NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2211362407|ref|NP_001389838|]
View 

lysine-specific histone demethylase 1B isoform 3 [Mus musculus]

Protein Classification

lysine-specific histone demethylase 1B( domain architecture ID 13726372)

lysine-specific histone demethylase 1B (KDM1B) demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor

EC:  1.14.99.66
Gene Symbol:  KDM1B
Gene Ontology:  GO:0008270|GO:0050660|GO:0032452|GO:0042393
PubMed:  23266887|23260659

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN02328 super family cl33466
lysine-specific histone demethylase 1 homolog
 315-830 3.22e-94

lysine-specific histone demethylase 1 homolog


The actual alignment was detected with superfamily member PLN02328:

Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 313.47  E-value: 3.22e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 315 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LTVAAGQHLLPKHY 393
Cdd:PLN02328  163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 394 HNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVwddKSFK----GVVVGR--GPQIVNGCINNPVALMCEQL 467
Cdd:PLN02328  237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV---KTMKmkgdGVVAAAdlGGSVLTGINGNPLGVLARQL 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 468 GISMRKLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRK---DKTLLQDVPLGEKIEeiyrAFVKESGIQFSEL 544
Cdd:PLN02328  314 GLPLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQ 389

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 545 EGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVT 624
Cdd:PLN02328  390 ERMLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVY 468

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 625 TTdGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQR 704
Cdd:PLN02328  469 AG-GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMR 544

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 705 GLFAVFYDMDSQQ--SVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSF 780
Cdd:PLN02328  545 GEFFLFYSYSSVSggPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFHPKGIvvPDPVQAVCTRWGKDCFTYGSYSY 624

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2211362407 781 VKTFGSGEAYDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 830
Cdd:PLN02328  625 VAVGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-198 6.06e-08

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 49.61  E-value: 6.06e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2211362407 138 YWVQCTKpeCGKWRQLTKEIQlTPHMARTYRCGMKPNtitKWDISellpdtpdhCSFPEDL 198
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPD---PKYNS---------CDAPEEI 46
 
Name Accession Description Interval E-value
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 315-830 3.22e-94

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 313.47  E-value: 3.22e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 315 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LTVAAGQHLLPKHY 393
Cdd:PLN02328  163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 394 HNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVwddKSFK----GVVVGR--GPQIVNGCINNPVALMCEQL 467
Cdd:PLN02328  237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV---KTMKmkgdGVVAAAdlGGSVLTGINGNPLGVLARQL 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 468 GISMRKLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRK---DKTLLQDVPLGEKIEeiyrAFVKESGIQFSEL 544
Cdd:PLN02328  314 GLPLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQ 389

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 545 EGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVT 624
Cdd:PLN02328  390 ERMLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVY 468

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 625 TTdGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQR 704
Cdd:PLN02328  469 AG-GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMR 544

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 705 GLFAVFYDMDSQQ--SVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSF 780
Cdd:PLN02328  545 GEFFLFYSYSSVSggPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFHPKGIvvPDPVQAVCTRWGKDCFTYGSYSY 624

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2211362407 781 VKTFGSGEAYDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 830
Cdd:PLN02328  625 VAVGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 412-830 9.26e-73

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 245.48  E-value: 9.26e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 412 RQLHNFGMKVTVLEAKDRIGGRVWDDKsFKGVVVGRGPQIVNGCiNNPVALMCEQLGI----SMRKLGERCDLIQEGGRI 487
Cdd:pfam01593   8 RELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGA-QPPLLALLKELGLedrlVLPDPAPFYTVLFAGGRR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 488 TDPTVDkRMDFHFNALLDVVSEW----------------RKDKTLLQDVPLGEKIEEIYR-AFVKESGIQFSELEGQVLQ 550
Cdd:pfam01593  86 YPGDFR-RVPAGWEGLLEFGRLLsipeklrlglaalasdALDEFDLDDFSLAESLLFLGRrGPGDVEVWDRLIDPELFAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 551 FHLSNLEYACGSSLHQVSArSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAE---GLDIRLKSPVQSIDYTGDEVQVTTTD 627
Cdd:pfam01593 165 LPFASGAFAGDPSELSAGL-ALPLLWALLGEGGSLLLPRGGLGALPDALAAqllGGDVRLNTRVRSIDREGDGVTVTLTD 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 628 GMGHSAQKVLVTVPLAILQRgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKvqgaDFFGHVPPSASQRGLF 707
Cdd:pfam01593 244 GEVIEADAVIVTVPLGVLKR--ILFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWPDL----GLLGLLSELLTGLGTA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 708 AVFYDMDS-----QQSVLMSVIT-GEAVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFV 781
Cdd:pfam01593 318 FSWLTFPNrappgKGLLLLVYVGpGDRARELEGLSDEELLQAVLRDLRKLFGE-EAPEPLRVLVSDWHTDPWPRGSYSLP 396

