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Conserved domains on  [gi|1972256961|ref|NP_001379014|]
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pre-mRNA 3' end processing protein pfs-2 [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10646020)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-161 2.44e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 2.44e-03
                           10        20
                   ....*....|....*....|....*..
gi 1972256961  135 PVYSVCWSPEGKRLITGCQTGEFTLWN 161
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-161 2.44e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 2.44e-03
                           10        20
                   ....*....|....*....|....*..
gi 1972256961  135 PVYSVCWSPEGKRLITGCQTGEFTLWN 161
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
135-161 2.98e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 37.97  E-value: 2.98e-03
                          10        20
                  ....*....|....*....|....*..
gi 1972256961 135 PVYSVCWSPEGKRLITGCQTGEFTLWN 161
Cdd:COG2319   290 GVNSVAFSPDGKLLASGSDDGTVRLWD 316
 
Name Accession Description Interval E-value
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-161 2.44e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 2.44e-03
                           10        20
                   ....*....|....*....|....*..
gi 1972256961  135 PVYSVCWSPEGKRLITGCQTGEFTLWN 161
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
135-161 2.98e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 37.97  E-value: 2.98e-03
                          10        20
                  ....*....|....*....|....*..
gi 1972256961 135 PVYSVCWSPEGKRLITGCQTGEFTLWN 161
Cdd:COG2319   290 GVNSVAFSPDGKLLASGSDDGTVRLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
135-181 5.38e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 37.20  E-value: 5.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1972256961 135 PVYSVCWSPEGKRLITGCQTGEFTLWNgtAFNFETILQVKHTTRWIT 181
Cdd:COG2319   164 AVTSVAFSPDGKLLASGSDDGTVRLWD--LATGKLLRTLTGHTGAVR 208
WD40 COG2319
WD40 repeat [General function prediction only];
135-161 7.19e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 36.81  E-value: 7.19e-03
                          10        20
                  ....*....|....*....|....*..
gi 1972256961 135 PVYSVCWSPEGKRLITGCQTGEFTLWN 161
Cdd:COG2319   374 AVTSVAFSPDGRTLASGSADGTVRLWD 400
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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