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Conserved domains on  [gi|1972285645|ref|NP_001379911|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box protein( domain architecture ID 12004606)

F-box protein containing a FTH domain may function as the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins; similar to Caenorhabditis elegans F-box A protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FTH super family cl28746
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 123-227 8.10e-04

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


The actual alignment was detected with superfamily member pfam01827:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 38.32  E-value: 8.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972285645 123 KSENFLKVKNLY-WRCCPPEIdekhsarvfIKFLKLFDENSLKMIHndmLQF--PPEELNILAETSQWKRASTISLANGQ 199
Cdd:pfam01827  12 KSKKCLHVKEISlSGLSFSEV---------ASILPYFDAGTLEEIE---LSSesDEDQFEEIVELEQWKNAKSLKIEGSS 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1972285645 200 VES--IEPFLHTTNCTVYFKKLEIEHILKM 227
Cdd:pfam01827  80 LSSfpIEHLFHFEEFDIKLDSFSVEDAIKI 109
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 10-49 4.26e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 425796  Cd Length: 43  Bit Score: 34.05  E-value: 4.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1972285645  10 WTNLPNLFKRNIISHLDLKHRNALRQCSKEDKKLVDTCQL 49
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 123-227 8.10e-04

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 38.32  E-value: 8.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972285645 123 KSENFLKVKNLY-WRCCPPEIdekhsarvfIKFLKLFDENSLKMIHndmLQF--PPEELNILAETSQWKRASTISLANGQ 199
Cdd:pfam01827  12 KSKKCLHVKEISlSGLSFSEV---------ASILPYFDAGTLEEIE---LSSesDEDQFEEIVELEQWKNAKSLKIEGSS 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1972285645 200 VES--IEPFLHTTNCTVYFKKLEIEHILKM 227
Cdd:pfam01827  80 LSSfpIEHLFHFEEFDIKLDSFSVEDAIKI 109
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 10-49 4.26e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 34.05  E-value: 4.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1972285645  10 WTNLPNLFKRNIISHLDLKHRNALRQCSKEDKKLVDTCQL 49
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 123-227 8.10e-04

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 38.32  E-value: 8.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972285645 123 KSENFLKVKNLY-WRCCPPEIdekhsarvfIKFLKLFDENSLKMIHndmLQF--PPEELNILAETSQWKRASTISLANGQ 199
Cdd:pfam01827  12 KSKKCLHVKEISlSGLSFSEV---------ASILPYFDAGTLEEIE---LSSesDEDQFEEIVELEQWKNAKSLKIEGSS 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1972285645 200 VES--IEPFLHTTNCTVYFKKLEIEHILKM 227
Cdd:pfam01827  80 LSSfpIEHLFHFEEFDIKLDSFSVEDAIKI 109
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 10-49 4.26e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 34.05  E-value: 4.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1972285645  10 WTNLPNLFKRNIISHLDLKHRNALRQCSKEDKKLVDTCQL 49
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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