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Conserved domains on  [gi|2188194549|ref|NP_001388095|]
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tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase [Rattus norvegicus]

Protein Classification

RlmE family RNA methyltransferase( domain architecture ID 10000968)

RlmE (ribosomal RNA large subunit methyltransferase E) family RNA methyltransferase such as 23S rRNA (uridine(2552)-2'-O)-methyltransferase from bacteria and archaea, and tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase/16S rRNA (uridine(1369)-2'-O)-methyltransferase from eukaryota

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0001510|GO:1904047
PubMed:  31586407|10748051
SCOP:  4000658

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RlmE COG0293
23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and ...
 1-199 1.67e-74

23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ is part of the Pathway/BioSystem: 23S rRNA modification


:

Pssm-ID: 440062 [Multi-domain]  Cd Length: 208  Bit Score: 228.03  E-value: 1.67e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549   1 MGRTSKDKR-------DVYYRLAKEKGWRARSAFKLLQLDEEFQLFKGVKRAVDLCAAPGSWSQVLSQKVGGQssGQVVA 73
Cdd:COG0293     3 MKRSKSSKRwlqrhlnDPYVKRAKKEGYRSRAAYKLLEIDEKDKLIKPGMRVVDLGAAPGGWSQVAAKRVGGK--GRVIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  74 VDLQAMAPLPGVIQIQGDITQLSTAKEIIQHFEGCPADLVVCDGAPDVTGLHDVDEYMQAQLLLAALNIATHVLKPGGCF 153
Cdd:COG0293    81 LDLLPMEPIPGVEFIQGDFREDEVLDQLLEALGGRKVDLVLSDMAPNTSGHKSVDHARSMYLVELALDFARKVLKPGGAF 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2188194549 154 VAKIFRGRDVTLLYSQLRIFFSSVLCAKPKSSRNSSIEAFAVCQGY 199
Cdd:COG0293   161 VVKVFQGEGFDELLKELKKLFKKVKHRKPKASRARSSEVYLVAKGF 206
 
Name Accession Description Interval E-value
RlmE COG0293
23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and ...
 1-199 1.67e-74

23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440062 [Multi-domain]  Cd Length: 208  Bit Score: 228.03  E-value: 1.67e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549   1 MGRTSKDKR-------DVYYRLAKEKGWRARSAFKLLQLDEEFQLFKGVKRAVDLCAAPGSWSQVLSQKVGGQssGQVVA 73
Cdd:COG0293     3 MKRSKSSKRwlqrhlnDPYVKRAKKEGYRSRAAYKLLEIDEKDKLIKPGMRVVDLGAAPGGWSQVAAKRVGGK--GRVIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  74 VDLQAMAPLPGVIQIQGDITQLSTAKEIIQHFEGCPADLVVCDGAPDVTGLHDVDEYMQAQLLLAALNIATHVLKPGGCF 153
Cdd:COG0293    81 LDLLPMEPIPGVEFIQGDFREDEVLDQLLEALGGRKVDLVLSDMAPNTSGHKSVDHARSMYLVELALDFARKVLKPGGAF 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2188194549 154 VAKIFRGRDVTLLYSQLRIFFSSVLCAKPKSSRNSSIEAFAVCQGY 199
Cdd:COG0293   161 VVKVFQGEGFDELLKELKKLFKKVKHRKPKASRARSSEVYLVAKGF 206
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 21-199 8.11e-69

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 212.45  E-value: 8.11e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  21 WRARSAFKLLQLDEEFQLFKGVKRAVDLCAAPGSWSQVLSQKvggqSSGQVVAVDLQAMA-----PLPGVIQIQGDITQL 95
Cdd:pfam01728   1 YRSRAAYKLLEIDEKFGLLKPGKTVLDLGAAPGGWSQVALQR----GAGKVVGVDLGPMQlwkprNDPGVTFIQGDIRDP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  96 STAKEIIQHFEGcPADLVVCDGAPDVTGLHDVDEYMQAQLLLAALNIATHVLKPGGCFVAKIFRGRDVTLLYSQLRIFFS 175
Cdd:pfam01728  77 ETLDLLEELLGR-KVDLVLSDGSPFISGNKVLDHLRSLDLVKAALEVALELLRKGGNFVCKVFQGEDFSELLYLLKLGFE 155

