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Conserved domains on  [gi|2213905870|ref|NP_001390235|]
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glycosyltransferase 8 domain-containing protein 1 isoform 1 [Mus musculus]

Protein Classification

glycosyltransferase family 8 protein( domain architecture ID 10157674)

glycosyltransferase family 8 protein similar to Homo sapiens glycosyltransferase 8 domain-containing protein 1 (GLT8D1), a UDP-dependent galactosyltransferase

CATH:  3.90.550.10
CAZY:  GT8
EC:  2.4.-.-
Gene Ontology:  GO:0008194
PubMed:  10521532|12691742|9445404|12200473|10508766
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT8_like_1 cd06429
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ...
 66-351 1.72e-107

GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.


:

Pssm-ID: 133051 [Multi-domain]  Cd Length: 257  Bit Score: 315.48  E-value: 1.72e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870  66 IPVVIAASEdRLGGTIAAINSVHQNTR-SNVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDTKLLEGKVKQDPD-- 142
Cdd:cd06429     1 IHVVIFSDN-RLAAAVVINSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSLmq 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 143 -------------QGESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEdcdsastkvii 209
Cdd:cd06429    80 leseadtsnlkqrKPEYISLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 210 rgagnqynyigyldykkerirklsmkastcSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGlysRTLAGSITTPPLL 289
Cdd:cd06429   149 ------------------------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEEE---VTLWKLITLPPGL 195

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2213905870 290 IVFYQQHSTIDPMWNVRHLGSSAGKRysPQFVKAAKLLHWNGHFKPWGRTA--SYADVWEKWYI 351
Cdd:cd06429   196 IVFYGLTSPLDPSWHVRGLGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAipSYKELWEKYLS 257
 
Name Accession Description Interval E-value
GT8_like_1 cd06429
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ...
 66-351 1.72e-107

GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.


Pssm-ID: 133051 [Multi-domain]  Cd Length: 257  Bit Score: 315.48  E-value: 1.72e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870  66 IPVVIAASEdRLGGTIAAINSVHQNTR-SNVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDTKLLEGKVKQDPD-- 142
Cdd:cd06429     1 IHVVIFSDN-RLAAAVVINSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSLmq 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 143 -------------QGESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEdcdsastkvii 209
Cdd:cd06429    80 leseadtsnlkqrKPEYISLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 210 rgagnqynyigyldykkerirklsmkastcSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGlysRTLAGSITTPPLL 289
Cdd:cd06429   149 ------------------------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEEE---VTLWKLITLPPGL 195

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2213905870 290 IVFYQQHSTIDPMWNVRHLGSSAGKRysPQFVKAAKLLHWNGHFKPWGRTA--SYADVWEKWYI 351
Cdd:cd06429   196 IVFYGLTSPLDPSWHVRGLGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAipSYKELWEKYLS 257
Glyco_transf_8 pfam01501
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ...
 67-340 5.95e-77

Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.


Pssm-ID: 279798 [Multi-domain]  Cd Length: 252  Bit Score: 237.61  E-value: 5.95e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870  67 PVVIAASEDRLGGTIAAINSVHQNT-RSNVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDTKLLEGKVKQDPDQGE 145
Cdd:pfam01501   1 CIALALDKNYLLGASVSIKSLLKNNsDFALNFHIFTDDIPVENLDILNWLASSYKPVLPLLESDIKIFEYFSKLKLRSPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 146 SMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDcdsastkviirgagnqyNYIGYLDYK 225
Cdd:pfam01501  81 YWSLLNYLRLYLPDLFPKLDKILYLDADIVVQGDLSPLWDIDLG-GKVLAAVED-----------------NYFQRYPNF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 226 KERIRKLSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVeeglySRTLAGSITTPPLLIVFYQQHSTIDPMWNV 305
Cdd:pfam01501 143 SEPIILENFGPPACYFNAGMLLFDLDAWRKENITERYIKWLNLNE-----NRTLWKLGDQDPLNIVFYGKVKPLDPRWNV 217

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2213905870 306 RHLGSSAGKRYSPQFVKAAKLLHWNGHFKPWGRTA 340
Cdd:pfam01501 218 LGLGYYNKKKSLNEITENAAVIHYNGPTKPWLDIA 252
RfaJ COG1442
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ...
 63-350 2.35e-24

Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441051 [Multi-domain]  Cd Length: 301  Bit Score: 101.20  E-value: 2.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870  63 QEEIPVVIAASEDRLGGTIAAINSVHQNTRS-NVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDTKLLegkvkQDP 141
Cdd:COG1442     3 KNTINIVFAIDDNYLPGLGVSIASLLENNPDrPYDFHILTDGLSDENKERLEALAAKYNVSIEFIDVDDELL-----KDL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 142 DQGESMKPLTFARFYLPILVPSA-KKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSAStkviirgagnqynyig 220
Cdd:COG1442    78 PVSKHISKATYYRLLIPELLPDDyDKVLYLDADTLVLGDLSELWDIDLG-GNLLAAVRDGTVTG---------------- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 221 yldYKKERIRKLSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGLYsrtlagsittpP----LLIVFYQQH 296
Cdd:COG1442   141 ---SQKKRAKRLGLPDDDGYFNSGVLLINLKKWREENITEKALEFLKENPDKLKY-----------PdqdiLNIVLGGKV 206

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2213905870 297 STIDPMWNV-----RHLGSSAGKRYSPQFVKAAKLLHWNGHFKPW--GRTASYADVWEKWY 350
Cdd:COG1442   207 KFLPPRYNYqyslyYELKDKSNKKELLEARKNPVIIHYTGPTKPWhkWCTHPYADLYWEYL 267
PLN02742 PLN02742
Probable galacturonosyltransferase
 75-349 1.78e-22

Probable galacturonosyltransferase


Pssm-ID: 215395 [Multi-domain]  Cd Length: 534  Bit Score: 98.69  E-value: 1.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870  75 DRLGGTIAAINSVHQNTR--SNVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDT-KLLEG------KVKQDPD--- 142
Cdd:PLN02742  235 DNILATSVVVNSTVSNAKhpDQLVFHLVTDEVNYGAMQAWFAMNDFKGVTVEVQKIEEfSWLNAsyvpvlKQLQDSDtqs 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 143 ------QGESMKPLTFA-----------RFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSASt 205
Cdd:PLN02742  315 yyfsgsQDDGKTEIKFRnpkylsmlnhlRFYIPEIYPALEKVVFLDDDVVVQKDLTPLFSIDLH-GNVNGAVETCLETF- 392

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 206 kviirgagnqYNYIGYLDYKKERIRKlSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEeglysRTLAGSITT 285
Cdd:PLN02742  393 ----------HRYHKYLNFSHPLISS-HFDPDACGWAFGMNVFDLVAWRKANVTAIYHYWQEQNVD-----RTLWKLGTL 456

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2213905870 286 PPLLIVFYQQHSTIDPMWNVRHLGSSAgkRYSPQFVKAAKLLHWNGHFKPWGRTA--SYADVWEKW 349
Cdd:PLN02742  457 PPGLLTFYGLTEPLDRRWHVLGLGYDT--NIDPRLIESAAVLHFNGNMKPWLKLAieRYKPLWERY 520
 
Name Accession Description Interval E-value
GT8_like_1 cd06429
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ...
 66-351 1.72e-107

GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.


Pssm-ID: 133051 [Multi-domain]  Cd Length: 257  Bit Score: 315.48  E-value: 1.72e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870  66 IPVVIAASEdRLGGTIAAINSVHQNTR-SNVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDTKLLEGKVKQDPD-- 142
Cdd:cd06429     1 IHVVIFSDN-RLAAAVVINSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSLmq 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 143 -------------QGESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEdcdsastkvii 209
Cdd:cd06429    80 leseadtsnlkqrKPEYISLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 210 rgagnqynyigyldykkerirklsmkastcSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGlysRTLAGSITTPPLL 289
Cdd:cd06429   149 ------------------------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEEE---VTLWKLITLPPGL 195

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2213905870 290 IVFYQQHSTIDPMWNVRHLGSSAGKRysPQFVKAAKLLHWNGHFKPWGRTA--SYADVWEKWYI 351
Cdd:cd06429   196 IVFYGLTSPLDPSWHVRGLGYNYGIR--PQDIKAAAVLHFNGNMKPWLRTAipSYKELWEKYLS 257
Glyco_transf_8 pfam01501
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ...
 67-340 5.95e-77

Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.


