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Conserved domains on  [gi|2175849779|ref|NP_001386443|]
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tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 2 [Rattus norvegicus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10614797)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.-.-|2.1.1.-
Gene Ontology:  GO:0032259|GO:0008757|GO:0008168|GO:1904047
PubMed:  12504684|12826405

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 114-217 3.20e-20

Methyltransferase domain; This family appears to be a methyltransferase domain.


:

Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 83.77  E-value: 3.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 114 ILEVGCGAGNSVFPILNTLqnipGSFLYCCDFAPEAVELVKSHEAYSEAHCSAfihdVCDDGLAYPFPDGTLDVILLVFV 193
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG----GARVTGVDLSPEMLERARERAAEAGLNVEF----VQGDAEDLPFPDGSFDLVVSSGV 72

                          90       100
                  ....*....|....*....|....
gi 2175849779 194 LSSIHPDRMQAVIHRLSRLLKPGG 217
Cdd:pfam13649  73 LHHLPDPDLEAALREIARVLKPGG 96
 
Name Accession Description Interval E-value
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 114-217 3.20e-20

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 83.77  E-value: 3.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 114 ILEVGCGAGNSVFPILNTLqnipGSFLYCCDFAPEAVELVKSHEAYSEAHCSAfihdVCDDGLAYPFPDGTLDVILLVFV 193
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG----GARVTGVDLSPEMLERARERAAEAGLNVEF----VQGDAEDLPFPDGSFDLVVSSGV 72

                          90       100
                  ....*....|....*....|....
gi 2175849779 194 LSSIHPDRMQAVIHRLSRLLKPGG 217
Cdd:pfam13649  73 LHHLPDPDLEAALREIARVLKPGG 96
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 113-233 4.38e-18

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 79.27  E-value: 4.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 113 RILEVGCGAGNSVFPILNTlqnipGSFLYCCDFAPEAVELVKSHEAYSEAHcsafIHDVCDDGLAYPFPDGTLDVILLVF 192
Cdd:COG2226    25 RVLDLGCGTGRLALALAER-----GARVTGVDISPEMLELARERAAEAGLN----VEFVVGDAEDLPFPDGSFDLVISSF 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2175849779 193 VLSSIhPDRmQAVIHRLSRLLKPGGMLLFRDHGRYDNAQLR 233
Cdd:COG2226    96 VLHHL-PDP-ERALAEIARVLKPGGRLVVVDFSPPDLAELE 134
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 113-221 4.83e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 64.37  E-value: 4.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 113 RILEVGCGAGNsvfpILNTLQNIPGSFLYCCDFAPEAVELVKSHEAYSEAHCSAFIHdvCDDGLAYPFPDGTLDVILLVF 192
Cdd:cd02440     1 RVLDLGCGTGA----LALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLK--GDAEELPPEADESFDVIISDP 74

                          90       100
                  ....*....|....*....|....*....
gi 2175849779 193 VLSSIHPDrMQAVIHRLSRLLKPGGMLLF 221
Cdd:cd02440    75 PLHHLVED-LARFLEEARRLLKPGGVLVL 102
PRK08317 PRK08317
hypothetical protein; Provisional
 113-217 2.57e-09

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 56.87  E-value: 2.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 113 RILEVGCGAGNSVFPILNTLQniPGSFLYCCDFAPEAVELVKSHeaySEAHCSaFIHDVCDDGLAYPFPDGTLDVILLVF 192
Cdd:PRK08317   22 RVLDVGCGPGNDARELARRVG--PEGRVVGIDRSEAMLALAKER---AAGLGP-NVEFVRGDADGLPFPDGSFDAVRSDR 95

                          90       100
                  ....*....|....*....|....*
gi 2175849779 193 VLSsiHPDRMQAVIHRLSRLLKPGG 217
Cdd:PRK08317   96 VLQ--HLEDPARALAEIARVLRPGG 118
 
Name Accession Description Interval E-value
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 114-217 3.20e-20

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 83.77  E-value: 3.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 114 ILEVGCGAGNSVFPILNTLqnipGSFLYCCDFAPEAVELVKSHEAYSEAHCSAfihdVCDDGLAYPFPDGTLDVILLVFV 193
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG----GARVTGVDLSPEMLERARERAAEAGLNVEF----VQGDAEDLPFPDGSFDLVVSSGV 72

                          90       100
                  ....*....|....*....|....
gi 2175849779 194 LSSIHPDRMQAVIHRLSRLLKPGG 217
Cdd:pfam13649  73 LHHLPDPDLEAALREIARVLKPGG 96
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 113-233 4.38e-18