                         170       180
                  ....*....|....*....|....
gi 2188194549 176 SVLCAKPKSSRNSSIEAFAVCQGY 199
Cdd:pfam01728 156 KVGVFKPPASRPESSEEYLVCLGF 179
rrmJ PRK11188
23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE;
10-199 5.90e-40

23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE;


Pssm-ID: 183025  Cd Length: 209  Bit Score: 139.48  E-value: 5.90e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  10 DVYYRLAKEKGWRARSAFKLLQLDEEFQLFKGVKRAVDLCAAPGSWSQVLSQKVGGqsSGQVVAVDLQAMAPLPGVIQIQ 89
Cdd:PRK11188   20 DKYVQQAQKKGLRSRAWFKLDEIQQSDKLFKPGMTVVDLGAAPGGWSQYAVTQIGD--KGRVIACDILPMDPIVGVDFLQ 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  90 GDITQLSTAKEIIQHFEGCPADLVVCDGAPDVTGLHDVDEYMQAQLLLAALNIATHVLKPGGCFVAKIFRGRDVTLLYSQ 169
Cdd:PRK11188   98 GDFRDELVLKALLERVGDSKVQVVMSDMAPNMSGTPAVDIPRAMYLVELALDMCRDVLAPGGSFVVKVFQGEGFDEYLRE 177

                         170       180       190
                  ....*....|....*....|....*....|
gi 2188194549 170 LRIFFSSVLCAKPKSSRNSSIEAFAVCQGY 199
Cdd:PRK11188  178 IRSLFTKVKVRKPDSSRARSREVYIVATGR 207
capping_2-OMTase_viral cd20754
viral Cap-0 specific (nucleoside-2'-O-)-methyltransferase; Cap-0 specific (nucleoside-2'-O-) ...
 28-160 8.49e-04

viral Cap-0 specific (nucleoside-2'-O-)-methyltransferase; Cap-0 specific (nucleoside-2'-O-)-methyltransferase (2'OMTase) catalyzes the methylation of Cap-0 (m7GpppNp) at the 2'-hydroxyl of the ribose of the first nucleotide, using S-adenosyl-L-methionine (AdoMet) as the methyl donor. This reaction is the fourth and last step in mRNA capping, the creation of the stabilizing five-prime cap (5' cap) on mRNA. Some dsDNA and dsRNA viruses, like the bluetongue virus (BTV), a member of the Reoviridae family, and Vaccinia virus, a member of the Poxviridae family, as well as some ss(+)RNA viruses, like Flaviviridae and Nidovirales, cap their mRNAs and encode their own 2'OMTase. In BTV, all four reactions are catalyzed by a single protein, VP4. In Vaccinia, the activity is located in the processing factor of the poly(A) polymerase, VP39.


Pssm-ID: 467730  Cd Length: 179  Bit Score: 39.73  E-value: 8.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  28 KLLQLDEEFQLFKGVKRAVDLCAAPGSWSQVLSQKVGGqssGQVVAVDLQAMAPLPG--VIQIQGDITQLSTAKEIIQHF 105
Cdd:cd20754     3 KLLQLEEYFLYKPEKMRVIYIGCAPGGWLYYLRDWFEG---TLWVGFDPRDTDPLGYnnVITVNKFFDHEHTKLKFLPNK 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2188194549 106 EgcpaDLVVCDGAPDVTGLHD-VDEYMQAQLLLAALNIATHVLKPGGCFVaKIFRG 160
Cdd:cd20754    80 K----DLLICDIRSDRSSHVTkEEDTTESFLTLQEGYIATKLAKVGSICV-KVRAP 130
 
Name Accession Description Interval E-value
RlmE COG0293
23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and ...
 1-199 1.67e-74