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 2211362407 782 KTFGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 830
Cdd:pfam01593 397 QYGPGHDDYRPLARTPDPGLFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
412-832 2.06e-72

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 244.06  E-value: 2.06e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 412 RQLHNFGMKVTVLEAKDRIGGRVW-DDKSFKGVVVGRGPQIVNGcinNPVALM--CEQLGISMRKL--GERCDLIQEGGR 486
Cdd:COG1231    24 RELRKAGLDVTVLEARDRVGGRVWtLRFGDDGLYAELGAMRIPP---SHTNLLalARELGLPLEPFpnENGNALLYLGGK 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 487 ITdptvdkRMDFHFNALLDVVSEWRK-DKTLLQDVPLGEKIEEIY-----RAFVKESGIQFSelegqVLQFHLSNLEYAC 560
Cdd:COG1231   101 RV------RAGEIAADLRGVAELLAKlLRALAAALDPWAHPAAELdreslAEWLRRNGASPS-----ARRLLGLLGAGEY 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 561 GSSLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGL--DIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLV 638
Cdd:COG1231   170 GADPDELSLLDLLRYAASAGGGAQQFRIVGGMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAVIV 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 639 TVPLAILQRgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFW--DSKVQGADFfghvppsaSQRGLFAVFY---DM 713
Cdd:COG1231   250 TVPPSVLRR--IEFDPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWeeDGLYGGISL--------TDLPIRQTWYpsnGP 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 714 DSQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDII 793
Cdd:COG1231   320 DGGAGVLLGYVGGDDARALAALSPEERVAAALEQLARIFGV-YAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLTAAGPAL 398

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 2211362407 794 AeEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAA 832
Cdd:COG1231   399 A-EPDGRIHFAGEHTSDEWPGWVEGALESGERAAAEILA 436
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-198 6.06e-08

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 49.61  E-value: 6.06e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2211362407 138 YWVQCTKpeCGKWRQLTKEIQlTPHMARTYRCGMKPNtitKWDISellpdtpdhCSFPEDL 198
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPD---PKYNS---------CDAPEEI 46
 
Name Accession Description Interval E-value
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 315-830 3.22e-94

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 313.47  E-value: 3.22e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 315 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LTVAAGQHLLPKHY 393
Cdd:PLN02328  163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 394 HNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVwddKSFK----GVVVGR--GPQIVNGCINNPVALMCEQL 467
Cdd:PLN02328  237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV---KTMKmkgdGVVAAAdlGGSVLTGINGNPLGVLARQL 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 468 GISMRKLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRK---DKTLLQDVPLGEKIEeiyrAFVKESGIQFSEL 544
Cdd:PLN02328  314 GLPLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQ 389

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 545 EGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVT 624
Cdd:PLN02328  390 ERMLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVY 468

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 625 TTdGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQR 704
Cdd:PLN02328  469 AG-GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMR 544

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 705 GLFAVFYDMDSQQ--SVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSF 780
Cdd:PLN02328  545 GEFFLFYSYSSVSggPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFHPKGIvvPDPVQAVCTRWGKDCFTYGSYSY 624

