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Conserved domains on  [gi|2056392215|ref|NP_001382246|]
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myomegalin isoform 36 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Cnn_1N pfam07989
Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated ...
143-210 2.33e-17

Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organizing activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.


:

Pssm-ID: 462333 [Multi-domain]  Cd Length: 69  Bit Score: 77.18  E-value: 2.33e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2056392215  143 RDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTW 210
Cdd:pfam07989    1 REQEKQIDKLKKENFNLKLKIHFLEERLEKLAPEQIEEALKENIELKVELETLQRELKKLKKLLREAE 68
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
140-816 5.57e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 73.55  E-value: 5.57e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  140 QALRDFEKHLNDLKKENFSLKLRIYFLE-ERMQQKYEASREDIYKRNIELkVEVESLKRELQDKKQHLDKTWADVENLNS 218
Cdd:TIGR02168  220 AELRELELALLVLRLEELREELEELQEElKEAEEELEELTAELQELEEKL-EELRLEVSELEEEIEELQKELYALANEIS 298
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  219 QNEAELRRQFEERQQ------ETEHVYELLENKIQLLQEESRL-------AKNEAARMAALVEAEKECNLELSEKLKGVT 285
Cdd:TIGR02168  299 RLEQQKQILRERLANlerqleELEAQLEELESKLDELAEELAEleekleeLKEELESLEAELEELEAELEELESRLEELE 378
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  286 KNWEDVPGDQvkpDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQklnshE 365
Cdd:TIGR02168  379 EQLETLRSKV---AQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEEL-----E 450
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  366 TTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRER------------E 433
Cdd:TIGR02168  451 ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGlsgilgvlseliS 530
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  434 TEELYQ--------------VIEGQNDTMAKLrEMLHQSQLGQLHSSEGTS----------------------------- 470
Cdd:TIGR02168  531 VDEGYEaaieaalggrlqavVVENLNAAKKAI-AFLKQNELGRVTFLPLDSikgteiqgndreilkniegflgvakdlvk 609
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  471 -PAQQQVALLDLQSALFCSQ-----LEIQKLQR----------------------------VVRQKERQLADAKQCVQFV 516
Cdd:TIGR02168  610 fDPKLRKALSYLLGGVLVVDdldnaLELAKKLRpgyrivtldgdlvrpggvitggsaktnsSILERRREIEELEEKIEEL 689
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  517 EAAAHESEQQkeaswkhnqelRKALQQLQEELQNKSQQLRAWEAEKYNEI----------RTQEQNIQHLNHSLSHK-EQ 585
Cdd:TIGR02168  690 EEKIAELEKA-----------LAELRKELEELEEELEQLRKELEELSRQIsalrkdlarlEAEVEQLEERIAQLSKElTE 758
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  586 LLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDkavaLERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLS 665
Cdd:TIGR02168  759 LEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQ----LKEELKALREALDELRAELTLLNEEAANLRERLESLERRIA 834
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  666 SNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQlqtsLHDRNKEVEDLSATLlcklgpg 745
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEA----LALLRSELEELSEEL------- 903
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2056392215  746 qsEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQA 816
Cdd:TIGR02168  904 --RELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARR 972
PRK02224 super family cl32023
DNA double-strand break repair Rad50 ATPase;
611-1088 2.29e-03

DNA double-strand break repair Rad50 ATPase;


The actual alignment was detected with superfamily member PRK02224:

Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.95  E-value: 2.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  611 LEKLRQRIHDKAVALERAIDEKFSALEEKEKE------------LRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLL 678
Cdd:PRK02224   164 LEEYRERASDARLGVERVLSDQRGSLDQLKAQieekeekdlherLNGLESELAELDEEIERYEEQREQARETRDEADEVL 243
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  679 ---RAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEqesiIQQLQTSLHDRNKEVEDLSATllCKLGPGQSEIAEELCQ 755
Cdd:PRK02224   244 eehEERREELETLEAEIEDLRETIAETEREREELAEE----VRDLRERLEELEEERDDLLAE--AGLDDADAEAVEARRE 317
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  756 RLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISN 835
Cdd:PRK02224   318 ELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELR 397
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  836 QQAEVTPTgRLGKQTDQGSMQIPSRDDS----TSLTAK---------------------------EDVSIPRSTLGDLDT 884
Cdd:PRK02224   398 ERFGDAPV-DLGNAEDFLEELREERDELrereAELEATlrtarerveeaealleagkcpecgqpvEGSPHVETIEEDRER 476
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  885 VAGLEKELSNAKEELELM------AKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDP 958
Cdd:PRK02224   477 VEELEAELEDLEEEVEEVeerlerAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEK 556
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  959 EDipAMERLTQEVLLLREKVASVESQGQEI-----SGNRRQQLLLMLEGLVDERSRLNEALQA------ERQLYSSlvkf 1027
Cdd:PRK02224   557 RE--AAAEAEEEAEEAREEVAELNSKLAELkerieSLERIRTLLAAIADAEDEIERLREKREAlaelndERRERLA---- 630
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2056392215 1028 hahpESSERDRTLQVE-----LEGAQVLRSRLEEVLGRSLERLNRL-----ETLAAIGG-----GELESVRIHHKH 1088
Cdd:PRK02224   631 ----EKRERKRELEAEfdearIEEAREDKERAEEYLEQVEEKLDELreerdDLQAEIGAvenelEELEELRERREA 702
 
Name Accession Description Interval E-value
Cnn_1N pfam07989
Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated ...
143-210 2.33e-17

Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organizing activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.


Pssm-ID: 462333 [Multi-domain]  Cd Length: 69  Bit Score: 77.18  E-value: 2.33e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2056392215  143 RDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTW 210
Cdd:pfam07989    1 REQEKQIDKLKKENFNLKLKIHFLEERLEKLAPEQIEEALKENIELKVELETLQRELKKLKKLLREAE 68
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
140-816 5.57e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 73.55  E-value: 5.57e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  140 QALRDFEKHLNDLKKENFSLKLRIYFLE-ERMQQKYEASREDIYKRNIELkVEVESLKRELQDKKQHLDKTWADVENLNS 218
Cdd:TIGR02168  220 AELRELELALLVLRLEELREELEELQEElKEAEEELEELTAELQELEEKL-EELRLEVSELEEEIEELQKELYALANEIS 298
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  219 QNEAELRRQFEERQQ------ETEHVYELLENKIQLLQEESRL-------AKNEAARMAALVEAEKECNLELSEKLKGVT 285
Cdd:TIGR02168  299 RLEQQKQILRERLANlerqleELEAQLEELESKLDELAEELAEleekleeLKEELESLEAELEELEAELEELESRLEELE 378
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  286 KNWEDVPGDQvkpDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQklnshE 365
Cdd:TIGR02168  379 EQLETLRSKV---AQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEEL-----E 450
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  366 TTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRER------------E 433
Cdd:TIGR02168  451 ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGlsgilgvlseliS 530
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  434 TEELYQ--------------VIEGQNDTMAKLrEMLHQSQLGQLHSSEGTS----------------------------- 470
Cdd:TIGR02168  531 VDEGYEaaieaalggrlqavVVENLNAAKKAI-AFLKQNELGRVTFLPLDSikgteiqgndreilkniegflgvakdlvk 609
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  471 -PAQQQVALLDLQSALFCSQ-----LEIQKLQR----------------------------VVRQKERQLADAKQCVQFV 516
Cdd:TIGR02168  610 fDPKLRKALSYLLGGVLVVDdldnaLELAKKLRpgyrivtldgdlvrpggvitggsaktnsSILERRREIEELEEKIEEL 689
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  517 EAAAHESEQQkeaswkhnqelRKALQQLQEELQNKSQQLRAWEAEKYNEI----------RTQEQNIQHLNHSLSHK-EQ 585
Cdd:TIGR02168  690 EEKIAELEKA-----------LAELRKELEELEEELEQLRKELEELSRQIsalrkdlarlEAEVEQLEERIAQLSKElTE 758
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  586 LLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDkavaLERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLS 665
Cdd:TIGR02168  759 LEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQ----LKEELKALREALDELRAELTLLNEEAANLRERLESLERRIA 834
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  666 SNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQlqtsLHDRNKEVEDLSATLlcklgpg 745
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEA----LALLRSELEELSEEL------- 903
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2056392215  746 qsEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQA 816
Cdd:TIGR02168  904 --RELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARR 972
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
197-724 1.60e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.81  E-value: 1.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  197 RELQDKKQHLDKTWADVENLNSQNEAELrRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLE 276
Cdd:COG1196    235 RELEAELEELEAELEELEAELEELEAEL-AELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRE 313
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  277 LSEKLKGVTKNWEDVP----GDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMT 352
Cdd:COG1196    314 LEERLEELEEELAELEeeleELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALR 393
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  353 EELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRER 432
Cdd:COG1196    394 AAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAA 473
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  433 ETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQ---------QQVALLDLQSALFCSQLEIQKLQRVVRQKE 503
Cdd:COG1196    474 LLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALllaglrglaGAVAVLIGVEAAYEAALEAALAAALQNIVV 553
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  504 RQLADAKQCVQFV--EAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS 581
Cdd:COG1196    554 EDDEVAAAAIEYLkaAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLE 633
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  582 HKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLR 661
Cdd:COG1196    634 AALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAE 713
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2056392215  662 DVLSSNEATMQSMESLLRAKG--LEVEQLSTTCQNLQWLKEEMETKFSRwqKEQESIIQQLQTSL 724
Cdd:COG1196    714 EERLEEELEEEALEEQLEAEReeLLEELLEEEELLEEEALEELPEPPDL--EELERELERLEREI 776
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
170-975 4.01e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 54.35  E-value: 4.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  170 MQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTwADVENLNSQNEAELRRQFEERQQETEHVYELLENKI--- 246
Cdd:pfam15921   90 LQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAM-ADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLeds 168
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  247 --QLLQEESRLAKNEAARM---AALVEAEKECNLELSEKLKGVTKNWEDVpGDQVkpdqyTEALAQRDKRIEELNQSLAA 321
Cdd:pfam15921  169 ntQIEQLRKMMLSHEGVLQeirSILVDFEEASGKKIYEHDSMSTMHFRSL-GSAI-----SKILRELDTEISYLKGRIFP 242
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  322 QERLVEQLSREKQQLLhlleeptsmevqpmteELLKQQKLNSHETTITQQSVsdsHLAELQEKIQQTEATNKILQEKLNE 401
Cdd:pfam15921  243 VEDQLEALKSESQNKI----------------ELLLQQHQDRIEQLISEHEV---EITGLTEKASSARSQANSIQSQLEI 303
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  402 MSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQviegqndtmAKLREMLHQSQLGQLHSSEGTSPAQQqvalLDL 481
Cdd:pfam15921  304 IQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYE---------DKIEELEKQLVLANSELTEARTERDQ----FSQ 370
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  482 QSALFCSQLeiQKLQRVVRQKERQLAdakqcvqfveaaaHESEQQKEAsWKHN-------QELRKALQQLQEELQNKSQQ 554
Cdd:pfam15921  371 ESGNLDDQL--QKLLADLHKREKELS-------------LEKEQNKRL-WDRDtgnsitiDHLRRELDDRNMEVQRLEAL 434
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  555 LRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALEraidEKFS 634
Cdd:pfam15921  435 LKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQ----EKER 510
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  635 ALEEKEKELRQLRLAVRERDHDLERLR---DVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQK 711
Cdd:pfam15921  511 AIEATNAEITKLRSRVDLKLQELQHLKnegDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQV 590
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  712 EQesiiQQLQTSLHDRNKEVEDLSatLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVST 791
Cdd:pfam15921  591 EK----AQLEKEINDRRLELQEFK--ILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKT 664
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  792 REQESQAAAEKLvqALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGRLGKQTDQGSMQIpsrddstSLTAKED 871
Cdd:pfam15921  665 SRNELNSLSEDY--EVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKV-------AMGMQKQ 735
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  872 VSIPRSTLGDLDT-VAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKD 950
Cdd:pfam15921  736 ITAKRGQIDALQSkIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDK 815
                          810       820
                   ....*....|....*....|....*
gi 2056392215  951 LQMQLVDPEDIpaMERLTQEVLLLR 975
Cdd:pfam15921  816 ASLQFAECQDI--IQRQEQESVRLK 838
PTZ00121 PTZ00121
MAEBL; Provisional
167-653 2.91e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 51.68  E-value: 2.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  167 EERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLE-NK 245
Cdd:PTZ00121  1313 EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEkKK 1392
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  246 IQLLQEESRLAKNEAARMAALVEAEKECNlELSEKLKGVTKNWE-DVPGDQVKPDQYTEALAQRDKRIEELNQSlAAQER 324
Cdd:PTZ00121  1393 ADEAKKKAEEDKKKADELKKAAAAKKKAD-EAKKKAEEKKKADEaKKKAEEAKKADEAKKKAEEAKKAEEAKKK-AEEAK 1470
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  325 LVEQLSREKQQLLHLLE-EPTSMEVQPMTEELLK--QQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNE 401
Cdd:PTZ00121  1471 KADEAKKKAEEAKKADEaKKKAEEAKKKADEAKKaaEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADE 1550
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  402 M--SYELKCAQESSQKQDGtiQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALL 479
Cdd:PTZ00121  1551 LkkAEELKKAEEKKKAEEA--KKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKA 1628
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  480 DlQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEA--SWKHNQELRKALQQL--QEELQNKSQQL 555
Cdd:PTZ00121  1629 E-EEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAeeAKKAEEDEKKAAEALkkEAEEAKKAEEL 1707
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  556 RAWEAEkynEIRTQEQNIQHLNHSLSHKEQLLQEFREllqyRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSA 635
Cdd:PTZ00121  1708 KKKEAE---EKKKAEELKKAEEENKIKAEEAKKEAEE----DKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAV 1780
                          490
                   ....*....|....*...
gi 2056392215  636 LEEKEKELRQLRLAVRER 653
Cdd:PTZ00121  1781 IEEELDEEDEKRRMEVDK 1798
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
611-1088 2.29e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.95  E-value: 2.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  611 LEKLRQRIHDKAVALERAIDEKFSALEEKEKE------------LRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLL 678
Cdd:PRK02224   164 LEEYRERASDARLGVERVLSDQRGSLDQLKAQieekeekdlherLNGLESELAELDEEIERYEEQREQARETRDEADEVL 243
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  679 ---RAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEqesiIQQLQTSLHDRNKEVEDLSATllCKLGPGQSEIAEELCQ 755
Cdd:PRK02224   244 eehEERREELETLEAEIEDLRETIAETEREREELAEE----VRDLRERLEELEEERDDLLAE--AGLDDADAEAVEARRE 317
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  756 RLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISN 835
Cdd:PRK02224   318 ELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELR 397
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  836 QQAEVTPTgRLGKQTDQGSMQIPSRDDS----TSLTAK---------------------------EDVSIPRSTLGDLDT 884
Cdd:PRK02224   398 ERFGDAPV-DLGNAEDFLEELREERDELrereAELEATlrtarerveeaealleagkcpecgqpvEGSPHVETIEEDRER 476
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  885 VAGLEKELSNAKEELELM------AKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDP 958
Cdd:PRK02224   477 VEELEAELEDLEEEVEEVeerlerAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEK 556
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  959 EDipAMERLTQEVLLLREKVASVESQGQEI-----SGNRRQQLLLMLEGLVDERSRLNEALQA------ERQLYSSlvkf 1027
Cdd:PRK02224   557 RE--AAAEAEEEAEEAREEVAELNSKLAELkerieSLERIRTLLAAIADAEDEIERLREKREAlaelndERRERLA---- 630
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2056392215 1028 hahpESSERDRTLQVE-----LEGAQVLRSRLEEVLGRSLERLNRL-----ETLAAIGG-----GELESVRIHHKH 1088
Cdd:PRK02224   631 ----EKRERKRELEAEfdearIEEAREDKERAEEYLEQVEEKLDELreerdDLQAEIGAvenelEELEELRERREA 702
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
602-1056 5.35e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.91  E-value: 5.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  602 KTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAK 681
Cdd:COG4717     49 ERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLL 128
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  682 GLEVEqlsttcqnLQWLKEEMETKFSRWQKEQESI--IQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELcQRLQR 759
Cdd:COG4717    129 PLYQE--------LEALEAELAELPERLEELEERLeeLRELEEELEELEAELAELQEELEELLEQLSLATEEEL-QDLAE 199
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  760 KERMLQDLLSDRNKQVLEHEMEIQGLlqsvstREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAE 839
Cdd:COG4717    200 ELEELQQRLAELEEELEEAQEELEEL------EEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLIL 273
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  840 VTPTGRLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDtvaglEKELSNAKEELELMAKKERESQMELSAlqsm 919
Cdd:COG4717    274 TIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELE-----EEELEELLAALGLPPDLSPEELLELLD---- 344
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  920 mavQEEELQVQAADMESLTRNIQIK--EDLIKDL--QMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQ 995
Cdd:COG4717    345 ---RIEELQELLREAEELEEELQLEelEQEIAALlaEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEEL 421
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2056392215  996 L-LLMLEGLVDERSRLNEALQAER----QLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE 1056
Cdd:COG4717    422 LeALDEEELEEELEELEEELEELEeeleELREELAELEAELEQLEEDGELAELLQELEELKAELRE 487
 
Name Accession Description Interval E-value
Cnn_1N pfam07989
Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated ...
143-210 2.33e-17

Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organizing activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.


Pssm-ID: 462333 [Multi-domain]  Cd Length: 69  Bit Score: 77.18  E-value: 2.33e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2056392215  143 RDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTW 210
Cdd:pfam07989    1 REQEKQIDKLKKENFNLKLKIHFLEERLEKLAPEQIEEALKENIELKVELETLQRELKKLKKLLREAE 68
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
140-816 5.57e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 73.55  E-value: 5.57e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  140 QALRDFEKHLNDLKKENFSLKLRIYFLE-ERMQQKYEASREDIYKRNIELkVEVESLKRELQDKKQHLDKTWADVENLNS 218
Cdd:TIGR02168  220 AELRELELALLVLRLEELREELEELQEElKEAEEELEELTAELQELEEKL-EELRLEVSELEEEIEELQKELYALANEIS 298
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  219 QNEAELRRQFEERQQ------ETEHVYELLENKIQLLQEESRL-------AKNEAARMAALVEAEKECNLELSEKLKGVT 285
Cdd:TIGR02168  299 RLEQQKQILRERLANlerqleELEAQLEELESKLDELAEELAEleekleeLKEELESLEAELEELEAELEELESRLEELE 378
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  286 KNWEDVPGDQvkpDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQklnshE 365
Cdd:TIGR02168  379 EQLETLRSKV---AQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEEL-----E 450
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  366 TTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRER------------E 433
Cdd:TIGR02168  451 ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGlsgilgvlseliS 530
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  434 TEELYQ--------------VIEGQNDTMAKLrEMLHQSQLGQLHSSEGTS----------------------------- 470
Cdd:TIGR02168  531 VDEGYEaaieaalggrlqavVVENLNAAKKAI-AFLKQNELGRVTFLPLDSikgteiqgndreilkniegflgvakdlvk 609
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  471 -PAQQQVALLDLQSALFCSQ-----LEIQKLQR----------------------------VVRQKERQLADAKQCVQFV 516
Cdd:TIGR02168  610 fDPKLRKALSYLLGGVLVVDdldnaLELAKKLRpgyrivtldgdlvrpggvitggsaktnsSILERRREIEELEEKIEEL 689
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  517 EAAAHESEQQkeaswkhnqelRKALQQLQEELQNKSQQLRAWEAEKYNEI----------RTQEQNIQHLNHSLSHK-EQ 585
Cdd:TIGR02168  690 EEKIAELEKA-----------LAELRKELEELEEELEQLRKELEELSRQIsalrkdlarlEAEVEQLEERIAQLSKElTE 758
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  586 LLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDkavaLERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLS 665
Cdd:TIGR02168  759 LEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQ----LKEELKALREALDELRAELTLLNEEAANLRERLESLERRIA 834
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  666 SNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQlqtsLHDRNKEVEDLSATLlcklgpg 745
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEA----LALLRSELEELSEEL------- 903
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2056392215  746 qsEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQA 816
Cdd:TIGR02168  904 --RELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARR 972
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
197-724 1.60e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.81  E-value: 1.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  197 RELQDKKQHLDKTWADVENLNSQNEAELrRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLE 276
Cdd:COG1196    235 RELEAELEELEAELEELEAELEELEAEL-AELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRE 313
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  277 LSEKLKGVTKNWEDVP----GDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMT 352
Cdd:COG1196    314 LEERLEELEEELAELEeeleELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALR 393
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  353 EELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRER 432
Cdd:COG1196    394 AAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAA 473
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  433 ETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQ---------QQVALLDLQSALFCSQLEIQKLQRVVRQKE 503
Cdd:COG1196    474 LLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALllaglrglaGAVAVLIGVEAAYEAALEAALAAALQNIVV 553
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  504 RQLADAKQCVQFV--EAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS 581
Cdd:COG1196    554 EDDEVAAAAIEYLkaAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLE 633
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  582 HKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLR 661
Cdd:COG1196    634 AALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAE 713
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2056392215  662 DVLSSNEATMQSMESLLRAKG--LEVEQLSTTCQNLQWLKEEMETKFSRwqKEQESIIQQLQTSL 724
Cdd:COG1196    714 EERLEEELEEEALEEQLEAEReeLLEELLEEEELLEEEALEELPEPPDL--EELERELERLEREI 776
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
489-994 1.12e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 66.11  E-value: 1.12e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  489 QLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRT 568
Cdd:COG1196    245 EAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEE 324
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  569 QEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSAL---EEKEKELRQ 645
Cdd:COG1196    325 LAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALraaAELAAQLEE 404
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  646 LRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLH 725
Cdd:COG1196    405 LEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLE 484
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  726 DRNKEVEDLSATLLCK---LGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEK 802
Cdd:COG1196    485 ELAEAAARLLLLLEAEadyEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIE 564
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  803 L------------------VQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGRLGKQTDQGSMQIPSRDDST 864
Cdd:COG1196    565 YlkaakagratflpldkirARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAG 644
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  865 SLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAA-DMESLTRNIQI 943
Cdd:COG1196    645 RLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAeEERLEEELEEE 724
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2056392215  944 KEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQ 994
Cdd:COG1196    725 ALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLERE 775
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
307-1016 1.26e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 65.85  E-value: 1.26e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  307 QRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEpTSMEVQPMTEELLKQQK-LNSH-------ETTITQQSVSDSHL 378
Cdd:TIGR02168  236 ELREELEELQEELKEAEEELEELTAELQELEEKLEE-LRLEVSELEEEIEELQKeLYALaneisrlEQQKQILRERLANL 314
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  379 ----AELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREM 454
Cdd:TIGR02168  315 erqlEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQ 394
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  455 L--HQSQLGQLhSSEGTSPAQQQVALLDLQSALFCSQLE--IQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEAS 530
Cdd:TIGR02168  395 IasLNNEIERL-EARLERLEDRRERLQQEIEELLKKLEEaeLKELQAELEELEEELEELQEELERLEEALEELREELEEA 473
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  531 WKHNQELR----------KALQQLQEELQNKSQQLRAWEAEKyneiRTQEQNIQHLNHSLSHKEQLLQEFRELLQYR--- 597
Cdd:TIGR02168  474 EQALDAAErelaqlqarlDSLERLQENLEGFSEGVKALLKNQ----SGLSGILGVLSELISVDEGYEAAIEAALGGRlqa 549
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  598 ---DNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLA--VRERDHDLERLRDVLSSNEATMQ 672
Cdd:TIGR02168  550 vvvENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAkdLVKFDPKLRKALSYLLGGVLVVD 629
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  673 SMESLLR-AKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ-----------KEQESIIQQLQTSLHDRNKEVEDLSATLlc 740
Cdd:TIGR02168  630 DLDNALElAKKLRPGYRIVTLDGDLVRPGGVITGGSAKTnssilerrreiEELEEKIEELEEKIAELEKALAELRKEL-- 707
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  741 klgpgqSEIAEELCQRLQRKERMLQDlLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQY 820
Cdd:TIGR02168  708 ------EELEEELEQLRKELEELSRQ-ISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEA 780
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  821 LGGRDSLMSQAP------------ISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLdtvAGL 888
Cdd:TIGR02168  781 EAEIEELEAQIEqlkeelkalreaLDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDI---ESL 857
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  889 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDipAMERLT 968
Cdd:TIGR02168  858 AAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLEL--RLEGLE 935
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*...
gi 2056392215  969 QEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQA 1016
Cdd:TIGR02168  936 VRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKE 983
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
213-818 3.69e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 64.31  E-value: 3.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  213 VENLNSQNEAELRRQfEERQQETEHVYELLENKIQLLQEESRLAKNEAARMA----ALVEAEKECNLELSEKLKGVTKNW 288
Cdd:TIGR02168  202 LKSLERQAEKAERYK-ELKAELRELELALLVLRLEELREELEELQEELKEAEeeleELTAELQELEEKLEELRLEVSELE 280
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  289 EDVPGDQVKPDQYTEALAQRDKRIEELNQSLAA----QERLVEQLSREKQQLLHLLEEPTSMEVQpmTEELLKQQKLNSH 364
Cdd:TIGR02168  281 EEIEELQKELYALANEISRLEQQKQILRERLANlerqLEELEAQLEELESKLDELAEELAELEEK--LEELKEELESLEA 358
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  365 EttitqqsvsdshLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQ 444
Cdd:TIGR02168  359 E------------LEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEEL 426
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  445 NDTMAKLREMLHQSQLGQLHSSEgtspAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEA--AAHE 522
Cdd:TIGR02168  427 LKKLEEAELKELQAELEELEEEL----EELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERlqENLE 502
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  523 SEQQKEASWKHNQELRKALQQ-------------------LQEELQ-----NKSQQLRAWEAEKYNEI------------ 566
Cdd:TIGR02168  503 GFSEGVKALLKNQSGLSGILGvlselisvdegyeaaieaaLGGRLQavvveNLNAAKKAIAFLKQNELgrvtflpldsik 582
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  567 --------RTQEQNIQHLNHSLSHKEQLLQEFRELLQYR-------DNSD------KTLEANEML--------------- 610
Cdd:TIGR02168  583 gteiqgndREILKNIEGFLGVAKDLVKFDPKLRKALSYLlggvlvvDDLDnalelaKKLRPGYRIvtldgdlvrpggvit 662
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  611 ----------------LEKLRQRI---HDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATM 671
Cdd:TIGR02168  663 ggsaktnssilerrreIEELEEKIeelEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEV 742
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  672 QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSA-----TLLCKLGPGQ 746
Cdd:TIGR02168  743 EQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDElraelTLLNEEAANL 822
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2056392215  747 SEIAEELCQRLQRKERMLQDlLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALR 818
Cdd:TIGR02168  823 RERLESLERRIAATERRLED-LEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLR 893
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
536-806 1.54e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 62.39  E-value: 1.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  536 ELRKALQQLQEE---------LQNKSQQLRAWEaeKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDnsdKTLEA 606
Cdd:TIGR02169  195 EKRQQLERLRRErekaeryqaLLKEKREYEGYE--LLKEKEALERQKEAIERQLASLEEELEKLTEEISELE---KRLEE 269
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  607 NEMLLEKLRQRIHDKAVALERAIDEKfsaLEEKEKELRQLRLAVRERDHDLERLrdvlssnEATMQSMESLLRAKGLEVE 686
Cdd:TIGR02169  270 IEQLLEELNKKIKDLGEEEQLRVKEK---IGELEAEIASLERSIAEKERELEDA-------EERLAKLEAEIDKLLAEIE 339
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  687 QLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQtSLHDRNKEVEDLSATLLCKLGPGQSEIAEelcqrLQRKERMLQD 766
Cdd:TIGR02169  340 ELEREIEEERKRRDKLTEEYAELKEELEDLRAELE-EVDKEFAETRDELKDYREKLEKLKREINE-----LKRELDRLQE 413
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 2056392215  767 LLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQA 806
Cdd:TIGR02169  414 ELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQ 453
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
146-647 2.95e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 61.19  E-value: 2.95e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  146 EKHLNDLKKENFSLKLRIYFLEERMQQ--KYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEaE 223
Cdd:TIGR04523  186 QKNIDKIKNKLLKLELLLSNLKKKIQKnkSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQN-K 264
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  224 LRRQFEERQQETEHVYELLENKIQLLQEesrlAKNEaarmaaLVEAEKECNLELSEKLKGVTKNWEDvpgdqvKPDQYTE 303
Cdd:TIGR04523  265 IKKQLSEKQKELEQNNKKIKELEKQLNQ----LKSE------ISDLNNQKEQDWNKELKSELKNQEK------KLEEIQN 328
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  304 ALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSmEVQPMTEEllKQQKLNSHETTITQQSvsdshlaELQE 383
Cdd:TIGR04523  329 QISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQN-EIEKLKKE--NQSYKQEIKNLESQIN-------DLES 398
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  384 KIQQTEATNKILQEKlnemsyelkcaqessqkqdgtIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQL 463
Cdd:TIGR04523  399 KIQNQEKLNQQKDEQ---------------------IKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIK 457
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  464 HSSEGTSPAQQQVALLdlqsalfcsQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKeaswkhnqelrKALQQ 543
Cdd:TIGR04523  458 NLDNTRESLETQLKVL---------SRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKV-----------KDLTK 517
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  544 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSH---KEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRiHD 620
Cdd:TIGR04523  518 KISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKenlEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQK-EK 596
                          490       500
                   ....*....|....*....|....*..
gi 2056392215  621 KAVALERAIDEKFSALEEKEKELRQLR 647
Cdd:TIGR04523  597 EKKDLIKEIEEKEKKISSLEKELEKAK 623
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
427-1069 6.22e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 60.46  E-value: 6.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  427 LKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVAllDLQSALFCSQLEIQKLQRVVRQKERQL 506
Cdd:TIGR02168  234 LEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIE--ELQKELYALANEISRLEQQKQILRERL 311
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  507 ADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAE--------------------KYNEI 566
Cdd:TIGR02168  312 ANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAEleelesrleeleeqletlrsKVAQL 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  567 RTQEQNIQ--------HLNHSLSHKEQLLQEFRELLQYRDNSDktLEANEMLLEKLRQRIHDKAVALERAIdekfSALEE 638
Cdd:TIGR02168  392 ELQIASLNneierleaRLERLEDRRERLQQEIEELLKKLEEAE--LKELQAELEELEEELEELQEELERLE----EALEE 465
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  639 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKfSRWQKEQESIIQ 718
Cdd:TIGR02168  466 LREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVD-EGYEAAIEAALG 544
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  719 QLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEElcqrlqrkermlqDLLSDRNKQVLEHEM--EIQGLLQSVSTREqES 796
Cdd:TIGR02168  545 GRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPL-------------DSIKGTEIQGNDREIlkNIEGFLGVAKDLV-KF 610
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  797 QAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAE-VTPTGRLGKQTDQGSMQIPSRdDSTSLTAKEDVSIP 875
Cdd:TIGR02168  611 DPKLRKALSYLLGGVLVVDDLDNALELAKKLRPGYRIVTLDGDlVRPGGVITGGSAKTNSSILER-RREIEELEEKIEEL 689
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  876 RSTLGDLDT-VAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQ 954
Cdd:TIGR02168  690 EEKIAELEKaLAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEER 769
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  955 LvdpedipamERLTQEVLLLREKVASVESQGQEISgNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAhpESS 1034
Cdd:TIGR02168  770 L---------EEAEEELAEAEAEIEELEAQIEQLK-EELKALREALDELRAELTLLNEEAANLRERLESLERRIA--ATE 837
                          650       660       670
                   ....*....|....*....|....*....|....*
gi 2056392215 1035 ERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLE 1069
Cdd:TIGR02168  838 RRLEDLEEQIEELSEDIESLAAEIEELEELIEELE 872
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
153-839 3.11e-08

