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Conserved domains on  [gi|1831506059|ref|NP_001367697|]
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Kinetochore null protein 2 [Caenorhabditis elegans]

Protein Classification

SANTA domain-containing protein( domain architecture ID 10557544)

SANTA (SANT Associated) domain-containing protein may play a role in regulating chromatin remodeling and in protein-protein interactions

PubMed:  16877755

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SANTA pfam09133
SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino ...
20-108 1.12e-30

SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino acids in length and is conserved in Eukaryota. It is sometimes found in association with the SANT domain (pfam00249, also known as Myb-like DNA-binding domain) implying a putative function in regulating chromatin remodelling. Sequence analysis has showed that the SANTA domain is likely to form four central beta-sheets with three flanking alpha- helixes. Many conserved hydrophobic residues are present which implying a possible role in protein-protein interactions.


:

Pssm-ID: 462689  Cd Length: 87  Bit Score: 115.43  E-value: 1.12e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059  20 IRLNLWSMKFNATSFKLEGFVRNEEGTMmqKVCSEFICRRFTSTLLFDVSGRFFDLVGQIDREYQQKMGMPSRIIDEFSN 99
Cdd:pfam09133   1 VTLKDWWLKKVSKTLAVEGFRRDSDGIR--VFHSSPIVKRISSTTLETSSGIIYILVGFINRSRMLENGFPSEVIKKFLF 78

                  ....*....
gi 1831506059 100 GIPENWADL 108
Cdd:pfam09133  79 GFPENWKEY 87
PRK12678 super family cl36163
transcription termination factor Rho; Provisional
339-509 2.65e-04

transcription termination factor Rho; Provisional


The actual alignment was detected with superfamily member PRK12678:

Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 44.51  E-value: 2.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059 339 ESTPGRVRKPGRRNVSSPSPEPRHRSSSRDGYEQSRYSQRYEH--DNSRWSRHNATYRRHEDESRMSRKRSIVRDDFEYS 416
Cdd:PRK12678  103 EAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAARKAgeGGEQPATEARADAAERTEEEERDERRRRGDREDRQ 182
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059 417 RRHDDGARRRDyyDADIQGDSKRYRGRDASSSSGRsvrfEEEHRRHGDEYRDPRGPRDYNDYGRRRNHANSRSGEDEEKL 496
Cdd:PRK12678  183 AEAERGERGRR--EERGRDGDDRDRRDRREQGDRR----EERGRRDGGDRRGRRRRRDRRDARGDDNREDRGDRDGDDGE 256
                         170
                  ....*....|...
gi 1831506059 497 NAIVRREKELRNR 509
Cdd:PRK12678  257 GRGGRRGRRFRDR 269
PTZ00121 super family cl31754
MAEBL; Provisional
394-729 9.44e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 9.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059  394 RRHEDESRMSRKRSIvrddfEYSRRHDDGARRRDYYDADIQGDSKRYRgRDASSSSGRSVRFEEEHRRHgDEYRDPRGPR 473
Cdd:PTZ00121  1146 RKAEDAKRVEIARKA-----EDARKAEEARKAEDAKKAEAARKAEEVR-KAEELRKAEDARKAEAARKA-EEERKAEEAR 1218
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059  474 DYNDygRRRNHANSRSGEDEEKLNAIVRREKELRNR-LQKSQKASSSSYRHRSNSSDAEESLNEWDIENQELLDNSmmfg 552
Cdd:PTZ00121  1219 KAED--AKKAEAVKKAEEAKKDAEEAKKAEEERNNEeIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKA---- 1292
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059  553 DGIPKRSNARKDKFVKKQATRSKPANSTKSPAQARKKKRASLEDNRDLNDSIACNRPRRSCVTPVAKKITWRKQDLDRLK 632
Cdd:PTZ00121  1293 DEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKK 1372
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059  633 RVIALKKPSASDADWTEV-----LRLLAKEGVVEPEVVRQIAITRLKWVEPEQNEEVLKQVEEV----EQKRRRGAVARV 703
Cdd:PTZ00121  1373 KEEAKKKADAAKKKAEEKkkadeAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAkkkaEEAKKADEAKKK 1452
                          330       340
                   ....*....|....*....|....*...
gi 1831506059  704 KENVKMHEELREGGNH--RAEDLQSGVE 729
Cdd:PTZ00121  1453 AEEAKKAEEAKKKAEEakKADEAKKKAE 1480
 
Name Accession Description Interval E-value
SANTA pfam09133
SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino ...
20-108 1.12e-30

SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino acids in length and is conserved in Eukaryota. It is sometimes found in association with the SANT domain (pfam00249, also known as Myb-like DNA-binding domain) implying a putative function in regulating chromatin remodelling. Sequence analysis has showed that the SANTA domain is likely to form four central beta-sheets with three flanking alpha- helixes. Many conserved hydrophobic residues are present which implying a possible role in protein-protein interactions.