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2211362407 781 VKTFGSGEAYDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 830
Cdd:PLN02328  625 VAVGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
PLN03000 PLN03000
amine oxidase
 320-831 4.07e-90

amine oxidase


Pssm-ID: 178578 [Multi-domain]  Cd Length: 881  Bit Score: 303.87  E-value: 4.07e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 320 YLALRNLILALWYTNCKEALTPQKCIphiivrGLVRIRCVQEVERILYFMTRKGLINTGVltVAAGQHLLPKHYHNKSVL 399
Cdd:PLN03000  117 YILIRNHIISKWRENISSWVTKEMFL------GSIPKHCSSLLDSAYNYLVTHGYINFGI--AQAIKDKFPAQSSKSSVV 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 400 VVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDK---SFKGVVVGRGPQIVNGCINNPVALMCEQLGISMRKLGE 476
Cdd:PLN03000  189 IVGAGLSGLAAARQLMRFGFKVTVLEGRKRPGGRVYTKKmeaNRVGAAADLGGSVLTGTLGNPLGIIARQLGSSLYKVRD 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 477 RCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRK---DKTLlqDVPLGEKIEeiyrAFVKESGIQFSELEGQVLQFHL 553
Cdd:PLN03000  269 KCPLYRVDGKPVDPDVDLKVEVAFNQLLDKASKLRQlmgDVSM--DVSLGAALE----TFRQVSGNDVATEEMGLFNWHL 342

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 554 SNLEYACGSSLHQVSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMgHSA 633
Cdd:PLN03000  343 ANLEYANAGLVSKLSLAFWDQDDPY-DMGGDHCFLPGGNGRLVQALAENVPILYEKTVQTIRYGSNGVKVIAGNQV-YEG 420

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 634 QKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFAVFYDM 713
Cdd:PLN03000  421 DMVLCTVPLGVLKNGSIKFVPELPQRKLDCIKRLGFGLLNKVAMLFPYVFWSTDL---DTFGHLTEDPNYRGEFFLFYSY 497

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 714 D--SQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEA 789
Cdd:PLN03000  498 ApvAGGPLLIALVAGEAAHKFETMPPTDAVTRVLHILRGIYEPQGInvPDPLQTVCTRWGGDPFSLGSYSNVAVGASGDD 577

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 2211362407 790 YDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKIA 831
Cdd:PLN03000  578 YDILAESVgDGRLFFAGEATTRRYPATMHGAFVTGLREAANMA 620
PLN02529 PLN02529
lysine-specific histone demethylase 1
 320-830 6.24e-89

lysine-specific histone demethylase 1


Pssm-ID: 178144 [Multi-domain]  Cd Length: 738  Bit Score: 297.19  E-value: 6.24e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 320 YLALRNLILALWYTNCKEALTpqkciphiivRGLVRIRCVQEVERILY----FMTRKGLINTGVLTVAAGQhlLPKHYHN 395
Cdd:PLN02529   93 YIVVRNHILARWRSNVGIWLS----------KGQIKETVSSEYEHLISaaydFLLYNGYINFGVSPSFASP--IPEEGTE 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 396 KSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDK-SFKG--VVVGRGPQIVNGCINNPVALMCEQLGISMR 472
Cdd:PLN02529  161 GSVIIVGAGLAGLAAARQLLSFGFKVVVLEGRNRPGGRVYTQKmGRKGqfAAVDLGGSVITGIHANPLGVLARQLSIPLH 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 473 KLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRK-DKTLLQDVPLGEKIEEIYRAFvkesGIQFSELEGQVLQF 551
Cdd:PLN02529  241 KVRDNCPLYKPDGALVDKEIDSNIEFIFNKLLDKVTELRQiMGGFANDISLGSVLERLRQLY----GVARSTEERQLLDW 316

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 552 HLSNLEYACGSSLHQVSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMgH 631
Cdd:PLN02529  317 HLANLEYANAGCLSDLSAAYWDQDDPY-EMGGDHCFLAGGNWRLINALCEGVPIFYGKTVDTIKYGNDGVEVIAGSQV-F 394

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 632 SAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFAVFY 711
Cdd:PLN02529  395 QADMVLCTVPLGVLKKRTIRFEPELPRRKLAAIDRLGFGLLNKVAMVFPSVFWGEEL---DTFGCLNESSNKRGEFFLFY 471