Pssm-ID: 279798 [Multi-domain]  Cd Length: 252  Bit Score: 237.61  E-value: 5.95e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870  67 PVVIAASEDRLGGTIAAINSVHQNT-RSNVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDTKLLEGKVKQDPDQGE 145
Cdd:pfam01501   1 CIALALDKNYLLGASVSIKSLLKNNsDFALNFHIFTDDIPVENLDILNWLASSYKPVLPLLESDIKIFEYFSKLKLRSPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 146 SMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDcdsastkviirgagnqyNYIGYLDYK 225
Cdd:pfam01501  81 YWSLLNYLRLYLPDLFPKLDKILYLDADIVVQGDLSPLWDIDLG-GKVLAAVED-----------------NYFQRYPNF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 226 KERIRKLSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVeeglySRTLAGSITTPPLLIVFYQQHSTIDPMWNV 305
Cdd:pfam01501 143 SEPIILENFGPPACYFNAGMLLFDLDAWRKENITERYIKWLNLNE-----NRTLWKLGDQDPLNIVFYGKVKPLDPRWNV 217

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2213905870 306 RHLGSSAGKRYSPQFVKAAKLLHWNGHFKPWGRTA 340
Cdd:pfam01501 218 LGLGYYNKKKSLNEITENAAVIHYNGPTKPWLDIA 252
Glyco_transf_8 cd00505
Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis ...
 68-338 2.26e-61

Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis; Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+.


Pssm-ID: 132996 [Multi-domain]  Cd Length: 246  Bit Score: 197.28  E-value: 2.26e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870  68 VVIAASEDRLGGTIAAINSVHQNTRSNVMFYIVTFNstadhlRSWLNSGSLKSIRYK---IVNFDTKLLEGKVKQDPdQG 144
Cdd:cd00505     4 VIVATGDEYLRGAIVLMKSVLRHRTKPLRFHVLTNP------LSDTFKAALDNLRKLynfNYELIPVDILDSVDSEH-LK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 145 ESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKPGHAAAFSEDCDSASTKViirgagnqynyigyldy 224
Cdd:cd00505    77 RPIKIVTLTKLHLPNLVPDYDKILYVDADILVLTDIDELWDTPLGGQELAAAPDPGDRREGKY----------------- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 225 kkeRIRKLSMKASTCSFNPGVFVANLTEWKR-QNVTNQLEKWMKLNVeeglysrtlAGSITTPPLLIVFYQQ----HSTI 299
Cdd:cd00505   140 ---YRQKRSHLAGPDYFNSGVFVVNLSKERRnQLLKVALEKWLQSLS---------SLSGGDQDLLNTFFKQvpfiVKSL 207

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2213905870 300 DPMWNVRHLGSSAGKRYSPQFVKAAKLLHWNGHFKPWGR 338
Cdd:cd00505   208 PCIWNVRLTGCYRSLNCFKAFVKNAKVIHFNGPTKPWNK 246
RfaJ COG1442
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ...
 63-350 2.35e-24

Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441051 [Multi-domain]  Cd Length: 301  Bit Score: 101.20  E-value: 2.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870  63 QEEIPVVIAASEDRLGGTIAAINSVHQNTRS-NVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDTKLLegkvkQDP 141
Cdd:COG1442     3 KNTINIVFAIDDNYLPGLGVSIASLLENNPDrPYDFHILTDGLSDENKERLEALAAKYNVSIEFIDVDDELL-----KDL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 142 DQGESMKPLTFARFYLPILVPSA-KKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSAStkviirgagnqynyig 220
Cdd:COG1442    78 PVSKHISKATYYRLLIPELLPDDyDKVLYLDADTLVLGDLSELWDIDLG-GNLLAAVRDGTVTG---------------- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 221 yldYKKERIRKLSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGLYsrtlagsittpP----LLIVFYQQH 296
Cdd:COG1442   141 ---SQKKRAKRLGLPDDDGYFNSGVLLINLKKWREENITEKALEFLKENPDKLKY-----------PdqdiLNIVLGGKV 206

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2213905870 297 STIDPMWNV-----RHLGSSAGKRYSPQFVKAAKLLHWNGHFKPW--GRTASYADVWEKWY 350
Cdd:COG1442   207 KFLPPRYNYqyslyYELKDKSNKKELLEARKNPVIIHYTGPTKPWhkWCTHPYADLYWEYL 267
PLN02742 PLN02742
Probable galacturonosyltransferase
 75-349 1.78e-22