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 79.27  E-value: 4.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 113 RILEVGCGAGNSVFPILNTlqnipGSFLYCCDFAPEAVELVKSHEAYSEAHcsafIHDVCDDGLAYPFPDGTLDVILLVF 192
Cdd:COG2226    25 RVLDLGCGTGRLALALAER-----GARVTGVDISPEMLELARERAAEAGLN----VEFVVGDAEDLPFPDGSFDLVISSF 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2175849779 193 VLSSIhPDRmQAVIHRLSRLLKPGGMLLFRDHGRYDNAQLR 233
Cdd:COG2226    96 VLHHL-PDP-ERALAEIARVLKPGGRLVVVDFSPPDLAELE 134
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 115-219 8.23e-16

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 71.63  E-value: 8.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 115 LEVGCGAGNSVFPILNTLqniPGSFLYCCDFAPEAVELVKSHEAYSEAHCSAFIHDVCDDGLAYPFPdgTLDVILLVFVL 194
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAL---PGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDPG--SFDVVVASNVL 75

                          90       100
                  ....*....|....*....|....*
gi 2175849779 195 SsiHPDRMQAVIHRLSRLLKPGGML 219
Cdd:pfam08242  76 H--HLADPRAVLRNIRRLLKPGGVL 98
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 99-267 1.20e-14

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 71.49  E-value: 1.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779  99 PRKAEQFPGSKATFRILEVGCGAGNSVFPILNTLqnipGSFLYCCDFAPEAVELVKshEAYSEAHCSA--FIH-DVCDDG 175
Cdd:COG0500    15 AALLALLERLPKGGRVLDLGCGTGRNLLALAARF----GGRVIGIDLSPEAIALAR--ARAAKAGLGNveFLVaDLAELD 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 176 layPFPDGTLDVILLVFVLSSIHPDRMQAVIHRLSRLLKPGGMLLF--------RDHGRYDNAQLRFKKGRCLSENFYVR 247
Cdd:COG0500    89 ---PLPAESFDLVVAFGVLHHLPPEEREALLRELARALKPGGVLLLsasdaaaaLSLARLLLLATASLLELLLLLRLLAL 165

                         170       180
                  ....*....|....*....|
gi 2175849779 248 GDGTRAYFFTKGEIHRMFCE 267
Cdd:COG0500   166 ELYLRALLAAAATEDLRSDA 185
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 115-221 8.49e-14

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 66.15  E-value: 8.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 115 LEVGCGAGNSVFPILNTlqnipGSFLYCCDFAPEAVELVKSHEAyseahcSAFIHDVCDDGLAYPFPDGTLDVILLVFVL 194
Cdd:pfam08241   1 LDVGCGTGLLTELLARL-----GARVTGVDISPEMLELAREKAP------REGLTFVVGDAEDLPFPDNSFDLVLSSEVL 69

                          90       100
                  ....*....|....*....|....*..
gi 2175849779 195 SsiHPDRMQAVIHRLSRLLKPGGMLLF 221
Cdd:pfam08241  70 H--HVEDPERALREIARVLKPGGILII 94
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 113-221 3.10e-13

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 65.42  E-value: 3.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 113 RILEVGCGAGNSVFPILNTlqnipGSFLYCCDFAPEAVELVKSHEAYSEAHCsafihdVCDDGLAYPFPDGTLDVILLVF 192
Cdd:COG2227    27 RVLDVGCGTGRLALALARR-----GADVTGVDISPEALEIARERAAELNVDF------VQGDLEDLPLEDGSFDLVICSE 95

                          90       100
                  ....*....|....*....|....*....
gi 2175849779 193 VLssIHPDRMQAVIHRLSRLLKPGGMLLF 221
Cdd:COG2227    96 VL--EHLPDPAALLRELARLLKPGGLLLL 122
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 113-221 4.83e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 64.37  E-value: 4.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 113 RILEVGCGAGNsvfpILNTLQNIPGSFLYCCDFAPEAVELVKSHEAYSEAHCSAFIHdvCDDGLAYPFPDGTLDVILLVF 192
Cdd:cd02440     1 RVLDLGCGTGA----LALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLK--GDAEELPPEADESFDVIISDP 74

                          90       100
                  ....*....|....*....|....*....
gi 2175849779 193 VLSSIHPDrMQAVIHRLSRLLKPGGMLLF 221
Cdd:cd02440    75 PLHHLVED-LARFLEEARRLLKPGGVLVL 102
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
113-277 5.53e-13