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 712 DMD--SQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELF--KEQEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSG 787
Cdd:PLN02529  472 GYHtvSGGPALVALVAGEAAQRFENTDPSTLLHRVLSVLRGIYnpKGINVPDPIQTICTRWGSDPLSYGSYSHVRVQSSG 551

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 2211362407 788 EAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 830
Cdd:PLN02529  552 SDYDILAESVSGRLFFAGEATTRQYPATMHGAFLSGLREASRI 594
PLN02976 PLN02976
amine oxidase
 396-830 2.30e-77

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 274.82  E-value: 2.30e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407  396 KSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDKSFKGVVVGRGPQIVNGC--------INNPVALMCEQL 467
Cdd:PLN02976   694 KKIIVVGAGPAGLTAARHLQRQGFSVTVLEARSRIGGRVYTDRSSLSVPVDLGASIITGVeadvaterRPDPSSLICAQL 773

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407  468 GISMRKLGERCDL--IQEGGRITDpTVDKRMDFHFNALLD----VVSE-----------------------------WRK 512
Cdd:PLN02976   774 GLELTVLNSDCPLydVVTGEKVPA-DLDEALEAEYNSLLDdmvlLVAQkgehamkmsledgleyalkrrrmprpgvdIDE 852

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407  513 DKTLLQDVPL--GEKIEEIYRAFVKESGIQF-SELEGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFAQFAGDHTLLT 589
Cdd:PLN02976   853 TELGNAADDLydSASTGVDGGHCEKESKEDVlSPLERRVMNWHFAHLEYGCAALLKEVSLPYWNQDDVYGGFGGAHCMIK 932

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407  590 PGYSTIIEKLAEGLDIRLKSPVQSIDYTGDE----------VQVTTTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEK 659
Cdd:PLN02976   933 GGYSNVVESLAEGLDIHLNHVVTDVSYGSKDagasgssrkkVKVSTSNGSEFLGDAVLITVPLGCLKAETIKFSPPLPDW 1012

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407  660 KMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFAVFYDMDSQ--QSVLMSVITGEAVASLRTMDD 737
Cdd:PLN02976  1013 KYSSIQRLGFGVLNKVVLEFPEVFWDDSV---DYFGATAEETDLRGQCFMFWNVKKTvgAPVLIALVVGKAAIDGQSMSS 1089

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407  738 KQVLQQCMGILRELFKEQEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVT 817
Cdd:PLN02976  1090 SDHVNHALMVLRKLFGEALVPDPVASVVTDWGRDPFSYGAYSYVAIGASGEDYDILGRPVENCLFFAGEATCKEHPDTVG 1169

                          490
                   ....*....|...
gi 2211362407  818 GAYLSGVREASKI 830
Cdd:PLN02976  1170 GAMMSGLREAVRI 1182
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 412-830 9.26e-73

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 245.48  E-value: 9.26e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 412 RQLHNFGMKVTVLEAKDRIGGRVWDDKsFKGVVVGRGPQIVNGCiNNPVALMCEQLGI----SMRKLGERCDLIQEGGRI 487
Cdd:pfam01593   8 RELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGA-QPPLLALLKELGLedrlVLPDPAPFYTVLFAGGRR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 488 TDPTVDkRMDFHFNALLDVVSEW----------------RKDKTLLQDVPLGEKIEEIYR-AFVKESGIQFSELEGQVLQ 550
Cdd:pfam01593  86 YPGDFR-RVPAGWEGLLEFGRLLsipeklrlglaalasdALDEFDLDDFSLAESLLFLGRrGPGDVEVWDRLIDPELFAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 551 FHLSNLEYACGSSLHQVSArSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAE---GLDIRLKSPVQSIDYTGDEVQVTTTD 627
Cdd:pfam01593 165 LPFASGAFAGDPSELSAGL-ALPLLWALLGEGGSLLLPRGGLGALPDALAAqllGGDVRLNTRVRSIDREGDGVTVTLTD 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 628 GMGHSAQKVLVTVPLAILQRgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKvqgaDFFGHVPPSASQRGLF 707
Cdd:pfam01593 244 GEVIEADAVIVTVPLGVLKR--ILFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWPDL----GLLGLLSELLTGLGTA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 708 AVFYDMDS-----QQSVLMSVIT-GEAVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFV 781
Cdd:pfam01593 318 FSWLTFPNrappgKGLLLLVYVGpGDRARELEGLSDEELLQAVLRDLRKLFGE-EAPEPLRVLVSDWHTDPWPRGSYSLP 396

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 2211362407 782 KTFGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 830
Cdd:pfam01593 397 QYGPGHDDYRPLARTPDPGLFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
412-832 2.06e-72

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 244.06  E-value: 2.06e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 412 RQLHNFGMKVTVLEAKDRIGGRVW-DDKSFKGVVVGRGPQIVNGcinNPVALM--CEQLGISMRKL--GERCDLIQEGGR 486
Cdd:COG1231    24 RELRKAGLDVTVLEARDRVGGRVWtLRFGDDGLYAELGAMRIPP---SHTNLLalARELGLPLEPFpnENGNALLYLGGK 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 487 ITdptvdkRMDFHFNALLDVVSEWRK-DKTLLQDVPLGEKIEEIY-----RAFVKESGIQFSelegqVLQFHLSNLEYAC 560
Cdd:COG1231   101 RV------RAGEIAADLRGVAELLAKlLRALAAALDPWAHPAAELdreslAEWLRRNGASPS-----ARRLLGLLGAGEY 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 561 GSSLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGL--DIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLV 638
Cdd:COG1231   170 GADPDELSLLDLLRYAASAGGGAQQFRIVGGMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAVIV 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 639 TVPLAILQRgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFW--DSKVQGADFfghvppsaSQRGLFAVFY---DM 713
Cdd:COG1231   250 TVPPSVLRR--IEFDPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWeeDGLYGGISL--------TDLPIRQTWYpsnGP 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 714 DSQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDII 793
Cdd:COG1231   320 DGGAGVLLGYVGGDDARALAALSPEERVAAALEQLARIFGV-YAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLTAAGPAL 398

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 2211362407 794 AeEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAA 832
Cdd:COG1231   399 A-EPDGRIHFAGEHTSDEWPGWVEGALESGERAAAEILA 436
PLN02268 PLN02268
probable polyamine oxidase
 397-830 1.57e-62

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 217.25  E-value: 1.57e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 397 SVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDKSFkGVVVGRGPQIVNG-CINNPVALMCEQLGISM-RKL 474
Cdd:PLN02268    2 SVIVIGGGIAGIAAARALHDASFKVTLLESRDRIGGRVHTDYSF-GFPVDMGASWLHGvCNENPLAPLIGRLGLPLyRTS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 475 G----------ERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRKDKTllQDVPLgekIEEIYRAFVKESGIQFSEL 544
Cdd:PLN02268   81 GdnsvlydhdlESYALFDMDGNQVPQELVTKVGETFERILEETEKVRDEHE--EDMSL---LQAISIVLERHPELRLEGL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 545 EGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFAqfaGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVT 624
Cdd:PLN02268  156 AHEVLQWYLCRMEGWFAADADTISLKSWDQEELLE---GGHGLMVRGYDPVINTLAKGLDIRLNHRVTKIVRRYNGVKVT 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 625 TTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSkvqgADFFGHVPPSASQR 704
Cdd:PLN02268  233 VEDGTTFVADAAIIAVPLGVLKANIIKFEPELPEWKEEAISDLGVGIENKIALHFDSVFWPN----VEFLGVVAPTSYGC 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 705 GLFAVFYDMdSQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQeiPEPTKYFVTRWSTEPWIQMAYSFVKTF 784
Cdd:PLN02268  309 SYFLNLHKA-TGHPVLVYMPAGRLARDIEKLSDEAAANFAMSQLKKMLPDA--TEPVQYLVSRWGSDPNSLGCYSYDLVG 385

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 2211362407 785 GSGEAYDIIAEEIqGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 830
Cdd:PLN02268  386 KPHDLYERLRAPV-DNLFFAGEATSSDFPGSVHGAYSTGVMAAEEC 430
PLN02676 PLN02676
polyamine oxidase
 397-830 6.41e-38

