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Conserved domains on  [gi|1767293850|ref|NP_001361897|]
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Potassium channel domain-containing protein [Caenorhabditis elegans]

Protein Classification

potassium channel family protein( domain architecture ID 10545436)

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium, translocate across cell membranes

Gene Ontology:  GO:0005267|GO:0034220|GO:0005216|GO:0071805|GO:0016020
PubMed:  15816170|9525859|11836519|11178249|1772658
SCOP:  4000034
TCDB:  1.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 217-274 3.36e-20

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 85.01  E-value: 3.36e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1767293850 217 GEGWRWDFWNSVFFSATIFTTIGYGNLACKTNLGRVATIIYGLIGIPLMLFVLKIFGE 274
Cdd:pfam07885  17 EEGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGR 74
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 335-413 1.52e-16

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 74.61  E-value: 1.52e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1767293850 335 WALFIVFFFMVVCSLIVSFWEkWDFLTAFYFFFVSLSTIGFGDVIPEHPRTACALFVLYFVGLALFSMVYAILQERVEN 413
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLEEGWE-WSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 217-274 3.36e-20

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 85.01  E-value: 3.36e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1767293850 217 GEGWRWDFWNSVFFSATIFTTIGYGNLACKTNLGRVATIIYGLIGIPLMLFVLKIFGE 274
Cdd:pfam07885  17 EEGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGR 74
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 335-413 1.52e-16

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 74.61  E-value: 1.52e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1767293850 335 WALFIVFFFMVVCSLIVSFWEkWDFLTAFYFFFVSLSTIGFGDVIPEHPRTACALFVLYFVGLALFSMVYAILQERVEN 413
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLEEGWE-WSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
PRK10537 PRK10537
voltage-gated potassium channel protein;
358-400 7.87e-04

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 42.32  E-value: 7.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1767293850 358 DFLTAFYFFFVSLSTIGFGDVIPeHPRTAcALFVLYFV--GLALF 400
Cdd:PRK10537  168 SLSTAFYFSIVTMSTVGYGDIVP-VSESA-RLFTISVIilGITVF 210
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 217-274 3.36e-20

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 85.01  E-value: 3.36e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1767293850 217 GEGWRWDFWNSVFFSATIFTTIGYGNLACKTNLGRVATIIYGLIGIPLMLFVLKIFGE 274
Cdd:pfam07885  17 EEGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGR 74
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 335-413 1.52e-16

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 74.61  E-value: 1.52e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1767293850 335 WALFIVFFFMVVCSLIVSFWEkWDFLTAFYFFFVSLSTIGFGDVIPEHPRTACALFVLYFVGLALFSMVYAILQERVEN 413
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLEEGWE-WSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 337-415 5.38e-05

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 45.34  E-value: 5.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767293850 337 LFIVFFFMVVCSLIV-----SFWEKW-----------DFLTAFYFFFVSLSTIGFGDVIP-----EHPRTACALFVLY-- 393
Cdd:pfam00520 133 LLLLLLFLFIFAIIGyqlfgGKLKTWenpdngrtnfdNFPNAFLWLFQTMTTEGWGDIMYdtidgKGEFWAYIYFVSFii 212

                          90       100
                  ....*....|....*....|..
gi 1767293850 394 FVGLALFSMVYAILQERVENQY 415
Cdd:pfam00520 213 LGGFLLLNLFIAVIIDNFQELT 234
PRK10537 PRK10537
voltage-gated potassium channel protein;
358-400 7.87e-04

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 42.32  E-value: 7.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1767293850 358 DFLTAFYFFFVSLSTIGFGDVIPeHPRTAcALFVLYFV--GLALF 400
Cdd:PRK10537  168 SLSTAFYFSIVTMSTVGYGDIVP-VSESA-RLFTISVIilGITVF 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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