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 58.06  E-value: 3.11e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  153 KKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQ 232
Cdd:TIGR00618  186 FAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQL 265
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  233 QETEHVYELLENKIQLLQEESRLAKnEAARMAALVEAEKECNLELSEKLKGVtknwedvpgdQVKPDQYTEALAQRDKRI 312
Cdd:TIGR00618  266 RARIEELRAQEAVLEETQERINRAR-KAAPLAAHIKAVTQIEQQAQRIHTEL----------QSKMRSRAKLLMKRAAHV 334
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  313 EElNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQ-----PMTEELLKQQKLNSHETTITQQSVSD-SHLAELQEKIQ 386
Cdd:TIGR00618  335 KQ-QSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREIscqqhTLTQHIHTLQQQKTTLTQKLQSLCKElDILQREQATID 413
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  387 QTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQviegqndtmaKLREMLHQSQLGQLHSS 466
Cdd:TIGR00618  414 TRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQ----------SLKEREQQLQTKEQIHL 483
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  467 EGTSPAQQQVALLdlqsalfcsqLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQE 546
Cdd:TIGR00618  484 QETRKKAVVLARL----------LELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTS 553
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  547 ELqNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDN-SDKTLEANEMLLEKLRQRIHDKAVAL 625
Cdd:TIGR00618  554 ER-KQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEaEDMLACEQHALLRKLQPEQDLQDVRL 632
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  626 ERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRD----VLSSNEATMQSMESLLRAKGLEVEQLStTCQNLQWLKEE 701
Cdd:TIGR00618  633 HLQQCSQELALKLTALHALQLTLTQERVREHALSIRVlpkeLLASRQLALQKMQSEKEQLTYWKEMLA-QCQTLLRELET 711
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  702 METKFSRWQKEQESIIQQLQTSLHDRN-------KEVEDLSATLLCKLGPGQSEIAEELCQRLQR--KERMLQDLLSDRN 772
Cdd:TIGR00618  712 HIEEYDREFNEIENASSSLGSDLAAREdalnqslKELMHQARTVLKARTEAHFNNNEEVTAALQTgaELSHLAAEIQFFN 791
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2056392215  773 KQVLEHEMEIQGLLQSVSTR----EQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAE 839
Cdd:TIGR00618  792 RLREEDTHLLKTLEAEIGQEipsdEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLA 862
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
376-661 2.86e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 55.07  E-value: 2.86e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  376 SHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREML 455
Cdd:TIGR02169  695 SELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDL 774
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  456 H--QSQLGQLHSSEGTSPAQQQVALL---------------DLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEA 518
Cdd:TIGR02169  775 HklEEALNDLEARLSHSRIPEIQAELskleeevsriearlrEIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEK 854
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  519 AAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAekynEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD 598
Cdd:TIGR02169  855 EIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEA----QLRELERKIEELEAQIEKKRKRLSELKAKLEALE 930
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  599 NSDKTLE----------ANEMLLEKLRQRIHDKAVALE-------RAIDE------KFSALEEKEKELRQLRLAVRERDH 655
Cdd:TIGR02169  931 EELSEIEdpkgedeeipEEELSLEDVQAELQRVEEEIRalepvnmLAIQEyeevlkRLDELKEKRAKLEEERKAILERIE 1010