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 148.32  E-value: 6.41e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 397 SVLVVGAGPAGLAAARQLHNFGMK-VTVLEAKDRIGGRVwDDKSFKGVVVGRGP---QIVNGCINNPVALMCEQLGisMR 472
Cdd:PLN02676   28 SVIIVGAGMSGISAAKTLSEAGIEdILILEATDRIGGRM-RKANFAGVSVELGAnwvEGVGGPESNPIWELANKLK--LR 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 473 KLGERCDLI------QEGGRITDPTVDKRMDfhfnaLLDVVSEWrkdKTLLQDVPLGEKIEEIyrafvkeSGIQFSELEG 546
Cdd:PLN02676  105 TFYSDFDNLssniykQDGGLYPKKVVQKSMK-----VADASDEF---GENLSISLSAKKAVDI-------SILTAQRLFG 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 547 Q--------VLQFHLSNLEYA---CGSSLHQVSARSwdhneFFAQFAGDHTLLTP--GYSTIIEKLAEG---------LD 604
Cdd:PLN02676  170 QvpktplemVIDYYNYDYEFAeppRVTSLKNTEPNP-----TFVDFGEDEYFVADprGYESLVYYLAEQflstksgkiTD 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 605 IRLK--SPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYR 682
Cdd:PLN02676  245 PRLKlnKVVREISYSKNGVTVKTEDGSVYRAKYVIVSVSLGVLQSDLIKFKPPLPDWKIEAIYQFDMAVYTKIFLKFPYK 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 683 FWDSKvQGADFFGHvppSASQRGLFAVFYDMDSQ---QSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQeIPE 759
Cdd:PLN02676  325 FWPSG-PGTEFFLY---AHERRGYYPFWQHLENEypgSNVLFVTVTDEESRRIEQQPDSETKAEIMEVLRKMFGPN-IPE 399

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2211362407 760 PTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEEIqGTVFFAGEATNRHFPQTVTGAYLSGVrEASKI 830
Cdd:PLN02676  400 ATDILVPRWWSNRFFKGSYSNWPIGVSRYEFDQIRAPV-GRVYFTGEHTSEKYNGYVHGAYLAGI-DTAND 468
PLN02568 PLN02568
polyamine oxidase
 420-830 4.84e-33

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 134.96  E-value: 4.84e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 420 KVTVLEAKDRIGGRVwDDKSFKGVVVGRGPQIVNGCINNPV--------ALMCEQLGISMRKLGERCDLIQEGGRITDPT 491
Cdd:PLN02568   35 ELTVVEGGDRIGGRI-NTSEFGGERIEMGATWIHGIGGSPVykiaqeagSLESDEPWECMDGFPDRPKTVAEGGFEVDPS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 492 VDKRMDFHFNALLDVVSEWRKDKTLLQDVPLGEKIE----------------------EIYRAFVKE-------SGIQFS 542
Cdd:PLN02568  114 IVESISTLFRGLMDDAQGKLIEPSEVDEVDFVKLAAkaarvcesggggsvgsflrrglDAYWDSVSAdeqikgyGGWSRK 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 543 ELEGQVLQFHlSNLEyACGSSLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGLD---IRLKSPVQSIDYTGD 619
Cdd:PLN02568  194 LLEEAIFTMH-ENTQ-RTYTSADDLSTLDLAAESEYRMFPGEEITIAKGYLSVIEALASVLPpgtIQLGRKVTRIEWQDE 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 620 EVQVTTTDGMGHSAQKVLVTVPLAILQRGAIQ----FNPPLSEKKMKAINSLGAGIIEKIALQFPYRFwDSKVQGAD--- 692
Cdd:PLN02568  272 PVKLHFADGSTMTADHVIVTVSLGVLKAGIGEdsglFSPPLPDFKTDAISRLGFGVVNKLFVELSPRP-DGSPEDVAkfp 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 693 -----FFGHVPPSASQ------RGLfAVFYDMDSQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEIPEP- 760
Cdd:PLN02568  351 flqmaFHRSDSEARHDkipwwmRRT-ASICPIHKNSSVLLSWFAGKEALELEKLSDEEIIRGVQTTLSSFLKRRVAGLGs 429