Pssm-ID: 462689  Cd Length: 87  Bit Score: 115.43  E-value: 1.12e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059  20 IRLNLWSMKFNATSFKLEGFVRNEEGTMmqKVCSEFICRRFTSTLLFDVSGRFFDLVGQIDREYQQKMGMPSRIIDEFSN 99
Cdd:pfam09133   1 VTLKDWWLKKVSKTLAVEGFRRDSDGIR--VFHSSPIVKRISSTTLETSSGIIYILVGFINRSRMLENGFPSEVIKKFLF 78

                  ....*....
gi 1831506059 100 GIPENWADL 108
Cdd:pfam09133  79 GFPENWKEY 87
PRK12678 PRK12678
transcription termination factor Rho; Provisional
339-509 2.65e-04

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 44.51  E-value: 2.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059 339 ESTPGRVRKPGRRNVSSPSPEPRHRSSSRDGYEQSRYSQRYEH--DNSRWSRHNATYRRHEDESRMSRKRSIVRDDFEYS 416
Cdd:PRK12678  103 EAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAARKAgeGGEQPATEARADAAERTEEEERDERRRRGDREDRQ 182
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059 417 RRHDDGARRRDyyDADIQGDSKRYRGRDASSSSGRsvrfEEEHRRHGDEYRDPRGPRDYNDYGRRRNHANSRSGEDEEKL 496
Cdd:PRK12678  183 AEAERGERGRR--EERGRDGDDRDRRDRREQGDRR----EERGRRDGGDRRGRRRRRDRRDARGDDNREDRGDRDGDDGE 256
                         170
                  ....*....|...
gi 1831506059 497 NAIVRREKELRNR 509
Cdd:PRK12678  257 GRGGRRGRRFRDR 269
PTZ00121 PTZ00121
MAEBL; Provisional
394-729 9.44e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 9.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059  394 RRHEDESRMSRKRSIvrddfEYSRRHDDGARRRDYYDADIQGDSKRYRgRDASSSSGRSVRFEEEHRRHgDEYRDPRGPR 473
Cdd:PTZ00121  1146 RKAEDAKRVEIARKA-----EDARKAEEARKAEDAKKAEAARKAEEVR-KAEELRKAEDARKAEAARKA-EEERKAEEAR 1218
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059  474 DYNDygRRRNHANSRSGEDEEKLNAIVRREKELRNR-LQKSQKASSSSYRHRSNSSDAEESLNEWDIENQELLDNSmmfg 552
Cdd:PTZ00121  1219 KAED--AKKAEAVKKAEEAKKDAEEAKKAEEERNNEeIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKA---- 1292
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059  553 DGIPKRSNARKDKFVKKQATRSKPANSTKSPAQARKKKRASLEDNRDLNDSIACNRPRRSCVTPVAKKITWRKQDLDRLK 632
Cdd:PTZ00121  1293 DEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKK 1372
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059  633 RVIALKKPSASDADWTEV-----LRLLAKEGVVEPEVVRQIAITRLKWVEPEQNEEVLKQVEEV----EQKRRRGAVARV 703
Cdd:PTZ00121  1373 KEEAKKKADAAKKKAEEKkkadeAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAkkkaEEAKKADEAKKK 1452
                          330       340
                   ....*....|....*....|....*...
gi 1831506059  704 KENVKMHEELREGGNH--RAEDLQSGVE 729
Cdd:PTZ00121  1453 AEEAKKAEEAKKKAEEakKADEAKKKAE 1480
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
367-463 2.65e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 41.42  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059 367 RDGYEQSRYSQRYEHDNSRWSRHNATYRRHEDESRMSRKRSIVRDDFEYSRRHDDgaRRRDYYDADIQGDSKRYRGRDAS 446
Cdd:TIGR01642   1 RDEEPDREREKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDR--RRYDSRSPRSLRYSSVRRSRDRP 78
                          90
                  ....*....|....*..
gi 1831506059 447 SSSGRSVRFEEEHRRHG 463
Cdd:TIGR01642  79 RRRSRSVRSIEQHRRRL 95
 
Name Accession Description Interval E-value
SANTA pfam09133
SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino ...
20-108 1.12e-30

SANTA (SANT Associated); The SANTA domain (SANT Associated domain) is approximately 90 amino acids in length and is conserved in Eukaryota. It is sometimes found in association with the SANT domain (pfam00249, also known as Myb-like DNA-binding domain) implying a putative function in regulating chromatin remodelling. Sequence analysis has showed that the SANTA domain is likely to form four central beta-sheets with three flanking alpha- helixes. Many conserved hydrophobic residues are present which implying a possible role in protein-protein interactions.