23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440062 [Multi-domain]  Cd Length: 208  Bit Score: 228.03  E-value: 1.67e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549   1 MGRTSKDKR-------DVYYRLAKEKGWRARSAFKLLQLDEEFQLFKGVKRAVDLCAAPGSWSQVLSQKVGGQssGQVVA 73
Cdd:COG0293     3 MKRSKSSKRwlqrhlnDPYVKRAKKEGYRSRAAYKLLEIDEKDKLIKPGMRVVDLGAAPGGWSQVAAKRVGGK--GRVIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  74 VDLQAMAPLPGVIQIQGDITQLSTAKEIIQHFEGCPADLVVCDGAPDVTGLHDVDEYMQAQLLLAALNIATHVLKPGGCF 153
Cdd:COG0293    81 LDLLPMEPIPGVEFIQGDFREDEVLDQLLEALGGRKVDLVLSDMAPNTSGHKSVDHARSMYLVELALDFARKVLKPGGAF 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2188194549 154 VAKIFRGRDVTLLYSQLRIFFSSVLCAKPKSSRNSSIEAFAVCQGY 199
Cdd:COG0293   161 VVKVFQGEGFDELLKELKKLFKKVKHRKPKASRARSSEVYLVAKGF 206
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 21-199 8.11e-69

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 212.45  E-value: 8.11e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  21 WRARSAFKLLQLDEEFQLFKGVKRAVDLCAAPGSWSQVLSQKvggqSSGQVVAVDLQAMA-----PLPGVIQIQGDITQL 95
Cdd:pfam01728   1 YRSRAAYKLLEIDEKFGLLKPGKTVLDLGAAPGGWSQVALQR----GAGKVVGVDLGPMQlwkprNDPGVTFIQGDIRDP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  96 STAKEIIQHFEGcPADLVVCDGAPDVTGLHDVDEYMQAQLLLAALNIATHVLKPGGCFVAKIFRGRDVTLLYSQLRIFFS 175
Cdd:pfam01728  77 ETLDLLEELLGR-KVDLVLSDGSPFISGNKVLDHLRSLDLVKAALEVALELLRKGGNFVCKVFQGEDFSELLYLLKLGFE 155

                         170       180
                  ....*....|....*....|....
gi 2188194549 176 SVLCAKPKSSRNSSIEAFAVCQGY 199
Cdd:pfam01728 156 KVGVFKPPASRPESSEEYLVCLGF 179
rrmJ PRK11188
23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE;
10-199 5.90e-40

23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE;


Pssm-ID: 183025  Cd Length: 209  Bit Score: 139.48  E-value: 5.90e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  10 DVYYRLAKEKGWRARSAFKLLQLDEEFQLFKGVKRAVDLCAAPGSWSQVLSQKVGGqsSGQVVAVDLQAMAPLPGVIQIQ 89
Cdd:PRK11188   20 DKYVQQAQKKGLRSRAWFKLDEIQQSDKLFKPGMTVVDLGAAPGGWSQYAVTQIGD--KGRVIACDILPMDPIVGVDFLQ 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  90 GDITQLSTAKEIIQHFEGCPADLVVCDGAPDVTGLHDVDEYMQAQLLLAALNIATHVLKPGGCFVAKIFRGRDVTLLYSQ 169
Cdd:PRK11188   98 GDFRDELVLKALLERVGDSKVQVVMSDMAPNMSGTPAVDIPRAMYLVELALDMCRDVLAPGGSFVVKVFQGEGFDEYLRE 177

                         170       180       190
                  ....*....|....*....|....*....|
gi 2188194549 170 LRIFFSSVLCAKPKSSRNSSIEAFAVCQGY 199
Cdd:PRK11188  178 IRSLFTKVKVRKPDSSRARSREVYIVATGR 207
RlmM COG2933
23S rRNA C2498 (ribose-2'-O)-methylase RlmM [Translation, ribosomal structure and biogenesis]; ...
 14-116 1.10e-06

23S rRNA C2498 (ribose-2'-O)-methylase RlmM [Translation, ribosomal structure and biogenesis]; 23S rRNA C2498 (ribose-2'-O)-methylase RlmM is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 442177 [Multi-domain]  Cd Length: 356  Bit Score: 49.46  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  14 RLAKEKGWRARSAFKLlqlDEEFQLFKGVK----------RAVDLCAAPGSWSQVLSQKvggqsSGQVVAVDLQAMAP-L 82
Cdd:COG2933   177 RLRFPADAPSRSTLKL---EEAFHVFLPRDeweerlrpgmRAVDLGAAPGGWTWQLVRR-----GMFVTAVDNGPMAPsL 248

