NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1831509951|ref|NP_001368051|]
View 

Methyltransferase FkbM domain-containing protein [Caenorhabditis elegans]

Protein Classification

FkbM family methyltransferase( domain architecture ID 10523603)

FkbM family methyltransferase is a class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Methyltransf_21 pfam05050
Methyltransferase FkbM domain; This family has members from bacteria to human, and appears to ...
106-274 5.90e-11

Methyltransferase FkbM domain; This family has members from bacteria to human, and appears to be a methyltransferase.


:

Pssm-ID: 428282  Cd Length: 170  Bit Score: 60.27  E-value: 5.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831509951 106 DLKAKEENIMVTLGIGHDTmaeeklnrtlpntkffGADPIIEPNrqlyTAFGKYFPFAIGKKPGFTKFRVLPNQNqrtrk 185
Cdd:pfam05050  34 NKLEKLDCTLLNLALGNDV----------------GLYEFYLGG----KGGGGYLLFAVGDPQGASTSSVLGGEE----- 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831509951 186 YQYQDVTTIPLTYFLSDIlGLEQIDIAWIDIEGGEFEFLDQlhkggplDEKGVSICQFNL---EVHskFHPPGAQIYHDF 262
Cdd:pfam05050  89 AKYIEVETVTLDSFLEEI-KKSDIDLLKIDVEGAELEVLEG-------AEKTLKRCQPNIiviEVH--FFHYFGGPLFDE 158
                         170
                  ....*....|..
gi 1831509951 263 VFKVLEDRRYVF 274
Cdd:pfam05050 159 IRQFLRECGYRL 170
 
Name Accession Description Interval E-value
Methyltransf_21 pfam05050
Methyltransferase FkbM domain; This family has members from bacteria to human, and appears to ...
106-274 5.90e-11

Methyltransferase FkbM domain; This family has members from bacteria to human, and appears to be a methyltransferase.


Pssm-ID: 428282  Cd Length: 170  Bit Score: 60.27  E-value: 5.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831509951 106 DLKAKEENIMVTLGIGHDTmaeeklnrtlpntkffGADPIIEPNrqlyTAFGKYFPFAIGKKPGFTKFRVLPNQNqrtrk 185
Cdd:pfam05050  34 NKLEKLDCTLLNLALGNDV----------------GLYEFYLGG----KGGGGYLLFAVGDPQGASTSSVLGGEE----- 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831509951 186 YQYQDVTTIPLTYFLSDIlGLEQIDIAWIDIEGGEFEFLDQlhkggplDEKGVSICQFNL---EVHskFHPPGAQIYHDF 262
Cdd:pfam05050  89 AKYIEVETVTLDSFLEEI-KKSDIDLLKIDVEGAELEVLEG-------AEKTLKRCQPNIiviEVH--FFHYFGGPLFDE 158
                         170
                  ....*....|..
gi 1831509951 263 VFKVLEDRRYVF 274
Cdd:pfam05050 159 IRQFLRECGYRL 170
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
138-227 5.16e-03

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 36.52  E-value: 5.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831509951 138 KFFGADPI-IEPNRQLYT------------AFgKYFPFAIGKKPGFTKFRVLPNQN-----QRTRKYQYQDVTTIPLTYf 199
Cdd:TIGR01444  19 KGAEGRVIaFEPLPDAYEileenvklnnlpNV-VLLNAAVGDRDGELEFNVSDDDTgnsslLPTPDADRESEIEVEVVT- 96
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1831509951 200 LSDIL---GLEQIDIAWIDIEGGEFEFLDQL 227
Cdd:TIGR01444  97 LDDLVeefGLDKVDLLKIDVEGAELEVLRGA 127
 
Name Accession Description Interval E-value
Methyltransf_21 pfam05050
Methyltransferase FkbM domain; This family has members from bacteria to human, and appears to ...
106-274 5.90e-11

Methyltransferase FkbM domain; This family has members from bacteria to human, and appears to be a methyltransferase.


Pssm-ID: 428282  Cd Length: 170  Bit Score: 60.27  E-value: 5.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831509951 106 DLKAKEENIMVTLGIGHDTmaeeklnrtlpntkffGADPIIEPNrqlyTAFGKYFPFAIGKKPGFTKFRVLPNQNqrtrk 185
Cdd:pfam05050  34 NKLEKLDCTLLNLALGNDV----------------GLYEFYLGG----KGGGGYLLFAVGDPQGASTSSVLGGEE----- 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831509951 186 YQYQDVTTIPLTYFLSDIlGLEQIDIAWIDIEGGEFEFLDQlhkggplDEKGVSICQFNL---EVHskFHPPGAQIYHDF 262
Cdd:pfam05050  89 AKYIEVETVTLDSFLEEI-KKSDIDLLKIDVEGAELEVLEG-------AEKTLKRCQPNIiviEVH--FFHYFGGPLFDE 158
                         170
                  ....*....|..
gi 1831509951 263 VFKVLEDRRYVF 274
Cdd:pfam05050 159 IRQFLRECGYRL 170
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
138-227 5.16e-03

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 36.52  E-value: 5.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831509951 138 KFFGADPI-IEPNRQLYT------------AFgKYFPFAIGKKPGFTKFRVLPNQN-----QRTRKYQYQDVTTIPLTYf 199
Cdd:TIGR01444  19 KGAEGRVIaFEPLPDAYEileenvklnnlpNV-VLLNAAVGDRDGELEFNVSDDDTgnsslLPTPDADRESEIEVEVVT- 96
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1831509951 200 LSDIL---GLEQIDIAWIDIEGGEFEFLDQL 227
Cdd:TIGR01444  97 LDDLVeefGLDKVDLLKIDVEGAELEVLRGA 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH