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Conserved domains on  [gi|2217262679|ref|NP_001390842|]
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potassium channel subfamily K member 4 isoform 1 precursor [Mus musculus]

Protein Classification

potassium channel family protein( domain architecture ID 10545436)

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium, translocate across cell membranes

Gene Ontology:  GO:0005267|GO:0034220|GO:0005216|GO:0071805|GO:0016020
PubMed:  15816170|9525859|11836519|11178249|1772658
SCOP:  4000034
TCDB:  1.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 85-143 6.99e-19

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 80.39  E-value: 6.99e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217262679  85 HSSAWNLGSAFFFSGTIITTIGYGNIVLHTDAGRLFCIFYALVGIPLFGMLLAGVGDRL 143
Cdd:pfam07885  18 EGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 181-259 9.67e-16

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 71.53  E-value: 9.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217262679 181 CLLFVLTPTFVFSYME---SWSKLEAIYFVIVTLTTVGFGDYVPGdgtgqnSPAYQPLVWFWILFGLAYFASVLTTIGNW 257
Cdd:pfam07885   2 VLLLVLIFGTVYYLLEegwEWSFLDALYFSFVTLTTVGYGDIVPL------TDAGRLFTIFYILIGIPLFAIFLAVLGRF 75


                  ..
gi 2217262679 258 LR 259
Cdd:pfam07885  76 LT 77
PLN02983 super family cl33616
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 293-345 4.31e-04

biotin carboxyl carrier protein of acetyl-CoA carboxylase


The actual alignment was detected with superfamily member PLN02983:

Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 41.75  E-value: 4.31e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217262679 293 PSAPPPEK----EQPLLPSSLPAPPAVVEPAGRPGSPAPAEKVETPSPPTASALDYP 345
Cdd:PLN02983  142 PQPPPPAPvvmmQPPPPHAMPPASPPAAQPAPSAPASSPPPTPASPPPAKAPKSSHP 198
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 85-143 6.99e-19

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 80.39  E-value: 6.99e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217262679  85 HSSAWNLGSAFFFSGTIITTIGYGNIVLHTDAGRLFCIFYALVGIPLFGMLLAGVGDRL 143
Cdd:pfam07885  18 EGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 181-259 9.67e-16

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 71.53  E-value: 9.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217262679 181 CLLFVLTPTFVFSYME---SWSKLEAIYFVIVTLTTVGFGDYVPGdgtgqnSPAYQPLVWFWILFGLAYFASVLTTIGNW 257
Cdd:pfam07885   2 VLLLVLIFGTVYYLLEegwEWSFLDALYFSFVTLTTVGYGDIVPL------TDAGRLFTIFYILIGIPLFAIFLAVLGRF 75


                  ..
gi 2217262679 258 LR 259
Cdd:pfam07885  76 LT 77
PRK10537 PRK10537
voltage-gated potassium channel protein;
90-155 3.77e-05

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 45.40  E-value: 3.77e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217262679  90 NLGSAFFFSGTIITTIGYGNIVLHTDAGRLFCIFYALVGIPLFGMLLAGV-----GDRLGSSLRRGIGHIE 155
Cdd:PRK10537  168 SLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSISAIfgpviRGNLKRLVKGRISHMH 238
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 293-345 4.31e-04

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 41.75  E-value: 4.31e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217262679 293 PSAPPPEK----EQPLLPSSLPAPPAVVEPAGRPGSPAPAEKVETPSPPTASALDYP 345
Cdd:PLN02983  142 PQPPPPAPvvmmQPPPPHAMPPASPPAAQPAPSAPASSPPPTPASPPPAKAPKSSHP 198
PRK10537 PRK10537
voltage-gated potassium channel protein;
203-254 6.42e-04

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 41.55  E-value: 6.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217262679 203 AIYFVIVTLTTVGFGDYVPgdgtgqNSPAYQPLVWFWILFGLAYFASVLTTI 254
Cdd:PRK10537  172 AFYFSIVTMSTVGYGDIVP------VSESARLFTISVIILGITVFATSISAI 217
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 275-350 2.00e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 39.88  E-value: 2.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217262679 275 QAASWTGTVTARVTQRTGPSAPPPEKEQPLLPSSLPAPPAVVEPAGRPGSPAPAEKVETPSPPTASALDYPSENLA 350
Cdd:TIGR00601  76 KPKTGTGKVAPPAATPTSAPTPTPSPPASPASGMSAAPASAVEEKSPSEESATATAPESPSTSVPSSGSDAASTLV 151
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 256-337 2.85e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 39.60  E-value: 2.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217262679 256 NWLRAVSRRTRAEMGGLTAQAASWTGTVTARVTQRTGPSAPPPEKEQPLLPSSLP---APPAVVEPAGRPGSPAPAEKVE 332
Cdd:NF041121   13 AQMGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPgslAPPPPPPPGPAGAAPGAALPVR 92


                  ....*
gi 2217262679 333 TPSPP 337
Cdd:NF041121   93 VPAPP 97
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 85-143 6.99e-19

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 80.39  E-value: 6.99e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217262679  85 HSSAWNLGSAFFFSGTIITTIGYGNIVLHTDAGRLFCIFYALVGIPLFGMLLAGVGDRL 143
Cdd:pfam07885  18 EGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 181-259 9.67e-16

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 71.53  E-value: 9.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217262679 181 CLLFVLTPTFVFSYME---SWSKLEAIYFVIVTLTTVGFGDYVPGdgtgqnSPAYQPLVWFWILFGLAYFASVLTTIGNW 257
Cdd:pfam07885   2 VLLLVLIFGTVYYLLEegwEWSFLDALYFSFVTLTTVGYGDIVPL------TDAGRLFTIFYILIGIPLFAIFLAVLGRF 75