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 66.18  E-value: 5.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 113 RILEVGCGAGNSVFPilntLQNIpGSFLYCCDFAPEAVELVKSHEAYSEAHCsafiHDVCDDglayPFPDGTLDVILLVF 192
Cdd:COG4976    49 RVLDLGCGTGLLGEA----LRPR-GYRLTGVDLSEEMLAKAREKGVYDRLLV----ADLADL----AEPDGRFDLIVAAD 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 193 VLSsiHPDRMQAVIHRLSRLLKPGGMLLFrdhgrydnaqlrfkkgrclSENfyvRGDGTRAYFFTKGEIHRMFCEAGLHE 272
Cdd:COG4976   116 VLT--YLGDLAAVFAGVARALKPGGLFIF-------------------SVE---DADGSGRYAHSLDYVRDLLAAAGFEV 171


                  ....*
gi 2175849779 273 KQNLV 277
Cdd:COG4976   172 PGLLV 176
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
113-221 7.81e-13

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 63.69  E-value: 7.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 113 RILEVGCGAGNSVFPILntlQNIPGSFLYCCDFAPEAVELVKshEAYSEAHCsafihdVCDDGLAYPfPDGTLDVILLVF 192
Cdd:COG4106     4 RVLDLGCGTGRLTALLA---ERFPGARVTGVDLSPEMLARAR--ARLPNVRF------VVADLRDLD-PPEPFDLVVSNA 71

                          90       100
                  ....*....|....*....|....*....
gi 2175849779 193 VLSsiHPDRMQAVIHRLSRLLKPGGMLLF 221
Cdd:COG4106    72 ALH--WLPDHAALLARLAAALAPGGVLAV 98
PRK08317 PRK08317
hypothetical protein; Provisional
 113-217 2.57e-09

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 56.87  E-value: 2.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 113 RILEVGCGAGNSVFPILNTLQniPGSFLYCCDFAPEAVELVKSHeaySEAHCSaFIHDVCDDGLAYPFPDGTLDVILLVF 192
Cdd:PRK08317   22 RVLDVGCGPGNDARELARRVG--PEGRVVGIDRSEAMLALAKER---AAGLGP-NVEFVRGDADGLPFPDGSFDAVRSDR 95

                          90       100
                  ....*....|....*....|....*
gi 2175849779 193 VLSsiHPDRMQAVIHRLSRLLKPGG 217
Cdd:PRK08317   96 VLQ--HLEDPARALAEIARVLRPGG 118
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 102-270 7.15e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 53.97  E-value: 7.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 102 AEQFPGSKATFRILEVGCGAGNsVFPILNTLQ-NIPGSflyccDFAPEAVELVKSheayseahcsaFIHDVCDDGLAYPF 180
Cdd:pfam13489  14 LRLLPKLPSPGRVLDFGCGTGI-FLRLLRAQGfSVTGV-----DPSPIAIERALL-----------NVRFDQFDEQEAAV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 181 PDGTLDVILLVFVLSSIHPdrMQAVIHRLSRLLKPGGMLLFRDHGRYDNAQLRFKKGRCLSENfyvrgdGTRAYFFTKGE 260
Cdd:pfam13489  77 PAGKFDVIVAREVLEHVPD--PPALLRQIAALLKPGGLLLLSTPLASDEADRLLLEWPYLRPR------NGHISLFSARS 148

                         170
                  ....*....|
gi 2175849779 261 IHRMFCEAGL 270
Cdd:pfam13489 149 LKRLLEEAGF 158
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 113-269 3.02e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 46.26  E-value: 3.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 113 RILEVGCGAGNSVFpILNTLQNiPGSFLYCCDFAPEAVELVKSHEAYSE-AHCSAFIHDVCDdgLAYPFPDGTLDVILLV 191
Cdd:pfam13847   6 RVLDLGCGTGHLSF-ELAEELG-PNAEVVGIDISEEAIEKARENAQKLGfDNVEFEQGDIEE--LPELLEDDKFDVVISN 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2175849779 192 FVLSSIhPDrMQAVIHRLSRLLKPGGMLLFRDHGRYDNAQLRFKKgrclsENFYVRGDGTRAYffTKGEIHRMFCEAG 269
Cdd:pfam13847  82 CVLNHI-PD-PDKVLQEILRVLKPGGRLIISDPDSLAELPAHVKE-----DSTYYAGCVGGAI--LKKKLYELLEEAG 150
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 100-223 1.80e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 44.15  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 100 RKAEQFPGSkatfRILEVGCGAG-NSVFpilntLQNIPGSFLYCCDFAPEAVELVKSHEAysEAHCSAFIHDVCDDGLAY 178
Cdd:COG2230    45 RKLGLKPGM----RVLDIGCGWGgLALY-----LARRYGVRVTGVTLSPEQLEYARERAA--EAGLADRVEVRLADYRDL 113

