MH2 domain-containing protein [Caenorhabditis elegans]
Protein Classification
mothers against decapentaplegic homolog; mothers against decapentaplegic homolog 4 family protein( domain architecture ID 10649998)
mothers against decapentaplegic homolog such as SMAD1, SMAD5 and SMAD9 (also known as SMAD8); all closely related receptor regulated SMADs (R-SMADs). SMAD1 plays an essential role in bone development and postnatal bone formation through activation by bone morphogenetic protein (BMP) type 1 receptor kinase. SMAD5 is involved in bone morphogenetic proteins (BMP) signal modulation and may also play a role in the pathway involving inhibition of hematopoietic progenitor cells by TGF-beta. SMAD9 mediates the differentiation of mesenchymal stem cells (MSCs) into tendon-like cells by inhibiting the osteogenic pathway| mothers against decapentaplegic homolog 4 family protein such as SMAD4, a common mediator SMAD (co-SMAD), which belongs to the Dwarfin family of proteins and is involved in many cell functions such as differentiation, apoptosis, gastrulation, embryonic development and cell cycle. SMAD4 binds receptor regulated SMADs (R-SMADs) such as SMAD1 or SMAD2, and forms an oligomeric complex that binds to DNA and serves as a transcription factor. SMAD4 is often mutated in several cancers, such as multiploid colorectal cancer and pancreatic carcinoma, as well as in juvenile polyposis syndrome (JPS)
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| DWB | smart00524 | Domain B in dwarfin family proteins; |
83-253 | 1.08e-57 | ||||
Domain B in dwarfin family proteins; : Pssm-ID: 197770 Cd Length: 171 Bit Score: 192.52 E-value: 1.08e-57
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| Name | Accession | Description | Interval | E-value | ||||
| DWB | smart00524 | Domain B in dwarfin family proteins; |
83-253 | 1.08e-57 | ||||
Domain B in dwarfin family proteins; Pssm-ID: 197770 Cd Length: 171 Bit Score: 192.52 E-value: 1.08e-57
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| MH2 | pfam03166 | MH2 domain; This is the MH2 (MAD homology 2) domain found at the carboxy terminus of MAD ... |
82-254 | 1.75e-36 | ||||
MH2 domain; This is the MH2 (MAD homology 2) domain found at the carboxy terminus of MAD related proteins such as Smads. This domain is separated from the MH1 domain by a non-conserved linker region. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. Unlike MH1, MH2 does not bind DNA. The well-studied MH2 domain of Smad4 is composed of five alpha helices and three loops enclosing a beta sandwich. Smads are involved in the propagation of TGF-beta signals by direct association with the TGF-beta receptor kinase which phosphorylates the last two Ser of a conserved 'SSXS' motif located at the C-terminus of MH2. Pssm-ID: 460834 Cd Length: 172 Bit Score: 134.67 E-value: 1.75e-36
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| MH2 | cd00050 | C-terminal Mad Homology 2 (MH2) domain; The MH2 domain is found in the SMAD (small mothers ... |
84-252 | 2.02e-04 | ||||
C-terminal Mad Homology 2 (MH2) domain; The MH2 domain is found in the SMAD (small mothers against decapentaplegic) family of proteins and is responsible for type I receptor interactions, phosphorylation-triggered homo- and hetero-oligomerization, and transactivation. It is negatively regulated by the N-terminal MH1 domain which prevents it from forming a complex with SMAD4. The MH2 domain is multifunctional and provides SMADs with their specificity and selectivity, as well as transcriptional activity. Several transcriptional co-activators and repressors have also been reported to regulate SMAD signaling by interacting with the MH2 domain. Mutations in the MH2 domains of SMAD2 and especially SMAD4 have been detected in colorectal and other human cancers. Pssm-ID: 199819 Cd Length: 170 Bit Score: 42.59 E-value: 2.02e-04
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| Name | Accession | Description | Interval | E-value | ||||
| DWB | smart00524 | Domain B in dwarfin family proteins; |
83-253 | 1.08e-57 | ||||
Domain B in dwarfin family proteins; Pssm-ID: 197770 Cd Length: 171 Bit Score: 192.52 E-value: 1.08e-57
|
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| MH2 | pfam03166 | MH2 domain; This is the MH2 (MAD homology 2) domain found at the carboxy terminus of MAD ... |
82-254 | 1.75e-36 | ||||
MH2 domain; This is the MH2 (MAD homology 2) domain found at the carboxy terminus of MAD related proteins such as Smads. This domain is separated from the MH1 domain by a non-conserved linker region. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. Unlike MH1, MH2 does not bind DNA. The well-studied MH2 domain of Smad4 is composed of five alpha helices and three loops enclosing a beta sandwich. Smads are involved in the propagation of TGF-beta signals by direct association with the TGF-beta receptor kinase which phosphorylates the last two Ser of a conserved 'SSXS' motif located at the C-terminus of MH2. Pssm-ID: 460834 Cd Length: 172 Bit Score: 134.67 E-value: 1.75e-36
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| MH2 | cd00050 | C-terminal Mad Homology 2 (MH2) domain; The MH2 domain is found in the SMAD (small mothers ... |
84-252 | 2.02e-04 | ||||
C-terminal Mad Homology 2 (MH2) domain; The MH2 domain is found in the SMAD (small mothers against decapentaplegic) family of proteins and is responsible for type I receptor interactions, phosphorylation-triggered homo- and hetero-oligomerization, and transactivation. It is negatively regulated by the N-terminal MH1 domain which prevents it from forming a complex with SMAD4. The MH2 domain is multifunctional and provides SMADs with their specificity and selectivity, as well as transcriptional activity. Several transcriptional co-activators and repressors have also been reported to regulate SMAD signaling by interacting with the MH2 domain. Mutations in the MH2 domains of SMAD2 and especially SMAD4 have been detected in colorectal and other human cancers. Pssm-ID: 199819 Cd Length: 170 Bit Score: 42.59 E-value: 2.02e-04
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| Blast search parameters | ||||
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