                  ..
gi 2217262679 258 LR 259
Cdd:pfam07885  76 LT 77
PRK10537 PRK10537
voltage-gated potassium channel protein;
90-155 3.77e-05

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 45.40  E-value: 3.77e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217262679  90 NLGSAFFFSGTIITTIGYGNIVLHTDAGRLFCIFYALVGIPLFGMLLAGV-----GDRLGSSLRRGIGHIE 155
Cdd:PRK10537  168 SLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSISAIfgpviRGNLKRLVKGRISHMH 238
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 293-345 4.31e-04

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 41.75  E-value: 4.31e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217262679 293 PSAPPPEK----EQPLLPSSLPAPPAVVEPAGRPGSPAPAEKVETPSPPTASALDYP 345
Cdd:PLN02983  142 PQPPPPAPvvmmQPPPPHAMPPASPPAAQPAPSAPASSPPPTPASPPPAKAPKSSHP 198
PRK10537 PRK10537
voltage-gated potassium channel protein;
203-254 6.42e-04

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 41.55  E-value: 6.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217262679 203 AIYFVIVTLTTVGFGDYVPgdgtgqNSPAYQPLVWFWILFGLAYFASVLTTI 254
Cdd:PRK10537  172 AFYFSIVTMSTVGYGDIVP------VSESARLFTISVIILGITVFATSISAI 217
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 275-350 2.00e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 39.88  E-value: 2.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217262679 275 QAASWTGTVTARVTQRTGPSAPPPEKEQPLLPSSLPAPPAVVEPAGRPGSPAPAEKVETPSPPTASALDYPSENLA 350
Cdd:TIGR00601  76 KPKTGTGKVAPPAATPTSAPTPTPSPPASPASGMSAAPASAVEEKSPSEESATATAPESPSTSVPSSGSDAASTLV 151
PHA03247 PHA03247
large tegument protein UL36; Provisional
 259-343 2.09e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 2.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217262679  259 RAVSRRTRAEMGGLTAQAASWTGTVTAR--------VTQRTGPSAPPPEKEQPLLPSSLPAPPAVVEPAGRPGSPAPAEK 330
Cdd:PHA03247  2659 GRVSRPRRARRLGRAAQASSPPQRPRRRaarptvgsLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAA 2738

                           90
                   ....*....|...
gi 2217262679  331 VETPSPPTASALD 343
Cdd:PHA03247  2739 PAPPAVPAGPATP 2751
PHA03247 PHA03247
large tegument protein UL36; Provisional
 293-397 2.38e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 2.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217262679  293 PSAPPPEKEQPLlPSSLPAP----PAVVEPAGRPGSPA---------------PAEKVETPSPPTASALDYPSENlafid 353
Cdd:PHA03247  2557 PAAPPAAPDRSV-PPPRPAPrpsePAVTSRARRPDAPPqsarprapvddrgdpRGPAPPSPLPPDTHAPDPPPPS----- 2630

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2217262679  354 eSSDTQSERGCALPRAPRGRRRPNPSKKPSRPRGPGRLRDKAVP 397
Cdd:PHA03247  2631 -PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA 2673
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 256-337 2.85e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 39.60  E-value: 2.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217262679 256 NWLRAVSRRTRAEMGGLTAQAASWTGTVTARVTQRTGPSAPPPEKEQPLLPSSLP---APPAVVEPAGRPGSPAPAEKVE 332
Cdd:NF041121   13 AQMGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPgslAPPPPPPPGPAGAAPGAALPVR 92


                  ....*
gi 2217262679 333 TPSPP 337
Cdd:NF041121   93 VPAPP 97
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 78-137 3.59e-03

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 38.79  E-value: 3.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217262679  78 SWTNSSNHSSAW-NLGSAFFFSGTIITTIGYGNIVLHTDAGR-------LFCIFYALVGIPLFGMLLA 137
Cdd:pfam00520 157 TWENPDNGRTNFdNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFLLLNLFIA 224
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 298-345 6.08e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 38.30  E-value: 6.08e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217262679 298 PEKEQPLLPSSLPAPPAVVEPAGRPGSPAPAEKVETPSP--PTASALDYP 345
Cdd:PHA02682   76 PSGQSPLAPSPACAAPAPACPACAPAAPAPAVTCPAPAPacPPATAPTCP 125
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 258-355 6.47e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 38.64  E-value: 6.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217262679 258 LRAVSRRTRAEMGGLTAQAASWTGTVTArVTQRTGPSAPPPEKEQPllpsSLPAPPAVVEPAGRPGSPAPAEKVETPSPP 337
Cdd:PRK14950  375 APSPVRPTPAPSTRPKAAAAANIPPKEP-VRETATPPPVPPRPVAP----PVPHTPESAPKLTRAAIPVDEKPKYTPPAP 449

                          90       100
                  ....*....|....*....|.
gi 2217262679 338 TA---SALDYPSENLAFIDES 355
Cdd:PRK14950  450 PKeeeKALIADGDVLEQLEAI 470
PHA03247 PHA03247
large tegument protein UL36; Provisional
 262-347 9.90e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.38  E-value: 9.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217262679  262 SRRTRAEMGGLTAQAASWTGTVTARvtQRTGPSAPPPEKEQPLLPSSLPAPPAVVEPAGRPGS---PAPAEKVETPSPPT 338
Cdd:PHA03247   382 TRKRRSARHAATPFARGPGGDDQTR--PAAPVPASVPTPAPTPVPASAPPPPATPLPSAEPGSddgPAPPPERQPPAPAT 459


                   ....*....
gi 2217262679  339 ASALDYPSE 347
Cdd:PHA03247   460 EPAPDDPDD 468
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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