Pssm-ID: 462689  Cd Length: 87  Bit Score: 115.43  E-value: 1.12e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059  20 IRLNLWSMKFNATSFKLEGFVRNEEGTMmqKVCSEFICRRFTSTLLFDVSGRFFDLVGQIDREYQQKMGMPSRIIDEFSN 99
Cdd:pfam09133   1 VTLKDWWLKKVSKTLAVEGFRRDSDGIR--VFHSSPIVKRISSTTLETSSGIIYILVGFINRSRMLENGFPSEVIKKFLF 78

                  ....*....
gi 1831506059 100 GIPENWADL 108
Cdd:pfam09133  79 GFPENWKEY 87
PRK12678 PRK12678
transcription termination factor Rho; Provisional
339-509 2.65e-04

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 44.51  E-value: 2.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059 339 ESTPGRVRKPGRRNVSSPSPEPRHRSSSRDGYEQSRYSQRYEH--DNSRWSRHNATYRRHEDESRMSRKRSIVRDDFEYS 416
Cdd:PRK12678  103 EAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAARKAgeGGEQPATEARADAAERTEEEERDERRRRGDREDRQ 182
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059 417 RRHDDGARRRDyyDADIQGDSKRYRGRDASSSSGRsvrfEEEHRRHGDEYRDPRGPRDYNDYGRRRNHANSRSGEDEEKL 496
Cdd:PRK12678  183 AEAERGERGRR--EERGRDGDDRDRRDRREQGDRR----EERGRRDGGDRRGRRRRRDRRDARGDDNREDRGDRDGDDGE 256
                         170
                  ....*....|...
gi 1831506059 497 NAIVRREKELRNR 509
Cdd:PRK12678  257 GRGGRRGRRFRDR 269
PTZ00121 PTZ00121
MAEBL; Provisional
394-729 9.44e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 9.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059  394 RRHEDESRMSRKRSIvrddfEYSRRHDDGARRRDYYDADIQGDSKRYRgRDASSSSGRSVRFEEEHRRHgDEYRDPRGPR 473
Cdd:PTZ00121  1146 RKAEDAKRVEIARKA-----EDARKAEEARKAEDAKKAEAARKAEEVR-KAEELRKAEDARKAEAARKA-EEERKAEEAR 1218
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059  474 DYNDygRRRNHANSRSGEDEEKLNAIVRREKELRNR-LQKSQKASSSSYRHRSNSSDAEESLNEWDIENQELLDNSmmfg 552
Cdd:PTZ00121  1219 KAED--AKKAEAVKKAEEAKKDAEEAKKAEEERNNEeIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKA---- 1292
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059  553 DGIPKRSNARKDKFVKKQATRSKPANSTKSPAQARKKKRASLEDNRDLNDSIACNRPRRSCVTPVAKKITWRKQDLDRLK 632
Cdd:PTZ00121  1293 DEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKK 1372
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059  633 RVIALKKPSASDADWTEV-----LRLLAKEGVVEPEVVRQIAITRLKWVEPEQNEEVLKQVEEV----EQKRRRGAVARV 703
Cdd:PTZ00121  1373 KEEAKKKADAAKKKAEEKkkadeAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAkkkaEEAKKADEAKKK 1452
                          330       340
                   ....*....|....*....|....*...
gi 1831506059  704 KENVKMHEELREGGNH--RAEDLQSGVE 729
Cdd:PTZ00121  1453 AEEAKKAEEAKKKAEEakKADEAKKKAE 1480
PRK12678 PRK12678
transcription termination factor Rho; Provisional
305-505 1.05e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 42.58  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059 305 AVPKAPPSKSVRNLAASNVDIFADVDSVLDTFHFESTPGRVRKPGRRNVSSPSPEPRHRSSSRDGYEQSRYSQRYEHDNS 384
Cdd:PRK12678   93 PAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAARKAGEGGEQPATEARADAAERTEEEERDER 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059 385 RWSRHNATYRRHEDESRMSRKRSIVRDDFEYSRRHDDGARRRDYYDADIQGDSKRYRGRDASSSSGRSVRFEEEHRRHGD 464
Cdd:PRK12678  173 RRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGDRREERGRRDGGDRRGRRRRRDRRDARGDDNREDRGDRDG 252
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1831506059 465 EYRDPRGPRDyNDYGRRRNHaNSRSGEDEEKLNAIVRREKE 505
Cdd:PRK12678  253 DDGEGRGGRR-GRRFRDRDR-RGRRGGDGGNEREPELREDD 291
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
367-463 2.65e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 41.42  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059 367 RDGYEQSRYSQRYEHDNSRWSRHNATYRRHEDESRMSRKRSIVRDDFEYSRRHDDgaRRRDYYDADIQGDSKRYRGRDAS 446
Cdd:TIGR01642   1 RDEEPDREREKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDR--RRYDSRSPRSLRYSSVRRSRDRP 78
                          90
                  ....*....|....*..
gi 1831506059 447 SSSGRSVRFEEEHRRHG 463
Cdd:TIGR01642  79 RRRSRSVRSIEQHRRRL 95
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
358-448 9.95e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 39.49  E-value: 9.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506059 358 PEPRHRSSSRDGYEQSRYSQRYEHDNSRWSRHNATYR--RHEDESRmSRKRSIVRDDFEYSRRHDDGARRRDYydADIQG 435
Cdd:TIGR01642  12 SRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREdsRPRDRRR-YDSRSPRSLRYSSVRRSRDRPRRRSR--SVRSI 88
                          90
                  ....*....|...
gi 1831506059 436 DSKRYRGRDASSS 448
Cdd:TIGR01642  89 EQHRRRLRDRSPS 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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