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Conserved domains on  [gi|2032329445|ref|NP_001381704|]
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COP9 signalosome complex subunit 1 isoform 19 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
123-305 2.09e-68

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


:

Pssm-ID: 431387  Cd Length: 174  Bit Score: 215.51  E-value: 2.09e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329445 123 DTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVI 202
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329445 203 KVSVYLQNWSHVLSYVSKAESTPEIAEQrgerdsqtQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDfPELLSP 282
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGD--------WERRNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTS-TELISY 151
                         170       180
                  ....*....|....*....|...
gi 2032329445 283 SNVAIYGGLCALATFDRQELQRN 305
Cdd:pfam10602 152 EDVAVYGVLCALASLDRVDLKAK 174
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
344-412 2.87e-10

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


:

Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 56.48  E-value: 2.87e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2032329445  344 MKYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRS----TTFEKSLLMG 412
Cdd:smart00088  16 LQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRseplAQFAETLKKL 88
 
Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
123-305 2.09e-68

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


Pssm-ID: 431387  Cd Length: 174  Bit Score: 215.51  E-value: 2.09e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329445 123 DTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVI 202
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329445 203 KVSVYLQNWSHVLSYVSKAESTPEIAEQrgerdsqtQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDfPELLSP 282
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGD--------WERRNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTS-TELISY 151
                         170       180
                  ....*....|....*....|...
gi 2032329445 283 SNVAIYGGLCALATFDRQELQRN 305
Cdd:pfam10602 152 EDVAVYGVLCALASLDRVDLKAK 174
RPN7 COG5187
26S proteasome regulatory complex component, contains PCI domain [Posttranslational ...
163-435 1.58e-10

26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227514 [Multi-domain]  Cd Length: 412  Bit Score: 62.63  E-value: 1.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329445 163 DLGDHYLDCGDLSNALKCYSRA--RDYCTSAKhvINMCLNVIKVSVYLQNWSHVLSYVSKAEStpeIAEQRGERDSQTqa 240
Cdd:COG5187   120 NIAEYYCQIMDIQNGFEWMRRLmrDAMSTGLK--IDVFLCKIRLGLIYGDRKVVEESLEVADD---IIEKGGDWERRN-- 192
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329445 241 iltKLKCAAGLAELAARKYKQAAKCLL--LASFDHCdfpELLSPSNVAIYGGLCALATFDRQELQRNVISSSSfklFLEL 318
Cdd:COG5187   193 ---RYKVYKGIFKMMRRNFKEAAILLSdiLPTFESS---ELISYSRAVRYAIFCGLLRLERRDIKTKILDSPE---VLDV 263
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329445 319 EPQ------VRDIIFKFYESKYASCLKMLDEM--------KY---FSPYVSADMHR-----------------MAAAFNT 364
Cdd:COG5187   264 IGSseklgsLVQLATSLYECDYGGDFMNLLYLfcnslqddVFlgrHVDLFVREMRRrvyaqllesyrllslesMAQTFGV 343
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2032329445 365 TVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMlrAAVLRNQIHV 435
Cdd:COG5187   344 SVEYVDRDLGEFIPEGRLNCVIDRVNGVVETNRPDEKNQQYSSVVKQGDDLLRKLQKYV--ATVMRGAFKV 412
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
344-412 2.87e-10

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 56.48  E-value: 2.87e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2032329445  344 MKYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRS----TTFEKSLLMG 412
Cdd:smart00088  16 LQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRseplAQFAETLKKL 88
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
320-397 1.07e-09

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 55.69  E-value: 1.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329445 320 PQVRDIIFKFYESKYASCLKMLDE---------------------------MKYFSPYVSADMHRMAAAFNTTVAALEDE 372
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADykeelllddglaehledlrrkirehnlRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 2032329445 373 LTQLILEGLISARVDSHSKILYARD 397
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
 
Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
123-305 2.09e-68

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


Pssm-ID: 431387  Cd Length: 174  Bit Score: 215.51  E-value: 2.09e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329445 123 DTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVI 202
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329445 203 KVSVYLQNWSHVLSYVSKAESTPEIAEQrgerdsqtQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDfPELLSP 282
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGD--------WERRNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTS-TELISY 151
                         170       180
                  ....*....|....*....|...
gi 2032329445 283 SNVAIYGGLCALATFDRQELQRN 305
Cdd:pfam10602 152 EDVAVYGVLCALASLDRVDLKAK 174
RPN7 COG5187
26S proteasome regulatory complex component, contains PCI domain [Posttranslational ...
163-435 1.58e-10

26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227514 [Multi-domain]  Cd Length: 412  Bit Score: 62.63  E-value: 1.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329445 163 DLGDHYLDCGDLSNALKCYSRA--RDYCTSAKhvINMCLNVIKVSVYLQNWSHVLSYVSKAEStpeIAEQRGERDSQTqa 240
Cdd:COG5187   120 NIAEYYCQIMDIQNGFEWMRRLmrDAMSTGLK--IDVFLCKIRLGLIYGDRKVVEESLEVADD---IIEKGGDWERRN-- 192
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329445 241 iltKLKCAAGLAELAARKYKQAAKCLL--LASFDHCdfpELLSPSNVAIYGGLCALATFDRQELQRNVISSSSfklFLEL 318
Cdd:COG5187   193 ---RYKVYKGIFKMMRRNFKEAAILLSdiLPTFESS---ELISYSRAVRYAIFCGLLRLERRDIKTKILDSPE---VLDV 263
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329445 319 EPQ------VRDIIFKFYESKYASCLKMLDEM--------KY---FSPYVSADMHR-----------------MAAAFNT 364
Cdd:COG5187   264 IGSseklgsLVQLATSLYECDYGGDFMNLLYLfcnslqddVFlgrHVDLFVREMRRrvyaqllesyrllslesMAQTFGV 343
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2032329445 365 TVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMlrAAVLRNQIHV 435
Cdd:COG5187   344 SVEYVDRDLGEFIPEGRLNCVIDRVNGVVETNRPDEKNQQYSSVVKQGDDLLRKLQKYV--ATVMRGAFKV 412
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
344-412 2.87e-10

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 56.48  E-value: 2.87e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2032329445  344 MKYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRS----TTFEKSLLMG 412
Cdd:smart00088  16 LQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRseplAQFAETLKKL 88
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
320-397 1.07e-09

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 55.69  E-value: 1.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329445 320 PQVRDIIFKFYESKYASCLKMLDE---------------------------MKYFSPYVSADMHRMAAAFNTTVAALEDE 372
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADykeelllddglaehledlrrkirehnlRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 2032329445 373 LTQLILEGLISARVDSHSKILYARD 397
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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