Probable galacturonosyltransferase


Pssm-ID: 215395 [Multi-domain]  Cd Length: 534  Bit Score: 98.69  E-value: 1.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870  75 DRLGGTIAAINSVHQNTR--SNVMFYIVTFNSTADHLRSWLNSGSLKSIRYKIVNFDT-KLLEG------KVKQDPD--- 142
Cdd:PLN02742  235 DNILATSVVVNSTVSNAKhpDQLVFHLVTDEVNYGAMQAWFAMNDFKGVTVEVQKIEEfSWLNAsyvpvlKQLQDSDtqs 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 143 ------QGESMKPLTFA-----------RFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSASt 205
Cdd:PLN02742  315 yyfsgsQDDGKTEIKFRnpkylsmlnhlRFYIPEIYPALEKVVFLDDDVVVQKDLTPLFSIDLH-GNVNGAVETCLETF- 392

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 206 kviirgagnqYNYIGYLDYKKERIRKlSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEeglysRTLAGSITT 285
Cdd:PLN02742  393 ----------HRYHKYLNFSHPLISS-HFDPDACGWAFGMNVFDLVAWRKANVTAIYHYWQEQNVD-----RTLWKLGTL 456

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2213905870 286 PPLLIVFYQQHSTIDPMWNVRHLGSSAgkRYSPQFVKAAKLLHWNGHFKPWGRTA--SYADVWEKW 349
Cdd:PLN02742  457 PPGLLTFYGLTEPLDRRWHVLGLGYDT--NIDPRLIESAAVLHFNGNMKPWLKLAieRYKPLWERY 520
PLN02829 PLN02829
Probable galacturonosyltransferase
 150-336 8.48e-21

Probable galacturonosyltransferase


Pssm-ID: 215443 [Multi-domain]  Cd Length: 639  Bit Score: 93.76  E-value: 8.48e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 150 LTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSastkviirgagNQYNYIGYLDYKKERI 229
Cdd:PLN02829  443 LNHLRFYLPEIFPKLNKVLFLDDDIVVQKDLTGLWSIDLK-GNVNGAVETCGE-----------SFHRFDRYLNFSNPLI 510

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 230 RKlSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNveeglYSRTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLG 309
Cdd:PLN02829  511 SK-NFDPHACGWAYGMNVFDLDEWKRQNITEVYHSWQKLN-----HDRQLWKLGTLPPGLITFWKRTYPLDRSWHVLGLG 584

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2213905870 310 ssagkrYSPQF----VKAAKLLHWNGHFKPW 336
Cdd:PLN02829  585 ------YNPNVnqrdIERAAVIHYNGNMKPW 609
PLN02910 PLN02910
polygalacturonate 4-alpha-galacturonosyltransferase
 150-353 9.38e-21

polygalacturonate 4-alpha-galacturonosyltransferase


Pssm-ID: 215493 [Multi-domain]  Cd Length: 657  Bit Score: 93.86  E-value: 9.38e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 150 LTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSAStkviirgagnqYNYIGYLDYKKERI 229
Cdd:PLN02910  461 LNHLRFYLPEVYPKLEKILFLDDDIVVQKDLTPLWSIDMQ-GMVNGAVETCKESF-----------HRFDKYLNFSNPKI 528

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 230 RKlSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEeglysRTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLG 309
Cdd:PLN02910  529 SE-NFDPNACGWAFGMNMFDLKEWRKRNITGIYHYWQDLNED-----RTLWKLGSLPPGLITFYNLTYPLDRSWHVLGLG 602

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2213905870 310 ssagkrYSPQF----VKAAKLLHWNGHFKPWGRTA--SYADVWEKWYIPD 353
Cdd:PLN02910  603 ------YDPALnqteIENAAVVHYNGNYKPWLDLAiaKYKPYWSRYVQYD 646
GT8_A4GalT_like cd04194
A4GalT_like proteins catalyze the addition of galactose or glucose residues to the ...
 66-336 1.16e-20

A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.


Pssm-ID: 133037 [Multi-domain]  Cd Length: 248  Bit Score: 89.97  E-value: 1.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870  66 IPVVIAASEDRLGGTIAAINS-VHQNTRSNVMFYIVTFNstadhlrswLNSGSLKSIRYKIVNFDTKLL-----EGKVKQ 139
Cdd:cd04194     1 MNIVFAIDDNYAPYLAVTIKSiLANNSKRDYDFYILNDD---------ISEENKKKLKELLKKYNSSIEfikidNDDFKF 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 140 DPDQGESMKPLTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCdsastkviirgagnqynyi 219
Cdd:cd04194    72 FPATTDHISYATYYRLLIPDLLPDYDKVLYLDADIIVLGDLSELFDIDLG-DNLLAAVRDP------------------- 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 220 gYLDYKKERIRKLSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGLYsrtlagsittpP----LLIVFYQQ 295
Cdd:cd04194   132 -FIEQEKKRKRRLGGYDDGSYFNSGVLLINLKKWREENITEKLLELIKEYGGRLIY-----------PdqdiLNAVLKDK 199

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2213905870 296 HSTIDPMWNV------RHLGSSAGKRYSPQFVKAAKLLHWNGHFKPW 336
Cdd:cd04194   200 ILYLPPRYNFqtgfyyLLKKKSKEEQELEEARKNPVIIHYTGSDKPW 246
PLN02523 PLN02523
galacturonosyltransferase
 150-349 1.73e-20

galacturonosyltransferase


Pssm-ID: 215286 [Multi-domain]  Cd Length: 559  Bit Score: 93.02  E-value: 1.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 150 LTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCdsastkviirgAGNQYNYIGYLDYKKERI 229
Cdd:PLN02523  363 LNHLRFYLPEMYPKLHRILFLDDDVVVQKDLTGLWKIDMD-GKVNGAVETC-----------FGSFHRYAQYLNFSHPLI 430

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 230 R-KLSMKAstCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEeglysRTLAGSITTPPLLIVFYQQHSTIDPMWNVRHL 308
Cdd:PLN02523  431 KeKFNPKA--CAWAYGMNIFDLDAWRREKCTEQYHYWQNLNEN-----RTLWKLGTLPPGLITFYSTTKPLDKSWHVLGL 503

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2213905870 309 GssagkrYSPQF----VKAAKLLHWNGHFKPWGRTA--SYADVWEKW 349
Cdd:PLN02523  504 G------YNPSIsmdeIRNAAVIHFNGNMKPWLDIAmnQFKPLWTKY 544
PLN02659 PLN02659
Probable galacturonosyltransferase
 154-336 5.82e-20

Probable galacturonosyltransferase


Pssm-ID: 215356 [Multi-domain]  Cd Length: 534  Bit Score: 91.25  E-value: 5.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 154 RFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSASTKVIIRGAGNqynyigYLDYKKERIRKlS 233
Cdd:PLN02659  334 RIHLPELFPSLNKVVFLDDDIVVQTDLSPLWDIDMN-GKVNGAVETCRGEDKFVMSKKLKS------YLNFSHPLIAK-N 405

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 234 MKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGLYSRTLAgsiTTPPLLIVFYQQHSTIDPMWNVRHLGSSAG 313
Cdd:PLN02659  406 FDPNECAWAYGMNIFDLEAWRKTNISSTYHHWLEENLKSDLSLWQLG---TLPPGLIAFHGHVHVIDPFWHMLGLGYQEN 482

                         170       180
                  ....*....|....*....|...
gi 2213905870 314 KRYSPqfVKAAKLLHWNGHFKPW 336
Cdd:PLN02659  483 TSLAD--AESAGVVHFNGRAKPW 503
PLN02870 PLN02870
Probable galacturonosyltransferase
 150-336 1.06e-19

Probable galacturonosyltransferase


Pssm-ID: 215468 [Multi-domain]  Cd Length: 533  Bit Score: 90.38  E-value: 1.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 150 LTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSASTKVIIRGAGNQYNYIGYLDYKkeri 229
Cdd:PLN02870  329 LNHLRIYLPELFPNLDKVVFLDDDVVIQRDLSPLWDIDLG-GKVNGAVETCRGEDEWVMSKRFRNYFNFSHPLIAK---- 403

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 230 rklSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMKLNVEEGLysrTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLG 309
Cdd:PLN02870  404 ---NLDPEECAWAYGMNIFDLRAWRKTNIRETYHSWLKENLKSNL---TMWKLGTLPPALIAFKGHVHPIDPSWHMLGLG 477

                         170       180
                  ....*....|....*....|....*..
gi 2213905870 310 SSagKRYSPQFVKAAKLLHWNGHFKPW 336
Cdd:PLN02870  478 YQ--SKTNIESVKKAAVIHYNGQSKPW 502
PLN02867 PLN02867
Probable galacturonosyltransferase
 69-370 4.26e-18

Probable galacturonosyltransferase


Pssm-ID: 178458 [Multi-domain]  Cd Length: 535  Bit Score: 85.72  E-value: 4.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870  69 VIAASedrlggtiAAINSVHQNTRS--NVMFYIVTFNSTADHLRSWLNSGSLKSIRYKI-----------VNFDTK---- 131
Cdd:PLN02867  221 VLAAS--------VVISSTVQNAANpeKLVFHIVTDKKTYTPMHAWFAINSIKSAVVEVkglhqydwsqeVNVGVKemle 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 132 ------------------LLEGKVKQDPdqgESMKP-----LTFARFYLPILVPSAKKAIYMDDDVIVQGDILALYNTPL 188
Cdd:PLN02867  293 ihrliwshyyqnlkesdfQFEGTHKRSL---EALSPsclslLNHLRIYIPELFPDLNKIVFLDDDVVVQHDLSSLWELDL 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 189 -KPGHAAAFSEDCDSASTkviirgAGNQYNyiGYLDYKKERIRKlSMKASTCSFNPGVFVANLTEWKRQNVTNQLEKWMK 267
Cdd:PLN02867  370 nGKVVGAVVDSWCGDNCC------PGRKYK--DYLNFSHPLISS-NLDQERCAWLYGMNVFDLKAWRRTNITEAYHKWLK 440

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 268 LNVEEGLysrTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLGSSAGKrYSPQFVKAAKLLHWNGHFKPWgRTASYADVWE 347
Cdd:PLN02867  441 LSLNSGL---QLWQPGALPPALLAFKGHVHPIDPSWHVAGLGSRPPE-VPREILESAAVLHFSGPAKPW-LEIGFPEVRS 515

                         330       340
                  ....*....|....*....|...
gi 2213905870 348 KWYipdptgkfslirRHMDTSNI 370
Cdd:PLN02867  516 LWY------------RHVNFSDK 526
PLN02718 PLN02718
Probable galacturonosyltransferase
 95-336 2.93e-16

Probable galacturonosyltransferase


Pssm-ID: 178320 [Multi-domain]  Cd Length: 603  Bit Score: 80.32  E-value: 2.93e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870  95 VMFYIVT--FNSTADHLRSWLNSGSLKSIRYK-IVNFD---TKLLEGKVKQDPDQGESMKPLTFARFYLPILVPSAKKAI 168
Cdd:PLN02718  343 IVFHVVTdsLNYPAISMWFLLNPPGKATIQILnIDDMNvlpADYNSLLMKQNSHDPRYISALNHARFYLPDIFPGLNKIV 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 169 YMDDDVIVQGDILALYNTPLKpGHAAAFSEDCDSASTKViirgaGNQYNYIGYLDykKERIRKLSMKASTCSFNPGVFva 248
Cdd:PLN02718  423 LFDHDVVVQRDLSRLWSLDMK-GKVVGAVETCLEGEPSF-----RSMDTFINFSD--PWVAKKFDPKACTWAFGMNLF-- 492

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 249 NLTEWKRQNVTNQLEKWMKLNVEEGLYSrtlAGSIttPPLLIVFYQQHSTIDPMWNVRHLGSSAGKRYSPqfVKAAKLLH 328
Cdd:PLN02718  493 DLEEWRRQKLTSVYHKYLQLGVKRPLWK---AGSL--PIGWLTFYNQTVALDKRWHVLGLGHESGVGASD--IEQAAVIH 565


                  ....*...
gi 2213905870 329 WNGHFKPW 336
Cdd:PLN02718  566 YDGVMKPW 573
PLN02769 PLN02769
Probable galacturonosyltransferase
 155-336 4.99e-11

Probable galacturonosyltransferase


Pssm-ID: 215412 [Multi-domain]  Cd Length: 629  Bit Score: 63.95  E-value: 4.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 155 FYLPILVPSAKKAIYMDDDVIVQGDILALYNTPLKpghaaafsedcdsasTKVIirGA--------GNQYNYIGyldykk 226
Cdd:PLN02769  443 FLLPEIFKKLKKVVVLDDDVVVQRDLSFLWNLDMG---------------GKVN--GAvqfcgvrlGQLKNYLG------ 499

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2213905870 227 erirKLSMKASTCSFNPGVFVANLTEWKRQNVTN---QLEKWMKLNVEEGLYSRTLAGSittpplLIVFYQQHSTIDPMW 303
Cdd:PLN02769  500 ----DTNFDTNSCAWMSGLNVIDLDKWRELDVTEtylKLLQKFSKDGEESLRAAALPAS------LLTFQDLIYPLDDRW 569

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2213905870 304 NVRHLGSSAGkrYSPQFVKAAKLLHWNGHFKPW 336
Cdd:PLN02769  570 VLSGLGHDYG--IDEQAIKKAAVLHYNGNMKPW 600
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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