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Conserved domains on  [gi|2184285234|ref|NP_001387763|]
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alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform f precursor [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 71-239 1.05e-124

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23978:

Pssm-ID: 480271  Cd Length: 229  Bit Score: 357.24  E-value: 1.05e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  71 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 150
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 151 PPSKMQKPQGS-LVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 229
Cdd:cd23978    81 PPNKMQKDGKSnLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                         170
                  ....*....|
gi 2184285234 230 MVPPNYCSGP 239
Cdd:cd23978   161 MVPPNYCSKR 170
 
Name Accession Description Interval E-value
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 71-239 1.05e-124

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 357.24  E-value: 1.05e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  71 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 150
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 151 PPSKMQKPQGS-LVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 229
Cdd:cd23978    81 PPNKMQKDGKSnLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                         170
                  ....*....|
gi 2184285234 230 MVPPNYCSGP 239
Cdd:cd23978   161 MVPPNYCSKR 170
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 68-234 2.93e-22

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 93.83  E-value: 2.93e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  68 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVV-AHSSVFRVLRRPQEFVNRTPETVF 146
Cdd:pfam00777  40 NKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFSHPRDPFVEF 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 147 IF---------WGPPSKMQKPQGSLVRVIQRAGLVFPNmeayaVSPGRMRQFDDLFRGETGKDREKSHSW----LSTGWF 213
Cdd:pfam00777 120 VLvpfkgrdllWLPAFLTKGNVSRSLRVLYTLKEVKIP-----VDPDKVLFLHPDFLRYVANFWLRSHGLkgrrPSTGLL 194

                         170       180
                  ....*....|....*....|.
gi 2184285234 214 TMVIAVELCDHVHVYGMVPPN 234
Cdd:pfam00777 195 MLSLALHLCDEVSLYGFGPFL 215
 
Name Accession Description Interval E-value
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 71-239 1.05e-124

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 357.24  E-value: 1.05e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  71 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 150
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 151 PPSKMQKPQGS-LVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 229
Cdd:cd23978    81 PPNKMQKDGKSnLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                         170
                  ....*....|
gi 2184285234 230 MVPPNYCSGP 239
Cdd:cd23978   161 MVPPNYCSKR 170
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 71-245 6.01e-93

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 276.43  E-value: 6.01e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  71 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRP-QEFVNRTPETVFIFW 149
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAiLLLAGTRAPTVVVFW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 150 GPPSKMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 229
Cdd:cd23965    81 GPETKMNKDGAGKYNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVYG 160

                         170
                  ....*....|....*.
gi 2184285234 230 MVPPNYCSGPASSACP 245
Cdd:cd23965   161 MVPENYCREHPNSKVP 176
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 57-283 5.29e-77

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 236.30  E-value: 5.29e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  57 GYVPILGNKTLPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQE 136
Cdd:cd23976     1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 137 FVNRTPETVFIFWGPPSKMQKP-QGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTM 215
Cdd:cd23976    81 LLNVSQGTVFIFWGPSNYMRRDgKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2184285234 216 VIAVELCDHVHVYGMVPPNYCSGPASSACPTTTTSPRGRTNvsptsrmstvARATTTASSPRKGSSHR 283
Cdd:cd23976   161 IIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPSGPDE----------CTMYISHERGRKGSHHR 218
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 71-245 1.85e-59

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 190.84  E-value: 1.85e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  71 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 150
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 151 PPSKM-QKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 229
Cdd:cd23977    81 PERNMdRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                         170
                  ....*....|....*.
gi 2184285234 230 MVPPNYCSGPASSACP 245
Cdd:cd23977   161 MVSDSYCRNKNHSSVP 176
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 71-236 8.00e-54

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 176.28  E-value: 8.00e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  71 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 150
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 151 PPSKMQKP-QGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 229
Cdd:cd23975    81 PFRNMRKDgKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160


                  ....*..
gi 2184285234 230 MVPPNYC 236
Cdd:cd23975   161 MINDTYC 167
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 74-230 9.81e-29

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 109.76  E-value: 9.81e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  74 CVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTP---ETVFIFWG 150
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPleeEVVLILSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 151 PPSKMQKpqgslvRVIQRAGLvfPNMEAYAVSPGR---MRQFDDLFRGETGKDrEKSHSWLSTGWFTMVIAVELCDHVHV 227
Cdd:cd19952    81 AAAADFK------RLKRRKKR--HDNAVLLLTDPApdlLSYVRKRLEKLGLKS-FFGGNAPSSGLLAVLLALQLCDSVDL 151


                  ...
gi 2184285234 228 YGM 230
Cdd:cd19952   152 YGF 154
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 68-234 2.93e-22

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 93.83  E-value: 2.93e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  68 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVV-AHSSVFRVLRRPQEFVNRTPETVF 146
Cdd:pfam00777  40 NKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFSHPRDPFVEF 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 147 IF---------WGPPSKMQKPQGSLVRVIQRAGLVFPNmeayaVSPGRMRQFDDLFRGETGKDREKSHSW----LSTGWF 213
Cdd:pfam00777 120 VLvpfkgrdllWLPAFLTKGNVSRSLRVLYTLKEVKIP-----VDPDKVLFLHPDFLRYVANFWLRSHGLkgrrPSTGLL 194

                         170       180
                  ....*....|....*....|.
gi 2184285234 214 TMVIAVELCDHVHVYGMVPPN 234
Cdd:pfam00777 195 MLSLALHLCDEVSLYGFGPFL 215
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 38-234 1.07e-20

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 90.02  E-value: 1.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  38 SLRGRSRRPVNLKKWSitdgYVPILGNKTLPSRCHQ-CVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNK 116
Cdd:cd23968    15 STLRKTTSPFKDLLSL----RYPFPESSLENTKRYNtCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 117 TTYRVVAH----SSVFRVLRRPqEFVNrtpETVFIfWGPPS-------KMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGR 185
Cdd:cd23968    91 TTLRLINSqilsKPEFNFLTDP-LYRN---VTLLV-WDPSSynvnlekWYKKPDFDFFPNYIKYRRRHPEEPFYLIDPRF 165

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2184285234 186 M-RQFDDLFRGETGKDREKSHswlSTGWFTMVIAVELCDHVHVYGMVPPN 234
Cdd:cd23968   166 LwRLWDILQEYTPEKIKPNPP---SSGFIGIVLMLHLCDWVDVYEYVPSV 212
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 70-234 2.86e-20

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 87.35  E-value: 2.86e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  70 RCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFrvlRRPQEFvnrTPETVFIF- 148
Cdd:cd23967     1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAF---RDPEEY---DSDWLLVLv 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 149 --------WGPPSKMQKPQGSLVRVIQRAGLVFPnmeayaVSPGRMRQFDDLFRGETG-------KDREKSHSWLSTGWF 213
Cdd:cd23967    75 pfksmdllWLQAVIKGKKPNGKGGFWKKIATSVP------KPPKKIRILNPYILQEAAfdliglpMNGKQGKNVPTTGII 148

                         170       180
                  ....*....|....*....|....*
gi 2184285234 214 TMVIAVELCDHVHV----YGMVPPN 234
Cdd:cd23967   149 AIVMALHYCDEVDIagfgYDPSDPN 173
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 36-229 3.39e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 83.08  E-value: 3.39e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  36 YGSLRGRSRRPVNLKKWSITDGYVPIlGNKTLPSrchqCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGN 115
Cdd:cd23963    33 YYSYFKKKTFKITKSLYELLPKTSPF-SHKRYKT----CAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGR 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 116 KTTYRVVAHSSVFRVL------RRPQEFVNRTPETV-FIFWGPPSKMQKPQGSLVRVIQRAGLVFPNME-AYAvSPGRMR 187
Cdd:cd23963   108 KTNLTTLNPSILKRRYnslkknRDRDKFLNRLKEYNgSILWYPKFSFKSSTNLLLKAARALKKNGLNLTvVYS-NPEHFL 186

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2184285234 188 QFDDlFRGETGKDRekshsWLSTGWFTMVIAVELCDHVHVYG 229
Cdd:cd23963   187 AVQK-FWKRRGLEK-----RPSTGLYLVSLALTFCDEIHLYG 222
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 58-232 3.57e-17

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 80.27  E-value: 3.57e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  58 YVP-ILGNKTLPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHssvfRVLRRPQE 136
Cdd:cd23986    35 YVPkIPLSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINS----QILTNPNH 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 137 FVNRTP---ETVFIFWGP-PSKM------QKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHS 206
Cdd:cd23986   111 HFIDSSlykDVILVAWDPaPYSAnlhkwyKKPDYNLFTPYVQYRKRNPNQPFYILHPKFIWQLWDIIQENTQEKIQPNPP 190

                         170       180
                  ....*....|....*....|....*.
gi 2184285234 207 wlSTGWFTMVIAVELCDHVHVYGMVP 232
Cdd:cd23986   191 --SSGFIGILIMMSMCREVHVYEYIP 214
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 46-232 1.03e-16

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 78.60  E-value: 1.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  46 PVNLKKWsitDGYVPILGNKTLPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVaHS 125
Cdd:cd23985    23 PFNTSEW---EGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLI-NS 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 126 SVfrVLRRPQEFVNRT--PETVFIFWGP-------PSKMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGE 196
Cdd:cd23985    99 QL--VTTEKHKFLKDSlyNEGILIVWDPapyhsdiPEWYKNPDYNFFENYKTYRRLNPNQPFYILHPQMQWELWDIIQEN 176

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2184285234 197 TGKDREKSHSwlSTGWFTMVIAVELCDHVHVYGMVP 232
Cdd:cd23985   177 SPEEIQPNPP--SSGMLGIILMMTLCDQVDVYEFLP 210
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 68-230 2.93e-14

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 71.93  E-value: 2.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  68 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVahssvfrvlrRPQEFVNRTPETVFI 147
Cdd:cd23966    74 PNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFM----------YPESAVDLDPGVHLV 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 148 ---FwgppskmqKPQGslvrvIQRAGLVFPNMEAyAVSPGRMRQFDDLfrgetgkDREK-----------SH-SWL---- 208
Cdd:cd23966   144 lvpF--------KVLD-----LQWLISALTTGEI-TRTYTPVKRFIKA-------DKDKvlvinpafikyVHdNWTehhg 202

                         170       180
                  ....*....|....*....|....*
gi 2184285234 209 ---STGWFTMVIAVELCDHVHVYGM 230
Cdd:cd23966   203 rypSTGFLALIFALHICDEVSVFGF 227
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 70-234 4.71e-13

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 67.00  E-value: 4.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  70 RCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVV-AHSSVFrvlrRPQEfvNRTPETVF-- 146
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFyPESAQF----DPGI--ENDPDTLLvl 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 147 -----------------------IFWGPPSKMQKPQGSLVRVIqraglvfpnmeayavSPGRMRQFDDLFRGETGKDREK 203
Cdd:cd23982    75 vpfkpldfywlyeilsnekrvrkGFWKQPPRIWDANPKQIRIL---------------NPYYTYVAATKLLQVPGQRKKK 139

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2184285234 204 SHSwlSTGWFTMVIAVELCDHVHVYGMVPPN 234
Cdd:cd23982   140 QKP--TTGLLAITLALHLCDEVHIAGFGYPD 168
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 42-229 5.71e-12

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 65.29  E-value: 5.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  42 RSRRPVNLKK-----WSITDGYVPILGNKTlPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNK 116
Cdd:cd23980    48 REKKPKNLNDtirelFQVVPGNVDPLLEKR-LVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSK 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 117 TTYRVVAHSSvFRVLRRPQEFVNRTPETVFIFW-------GPPSKMQKPQGSLVRVIQRAGLVFpnmeayavSPGRMRQ- 188
Cdd:cd23980   127 TTHHFVYPES-FRELAQNVSMILVPFKTLDLEWvisatttGTISHTYVPVPRKIKVKKEKILIY--------HPAFIKYv 197

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2184285234 189 FDDLFRGEtGKdrekshsWLSTGWFTMVIAVELCDHVHVYG 229
Cdd:cd23980   198 FDRWLQGH-GR-------YPSTGILSVIFSLHVCDEVDLYG 230
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 71-121 5.73e-12

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 63.99  E-value: 5.73e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2184285234  71 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRV 121
Cdd:cd23983     2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRM 52
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 71-229 5.45e-11

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 61.30  E-value: 5.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  71 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVF-------------------RVL 131
Cdd:cd23984     2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFsdpshydpnttvvlipfkpHDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 132 RRPQEFVNRTPETVFIFW-GPPSKMQ-KPqgSLVRVIqraglvfpnmeayavSPGRMRQFD-DLFRGETGKDREKSHSWL 208
Cdd:cd23984    82 RWLLDLLMGKKVSAKGFWkKPALNLIyKP--NQIRIL---------------NPFILRIAAyELLHFPKRFPKEKKPKHP 144

                         170       180
                  ....*....|....*....|.
gi 2184285234 209 STGWFTMVIAVELCDHVHVYG 229
Cdd:cd23984   145 TTGIIAITLALHICNEVHIAG 165
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 68-229 2.18e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 60.66  E-value: 2.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  68 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVfRVLRRPQEFVNRTPETVFI 147
Cdd:cd23979    77 PSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESA-KNLPANVSFVLVPFKTLDL 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 148 FW-------GPPSKMQKPQGSLVRVIQRAGLVFpnmeayavSPGRMRQFDDLFRGETGKdrekshsWLSTGWFTMVIAVE 220
Cdd:cd23979   156 LWitsalstGQIRFTYAPVKQFLRVDKDKVQIY--------NPAFFKYIHDRWTEHHGR-------YPSTGMLVLFFALH 220


                  ....*....
gi 2184285234 221 LCDHVHVYG 229
Cdd:cd23979   221 VCDEVNVYG 229
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 74-232 4.34e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 56.65  E-value: 4.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  74 CVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYrVVAHSSVfrVLRRPQEFVNRTPETVF------- 146
Cdd:cd23969    67 CAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNL-TTMNPSV--IPHAYGDLVNATDKEKFverlrql 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 147 ---IFWgPPSKMQKPQGSLVRVIQRAGL--VFPNMEAYAvsPGRMRQfddLFRG--ETGKDREKSHswlSTGWFTMVIAV 219
Cdd:cd23969   144 gdsILW-IPAFVSKGGEEHVQWTNEIILkhKLNVKTAYP--PLRLNH---AIRGywLTTKFRIKRP---STGLLMYTLAT 214

                         170
                  ....*....|...
gi 2184285234 220 ELCDHVHVYGMVP 232
Cdd:cd23969   215 RFCDEIHLYGFYP 227
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 70-150 1.51e-08

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 54.16  E-value: 1.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  70 RCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSvfrVLRRPQEFvnrTPETVFIFW 149
Cdd:cd23981     1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEG---AIQKPEQY---EKDSLFVLA 74


                  .
gi 2184285234 150 G 150
Cdd:cd23981    75 G 75
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 55-235 4.73e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 53.42  E-value: 4.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  55 TDGYVPILGNKTlPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRP 134
Cdd:cd23964    67 TSSRYMFVLRGG-RPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNSLLKH 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 135 qefVNRTPETVFIF----------------WGPPSKMQKPQGSlvrviqraglvFPNMEAYAVSPGRMRQFD-DLFRget 197
Cdd:cd23964   146 ---VPQDKDTKYLFipfkirdydyldavlsGKPVPDGCDKGKR-----------PPPLFGPKLNATNVRLLHpDFIR--- 208

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2184285234 198 gkdreksH---SWL--------STGWFTMVIAVELCDHVHVYGM-VPPNY 235
Cdd:cd23964   209 -------YlfnRWLnsstsyrpTTGALMLLTALHTCDQVSVYGFgYDPRF 251
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 69-235 5.43e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 53.60  E-value: 5.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  69 SRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEF----VNRTPET 144
Cdd:cd23973    81 DGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRgfknIPQDKDI 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 145 VFIF---------WGPPSKMQK--PQGSLVRVIQRA--GLVFpNMEAYAVS-PGRMRQFDDLFRgeTGKDREKSHSWL-- 208
Cdd:cd23973   161 KYILfpegprdyqWLEALLKNKtiPSGAYYGRRPRSyfSGDF-TEDKYLVLhPDFLRYVKNRFL--RSKTLKGKYWAIyr 237

                         170       180
                  ....*....|....*....|....*...
gi 2184285234 209 -STGWFTMVIAVELCDHVHVYGMVPPNY 235
Cdd:cd23973   238 pTTGAFLLLTALHLCDTVSAYGFITEDY 265
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 73-232 5.53e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 53.42  E-value: 5.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  73 QCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTgYSADVGNKTTYrVVAHSSVFR-----VLRRPQEFVNRtpetvfi 147
Cdd:cd23971    66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNL-VTANPSILRekfhnLKKRRRPFVER------- 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 148 fwgppskMQKPQGSLV------------------RVIQRAGlvfPNMEAYAVSPGRMRQFDDLFRGETGKDREkshswLS 209
Cdd:cd23971   137 -------MKVYGNALLllpafsytsntepslralYTLEDFG---SPQKVLFFNPEYLRNLSRYWKSKGLKARR-----LS 201

                         170       180
                  ....*....|....*....|....
gi 2184285234 210 TGwFTMV-IAVELCDHVHVYGMVP 232
Cdd:cd23971   202 TG-LMLVsAALELCENVHLYGFWP 224
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 73-232 1.28e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 52.06  E-value: 1.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  73 QCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTG-YSADVGNKTTYrVVAHSSVFrvLRRPQEFVNRtpetvfifwgp 151
Cdd:cd23991    66 QCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNL-VTANPSII--SIKYAKLNER----------- 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 152 pskmQKPQGSLVRVIQRAGLVFPnmeAYAVSPGRMRQFDDLFRGETGKDREK------------SHSW---------LST 210
Cdd:cd23991   132 ----RKPFLETVSVYGDAFLLLP---AFSYRSNTALSFKVYYTLEDFKAKQKviffhpiylkhlAQFWrskgvqvyrLST 204

                         170       180
                  ....*....|....*....|..
gi 2184285234 211 GWFTMVIAVELCDHVHVYGMVP 232
Cdd:cd23991   205 GLMITSAALELCEEVKLYGFWP 226
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 62-232 2.38e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 51.48  E-value: 2.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  62 LGNKTLPSrchqCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYrVVAHSSVfrVLRRPQEFVNRT 141
Cdd:cd23987    59 LKNKHFKT----CAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDL-VTMNPSV--VQRAFEDLVNET 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 142 PETVFIfwgppSKMQKPQGSLVRViqraglvfpnmEAYAVSPG--RMRQFDDLFRGETGKDREKSHS----------WL- 208
Cdd:cd23987   132 WKEKFL-----QRLQSLNGSILWI-----------PAFMAKGGeeRVEWVNDLILKHHINVRTAYPSlrllhavrgyWLt 195

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2184285234 209 --------STGWFTMVIAVELCDHVHVYGMVP 232
Cdd:cd23987   196 nkvhikrpTTGLLMYTLATRFCNRIHLYGFWP 227
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 6-232 3.86e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 50.72  E-value: 3.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234   6 EQRSAVFVILFALITILILYSSNSANEVFHYGSLRgrsRRPVNLKK--WSITDGYVPiLGNKTLPSrchqCVIVSSSSHL 83
Cdd:cd23988     5 EIRKDILRFLDAERDVSVVKSSFKPGDVIHYVLDR---RRTLNISQnlHSLLPEVSP-MKNRRFKT----CAVVGNSGIL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  84 LGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRV---LRRP---QEFVNRTPE-TVFIFWgPPSKMQ 156
Cdd:cd23988    77 LDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAfggFRNEsdrEKFVHRLSMlNDSVLW-IPAFMV 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2184285234 157 KpqGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLfRGE--TGKDREKSHswlSTGWFTMVIAVELCDHVHVYGMVP 232
Cdd:cd23988   156 K--GGEKHVEWVNALILKNKLKVRTAYPSLRLIHAV-RGYwlTNKVNIKRP---STGLLMYTLATRFCDEIHLYGFWP 227
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 74-232 6.94e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 47.00  E-value: 6.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  74 CVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVA-------HSSVFRVLRRPQEFVNRTPETVF 146
Cdd:cd23970    71 CAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNpsilekyYNNLLTIQDRNNFFLSLKKLDGA 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 147 IFWGPPSKMQKpqgslVRVIQRAGLVF-------PNME-AYavsPGR-MRQFDDLFRGETGKDREkshswLSTGWFTMVI 217
Cdd:cd23970   151 ILWIPAFFFHT-----SATVTRTLVDFfvehrgqLKVQlAW---PGNiMQHVNRYWKTKHLSPKR-----LSTGILMYTL 217

                         170
                  ....*....|....*
gi 2184285234 218 AVELCDHVHVYGMVP 232
Cdd:cd23970   218 ASAICEEIHLYGFWP 232
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 67-235 1.52e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 45.97  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  67 LPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEF-VNRTPET- 144
Cdd:cd23972    78 TPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMKNSLISYWNLgFTRTPQGq 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 145 ----VFIfwgpPSKMQK-------------PQGsLVRVIQRAGLVFPNMEAYA---VSPGRMRQFDDLFRGETGKDREKS 204
Cdd:cd23972   158 dlqyIFI----PSDIRDyvmlrsailgvpvPEG-LDKGDRPHKYFGPEASAKKfklLHPDFISYLTDRFLKSKLLNTHYG 232

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2184285234 205 HSWL-STGWFTMVIAVELCDHVHVYGMVPPNY 235
Cdd:cd23972   233 HLYMpSTGALMLLTALHTCDQVSAYGFITSNY 264
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 69-235 5.59e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 44.36  E-value: 5.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234  69 SRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRR---------PQefvn 139
Cdd:cd23974    82 SPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAyagvgfngpPQ---- 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2184285234 140 rTPETVFIFWgP---------------------PSKMQKPQ---GSLVRViqraglvfpnmEAYAV-SPGRMRQFDDLF- 193
Cdd:cd23974   158 -SKETRYIFL-PdhdrdyllvkaalthtpidrgRDKSKRPSkyfGKDVTA-----------EKFKIyHPDFIRYLRNRFl 224

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2184285234 194 RGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPNY 235
Cdd:cd23974   225 WSPILNTKQRDIYRPSTGAVMLLAALHTCDQVSAYGFMTPDY 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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