zinc-regulated GTPase metalloprotein activator 1A isoform 4 [Homo sapiens]
P-loop NTPase family protein( domain architecture ID 1562424)
P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation
List of domain hits
Name | Accession | Description | Interval | E-value | ||
P-loop_NTPase super family | cl38936 | P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ... |
43-113 | 7.50e-36 | ||
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families. The actual alignment was detected with superfamily member cd03112: Pssm-ID: 476819 Cd Length: 198 Bit Score: 121.09 E-value: 7.50e-36
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Name | Accession | Description | Interval | E-value | ||
CobW-like | cd03112 | cobalamin synthesis protein CobW; The function of this protein family is unknown. The amino ... |
43-113 | 7.50e-36 | ||
cobalamin synthesis protein CobW; The function of this protein family is unknown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage caused by mitomycin. YijA gene is a homologue of the CobW gene which encodes the cobalamin synthesis protein/P47K. Pssm-ID: 349766 Cd Length: 198 Bit Score: 121.09 E-value: 7.50e-36
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YejR | COG0523 | Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction ... |
40-112 | 2.45e-28 | ||
Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction only]; Pssm-ID: 440289 [Multi-domain] Cd Length: 318 Bit Score: 104.48 E-value: 2.45e-28
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cobW | pfam02492 | CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase ... |
43-113 | 4.26e-25 | ||
CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans. Pssm-ID: 396860 Cd Length: 179 Bit Score: 93.09 E-value: 4.26e-25
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CobW | TIGR02475 | cobalamin biosynthesis protein CobW; The family of proteins identified by this model is ... |
40-112 | 1.41e-20 | ||
cobalamin biosynthesis protein CobW; The family of proteins identified by this model is generally found proximal to the trimeric cobaltochelatase subunit CobN which is essential for vitamin B12 (cobalamin) biosynthesis. The protein contains an P-loop nucleotide-binding loop in the N-terminal domain and a histidine-rich region in the C-terminal portion suggesting a role in metal binding, possibly as an intermediary between the cobalt transport and chelation systems. A broader CobW family is delineated by two Pfam models which identify the N- and C-terminal domains (pfam02492 and pfam07683). [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin] Pssm-ID: 274151 [Multi-domain] Cd Length: 341 Bit Score: 84.03 E-value: 1.41e-20
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PRK11537 | PRK11537 | putative GTP-binding protein YjiA; Provisional |
42-111 | 1.17e-18 | ||
putative GTP-binding protein YjiA; Provisional Pssm-ID: 183183 [Multi-domain] Cd Length: 318 Bit Score: 78.59 E-value: 1.17e-18
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Name | Accession | Description | Interval | E-value | |||
CobW-like | cd03112 | cobalamin synthesis protein CobW; The function of this protein family is unknown. The amino ... |
43-113 | 7.50e-36 | |||
cobalamin synthesis protein CobW; The function of this protein family is unknown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage caused by mitomycin. YijA gene is a homologue of the CobW gene which encodes the cobalamin synthesis protein/P47K. Pssm-ID: 349766 Cd Length: 198 Bit Score: 121.09 E-value: 7.50e-36
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YejR | COG0523 | Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction ... |
40-112 | 2.45e-28 | |||
Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction only]; Pssm-ID: 440289 [Multi-domain] Cd Length: 318 Bit Score: 104.48 E-value: 2.45e-28
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cobW | pfam02492 | CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase ... |
43-113 | 4.26e-25 | |||
CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans. Pssm-ID: 396860 Cd Length: 179 Bit Score: 93.09 E-value: 4.26e-25
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CobW | TIGR02475 | cobalamin biosynthesis protein CobW; The family of proteins identified by this model is ... |
40-112 | 1.41e-20 | |||
cobalamin biosynthesis protein CobW; The family of proteins identified by this model is generally found proximal to the trimeric cobaltochelatase subunit CobN which is essential for vitamin B12 (cobalamin) biosynthesis. The protein contains an P-loop nucleotide-binding loop in the N-terminal domain and a histidine-rich region in the C-terminal portion suggesting a role in metal binding, possibly as an intermediary between the cobalt transport and chelation systems. A broader CobW family is delineated by two Pfam models which identify the N- and C-terminal domains (pfam02492 and pfam07683). [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin] Pssm-ID: 274151 [Multi-domain] Cd Length: 341 Bit Score: 84.03 E-value: 1.41e-20
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PRK11537 | PRK11537 | putative GTP-binding protein YjiA; Provisional |
42-111 | 1.17e-18 | |||
putative GTP-binding protein YjiA; Provisional Pssm-ID: 183183 [Multi-domain] Cd Length: 318 Bit Score: 78.59 E-value: 1.17e-18
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RecD | COG0507 | ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
43-73 | 6.47e-05 | |||
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair]; Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 40.35 E-value: 6.47e-05
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DEXSc_RecD-like | cd17933 | DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1. ... |
43-73 | 7.66e-04 | |||
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Pssm-ID: 350691 [Multi-domain] Cd Length: 155 Bit Score: 36.76 E-value: 7.66e-04
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NACHT | COG5635 | Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
23-106 | 1.01e-03 | |||
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 37.09 E-value: 1.01e-03
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MobB | COG1763 | Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; ... |
47-74 | 7.18e-03 | |||
Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; Molybdopterin-guanine dinucleotide biosynthesis protein is part of the Pathway/BioSystem: Molybdopterin biosynthesis Pssm-ID: 441369 [Multi-domain] Cd Length: 162 Bit Score: 34.00 E-value: 7.18e-03
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PRK13949 | PRK13949 | shikimate kinase; Provisional |
47-80 | 9.90e-03 | |||
shikimate kinase; Provisional Pssm-ID: 140006 [Multi-domain] Cd Length: 169 Bit Score: 33.93 E-value: 9.90e-03
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Blast search parameters | ||||
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