                   ....*.
gi 2056392215  656 DLERLR 661
Cdd:TIGR02169 1011 EYEKKK 1016
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
143-739 2.87e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 54.64  E-value: 2.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  143 RDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIeLKVEVESLKRELQDKKQHLDKTWADVENLNSQ--- 219
Cdd:TIGR04523   36 KQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKI-LEQQIKDLNDKLKKNKDKINKLNSDLSKINSEikn 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  220 -------NEAELRRQFEERQQETEHVYELLeNKIQLLQEESRLAKNEAARMAALVEA-EKECNLELSEKLKgVTKNWEDV 291
Cdd:TIGR04523  115 dkeqknkLEVELNKLEKQKKENKKNIDKFL-TEIKKKEKELEKLNNKYNDLKKQKEElENELNLLEKEKLN-IQKNIDKI 192
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  292 PGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEptsmevqpmteellKQQKLNSHETTITQQ 371
Cdd:TIGR04523  193 KNKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINE--------------KTTEISNTQTQLNQL 258
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  372 SVSDSH-LAELQEKIQQTEATNKILQEKLNEMS-YELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMA 449
Cdd:TIGR04523  259 KDEQNKiKKQLSEKQKELEQNNKKIKELEKQLNqLKSEISDLNNQKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIIS 338
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  450 KLREmlhqsQLGQLHSSegtspaqqqvaLLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEA 529
Cdd:TIGR04523  339 QLNE-----QISQLKKE-----------LTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQN 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  530 SWKHNQELRKALQQLQEELQNKSQQ---LRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEA 606
Cdd:TIGR04523  403 QEKLNQQKDEQIKKLQQEKELLEKEierLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQ 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  607 NemlLEKLRQRIHDKAVALERAIDEKfSALEEKEKELRQLRLAVRERDHDLE----RLRDVLSSNEATMQSMESLLRAKG 682
Cdd:TIGR04523  483 N---LEQKQKELKSKEKELKKLNEEK-KELEEKVKDLTKKISSLKEKIEKLEsekkEKESKISDLEDELNKDDFELKKEN 558
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2056392215  683 LEvEQLSTTCQNLQWLKEEmETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLL 739
Cdd:TIGR04523  559 LE-KEIDEKNKEIEELKQT-QKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKIS 613
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
170-975 4.01e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 54.35  E-value: 4.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  170 MQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTwADVENLNSQNEAELRRQFEERQQETEHVYELLENKI--- 246
Cdd:pfam15921   90 LQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAM-ADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLeds 168
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  247 --QLLQEESRLAKNEAARM---AALVEAEKECNLELSEKLKGVTKNWEDVpGDQVkpdqyTEALAQRDKRIEELNQSLAA 321
Cdd:pfam15921  169 ntQIEQLRKMMLSHEGVLQeirSILVDFEEASGKKIYEHDSMSTMHFRSL-GSAI-----SKILRELDTEISYLKGRIFP 242
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  322 QERLVEQLSREKQQLLhlleeptsmevqpmteELLKQQKLNSHETTITQQSVsdsHLAELQEKIQQTEATNKILQEKLNE 401
Cdd:pfam15921  243 VEDQLEALKSESQNKI----------------ELLLQQHQDRIEQLISEHEV---EITGLTEKASSARSQANSIQSQLEI 303
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  402 MSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQviegqndtmAKLREMLHQSQLGQLHSSEGTSPAQQqvalLDL 481
Cdd:pfam15921  304 IQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYE---------DKIEELEKQLVLANSELTEARTERDQ----FSQ 370
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  482 QSALFCSQLeiQKLQRVVRQKERQLAdakqcvqfveaaaHESEQQKEAsWKHN-------QELRKALQQLQEELQNKSQQ 554
Cdd:pfam15921  371 ESGNLDDQL--QKLLADLHKREKELS-------------LEKEQNKRL-WDRDtgnsitiDHLRRELDDRNMEVQRLEAL 434
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  555 LRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALEraidEKFS 634
Cdd:pfam15921  435 LKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQ----EKER 510
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  635 ALEEKEKELRQLRLAVRERDHDLERLR---DVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQK 711
Cdd:pfam15921  511 AIEATNAEITKLRSRVDLKLQELQHLKnegDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQV 590
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  712 EQesiiQQLQTSLHDRNKEVEDLSatLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVST 791
Cdd:pfam15921  591 EK----AQLEKEINDRRLELQEFK--ILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKT 664
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  792 REQESQAAAEKLvqALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGRLGKQTDQGSMQIpsrddstSLTAKED 871
Cdd:pfam15921  665 SRNELNSLSEDY--EVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKV-------AMGMQKQ 735
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  872 VSIPRSTLGDLDT-VAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKD 950
Cdd:pfam15921  736 ITAKRGQIDALQSkIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDK 815
                          810       820
                   ....*....|....*....|....*
gi 2056392215  951 LQMQLVDPEDIpaMERLTQEVLLLR 975
Cdd:pfam15921  816 ASLQFAECQDI--IQRQEQESVRLK 838
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
169-679 1.05e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 53.05  E-value: 1.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  169 RMQQKYEASREDIYKRNIELKVEVESL---KRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEhvyelLENK 245
Cdd:TIGR00618  358 RDAHEVATSIREISCQQHTLTQHIHTLqqqKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAH-----AKKQ 432
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  246 IQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVpgdQVKPDQYTEALAQRDKRIEELnqslAAQERL 325
Cdd:TIGR00618  433 QELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTK---EQIHLQETRKKAVVLARLLEL----QEEPCP 505
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  326 VEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYE 405
Cdd:TIGR00618  506 LCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKED 585
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  406 L-KCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDtmakLREMLHQSQLGQLHSSEGTSPAQQQVALL---DL 481
Cdd:TIGR00618  586 IpNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDL----QDVRLHLQQCSQELALKLTALHALQLTLTqerVR 661
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  482 QSALFCSQLEIQKLQRVVRQ------KERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNK---- 551
Cdd:TIGR00618  662 EHALSIRVLPKELLASRQLAlqkmqsEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAARedal 741
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  552 SQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALEraiDE 631
Cdd:TIGR00618  742 NQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDE---DI 818
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*...
gi 2056392215  632 KFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLR 679
Cdd:TIGR00618  819 LNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQ 866
PTZ00121 PTZ00121
MAEBL; Provisional
167-653 2.91e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 51.68  E-value: 2.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  167 EERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLE-NK 245
Cdd:PTZ00121  1313 EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEkKK 1392
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  246 IQLLQEESRLAKNEAARMAALVEAEKECNlELSEKLKGVTKNWE-DVPGDQVKPDQYTEALAQRDKRIEELNQSlAAQER 324
Cdd:PTZ00121  1393 ADEAKKKAEEDKKKADELKKAAAAKKKAD-EAKKKAEEKKKADEaKKKAEEAKKADEAKKKAEEAKKAEEAKKK-AEEAK 1470
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  325 LVEQLSREKQQLLHLLE-EPTSMEVQPMTEELLK--QQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNE 401
Cdd:PTZ00121  1471 KADEAKKKAEEAKKADEaKKKAEEAKKKADEAKKaaEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADE 1550
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  402 M--SYELKCAQESSQKQDGtiQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALL 479
Cdd:PTZ00121  1551 LkkAEELKKAEEKKKAEEA--KKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKA 1628
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  480 DlQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEA--SWKHNQELRKALQQL--QEELQNKSQQL 555
Cdd:PTZ00121  1629 E-EEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAeeAKKAEEDEKKAAEALkkEAEEAKKAEEL 1707
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  556 RAWEAEkynEIRTQEQNIQHLNHSLSHKEQLLQEFREllqyRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSA 635
Cdd:PTZ00121  1708 KKKEAE---EKKKAEELKKAEEENKIKAEEAKKEAEE----DKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAV 1780
                          490
                   ....*....|....*...
gi 2056392215  636 LEEKEKELRQLRLAVRER 653
Cdd:PTZ00121  1781 IEEELDEEDEKRRMEVDK 1798
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
168-691 3.48e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 51.19  E-value: 3.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  168 ERMQQKYEASREDIyKRNIELKVEVESLKReLQDKKQHLDKTWADVENLNSQNE-AELRRQ--------FEERQQETEHv 238
Cdd:PRK02224   179 ERVLSDQRGSLDQL-KAQIEEKEEKDLHER-LNGLESELAELDEEIERYEEQREqARETRDeadevleeHEERREELET- 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  239 yelLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEE-LNQ 317
Cdd:PRK02224   256 ---LEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDrLEE 332
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  318 SLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQE 397
Cdd:PRK02224   333 CRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAED 412
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  398 KLNEMSYELKCAQESSQKQDGTIQNLKETLKSRER--------------ETEELYQVIEGQNDTMAKLREMLHQSQLGQ- 462
Cdd:PRK02224   413 FLEELREERDELREREAELEATLRTARERVEEAEAlleagkcpecgqpvEGSPHVETIEEDRERVEELEAELEDLEEEVe 492
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  463 -----LHSSEGTSPAQQQVALLDLQSALFCSQLEIQKlqRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQEL 537
Cdd:PRK02224   493 eveerLERAEDLVEAEDRIERLEERREDLEELIAERR--ETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEA 570
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  538 RKALQQLQEELQNKSQQLRAWE--AEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEA--NEMLLEK 613
Cdd:PRK02224   571 REEVAELNSKLAELKERIESLEriRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAefDEARIEE 650
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2056392215  614 LRQRiHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRakglEVEQLSTT 691
Cdd:PRK02224   651 ARED-KERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELEELRERREALENRVEALEALYD----EAEELESM 723
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
378-592 4.26e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.15  E-value: 4.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  378 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLhQ 457
Cdd:COG4942     29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEEL-A 107
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  458 SQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLeIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQEL 537
Cdd:COG4942    108 ELLRALYRLGRQPPLALLLSPEDFLDAVRRLQY-LKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEE 186
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2056392215  538 RKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRE 592
Cdd:COG4942    187 RAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
229-561 4.60e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 50.84  E-value: 4.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  229 EERQQETEHVYELLENKIQLLQEEsrlaKNEAARMAALVEAEKEcnLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQR 308
Cdd:TIGR02169  183 EENIERLDLIIDEKRQQLERLRRE----REKAERYQALLKEKRE--YEGYELLKEKEALERQKEAIERQLASLEEELEKL 256
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  309 DKRIEELNQSLAAQERLVEQLSREkqqllhlleeptsmeVQPMTEELLKQQKLNSHETTITQQSVSDShLAELQEKIQQT 388
Cdd:TIGR02169  257 TEEISELEKRLEEIEQLLEELNKK---------------IKDLGEEEQLRVKEKIGELEAEIASLERS-IAEKERELEDA 320
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  389 EATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLhqsqlgqlhsseg 468
Cdd:TIGR02169  321 EERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDEL------------- 387
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  469 tspAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKE--------ASWKHNQ----- 535
Cdd:TIGR02169  388 ---KDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEdkaleikkQEWKLEQlaadl 464
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 2056392215  536 ---------------ELRKALQQLQEELQNKSQQLRAWEAE 561
Cdd:TIGR02169  465 skyeqelydlkeeydRVEKELSKLQRELAEAEAQARASEER 505
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
142-716 7.35e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 50.06  E-value: 7.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  142 LRDFEKHLNDLKKENFSLKLRIYFLEermqqKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLnsqne 221
Cdd:PRK03918   157 LDDYENAYKNLGEVIKEIKRRIERLE-----KFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKL----- 226
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  222 aelrrqfEERQQETEHVYELLEN-KIQLLQEESRLAKNEaarmAALVEAEKECNlELSEKLKGVTKNWEDVPGDQVKPDQ 300
Cdd:PRK03918   227 -------EKEVKELEELKEEIEElEKELESLEGSKRKLE----EKIRELEERIE-ELKKEIEELEEKVKELKELKEKAEE 294
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  301 YTEALAQRDKRIEELNQSlaaqERLVEQLSREKQQLLHLLEEPTSMEVQpmTEELLKQQKLNSHETTITQQSVSDSHLA- 379
Cdd:PRK03918   295 YIKLSEFYEEYLDELREI----EKRLSRLEEEINGIEERIKELEEKEER--LEELKKKLKELEKRLEELEERHELYEEAk 368
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  380 ELQEKIQQTEATNKILQ-EKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREML--- 455
Cdd:PRK03918   369 AKKEELERLKKRLTGLTpEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELtee 448
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  456 HQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKlqrvVRQKERQLADAKQCVQFVEAAAHESE----QQKEASW 531
Cdd:PRK03918   449 HRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEK----VLKKESELIKLKELAEQLKELEEKLKkynlEELEKKA 524
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  532 KHNQELRKALQQLQEELQN------KSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHK-----EQLLQEFRELLQYRD-- 598
Cdd:PRK03918   525 EEYEKLKEKLIKLKGEIKSlkkeleKLEELKKKLAELEKKLDELEEELAELLKELEELgfesvEELEERLKELEPFYNey 604
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  599 ----NSDKTLEANEMLLEKLRqrihDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHdlERLRDVLSSNEATMQSM 674
Cdd:PRK03918   605 lelkDAEKELEREEKELKKLE----EELDKAFEELAETEKRLEELRKELEELEKKYSEEEY--EELREEYLELSRELAGL 678
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|..
gi 2056392215  675 ESllRAKGLEvEQLSTTCQNLQWLKEEMEtKFSRWQKEQESI 716
Cdd:PRK03918   679 RA--ELEELE-KRREEIKKTLEKLKEELE-EREKAKKELEKL 716
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
143-719 1.39e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 49.33  E-value: 1.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  143 RDFEKHLNDLKKENFSLKLRIYFLEERMQQK---YEASREDIYKRNIELKVEVESLKrELQDKKQHLDKTWADVENLNSQ 219
Cdd:pfam05483  229 EEYKKEINDKEKQVSLLLIQITEKENKMKDLtflLEESRDKANQLEEKTKLQDENLK-ELIEKKDHLTKELEDIKMSLQR 307
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  220 NEAELRRQFEERQQETEHVYELLENKIQLLQEesrlaKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKP- 298
Cdd:pfam05483  308 SMSTQKALEEDLQIATKTICQLTEEKEAQMEE-----LNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIi 382
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  299 -----------DQYTEALAQRDKRIEELNQSLAAQERLVEqlsrEKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETT 367
Cdd:pfam05483  383 tmelqkksselEEMTKFKNNKEVELEELKKILAEDEKLLD----EKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQ 458
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  368 ITQQSVSDSH----LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEG 443
Cdd:pfam05483  459 LTAIKTSEEHylkeVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIEN 538
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  444 QNDTMAKLREMLHQSQLGQLHSSEGTspaqqqvalldlqsalfcsQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHES 523
Cdd:pfam05483  539 LEEKEMNLRDELESVREEFIQKGDEV-------------------KCKLDKSEENARSIEYEVLKKEKQMKILENKCNNL 599
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  524 EQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEkyneirtqeqnIQHLNHSLSHKEQLLQEFRELLQYRDNSDKT 603
Cdd:pfam05483  600 KKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIK-----------VNKLELELASAKQKFEEIIDNYQKEIEDKKI 668
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  604 LEANEMLLEKLRQRIHDKAVALERAIDEK-------FSALEEKEKElrQLRLAVRERDHDLERLRDVLSSNEATMQSMES 676
Cdd:pfam05483  669 SEEKLLEEVEKAKAIADEAVKLQKEIDKRcqhkiaeMVALMEKHKH--QYDKIIEERDSELGLYKNKEQEQSSAKAALEI 746
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|...
gi 2056392215  677 LLraKGLEVEQLSTTCQnLQWLKEEMEtKFSRWQKEQESIIQQ 719
Cdd:pfam05483  747 EL--SNIKAELLSLKKQ-LEIEKEEKE-KLKMEAKENTAILKD 785
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
393-1018 1.83e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 48.91  E-value: 1.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  393 KILQEKLNEMSYELKCAQEssQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSpa 472
Cdd:TIGR02169  214 QALLKEKREYEGYELLKEK--EALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQ-- 289
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  473 qqqvalLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKS 552
Cdd:TIGR02169  290 ------LRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELK 363
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  553 QQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDkavaLERAIDEK 632
Cdd:TIGR02169  364 EELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAG----IEAKINEL 439
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  633 FSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLqwlkEEMETKFSRWQKE 712
Cdd:TIGR02169  440 EEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARAS----EERVRGGRAVEEV 515
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  713 QESIIQQLQTSLHDRNKEVEDLSATLLCKLGP-------GQSEIAEELCQRLQRKE--RM----LQDLLSDRNKQVLEHE 779
Cdd:TIGR02169  516 LKASIQGVHGTVAQLGSVGERYATAIEVAAGNrlnnvvvEDDAVAKEAIELLKRRKagRAtflpLNKMRDERRDLSILSE 595
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  780 MEIQGLLQSVSTREQESQAAAEKLVQALMERNSeLQALRQYLGG------------RDSLMSQAPISNQQAEVTPTgRLG 847
Cdd:TIGR02169  596 DGVIGFAVDLVEFDPKYEPAFKYVFGDTLVVED-IEAARRLMGKyrmvtlegelfeKSGAMTGGSRAPRGGILFSR-SEP 673
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  848 KQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEEL 927
Cdd:TIGR02169  674 AELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEI 753
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  928 QVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMER---LTQEVLLLREKVASVESQGQEISG--NRRQQLLLMLEG 1002
Cdd:TIGR02169  754 ENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRipeIQAELSKLEEEVSRIEARLREIEQklNRLTLEKEYLEK 833
                          650
                   ....*....|....*.
gi 2056392215 1003 LVDERSRLNEALQAER 1018
Cdd:TIGR02169  834 EIQELQEQRIDLKEQI 849
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
489-779 3.89e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 48.14  E-value: 3.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  489 QLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWE-AEKYNEIR 567
Cdd:TIGR02169  722 EKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRiPEIQAELS 801
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  568 TQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLr 647
Cdd:TIGR02169  802 KLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDL- 880
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  648 lavRERDHDLERLRDVLSsneatmqsmesllrakglevEQLSTTCQNLQWLKEEMETKFSRwQKEQESIIQQLQtslhDR 727
Cdd:TIGR02169  881 ---ESRLGDLKKERDELE--------------------AQLRELERKIEELEAQIEKKRKR-LSELKAKLEALE----EE 932
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2056392215  728 NKEVEDLSATLLCKlgPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHE 779
Cdd:TIGR02169  933 LSEIEDPKGEDEEI--PEEELSLEDVQAELQRVEEEIRALEPVNMLAIQEYE 982
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
468-680 6.68e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.68  E-value: 6.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  468 GTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEE 547
Cdd:COG4942     12 ALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKE 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  548 LQNKSQQLRAWEAEKYNEIRTQEQNIQH-------LNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHD 620
Cdd:COG4942     92 IAELRAELEAQKEELAELLRALYRLGRQpplalllSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEA 171
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  621 KAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRA 680
Cdd:COG4942    172 ERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
PTZ00121 PTZ00121
MAEBL; Provisional
120-819 1.16e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.67  E-value: 1.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  120 VPFVQTYSLRAFEKPPQVQTQALRDFEKHLNDLKKENFS---LKLRIYF-LEERMQQKYEASREDIYKRNIELKVEVESL 195
Cdd:PTZ00121  1018 IDFNQNFNIEKIEELTEYGNNDDVLKEKDIIDEDIDGNHegkAEAKAHVgQDEGLKPSYKDFDFDAKEDNRADEATEEAF 1097
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  196 KRELQDKKQHLDKTWADVENLNSQNEAELRRQFEE--RQQETEHVYELLENKIQLLQEESRLAKnEAARMAALVEAEKEC 273
Cdd:PTZ00121  1098 GKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEarKAEDARKAEEARKAEDAKRVEIARKAE-DARKAEEARKAEDAK 1176
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  274 NLELSEKLKGVTKNWEDVPGDQVKPDQYTEAlAQRDKRIEELNQslAAQERLVEQLSREKqqllhlleeptsmEVQPMTE 353
Cdd:PTZ00121  1177 KAEAARKAEEVRKAEELRKAEDARKAEAARK-AEEERKAEEARK--AEDAKKAEAVKKAE-------------EAKKDAE 1240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  354 ELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSY--------------ELKCAQESSQKQDGT 419
Cdd:PTZ00121  1241 EAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKadeakkaeekkkadEAKKKAEEAKKADEA 1320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  420 IQNLKETLKSRE---RETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQ 496
Cdd:PTZ00121  1321 KKKAEEAKKKADaakKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKA 1400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  497 RVVRQKERQLADAKQCVQFVEAAAHESEQQKEASW--KHNQELRKAlqqlqEELQNKSQQLR-AWEAEKYNEIRTQEQNI 573
Cdd:PTZ00121  1401 EEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEakKKAEEAKKA-----DEAKKKAEEAKkAEEAKKKAEEAKKADEA 1475
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  574 QHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAiDEKFSALEEKEKELRQLRLAVR-- 651
Cdd:PTZ00121  1476 KKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKA-EEAKKADEAKKAEEKKKADELKka 1554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  652 ERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTslhdRNKEV 731
Cdd:PTZ00121  1555 EELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEEL----KKAEE 1630
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  732 EDLSATLLCKLGPGQSEIAEELCQRLQ----RKERMLQDLLSDRNK-QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQA 806
Cdd:PTZ00121  1631 EKKKVEQLKKKEAEEKKKAEELKKAEEenkiKAAEEAKKAEEDKKKaEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKK 1710
                          730
                   ....*....|...
gi 2056392215  807 LMERNSELQALRQ 819
Cdd:PTZ00121  1711 EAEEKKKAEELKK 1723
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
147-716 1.17e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 46.25  E-value: 1.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  147 KHLNDLKKENFSLKLRIYFLEERMQQK---YEASREDIYKRNIELKVEVESLKRELQD-----KKQHLDKTWADVENLNS 218
Cdd:pfam05483   85 KEAEKIKKWKVSIEAELKQKENKLQENrkiIEAQRKAIQELQFENEKVSLKLEEEIQEnkdliKENNATRHLCNLLKETC 164
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  219 QNEAELRRQFEERQQETEHVYELLENKIqllqeESRLAKNEAARMAAlveaeKECNLELSEKLKgvtknwEDVPGDQVKP 298
Cdd:pfam05483  165 ARSAEKTKKYEYEREETRQVYMDLNNNI-----EKMILAFEELRVQA-----ENARLEMHFKLK------EDHEKIQHLE 228
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  299 DQYTEALAQRDKRIEELNQSLAAQERLVEQLS---REKQQLLHLLEEPTSMEVQPMTEELLKQQKLNshettitqqsvsd 375
Cdd:pfam05483  229 EEYKKEINDKEKQVSLLLIQITEKENKMKDLTfllEESRDKANQLEEKTKLQDENLKELIEKKDHLT------------- 295
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  376 SHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQdgtiqnLKETLKSRERETeelyQVIEGQNDTMAKLREML 455
Cdd:pfam05483  296 KELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQ------MEELNKAKAAHS----FVVTEFEATTCSLEELL 365
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  456 HQSQlGQLHSSEGtspaQQQVALLDLQSalfcSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWK--- 532
Cdd:pfam05483  366 RTEQ-QRLEKNED----QLKIITMELQK----KSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEElkg 436
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  533 HNQELRKALQQLQEELQNKSQQLRA------WEAEKYNEIRTQEQNIQHLNHSL-SHKEQLLQEFRELLQyrDNSDKTLE 605
Cdd:pfam05483  437 KEQELIFLLQAREKEIHDLEIQLTAiktseeHYLKEVEDLKTELEKEKLKNIELtAHCDKLLLENKELTQ--EASDMTLE 514
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  606 anemlLEKLRQRIHDKAVALERAIdEKFSALEEKEKELRQLRLAVRER-DHDLERLRDVLSSNEATMQSMESLLRAKGLE 684
Cdd:pfam05483  515 -----LKKHQEDIINCKKQEERML-KQIENLEEKEMNLRDELESVREEfIQKGDEVKCKLDKSEENARSIEYEVLKKEKQ 588
                          570       580       590
                   ....*....|....*....|....*....|..
gi 2056392215  685 VEQLSTTCQNLQWLKEEMETKFSRWQKEQESI 716
Cdd:pfam05483  589 MKILENKCNNLKKQIENKNKNIEELHQENKAL 620
mukB PRK04863
chromosome partition protein MukB;
306-684 1.31e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 46.10  E-value: 1.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  306 AQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEE---------PTSMEVQPMTEELLKQQKLNSHETtitqqsvsds 376
Cdd:PRK04863   782 AAREKRIEQLRAEREELAERYATLSFDVQKLQRLHQAfsrfigshlAVAFEADPEAELRQLNRRRVELER---------- 851
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  377 HLAELQEKIQQTEATNKILQEKLNEMSyelKCAQESSQKQDgtiqnlkETLKSRERETEElyQVIEGQNdtmAKLREMLH 456
Cdd:PRK04863   852 ALADHESQEQQQRSQLEQAKEGLSALN---RLLPRLNLLAD-------ETLADRVEEIRE--QLDEAEE---AKRFVQQH 916
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  457 QSQLGQLhssegtspaQQQVALLDlqsalfCSQLEIQKLQRVVRQKERQLADAKQCV----QFVEAAAH----ESEQQKE 528
Cdd:PRK04863   917 GNALAQL---------EPIVSVLQ------SDPEQFEQLKQDYQQAQQTQRDAKQQAfaltEVVQRRAHfsyeDAAEMLA 981
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  529 ASWKHNQELRKALQQLQEELQNKSQQLRAWEAE--KYNEIRTQeqniqhLNHSLSHKEQLLQEFRELLQyrdnsDKTLEA 606
Cdd:PRK04863   982 KNSDLNEKLRQRLEQAEQERTRAREQLRQAQAQlaQYNQVLAS------LKSSYDAKRQMLQELKQELQ-----DLGVPA 1050
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  607 NEMLLEKLRQRiHDKAVALERAIDEKFSALEEK----EKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKG 682
Cdd:PRK04863  1051 DSGAEERARAR-RDELHARLSANRSRRNQLEKQltfcEAEMDNLTKKLRKLERDYHEMREQVVNAKAGWCAVLRLVKDNG 1129

                   ..
gi 2056392215  683 LE 684
Cdd:PRK04863  1130 VE 1131
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
488-664 1.61e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 1.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  488 SQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEEL-QNKSQQLRAWEAekynEI 566
Cdd:COG4913    272 AELEYLRAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIrGNGGDRLEQLER----EI 347
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  567 RTQEQNIQHLNHSLSHKEQLLQEF--------RELLQYRDNSDKTLEAnemlLEKLRQRIHDKAVALERAIDEKFSALEE 638
Cdd:COG4913    348 ERLERELEERERRRARLEALLAALglplpasaEEFAALRAEAAALLEA----LEEELEALEEALAEAEAALRDLRRELRE 423
                          170       180
                   ....*....|....*....|....*.
gi 2056392215  639 KEKELRQLRLAVRERDHDLERLRDVL 664
Cdd:COG4913    424 LEAEIASLERRKSNIPARLLALRDAL 449
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
472-684 1.85e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.14  E-value: 1.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  472 AQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNK 551
Cdd:COG4942     23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  552 SQQLRAWEAEKY--------------NEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR 617
Cdd:COG4942    103 KEELAELLRALYrlgrqpplalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAE 182
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2056392215  618 IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLE 684
Cdd:COG4942    183 LEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFA 249
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
300-669 1.86e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 45.53  E-value: 1.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  300 QYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLE-EPTSMEVQPMTEELLK-QQKLNSHETTITQQSVSDSH 377
Cdd:COG4717     92 ELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQElEALEAELAELPERLEElEERLEELRELEEELEELEAE 171
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  378 LAELQEKIQQTEATNKILQEK-LNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLH 456
Cdd:COG4717    172 LAELQEELEELLEQLSLATEEeLQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLL 251
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  457 QSQLGQLHS-----SEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQK---- 527
Cdd:COG4717    252 LLIAAALLAllglgGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAAlglp 331
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  528 -EASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLnhslSHKEQLLQEFRELLQYRDNSDKTLEA 606
Cdd:COG4717    332 pDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGV----EDEEELRAALEQAEEYQELKEELEEL 407
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2056392215  607 NEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEA 669
Cdd:COG4717    408 EEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGE 470
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
360-830 2.39e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 45.42  E-value: 2.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  360 KLNSHETTITQqsvSDSHLAELQEKIQQTEATNKILQEKLNEmsYELKcaQESSQKQDGTIQNLKETLKSRERETEELYQ 439
Cdd:PRK02224   207 RLNGLESELAE---LDEEIERYEEQREQARETRDEADEVLEE--HEER--REELETLEAEIEDLRETIAETEREREELAE 279
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  440 VIEGQNDTMAKLREMLHqsqlGQLHSSEGTSPAQQqvALLDLQSALfcsQLEIQKLQRVVRQKERQLADAKQCVQFVEAA 519
Cdd:PRK02224   280 EVRDLRERLEELEEERD----DLLAEAGLDDADAE--AVEARREEL---EDRDEELRDRLEECRVAAQAHNEEAESLRED 350
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  520 AHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAE------KYNEIRTQEQNIQHLNHSL-SHKEQLLQEFRE 592
Cdd:PRK02224   351 ADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEieelreRFGDAPVDLGNAEDFLEELrEERDELREREAE 430
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  593 LLQYRDNSDKTLEANEMLLEKLR-----QRIHDKAVAleRAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDV---- 663
Cdd:PRK02224   431 LEATLRTARERVEEAEALLEAGKcpecgQPVEGSPHV--ETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLveae 508
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  664 --LSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQK---EQESIIQQLQTSLHDRNKEVEDLSATL 738
Cdd:PRK02224   509 drIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREaaaEAEEEAEEAREEVAELNSKLAELKERI 588
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  739 --LCKLGPGQSEIAE--ELCQRLQRKERMLQDL-------LSDRNKQVLEHEMEIQGllqsvsTREQESQAAAEKLVQAL 807
Cdd:PRK02224   589 esLERIRTLLAAIADaeDEIERLREKREALAELnderrerLAEKRERKRELEAEFDE------ARIEEAREDKERAEEYL 662
                          490       500
                   ....*....|....*....|...
gi 2056392215  808 MERNSELQALRQylgGRDSLMSQ 830
Cdd:PRK02224   663 EQVEEKLDELRE---ERDDLQAE 682
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
302-602 2.94e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.06  E-value: 2.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  302 TEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSM------EVQPMTEELLK-QQKLNSHETTITQQSV- 373
Cdd:TIGR02169  715 SRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSElkeleaRIEELEEDLHKlEEALNDLEARLSHSRIp 794
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  374 -SDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEgqnDTMAKLR 452
Cdd:TIGR02169  795 eIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKE---ELEEELE 871
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  453 EmlHQSQLGQLHSSegtspaqqqvaLLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQK---EA 529
Cdd:TIGR02169  872 E--LEAALRDLESR-----------LGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELseiED 938
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2056392215  530 SWKHNQELRKA---LQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDK 602
Cdd:TIGR02169  939 PKGEDEEIPEEelsLEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRLDELKEKRAKLEEERKAILERIEEYEK 1014
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
195-696 3.29e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.76  E-value: 3.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  195 LKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECN 274
Cdd:COG4717     47 LLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQ 126
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  275 L-ELSEKLKGVTKNWEDVpgdqvkPDQYtEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTE 353
Cdd:COG4717    127 LlPLYQELEALEAELAEL------PERL-EELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAE 199
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  354 ELLKQQKLnshettitqqsvsdshLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKET----LKS 429
Cdd:COG4717    200 ELEELQQR----------------LAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAallaLLG 263
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  430 RERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSS-EGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVrQKERQLAD 508
Cdd:COG4717    264 LGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLgKEAEELQALPALEELEEEELEELLAALGLPPDL-SPEELLEL 342
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  509 AKQCVQFVEAAAHESEQQKEASWKHNQELRKALqqLQEELQNKSQQLRAWeAEKYNEIRTQEQNIQHLnhslshKEQLLQ 588
Cdd:COG4717    343 LDRIEELQELLREAEELEEELQLEELEQEIAAL--LAEAGVEDEEELRAA-LEQAEEYQELKEELEEL------EEQLEE 413
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  589 EFRELLQYRDNSDKtleanemllEKLRQRIHDKAVALErAIDEKFSALEEKEKELRQlRLAVRERDHDLERLRDVLSSNE 668
Cdd:COG4717    414 LLGELEELLEALDE---------EELEEELEELEEELE-ELEEELEELREELAELEA-ELEQLEEDGELAELLQELEELK 482
                          490       500
                   ....*....|....*....|....*...
gi 2056392215  669 ATMQSMESLLRAKGLEVEQLSTTCQNLQ 696
Cdd:COG4717    483 AELRELAEEWAALKLALELLEEAREEYR 510
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
394-831 3.46e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.76  E-value: 3.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  394 ILQEKLNEMSYEL-KCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREmlhqsqlgqlhssegtspA 472
Cdd:COG4717     46 MLLERLEKEADELfKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEE------------------L 107
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  473 QQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKS 552
Cdd:COG4717    108 EAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLS 187
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  553 QQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEK 632
Cdd:COG4717    188 LATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGS 267
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  633 FSALEEKEKELRQLRLAVRErdHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLqWLKEEMETKFSRWQKE 712
Cdd:COG4717    268 LLSLILTIAGVLFLVLGLLA--LLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAAL-GLPPDLSPEELLELLD 344
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  713 QESIIQQLQTSLHDRNKEV-----EDLSATLLCKLGPGQSEIAEELCQRLQRKERmLQDLLSDRNKQVLEHEMEIQGLLQ 787
Cdd:COG4717    345 RIEELQELLREAEELEEELqleelEQEIAALLAEAGVEDEEELRAALEQAEEYQE-LKEELEELEEQLEELLGELEELLE 423
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 2056392215  788 SVSTREQESQaaAEKLVQALMERNSELQALRQYLGGRDSLMSQA 831
Cdd:COG4717    424 ALDEEELEEE--LEELEEELEELEEELEELREELAELEAELEQL 465
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
374-562 3.53e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.05  E-value: 3.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  374 SDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAK-LR 452
Cdd:COG3883     14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGErAR 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  453 EMLHQ----SQLGQLHSSEGTSPAQQQVALLDLQSALfcSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKE 528
Cdd:COG3883     94 ALYRSggsvSYLDVLLGSESFSDFLDRLSALSKIADA--DADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA 171
                          170       180       190
                   ....*....|....*....|....*....|....
gi 2056392215  529 ASWKHNQELRKALQQLQEELQNKSQQLRAWEAEK 562
Cdd:COG3883    172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAEL 205
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
187-399 4.08e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 4.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  187 ELKVEVESLKRELQDKKQHLDKTWADVENLNSQneaelRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAAL 266
Cdd:COG4942     24 EAEAELEQLQQEIAELEKELAALKKEEKALLKQ-----LAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  267 VEAEKEcnlELSEKLKGVTKNWE----------DVPGDQVKPDQYTEALAQ-RDKRIEELNQSLAAQERLVEQLSREKQQ 335
Cdd:COG4942     99 LEAQKE---ELAELLRALYRLGRqpplalllspEDFLDAVRRLQYLKYLAPaRREQAEELRADLAELAALRAELEAERAE 175
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2056392215  336 LLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSdshLAELQEKIQQTEATNKILQEKL 399
Cdd:COG4942    176 LEALLAELEEERAALEALKAERQKLLARLEKELAELAAE---LAELQQEAEELEALIARLEAEA 236
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
427-928 4.32e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.37  E-value: 4.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  427 LKSRERETEELYQVIEGQND-----TMAKLREMLHQS---QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRV 498
Cdd:COG4717     14 FRDRTIEFSPGLNVIYGPNEagkstLLAFIRAMLLERlekEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAEL 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  499 VRQKERQLADAKQCVQFVEAAAHESEQQKEAswKHNQELRKALQQLQEELQNKSQQLRAWEaEKYNEIRTQEQNIQHLNH 578
Cdd:COG4717     94 QEELEELEEELEELEAELEELREELEKLEKL--LQLLPLYQELEALEAELAELPERLEELE-ERLEELRELEEELEELEA 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  579 SLSHKEQLLQEfrellQYRDNSDKTLEANEMLLEKLrQRIHDKAVALERAIDEKFSALEEKEKELRQLRlAVRERDHDLE 658
Cdd:COG4717    171 ELAELQEELEE-----LLEQLSLATEEELQDLAEEL-EELQQRLAELEEELEEAQEELEELEEELEQLE-NELEAAALEE 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  659 RLRDVLSSNEATmqSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEvEDLSATL 738
Cdd:COG4717    244 RLKEARLLLLIA--AALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPAL-EELEEEE 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  739 LCKL-------GPGQSEIAEELCQRLQRKERMLQDLLSDRNK-QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMER 810
Cdd:COG4717    321 LEELlaalglpPDLSPEELLELLDRIEELQELLREAEELEEElQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQEL 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  811 NSELQALRQYLGgrdslmSQAPISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTS--LTAKEDVSIPRSTLGDLDTVAGL 888
Cdd:COG4717    401 KEELEELEEQLE------ELLGELEELLEALDEEELEEELEELEEELEELEEELEelREELAELEAELEQLEEDGELAEL 474
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 2056392215  889 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQ 928
Cdd:COG4717    475 LQELEELKAELRELAEEWAALKLALELLEEAREEYREERL 514
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
166-439 5.35e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 44.17  E-value: 5.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  166 LEERMQQKYEA--SREDIYKRNIELKVEVESLKRELQDKKQHLD-------------------KTWADVENLNSQNEAEL 224
Cdd:COG3096    363 LEEQEEVVEEAaeQLAEAEARLEAAEEEVDSLKSQLADYQQALDvqqtraiqyqqavqalekaRALCGLPDLTPENAEDY 442
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  225 RRQFEERQQETEHvyellenkiQLLQEESRLAKNEAARmaalveAEKECNLELSEKLKGVTKNWE--DVPGDQVKPDQYT 302
Cdd:COG3096    443 LAAFRAKEQQATE---------EVLELEQKLSVADAAR------RQFEKAYELVCKIAGEVERSQawQTARELLRRYRSQ 507
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  303 EALAQRDKRIE----ELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHL 378
Cdd:COG3096    508 QALAQRLQQLRaqlaELEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQL 587
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2056392215  379 AELQEKIQQTEATNKI---LQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQ 439
Cdd:COG3096    588 EQLRARIKELAARAPAwlaAQDALERLREQSGEALADSQEVTAAMQQLLEREREATVERDELAA 651
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
583-837 6.08e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.60  E-value: 6.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  583 KEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIhdkaVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRD 662
Cdd:COG4942     29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRI----AALARRIRALEQELAALEAELAELEKEIAELRAELEAQKE 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  663 VLSSNEATMQSMESLLRAK-GLEVEQLSTTCQNLQWLKEemetkFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLlck 741
Cdd:COG4942    105 ELAELLRALYRLGRQPPLAlLLSPEDFLDAVRRLQYLKY-----LAPARREQAEELRADLAELAALRAELEAERAEL--- 176
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  742 lgpgqseiaEELCQRLQRKERMLQDLLSDRNKqvlehemeiqgLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYL 821
Cdd:COG4942    177 ---------EALLAELEEERAALEALKAERQK-----------LLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
                          250
                   ....*....|....*.
gi 2056392215  822 GGRDSLMSQAPISNQQ 837
Cdd:COG4942    237 AAAAERTPAAGFAALK 252
PTZ00121 PTZ00121
MAEBL; Provisional
172-835 7.71e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 7.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  172 QKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEE---RQQETEHVYELLENKIQL 248
Cdd:PTZ00121  1176 KKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEakkDAEEAKKAEEERNNEEIR 1255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  249 LQEESRLAknEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQ 328
Cdd:PTZ00121  1256 KFEEARMA--HFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADA 1333
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  329 LSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKlNEMSYELKC 408
Cdd:PTZ00121  1334 AKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEED-KKKADELKK 1412
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  409 AQESSQKQDGTIQNLKETLKSRE---------------------RETEELYQVIE---------GQNDTMAKLREMLHQS 458
Cdd:PTZ00121  1413 AAAAKKKADEAKKKAEEKKKADEakkkaeeakkadeakkkaeeaKKAEEAKKKAEeakkadeakKKAEEAKKADEAKKKA 1492
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  459 QLGQLHSSEGTSPAQQQVALLDLQSALfcsqlEIQKLQRVVRQKERQLADAKQCVQFVEAAaheSEQQKEASWKHNQELR 538
Cdd:PTZ00121  1493 EEAKKKADEAKKAAEAKKKADEAKKAE-----EAKKADEAKKAEEAKKADEAKKAEEKKKA---DELKKAEELKKAEEKK 1564
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  539 KALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQL---------LQEFRELLQYRDNSDKTLEANEM 609
Cdd:PTZ00121  1565 KAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAkkaeeakikAEELKKAEEEKKKVEQLKKKEAE 1644
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  610 LLEKLRQRIHDKAVALERAIDEKFSALEEKEK--ELRQLRLAVRERDHDLER-LRDVLSSNEATMQSMESLLRAKGLEVE 686
Cdd:PTZ00121  1645 EKKKAEELKKAEEENKIKAAEEAKKAEEDKKKaeEAKKAEEDEKKAAEALKKeAEEAKKAEELKKKEAEEKKKAEELKKA 1724
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  687 QLSTTCQNLQWLKEEMETKF----SRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLcklgpgQSEIAEELCQRLQRKER 762
Cdd:PTZ00121  1725 EEENKIKAEEAKKEAEEDKKkaeeAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVI------EEELDEEDEKRRMEVDK 1798
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2056392215  763 MLQDLLSdrNKQVLEhEMEIQGLLQSVSTREQESQAAAEKLVQALMERNsELQALRQYLGGRDSLMSQAPISN 835
Cdd:PTZ00121  1799 KIKDIFD--NFANII-EGGKEGNLVINDSKEMEDSAIKEVADSKNMQLE-EADAFEKHKFNKNNENGEDGNKE 1867
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
532-815 7.94e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 43.81  E-value: 7.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  532 KHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQ---------------------HLNHSLSHKEQLLQEF 590
Cdd:pfam02463  166 RLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKaleyyqlkekleleeeyllylDYLKLNEERIDLLQEL 245
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  591 RELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEAT 670
Cdd:pfam02463  246 LRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKK 325
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  671 MQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHD----RNKEVEDLSATLLCKLGPGQ 746
Cdd:pfam02463  326 AEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLeserLSSAAKLKEEELELKSEEEK 405
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2056392215  747 SEiaeelcQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQ 815
Cdd:pfam02463  406 EA------QLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELK 468
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
171-819 8.36e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 43.50  E-value: 8.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  171 QQKYEASREDIYKRNIELKvEVESLKRELQDKKQHLDKTWADV-----ENLNS--QNEAELRRQFEERQQETEHVYELLE 243
Cdd:TIGR00606  254 LKEIEHNLSKIMKLDNEIK-ALKSRKKQMEKDNSELELKMEKVfqgtdEQLNDlyHNHQRTVREKERELVDCQRELEKLN 332
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  244 NKIQLLQEESRLAKNEAARMAALVEAEKECNLE-----LSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQS 318
Cdd:TIGR00606  333 KERRLLNQEKTELLVEQGRLQLQADRHQEHIRArdsliQSLATRLELDGFERGPFSERQIKNFHTLVIERQEDEAKTAAQ 412
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  319 LAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDS-HLAELQEKIQQTEATNKILQE 397
Cdd:TIGR00606  413 LCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSdRILELDQELRKAERELSKAEK 492
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  398 KLNE--MSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMlhqSQLGQLHSSEGTSPAQQQ 475
Cdd:TIGR00606  493 NSLTetLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQI---RKIKSRHSDELTSLLGYF 569
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  476 VALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQkEASWKHN-------QELRKALQQLQEEL 548
Cdd:TIGR00606  570 PNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQ-LSSYEDKlfdvcgsQDEESDLERLKEEI 648
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  549 QNKSQQLRAWEAEK------YNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKT-LEANEMLLEKLRQRIHDK 621
Cdd:TIGR00606  649 EKSSKQRAMLAGATavysqfITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDkLKSTESELKKKEKRRDEM 728
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  622 AVALERaideKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQS-MESLLRAKGLEVEqlSTTCQNLQWLKE 700
Cdd:TIGR00606  729 LGLAPG----RQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTiMPEEESAKVCLTD--VTIMERFQMELK 802
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  701 EMETKFSRWQKEQESIiqQLQTSLHDRNKEVEDlsatllcklgpgqseiAEELCQRLQRKERMLQDLLSDRNKQVLEHEM 780
Cdd:TIGR00606  803 DVERKIAQQAAKLQGS--DLDRTVQQVNQEKQE----------------KQHELDTVVSKIELNRKLIQDQQEQIQHLKS 864
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|..
gi 2056392215  781 EIQGLLQ---SVSTREQESQAAAEKLVQALMERNSELQALRQ 819
Cdd:TIGR00606  865 KTNELKSeklQIGTNLQRRQQFEEQLVELSTEVQSLIREIKD 906
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
302-664 8.86e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.37  E-value: 8.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  302 TEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLlhlleeptsmevqpmTEELLKQQKLNSHETTITQQSVSDSHLAEL 381
Cdd:COG4913    609 RAKLAALEAELAELEEELAEAEERLEALEAELDAL---------------QERREALQRLAEYSWDEIDVASAEREIAEL 673
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  382 QEKIQQTEATNKILQEkLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLG 461
Cdd:COG4913    674 EAELERLDASSDDLAA-LEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLE 752
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  462 QLHSSEGTSPAQQQVAlLDLQSalfcsqlEIQKLQRVVRQKERQLADAKQcvQFVEAAAHESeQQKEASWKHNQELRKAL 541
Cdd:COG4913    753 ERFAAALGDAVERELR-ENLEE-------RIDALRARLNRAEEELERAMR--AFNREWPAET-ADLDADLESLPEYLALL 821
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  542 QQLQEE------------LQNKSQQLRAWEAEK-YNEIRTQEQNIQHLNHSLSHkeqllqefrelLQYRDNSDKTLEANE 608
Cdd:COG4913    822 DRLEEDglpeyeerfkelLNENSIEFVADLLSKlRRAIREIKERIDPLNDSLKR-----------IPFGPGRYLRLEARP 890
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2056392215  609 MLLE---KLRQRIHDkavALERAIDEKFSALEEKEKELRQL--RLAVRERDHDLERLRDVL 664
Cdd:COG4913    891 RPDPevrEFRQELRA---VTSGASLFDEELSEARFAALKRLieRLRSEEEESDRRWRARVL 948
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
495-714 1.07e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 43.19  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  495 LQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRaweaEKYNEIRTQEQNIQ 574
Cdd:pfam05557   11 LSQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALR----EQAELNRLKKKYLE 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  575 HLNHSLSHKEQLL-----------QEFRELLQYRDNSDKTLEANEMLLEKLRQRiHDKAVALERAIDEKFSALEEKEKEL 643
Cdd:pfam05557   87 ALNKKLNEKESQLadarevisclkNELSELRRQIQRAELELQSTNSELEELQER-LDLLKAKASEAEQLRQNLEKQQSSL 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  644 RQLRLAVRERDHDLERLRD------VLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEE---METKFSRWQKEQE 714
Cdd:pfam05557  166 AEAEQRIKELEFEIQSQEQdseivkNSKSELARIPELEKELERLREHNKHLNENIENKLLLKEEvedLKRKLEREEKYRE 245
PTZ00121 PTZ00121
MAEBL; Provisional
168-819 1.82e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 1.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  168 ERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ 247
Cdd:PTZ00121  1112 EEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAE 1191
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  248 LLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVE 327
Cdd:PTZ00121  1192 ELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAA 1271
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  328 QLSREKQQllhlLEEPTSMEVQPMTEELLKQQKLNSHEtTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELK 407
Cdd:PTZ00121  1272 IKAEEARK----ADELKKAEEKKKADEAKKAEEKKKAD-EAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAE 1346
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  408 CAQESSQKQDGTIQNLKETLKSRERETEELYQviegQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQqvalLDLQSALFC 487
Cdd:PTZ00121  1347 AAKAEAEAAADEAEAAEEKAEAAEKKKEEAKK----KADAAKKKAEEKKKADEAKKKAEEDKKKADE----LKKAAAAKK 1418
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  488 SQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQK-EASWKHNQELRKAlqqlqEELQNKSQqlrawEAEKYNEI 566
Cdd:PTZ00121  1419 KADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKaEEAKKKAEEAKKA-----DEAKKKAE-----EAKKADEA 1488
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  567 RTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD--NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKeLR 644
Cdd:PTZ00121  1489 KKKAEEAKKKADEAKKAAEAKKKADEAKKAEEakKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKK-AE 1567
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  645 QLRLAVRERDHDLERLRDVLSSNEATMQS-MESLLRAKGLEVEQLSTtcqnlqwlKEEMETKFSRWQKEQE--SIIQQLQ 721
Cdd:PTZ00121  1568 EAKKAEEDKNMALRKAEEAKKAEEARIEEvMKLYEEEKKMKAEEAKK--------AEEAKIKAEELKKAEEekKKVEQLK 1639
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  722 TSLHDRNKEVEDLSatllcKLGPGQSEIAEELCQRLQRKERMLQDLLSD-----RNKQVLEHEMEIQGLLQSVSTREQES 796
Cdd:PTZ00121  1640 KKEAEEKKKAEELK-----KAEEENKIKAAEEAKKAEEDKKKAEEAKKAeedekKAAEALKKEAEEAKKAEELKKKEAEE 1714
                          650       660
                   ....*....|....*....|...
gi 2056392215  797 QAAAEKLVQALMERNSELQALRQ 819
Cdd:PTZ00121  1715 KKKAEELKKAEEENKIKAEEAKK 1737
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
299-567 2.14e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.93  E-value: 2.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  299 DQYTEALAQRDKRIEELNQSLAAQERLVEQLsREKQQLLHLleeptSMEVQPMTEELlkqqklnsheTTITQQsvsdshL 378
Cdd:COG3206    171 EEARKALEFLEEQLPELRKELEEAEAALEEF-RQKNGLVDL-----SEEAKLLLQQL----------SELESQ------L 228
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  379 AELQEKIQQTEATNKILQEKLNEMSYELkcaqeSSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREmlhqs 458
Cdd:COG3206    229 AEARAELAEAEARLAALRAQLGSGPDAL-----PELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRA----- 298
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  459 qlgQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQcvQFVEAAAHESEQQkeaswkhnqelr 538
Cdd:COG3206    299 ---QIAALRAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPE--LEAELRRLEREVE------------ 361
                          250       260
                   ....*....|....*....|....*....
gi 2056392215  539 kALQQLQEELQNKSQQLRAWEAEKYNEIR 567
Cdd:COG3206    362 -VARELYESLLQRLEEARLAEALTVGNVR 389
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
611-1088 2.29e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.95  E-value: 2.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  611 LEKLRQRIHDKAVALERAIDEKFSALEEKEKE------------LRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLL 678
Cdd:PRK02224   164 LEEYRERASDARLGVERVLSDQRGSLDQLKAQieekeekdlherLNGLESELAELDEEIERYEEQREQARETRDEADEVL 243
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  679 ---RAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEqesiIQQLQTSLHDRNKEVEDLSATllCKLGPGQSEIAEELCQ 755
Cdd:PRK02224   244 eehEERREELETLEAEIEDLRETIAETEREREELAEE----VRDLRERLEELEEERDDLLAE--AGLDDADAEAVEARRE 317
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  756 RLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISN 835
Cdd:PRK02224   318 ELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELR 397
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  836 QQAEVTPTgRLGKQTDQGSMQIPSRDDS----TSLTAK---------------------------EDVSIPRSTLGDLDT 884
Cdd:PRK02224   398 ERFGDAPV-DLGNAEDFLEELREERDELrereAELEATlrtarerveeaealleagkcpecgqpvEGSPHVETIEEDRER 476
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  885 VAGLEKELSNAKEELELM------AKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDP 958
Cdd:PRK02224   477 VEELEAELEDLEEEVEEVeerlerAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEK 556
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  959 EDipAMERLTQEVLLLREKVASVESQGQEI-----SGNRRQQLLLMLEGLVDERSRLNEALQA------ERQLYSSlvkf 1027
Cdd:PRK02224   557 RE--AAAEAEEEAEEAREEVAELNSKLAELkerieSLERIRTLLAAIADAEDEIERLREKREAlaelndERRERLA---- 630
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2056392215 1028 hahpESSERDRTLQVE-----LEGAQVLRSRLEEVLGRSLERLNRL-----ETLAAIGG-----GELESVRIHHKH 1088
Cdd:PRK02224   631 ----EKRERKRELEAEfdearIEEAREDKERAEEYLEQVEEKLDELreerdDLQAEIGAvenelEELEELRERREA 702
PLN02939 PLN02939
transferase, transferring glycosyl groups
514-797 2.67e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 41.81  E-value: 2.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  514 QFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNksqqlraweAEK----YNEIRTQEqnIQHLNHSLSHKEQLLQE 589
Cdd:PLN02939   103 QRDEAIAAIDNEQQTNSKDGEQLSDFQLEDLVGMIQN---------AEKnillLNQARLQA--LEDLEKILTEKEALQGK 171
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  590 FREL---LQYRDNSDKT-------LEANEMLLEKLRQRIHDKAV---ALERAIDEKFSALEEKEKELRQLRLAVR----- 651
Cdd:PLN02939   172 INILemrLSETDARIKLaaqekihVEILEEQLEKLRNELLIRGAtegLCVHSLSKELDVLKEENMLLKDDIQFLKaelie 251
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  652 -----ERDHDLERLRDVLssnEATMQSMESLLRAKGLEVEQLSTTCQNLQWLK-EEMETKFSRWQKEQESIIQQLQTSlH 725
Cdd:PLN02939   252 vaeteERVFKLEKERSLL---DASLRELESKFIVAQEDVSKLSPLQYDCWWEKvENLQDLLDRATNQVEKAALVLDQN-Q 327
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2056392215  726 DRNKEVEDLSATLL-CKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ 797
Cdd:PLN02939   328 DLRDKVDKLEASLKeANVSKFSSYKVELLQQKLKLLEERLQASDHEIHSYIQLYQESIKEFQDTLSKLKEESK 400
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
146-631 2.90e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.59  E-value: 2.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  146 EKHLNDLKKENFSLKLRIYFLEERMQQKYEASR--EDIYKRNIELK------VEVESLKRELQDKKQHLDKTWADVENLN 217
Cdd:PRK03918   244 EKELESLEGSKRKLEEKIRELEERIEELKKEIEelEEKVKELKELKekaeeyIKLSEFYEEYLDELREIEKRLSRLEEEI 323
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  218 SQNEAELR---------RQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKEcnlELSEKLKGVTKNW 288
Cdd:PRK03918   324 NGIEERIKeleekeerlEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPE---KLEKELEELEKAK 400
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  289 EDVpgdQVKPDQYTEALAQRDKRIEELNQSLAA-------------------QERLVEQLSREKQQLLHLLEEPTSMEVQ 349
Cdd:PRK03918   401 EEI---EEEISKITARIGELKKEIKELKKAIEElkkakgkcpvcgrelteehRKELLEEYTAELKRIEKELKEIEEKERK 477
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  350 PMTEELLKQQKLNSHETTITQQSVSDsHLAELQEKiqqteaTNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKS 429
Cdd:PRK03918   478 LRKELRELEKVLKKESELIKLKELAE-QLKELEEK------LKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEK 550
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  430 RERETEELYQVIEGQNDTMAKLREMLHQ------SQLGQLHS--SEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQ 501
Cdd:PRK03918   551 LEELKKKLAELEKKLDELEEELAELLKEleelgfESVEELEErlKELEPFYNEYLELKDAEKELEREEKELKKLEEELDK 630
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  502 KERQLADAKQCVQfvEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEaekyNEIRTQEQNIQHLNHSLS 581
Cdd:PRK03918   631 AFEELAETEKRLE--ELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELE----KRREEIKKTLEKLKEELE 704
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|
gi 2056392215  582 HKEQLLQEFRELlqyrdnsDKTLEANEMLLEKLRQRihdKAVALERAIDE 631
Cdd:PRK03918   705 EREKAKKELEKL-------EKALERVEELREKVKKY---KALLKERALSK 744
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
170-422 4.03e-03

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 41.38  E-value: 4.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  170 MQQKYEASREDIYKRNIE-------LKVEVESLKRE-------------LQDKKQHLDKTWADVENLNSQNEAE-LRRQF 228
Cdd:PLN03229   484 LQERLENLREEFSKANSQdqlmhpvLMEKIEKLKDEfnkrlsrapnylsLKYKLDMLNEFSRAKALSEKKSKAEkLKAEI 563
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  229 EERQQETEHVYELLEnKIQLLQEEsrLAKNEAARMAAL--------VEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQ 300
Cdd:PLN03229   564 NKKFKEVMDRPEIKE-KMEALKAE--VASSGASSGDELdddlkekvEKMKKEIELELAGVLKSMGLEVIGVTKKNKDTAE 640
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  301 YTEALAQRDKrIEELNqslaaqerlvEQLSREKQQLLHlleeptSMEVQPMTEELlkqqKLNSHETTITQQSVSDSHLAE 380
Cdd:PLN03229   641 QTPPPNLQEK-IESLN----------EEINKKIERVIR------SSDLKSKIELL----KLEVAKASKTPDVTEKEKIEA 699
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 2056392215  381 LQEKIQQ--TEATNKI-LQEKLNEMSYELKCAQESSQKQDGTIQN 422
Cdd:PLN03229   700 LEQQIKQkiAEALNSSeLKEKFEELEAELAAARETAAESNGSLKN 744
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
493-714 4.31e-03