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2188194549  83 ---PGVIQIQGDITQLSTAKeiiqhfegcPADLVVCD 116
Cdd:COG2933   249 mdtGQVEHLREDGFKYRPPK---------PVDWLVCD 276
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 47-151 6.70e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 44.09  E-value: 6.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  47 DLCAAPGSWSQVLSQKVGGQssgqVVAVDL----------QAMAPLPGVIQIQGDITQLStakeiiqhFEGCPADLVVCD 116
Cdd:pfam13649   3 DLGCGTGRLTLALARRGGAR----VTGVDLspemlerareRAAEAGLNVEFVQGDAEDLP--------FPDGSFDLVVSS 70

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2188194549 117 GApdvtgLHdvdeYMQAQLLLAALNIATHVLKPGG 151
Cdd:pfam13649  71 GV-----LH----HLPDPDLEAALREIARVLKPGG 96
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 18-159 9.74e-05

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 42.60  E-value: 9.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  18 EKGWRARSAFKLLQLDEEFQLFKGVKRAVDLCAAPGSWSQVLSQKVGGQssgqVVAVDL--------QAMAP---LPGVI 86
Cdd:COG0500     3 DSYYSDELLPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGR----VIGIDLspeaialaRARAAkagLGNVE 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2188194549  87 QIQGDITQLSTAKEiiQHFegcpaDLVVCDGApdvtgLHDVDEymqaQLLLAALNIATHVLKPGGCFVAKIFR 159
Cdd:COG0500    79 FLVADLAELDPLPA--ESF-----DLVVAFGV-----LHHLPP----EEREALLRELARALKPGGVLLLSASD 135
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 43-154 1.03e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 41.54  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  43 KRAVDLCAAPGSWSQVLSQKvggqssG-QVVAVDL--------QAMAPLPGVIQIQGDITQLStakeiiqhFEGCPADLV 113
Cdd:COG2227    26 GRVLDVGCGTGRLALALARR------GaDVTGVDIspealeiaRERAAELNVDFVQGDLEDLP--------LEDGSFDLV 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2188194549 114 VCDGApdvtgLHDVDEymqaqlLLAALNIATHVLKPGGCFV 154
Cdd:COG2227    92 ICSEV-----LEHLPD------PAALLRELARLLKPGGLLL 121
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 43-171 2.28e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 40.75  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  43 KRAVDLCAAPGSWSQVLSQKvggqsSGQVVAVDL-QAM---------APLPGVIQIQGDITQLStakeiiqhFEGCPADL 112
Cdd:COG2226    24 ARVLDLGCGTGRLALALAER-----GARVTGVDIsPEMlelareraaEAGLNVEFVVGDAEDLP--------FPDGSFDL 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2188194549 113 VVCdgapdVTGLHDVDEymqaqlLLAALNIATHVLKPGGCFVAKIFRGRDVTLLYSQLR 171
Cdd:COG2226    91 VIS-----SFVLHHLPD------PERALAEIARVLKPGGRLVVVDFSPPDLAELEELLA 138
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 19-154 3.33e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 41.29  E-value: 3.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  19 KGWRaRSAFKLLQLdeefqlFKGvKRAVDLCAAPGSWSQVLSQKVGgqSSGQVVAVDL-QAMaplpgviqiqgditqLST 97
Cdd:PRK00216   37 RVWR-RKTIKWLGV------RPG-DKVLDLACGTGDLAIALAKAVG--KTGEVVGLDFsEGM---------------LAV 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  98 AKEIIQHFEGCP-ADLVVCDGA----PD-----VT---GLHDVDEYMQAqlllaaLNIATHVLKPGGCFV 154
Cdd:PRK00216   92 GREKLRDLGLSGnVEFVQGDAEalpfPDnsfdaVTiafGLRNVPDIDKA------LREMYRVLKPGGRLV 155
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 44-168 6.51e-04

