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Conserved domains on  [gi|2215160226|ref|NP_001390604|]
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bcl-2-binding component 3 isoform c [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PUMA super family cl25492
Bcl-2-binding component 3, p53 upregulated modulator of apoptosis; PUMA (p53 upregulated ...
 21-122 9.94e-43

Bcl-2-binding component 3, p53 upregulated modulator of apoptosis; PUMA (p53 upregulated modulator of apoptosis) is a family of eukaryotic proteins that are a target for activation by p53. The proteins contain BH3 domains and are induced in cells after p53 activation. They bind to Bcl-2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of apoptosis.


The actual alignment was detected with superfamily member pfam15826:

Pssm-ID: 374148 [Multi-domain]  Cd Length: 189  Bit Score: 138.55  E-value: 9.94e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215160226  21 GPQPSLSPAQQHLESPVpsapealAGGPTQAAPGVRVEEEEWAREIGAQLRRMADDLNAQYERR-RQEEQHRHRPSPWRV 99
Cdd:pfam15826  94 GPQPSLSPAEPHLESPV-------AGGPTQAAPGVRGEEEQWAREIGAQLRRMADDLNALYERRrRQEEQQRHRPSPWRV 166

                          90       100
                  ....*....|....*....|...
gi 2215160226 100 MYNLFMGLLPLPRDPGAPEMEPN 122
Cdd:pfam15826 167 LYNLIMGLLPLPRGHRAPEMEPN 189
 
Name Accession Description Interval E-value
PUMA pfam15826
Bcl-2-binding component 3, p53 upregulated modulator of apoptosis; PUMA (p53 upregulated ...
 21-122 9.94e-43

Bcl-2-binding component 3, p53 upregulated modulator of apoptosis; PUMA (p53 upregulated modulator of apoptosis) is a family of eukaryotic proteins that are a target for activation by p53. The proteins contain BH3 domains and are induced in cells after p53 activation. They bind to Bcl-2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of apoptosis.


Pssm-ID: 374148 [Multi-domain]  Cd Length: 189  Bit Score: 138.55  E-value: 9.94e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215160226  21 GPQPSLSPAQQHLESPVpsapealAGGPTQAAPGVRVEEEEWAREIGAQLRRMADDLNAQYERR-RQEEQHRHRPSPWRV 99
Cdd:pfam15826  94 GPQPSLSPAEPHLESPV-------AGGPTQAAPGVRGEEEQWAREIGAQLRRMADDLNALYERRrRQEEQQRHRPSPWRV 166

                          90       100
                  ....*....|....*....|...
gi 2215160226 100 MYNLFMGLLPLPRDPGAPEMEPN 122
Cdd:pfam15826 167 LYNLIMGLLPLPRGHRAPEMEPN 189
 
Name Accession Description Interval E-value
PUMA pfam15826
Bcl-2-binding component 3, p53 upregulated modulator of apoptosis; PUMA (p53 upregulated ...
 21-122 9.94e-43

Bcl-2-binding component 3, p53 upregulated modulator of apoptosis; PUMA (p53 upregulated modulator of apoptosis) is a family of eukaryotic proteins that are a target for activation by p53. The proteins contain BH3 domains and are induced in cells after p53 activation. They bind to Bcl-2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of apoptosis.


Pssm-ID: 374148 [Multi-domain]  Cd Length: 189  Bit Score: 138.55  E-value: 9.94e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2215160226  21 GPQPSLSPAQQHLESPVpsapealAGGPTQAAPGVRVEEEEWAREIGAQLRRMADDLNAQYERR-RQEEQHRHRPSPWRV 99
Cdd:pfam15826  94 GPQPSLSPAEPHLESPV-------AGGPTQAAPGVRGEEEQWAREIGAQLRRMADDLNALYERRrRQEEQQRHRPSPWRV 166

                          90       100
                  ....*....|....*....|...
gi 2215160226 100 MYNLFMGLLPLPRDPGAPEMEPN 122
Cdd:pfam15826 167 LYNLIMGLLPLPRGHRAPEMEPN 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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