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 40.51  E-value: 4.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  493 QKLQRVVRQKERQLADAKqcvqfvEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEkyneirTQEQN 572
Cdd:pfam09787   14 QKAARILQSKEKLIASLK------EGSGVEGLDSSTALTLELEELRQERDLLREEIQKLRGQIQQLRTE------LQELE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  573 IQHLNHSLSHKEQLlQEFRELLQYRDNSDKTLEANemlLEKLRQRIHdkavaleraidekfSALEEKEKELRQLRLAVRE 652
Cdd:pfam09787   82 AQQQEEAESSREQL-QELEEQLATERSARREAEAE---LERLQEELR--------------YLEEELRRSKATLQSRIKD 143
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2056392215  653 RDHDLERLRDVL---SSNEATMQSMESLLR-------AKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 714
Cdd:pfam09787  144 REAEIEKLRNQLtskSQSSSSQSELENRLHqltetliQKQTMLEALSTEKNSLVLQLERMEQQIKELQGEGS 215
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
602-1056 5.35e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.91  E-value: 5.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  602 KTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAK 681
Cdd:COG4717     49 ERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLL 128
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  682 GLEVEqlsttcqnLQWLKEEMETKFSRWQKEQESI--IQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELcQRLQR 759
Cdd:COG4717    129 PLYQE--------LEALEAELAELPERLEELEERLeeLRELEEELEELEAELAELQEELEELLEQLSLATEEEL-QDLAE 199
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  760 KERMLQDLLSDRNKQVLEHEMEIQGLlqsvstREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAE 839
Cdd:COG4717    200 ELEELQQRLAELEEELEEAQEELEEL------EEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLIL 273
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  840 VTPTGRLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDtvaglEKELSNAKEELELMAKKERESQMELSAlqsm 919
Cdd:COG4717    274 TIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELE-----EEELEELLAALGLPPDLSPEELLELLD---- 344
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  920 mavQEEELQVQAADMESLTRNIQIK--EDLIKDL--QMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQ 995
Cdd:COG4717    345 ---RIEELQELLREAEELEEELQLEelEQEIAALlaEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEEL 421
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2056392215  996 L-LLMLEGLVDERSRLNEALQAER----QLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE 1056
Cdd:COG4717    422 LeALDEEELEEELEELEEELEELEeeleELREELAELEAELEQLEEDGELAELLQELEELKAELRE 487
PRK11281 PRK11281
mechanosensitive channel MscK;
505-821 5.50e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.05  E-value: 5.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  505 QLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQlraweaekyneIRTQEQNIQHLNHSLSHKE 584
Cdd:PRK11281    25 AFARAASNGDLPTEADVQAQLDALNKQKLLEAEDKLVQQDLEQTLALLDK-----------IDRQKEETEQLKQQLAQAP 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  585 QLLQEF-RELLQYRDNSDKTLEANemlLEKLRQRihdkavALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDV 663
Cdd:PRK11281    94 AKLRQAqAELEALKDDNDEETRET---LSTLSLR------QLESRLAQTLDQLQNAQNDLAEYNSQLVSLQTQPERAQAA 164
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  664 LSSNEATMQSMESLLRAKGLEVEQLSTTCQNLqwlkeemetkfsrWQKEQESIiqQLQTSLhdRNKEVEdlSATLLCKLG 743
Cdd:PRK11281   165 LYANSQRLQQIRNLLKGGKVGGKALRPSQRVL-------------LQAEQALL--NAQNDL--QRKSLE--GNTQLQDLL 225
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2056392215  744 PGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMeiqgllQSVSTREQESQAAAEKLVQALMERNSELQalrQYL 821
Cdd:PRK11281   226 QKQRDYLTARIQRLEHQLQLLQEAINSKRLTLSEKTV------QEAQSQDEAARIQANPLVAQELEINLQLS---QRL 294
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
142-437 6.04e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 6.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  142 LRDFEKHLNDLKKENFSLKLRIYFLEERMQQKyEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNE 221
Cdd:TIGR02169  683 LEGLKRELSSLQSELRRIENRLDELSQELSDA-SRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELK 761
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  222 ------AELRRQFEERQQETEHVY-ELLENKIQLLQEESRLAKNEAARM-AALVEAEKECNLELSEKlkgvTKNWEDVPG 293
Cdd:TIGR02169  762 eleariEELEEDLHKLEEALNDLEaRLSHSRIPEIQAELSKLEEEVSRIeARLREIEQKLNRLTLEK----EYLEKEIQE 837
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  294 DQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEpTSMEVQPMTEELLK-QQKLNSHETTITQQs 372
Cdd:TIGR02169  838 LQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGD-LKKERDELEAQLRElERKIEELEAQIEKK- 915
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2056392215  373 vsDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCaqessqkqDGTIQNLKETLKSRERETEEL 437
Cdd:TIGR02169  916 --RKRLSELKAKLEALEEELSEIEDPKGEDEEIPEE--------ELSLEDVQAELQRVEEEIRAL 970
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
626-998 6.63e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 6.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  626 ERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDvlssneatmqSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETK 705
Cdd:TIGR02169  169 DRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRR----------EREKAERYQALLKEKREYEGYELLKEKEALERQ 238
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  706 FSRWQKEQESI---IQQLQTSLHDRNKEVEDLSATLlcklgpgqSEIAEELcqrlqrkERMLQDLLSDRNKQVLEHEMEI 782
Cdd:TIGR02169  239 KEAIERQLASLeeeLEKLTEEISELEKRLEEIEQLL--------EELNKKI-------KDLGEEEQLRVKEKIGELEAEI 303
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  783 QGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQylggrdslmSQAPISNQQAEVTPTGRLGKQTDQGSMQIPSR-- 860
Cdd:TIGR02169  304 ASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEE---------LEREIEEERKRRDKLTEEYAELKEELEDLRAEle 374
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  861 -DDSTSLTAKEDVSIPRSTLGDL-DTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLT 938
Cdd:TIGR02169  375 eVDKEFAETRDELKDYREKLEKLkREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQE 454
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2056392215  939 RNI-QIKEDLIKDLQMQLVDPEDIPAME-RLTQEVLLLREKVASVESQGQEISGNRRQQLLL 998
Cdd:TIGR02169  455 WKLeQLAADLSKYEQELYDLKEEYDRVEkELSKLQRELAEAEAQARASEERVRGGRAVEEVL 516
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
300-819 8.09e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 40.34  E-value: 8.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  300 QYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 379
Cdd:TIGR00618  153 EFAQFLKAKSKEKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLR 232
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  380 ELQEKIQQTEATNKILQEKLNEmsyelkcaQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDtmaKLREMLHQSQ 459
Cdd:TIGR00618  233 EALQQTQQSHAYLTQKREAQEE--------QLKKQQLLKQLRARIEELRAQEAVLEETQERINRARK---AAPLAAHIKA 301
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  460 LGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFveAAAHESEQQKEASWKHNQELRK 539
Cdd:TIGR00618  302 VTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHI--RDAHEVATSIREISCQQHTLTQ 379
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  540 ALQQLQEELQNKSQQLRAWEAEKYN--------EIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ--YRDNSDKTLEANEM 609
Cdd:TIGR00618  380 HIHTLQQQKTTLTQKLQSLCKELDIlqreqatiDTRTSAFRDLQGQLAHAKKQQELQQRYAELCaaAITCTAQCEKLEKI 459
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  610 LLEKLRQRIHDKAVALERAidekfSALEEKEKELRQLRLAVRERDHDLER-LRDVLSSNEATMQSM------ESLLRAKG 682
Cdd:TIGR00618  460 HLQESAQSLKEREQQLQTK-----EQIHLQETRKKAVVLARLLELQEEPCpLCGSCIHPNPARQDIdnpgplTRRMQRGE 534
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  683 LEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATL-----LCKLGPGQSEIAEELCQRL 757
Cdd:TIGR00618  535 QTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQnitvrLQDLTEKLSEAEDMLACEQ 614
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2056392215  758 QRKERMLQDLLSDRNK-QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQ 819
Cdd:TIGR00618  615 HALLRKLQPEQDLQDVrLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVLPKELLAS 677
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
524-673 8.81e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 38.73  E-value: 8.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  524 EQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEK--YNEIRTQ-EQNIQHLNHSLSHKEQLLQEFRELLQYRDNs 600
Cdd:pfam13851   46 EKLMSEIQQENKRLTEPLQKAQEEVEELRKQLENYEKDKqsLKNLKARlKVLEKELKDLKWEHEVLEQRFEKVERERDE- 124
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2056392215  601 dkTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL----ERLRDVLSSNEATMQS 673
Cdd:pfam13851  125 --LYDKFEAAIQDVQQKTGLKNLLLEKKLQALGETLEKKEAQLNEVLAAANLDPDALqavtEKLEDVLESKNQLIKD 199
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
875-1083 9.17e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 40.28  E-value: 9.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  875 PRSTLGDLDTVAGLEKELSNAKEELELmAKKERESQMELSALQSMMAVQEEELQVQAADMESLT-----RNIQIKEDLIK 949
Cdd:COG4913    220 EPDTFEAADALVEHFDDLERAHEALED-AREQIELLEPIRELAERYAAARERLAELEYLRAALRlwfaqRRLELLEAELE 298
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2056392215  950 DLQMQLVDPEDipAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLvkfHA 1029
Cdd:COG4913    299 ELRAELARLEA--ELERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLERELEERERRRARLEALLAAL---GL 373
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2056392215 1030 HPESSERD-----RTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGGELESVR 1083
Cdd:COG4913    374 PLPASAEEfaalrAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLE 432
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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