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 41.15  E-value: 6.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  44 RAVDLCAAPGSWSQVLSQKVGGQssGQVVAVDLQAM-----------APLPGVIQIQGDitqlstAKEIIQHFEGcPADL 112
Cdd:COG0144   252 RVLDLCAAPGGKTLHLAELMGNK--GRVVAVDISEHrlkrlrenlarLGLSNVEVVVAD------ARELLEWLPG-KFDR 322

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2188194549 113 VVCD------GA----PDV---TGLHDVDEY--MQAQLLLAALNIathvLKPGGcfvakifrgrdvTLLYS 168
Cdd:COG0144   323 VLLDapcsgtGTlrrhPDIkwrRTPEDIAELaaLQRELLDAAARL----LKPGG------------RLVYS 377
capping_2-OMTase_viral cd20754
viral Cap-0 specific (nucleoside-2'-O-)-methyltransferase; Cap-0 specific (nucleoside-2'-O-) ...
 28-160 8.49e-04

viral Cap-0 specific (nucleoside-2'-O-)-methyltransferase; Cap-0 specific (nucleoside-2'-O-)-methyltransferase (2'OMTase) catalyzes the methylation of Cap-0 (m7GpppNp) at the 2'-hydroxyl of the ribose of the first nucleotide, using S-adenosyl-L-methionine (AdoMet) as the methyl donor. This reaction is the fourth and last step in mRNA capping, the creation of the stabilizing five-prime cap (5' cap) on mRNA. Some dsDNA and dsRNA viruses, like the bluetongue virus (BTV), a member of the Reoviridae family, and Vaccinia virus, a member of the Poxviridae family, as well as some ss(+)RNA viruses, like Flaviviridae and Nidovirales, cap their mRNAs and encode their own 2'OMTase. In BTV, all four reactions are catalyzed by a single protein, VP4. In Vaccinia, the activity is located in the processing factor of the poly(A) polymerase, VP39.


Pssm-ID: 467730  Cd Length: 179  Bit Score: 39.73  E-value: 8.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  28 KLLQLDEEFQLFKGVKRAVDLCAAPGSWSQVLSQKVGGqssGQVVAVDLQAMAPLPG--VIQIQGDITQLSTAKEIIQHF 105
Cdd:cd20754     3 KLLQLEEYFLYKPEKMRVIYIGCAPGGWLYYLRDWFEG---TLWVGFDPRDTDPLGYnnVITVNKFFDHEHTKLKFLPNK 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2188194549 106 EgcpaDLVVCDGAPDVTGLHD-VDEYMQAQLLLAALNIATHVLKPGGCFVaKIFRG 160
Cdd:cd20754    80 K----DLLICDIRSDRSSHVTkEEDTTESFLTLQEGYIATKLAKVGSICV-KVRAP 130
PRK11760 PRK11760
putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional
 24-81 4.67e-03

putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional


Pssm-ID: 236971 [Multi-domain]  Cd Length: 357  Bit Score: 38.28  E-value: 4.67e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2188194549  24 RSAFKLlqlDEEFQLF----------KGVKRAVDLCAAPGSWSQVLSQKvggqsSGQVVAVDLQAMAP 81
Cdd:PRK11760  187 RSTLKL---EEAFHVFiprdewderlAPGMRAVDLGAAPGGWTYQLVRR-----GMFVTAVDNGPMAQ 246
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
41-154 6.50e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 36.90  E-value: 6.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2188194549  41 GVKRAVDLCAAPGSWSQVLSQKVGgqssgQVVAVDL-QAMAPL----PGVIQ-IQGDITQLSTAKEiiqhfegcPADLVV 114
Cdd:COG4976    46 PFGRVLDLGCGTGLLGEALRPRGY-----RLTGVDLsEEMLAKarekGVYDRlLVADLADLAEPDG--------RFDLIV 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2188194549 115 CdgaPDV-TGLHDVDEYMQAqlllaalniATHVLKPGGCFV 154
Cdd:COG4976   113 A---ADVlTYLGDLAAVFAG---------VARALKPGGLFI 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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