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 761 --------------------TKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEEIQGT------------VFFAGEAT 808
Cdd:PLN02568  430 qshplcnggassndgsrwkfVKVLKSKWGTDPLFLGSYSYVAVGSSGDDLDRMAEPLPRIsdhdqaggpplqLLFAGEAT 509

                         490       500
                  ....*....|....*....|..
gi 2211362407 809 NRHFPQTVTGAYLSGVREASKI 830
Cdd:PLN02568  510 HRTHYSTTHGAYFSGLREANRL 531
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 412-768 1.81e-11

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 67.16  E-value: 1.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 412 RQLHNFGMKVTVLEAKDRIGGRVwddKSF--KGVVVGRGPQIVngCINNPVAL-MCEQLGIS--MRKLGERCDLIQEGGR 486
Cdd:COG1232    18 YRLAKAGHEVTVLEASDRVGGLI---RTVevDGFRIDRGPHSF--LTRDPEVLeLLRELGLGdeLVWPNTRKSYIYYGGK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 487 ITD-PTvdKRMDFHFNALLDVVSEWR-------KDKTLLQDVPLGEKI-----EEIYRAFVKE--SGIqFS----ELEGQ 547
Cdd:COG1232    93 LHPlPQ--GPLALLRSPLLSLAGKLRallellaPRRPPGEDESLAEFVrrrfgREVYERLVEPllEGV-YAgdpdELSAD 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 548 -VLQFhLSNLEYACGSSLHQVSA--RSWDHNEFFAQFAGdhtlltpGYSTIIEKLAEGL---DIRLKSPVQSIDYTGDEV 621
Cdd:COG1232   170 wAFPR-LKRLELEHGSLIKGALAlrKGAKAGEVFGYLRG-------GLGTLVEALAEALeagEIRLGTRVTAIEREGGGW 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 622 QVTTTDGMGHSAQKVLVTVPLAILQRgAIQFNPPLSEKKMKAINSLGAGIiekIALQFPyrfwDSKVQGADFFGHVPPSA 701
Cdd:COG1232   242 RVTTSDGETIEADAVVSATPAPALAR-LLAPLPPEVAAALAGIPYASVAV---VALGFD----RPDLPPPDGFGWLVPRD 313

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2211362407 702 SQRGLFAVFY------DMDSQQSVLMSV-ITGEAVASLRTMDDKQVLQQCMGILRELFKEQeiPEPTKYFVTRW 768
Cdd:COG1232   314 EGVPILAVTFssnkwpHRAPDGKVLLRLeVGGAGDPELWQLSDEELVALALADLRKLLGID--AEPVDTRVVRW 385
PRK07233 PRK07233
hypothetical protein; Provisional
 591-669 1.18e-09

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 61.44  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2211362407 591 GYSTIIEKLAE-----GLDIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRgaiqFNPPLSEK---KMK 662
Cdd:PRK07233  196 GFATLIDALAEaiearGGEIRLGTPVTSVVIDGGGVTGVEVDGEEEDFDAVISTAPPPILAR----LVPDLPADvlaRLR 271


                  ....*..
gi 2211362407 663 AINSLGA 669
Cdd:PRK07233  272 RIDYQGV 278
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-198 6.06e-08

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 49.61  E-value: 6.06e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2211362407 138 YWVQCTKpeCGKWRQLTKEIQlTPHMARTYRCGMKPNtitKWDISellpdtpdhCSFPEDL 198
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPD---PKYNS---------CDAPEEI 46
SWIRM pfam04433
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ...
 305-376 5.64e-05

SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.


Pssm-ID: 461307 [Multi-domain]  Cd Length: 78  Bit Score: 42.16  E-value: 5.64e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2211362407 305 DELYEFPEY----SRDPTMYLALRNLILALWYTNCKEALTPQKCiphiivRGLVRIrCVQEVERILYFMTRKGLIN 376
Cdd:pfam04433   9 IEKRLLPEFfngkSKTPEVYLEIRNFILNLWRENPKEYLTKTDA------RRALKG-DVNLISRIHEFLERWGLIN 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH