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Conserved domains on  [gi|1571052954|ref|NP_001355332|]
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centromere protein U isoform 2 [Mus musculus]

Protein Classification

CENP-U and Mplasa_alph_rch domain-containing protein( domain architecture ID 10586794)

CENP-U and Mplasa_alph_rch domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CENP-U pfam13097
CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that ...
 134-307 1.05e-66

CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. FTA4 is the equivalent component of the fission yeast Sim4 complex.


:

Pssm-ID: 463785  Cd Length: 180  Bit Score: 209.95  E-value: 1.05e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052954 134 DDVRRRVASAEGPRSQQRQAAPAAPSPPERPAE----PVTPRRTRLHSAQLSPVDETPA-TQSQLKTQKKVRPSPGRRKR 208
Cdd:pfam13097   2 SDVRRKVQSAEKISTQQREAVPATASASSELSEkpaeSVTPRKTGPLSASSSVEKETLAwTQSQLKTQKKVKMSHGKRKK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052954 209 PRRGHTDTDGSESMHIWCLEGKRQSDITELDVILSVFEKTFLEYKQRVESESCNQAINKFYFKMKGELIRMLKEAQMLKA 288
Cdd:pfam13097  82 SRSKATDSDSSDSVHIWCLKGKKRSDIMELDVVLSAFEKTCLEYKQRIESKICREAINKFHSNIKEELIKMIKEVQMLKN 161

                         170
                  ....*....|....*....
gi 1571052954 289 LKMKNTKIIANMEKKRQRL 307
Cdd:pfam13097 162 LKRKNAKVISDIEKKRQRL 180
Mplasa_alph_rch super family cl37461
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 271-350 5.69e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


The actual alignment was detected with superfamily member TIGR04523:

Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 38.85  E-value: 5.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052954 271 KMKGELIRMLKEAQMLKALKMKNTKIIANMEKKRQR----LIEVQDELIRLEPQLKQLQTKYDDLKERKSSLKKSKHFLS 346
Cdd:TIGR04523 100 KLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKEnkknIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLE 179


                  ....
gi 1571052954 347 NLKQ 350
Cdd:TIGR04523 180 KEKL 183
 
Name Accession Description Interval E-value
CENP-U pfam13097
CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that ...
 134-307 1.05e-66

CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. FTA4 is the equivalent component of the fission yeast Sim4 complex.


Pssm-ID: 463785  Cd Length: 180  Bit Score: 209.95  E-value: 1.05e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052954 134 DDVRRRVASAEGPRSQQRQAAPAAPSPPERPAE----PVTPRRTRLHSAQLSPVDETPA-TQSQLKTQKKVRPSPGRRKR 208
Cdd:pfam13097   2 SDVRRKVQSAEKISTQQREAVPATASASSELSEkpaeSVTPRKTGPLSASSSVEKETLAwTQSQLKTQKKVKMSHGKRKK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052954 209 PRRGHTDTDGSESMHIWCLEGKRQSDITELDVILSVFEKTFLEYKQRVESESCNQAINKFYFKMKGELIRMLKEAQMLKA 288
Cdd:pfam13097  82 SRSKATDSDSSDSVHIWCLKGKKRSDIMELDVVLSAFEKTCLEYKQRIESKICREAINKFHSNIKEELIKMIKEVQMLKN 161

                         170
                  ....*....|....*....
gi 1571052954 289 LKMKNTKIIANMEKKRQRL 307
Cdd:pfam13097 162 LKRKNAKVISDIEKKRQRL 180
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 271-350 5.69e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 38.85  E-value: 5.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052954 271 KMKGELIRMLKEAQMLKALKMKNTKIIANMEKKRQR----LIEVQDELIRLEPQLKQLQTKYDDLKERKSSLKKSKHFLS 346
Cdd:TIGR04523 100 KLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKEnkknIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLE 179


                  ....
gi 1571052954 347 NLKQ 350
Cdd:TIGR04523 180 KEKL 183
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 275-360 5.79e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 37.58  E-value: 5.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052954 275 ELIRMLKE--AQMlKALKMKNTKIIANMEKKRQRLIE----VQDELIRLEPQLKQLQTKYDDLKERKSSLKKSKHFLSNL 348
Cdd:pfam13851  26 ELIKSLKEeiAEL-KKKEERNEKLMSEIQQENKRLTEplqkAQEEVEELRKQLENYEKDKQSLKNLKARLKVLEKELKDL 104

                          90
                  ....*....|....*.
gi 1571052954 349 KQ----LCQDYSNVQE 360
Cdd:pfam13851 105 KWehevLEQRFEKVER 120
 
Name Accession Description Interval E-value
CENP-U pfam13097
CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that ...
 134-307 1.05e-66

CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. FTA4 is the equivalent component of the fission yeast Sim4 complex.


Pssm-ID: 463785  Cd Length: 180  Bit Score: 209.95  E-value: 1.05e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052954 134 DDVRRRVASAEGPRSQQRQAAPAAPSPPERPAE----PVTPRRTRLHSAQLSPVDETPA-TQSQLKTQKKVRPSPGRRKR 208
Cdd:pfam13097   2 SDVRRKVQSAEKISTQQREAVPATASASSELSEkpaeSVTPRKTGPLSASSSVEKETLAwTQSQLKTQKKVKMSHGKRKK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052954 209 PRRGHTDTDGSESMHIWCLEGKRQSDITELDVILSVFEKTFLEYKQRVESESCNQAINKFYFKMKGELIRMLKEAQMLKA 288
Cdd:pfam13097  82 SRSKATDSDSSDSVHIWCLKGKKRSDIMELDVVLSAFEKTCLEYKQRIESKICREAINKFHSNIKEELIKMIKEVQMLKN 161

                         170
                  ....*....|....*....
gi 1571052954 289 LKMKNTKIIANMEKKRQRL 307
Cdd:pfam13097 162 LKRKNAKVISDIEKKRQRL 180
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 271-350 5.69e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 38.85  E-value: 5.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052954 271 KMKGELIRMLKEAQMLKALKMKNTKIIANMEKKRQR----LIEVQDELIRLEPQLKQLQTKYDDLKERKSSLKKSKHFLS 346
Cdd:TIGR04523 100 KLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKEnkknIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLE 179


                  ....
gi 1571052954 347 NLKQ 350
Cdd:TIGR04523 180 KEKL 183
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 275-360 5.79e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 37.58  E-value: 5.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052954 275 ELIRMLKE--AQMlKALKMKNTKIIANMEKKRQRLIE----VQDELIRLEPQLKQLQTKYDDLKERKSSLKKSKHFLSNL 348
Cdd:pfam13851  26 ELIKSLKEeiAEL-KKKEERNEKLMSEIQQENKRLTEplqkAQEEVEELRKQLENYEKDKQSLKNLKARLKVLEKELKDL 104

                          90
                  ....*....|....*.
gi 1571052954 349 KQ----LCQDYSNVQE 360
Cdd:pfam13851 105 KWehevLEQRFEKVER 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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