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2175849779 179 PfPDGTLDVILLVFVLSSIHPDRMQAVIHRLSRLLKPGGMLLFRD 223
Cdd:COG2230   114 P-ADGQFDAIVSIGMFEHVGPENYPAYFAKVARLLKPGGRLLLHT 157
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
100-220 3.78e-05

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 44.35  E-value: 3.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 100 RKAEQFPGSKATFRILEVGCGAGNSVFPILNTLQniPGSFLYCCDFAPEAVELVKS---HEAYSEahcsafIHDVCDDGL 176
Cdd:pfam01209  32 DFTMKCMGVKRGNKFLDVAGGTGDWTFGLSDSAG--SSGKVVGLDINENMLKEGEKkakEEGKYN------IEFLQGNAE 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2175849779 177 AYPFPDGTLDVILLVFVLSSIhPDRmQAVIHRLSRLLKPGGMLL 220
Cdd:pfam01209 104 ELPFEDDSFDIVTISFGLRNF-PDY-LKVLKEAFRVLKPGGRVV 145
Methyltransf_24 pfam13578
Methyltransferase domain; This family appears to be a methyltransferase domain.
 115-223 1.89e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 433324 [Multi-domain]  Cd Length: 106  Bit Score: 39.98  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 115 LEVGCGAGNSVFPILNTLQNIPGSFLYCCD---FAPEAVELVKSH--EAYSEAHCSAFIHdvcddgLAYPFPDGTLDvil 189
Cdd:pfam13578   1 VEIGTYSGVSTLWLAAALRDNGLGRLTAVDpdpGAEEAGALLRKAglDDRVRLIVGDSRE------ALPSLADGPID--- 71

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2175849779 190 LVFVLSSIHPDRMQAVIHRLSRLLKPGGMLLFRD 223
Cdd:pfam13578  72 LLFIDGDHTYEAVLNDLELWLPRLAPGGVILFHD 105
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 113-230 2.39e-04

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 40.94  E-value: 2.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 113 RILEVGCGAGNSVFPILNTLQniPGSFLYCCDFAPEAVELVKSHeaYSEAHCSAFIHDVCDDGLAY--PFPDGTLDvilL 190
Cdd:COG4122    19 RILEIGTGTGYSTLWLARALP--DDGRLTTIEIDPERAAIAREN--FARAGLADRIRLILGDALEVlpRLADGPFD---L 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2175849779 191 VFVlsSIHPDRMQAVIHRLSRLLKPGGMLLFrdhgryDNA 230
Cdd:COG4122    92 VFI--DADKSNYPDYLELALPLLRPGGLIVA------DNV 123
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 107-220 2.62e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 41.68  E-value: 2.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 107 GSKATFRILEVGCGAGNSVFPILNTLQNIpGSfLYCCDFAPEAVELVKshEAYSEAHCSAFIHDVCDDGLAYPFPDGTLD 186
Cdd:PRK00216   48 GVRPGDKVLDLACGTGDLAIALAKAVGKT-GE-VVGLDFSEGMLAVGR--EKLRDLGLSGNVEFVQGDAEALPFPDNSFD 123

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2175849779 187 VILLVFVLSSIhPDRMQAvIHRLSRLLKPGGMLL 220
Cdd:PRK00216  124 AVTIAFGLRNV-PDIDKA-LREMYRVLKPGGRLV 155
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 144-237 7.09e-03

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 36.59  E-value: 7.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2175849779 144 DFAPEAVELVKSHEAYSEAHCSAFIHDVCDDGLAYPFPDGTLDVILLVFVLSSIhPDRMQAvIHRLSRLLKPGGMLLFRD 223
Cdd:PLN02232    4 DFSSEQLAVAATRQSLKARSCYKCIEWIEGDAIDLPFDDCEFDAVTMGYGLRNV-VDRLRA-MKEMYRVLKPGSRVSILD 81

                          90
                  ....*....|....
gi 2175849779 224 HGRYDNAQLRFKKG 237
Cdd:PLN02232   82 FNKSNQSVTTFMQG 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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