffslfafTNKITSV---HSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksshnpmehpir 667
Cdd:cd00200    76 RLWDLE----------------TGECVRTltgHTSYVSSVAFSPDGRILSSSSRDKTIKVWdvetGKC------------ 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 668 pCSSILDVGSSVTAVSVcpvlNPAQRYIVAIGLESgkiCIYSWNKTNQeindwtSCVETNPsqSHSLGIRRLCWKscsdd 747
Cdd:cd00200   128 -LTTLRGHTDWVNSVAF----SPDGTFVASSSQDG---TIKLWDLRTG------KCVATLT--GHTGEVNSVAFS----- 186

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1344537288 748 ddddddddteqseegPEWLHFASCGEDHTVKIY 780
Cdd:cd00200   187 ---------------PDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
507-787 1.15e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.79  E-value: 1.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 507 LLQNTLWPEIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLL 586
Cdd:COG2319    62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS-----ADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLA 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 587 AVSRDRTWSLWkrqDATSSEFdpffsLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksshnpm 662
Cdd:COG2319   137 SGSADGTVRLW---DLATGKL-----LRTLTG-----HSGAVTSVAFSPDGKLLASGSDDGTVRLWdlatGKL------- 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 663 ehpIRpcsSILDVGSSVTAVSVcpvlNPAQRYIvAIGLESGKICIYSWnKTNQEINDWTscvetnpsqSHSLGIRRLCWk 742
Cdd:COG2319   197 ---LR---TLTGHTGAVRSVAF----SPDGKLL-ASGSADGTVRLWDL-ATGKLLRTLT---------GHSGSVRSVAF- 254

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1344537288 743 scsddddddddddteqSEEGPewlHFASCGEDHTVKIYRVNRRAL 787
Cdd:COG2319   255 ----------------SPDGR---LLASGSADGTVRLWDLATGEL 280
WD40 COG2319
WD40 repeat [General function prediction only];
544-787 5.41e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 5.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 544 ASQKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWkrqDATSSEFDPFFSLfaftnkitsv 623
Cdd:COG2319    52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG---------- 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 624 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksSHNPMEHPirpcssildvgSSVTAVSVcpvlNPAQRYIVAiG 699
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWdlatGKL--LRTLTGHS-----------GAVTSVAF----SPDGKLLAS-G 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 700 LESGKICIYSWnKTNQEINDWTscvetnpsqSHSLGIRRLCWkscsddddddddddteqSEEGpEWLhfASCGEDHTVKI 779
Cdd:COG2319   181 SDDGTVRLWDL-ATGKLLRTLT---------GHTGAVRSVAF-----------------SPDG-KLL--ASGSADGTVRL 230


                  ....*...
gi 1344537288 780 YRVNRRAL 787
Cdd:COG2319   231 WDLATGKL 238
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 624-652 1.23e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.23e-05
                           10        20
                   ....*....|....*....|....*....
gi 1344537288  624 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW 652
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
624-652 1.85e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.85e-05
                          10        20
                  ....*....|....*....|....*....
gi 1344537288 624 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW 652
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 559-598 4.13e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 4.13e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1344537288  559 SWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWK 598
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
560-597 4.30e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.30e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1344537288 560 WKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLW 597
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
202-236 1.44e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1344537288 202 SLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIW 236
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 202-236 1.79e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.79e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1344537288  202 SLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIW 236
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
29-94 2.56e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.05  E-value: 2.56e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1344537288  29 GGLLAFGTS-CSVVLYDPQKKVVITNLNGHTARVNCLQWirTEDGspsNELVSGGSDNRVIHWELEN 94
Cdd:COG2319   342 GKTLASGSDdGTVRLWDLATGELLRTLTGHTGAVTSVAF--SPDG---RTLASGSADGTVRLWDLAT 403
PTZ00421 PTZ00421
coronin; Provisional
 278-393 2.61e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344537288 278 LAGHENWVNAVHWQPSfyKDGVLQqpvrllSASMDKTMILWapDEESGVWLEqrqwapeiVISGHFDGVQDLMWDPEGEF 357
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPS--AMNVLA------SAGADMVVNVW--DVERGKAVE--------VIKCHSDQITSLEWNLDGSL 182

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1344537288 358 IITTSTDQTTRLFAPwkkKDQKDRSQVTWHEIARPQ 393
Cdd:PTZ00421  183 LCTTSKDKKLNIIDP---RDGTIVSSVEAHASAKSQ 215
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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