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Conserved domains on  [gi|2246031128|ref|NP_001394212|]
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transmembrane protein 127 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM127 pfam20517
Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its ...
 1-112 3.10e-43

Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its interaction with early endosomal GTPase Rab5 to inhibit mTOR signalling seems to be related with its tumour-suppressing properties.


:

Pssm-ID: 466666  Cd Length: 113  Bit Score: 138.55  E-value: 3.10e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2246031128   1 MNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKY 80
Cdd:pfam20517   2 VTNEIVLLMRVIIALCFMAIIFSLFGFLLDLFGPNQRALKVIRRNAVGSILTVIWCVAIVGFCYWVTELILDLQRETKLY 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2246031128  81 HGSQVYVTFAVSFYLVAGAGGASILATAANLL 112
Cdd:pfam20517  82 PGSKVQVSFDVGFYLITAAGALSVLATACNLL 113
 
Name Accession Description Interval E-value
TMEM127 pfam20517
Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its ...
 1-112 3.10e-43

Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its interaction with early endosomal GTPase Rab5 to inhibit mTOR signalling seems to be related with its tumour-suppressing properties.


Pssm-ID: 466666  Cd Length: 113  Bit Score: 138.55  E-value: 3.10e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2246031128   1 MNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKY 80
Cdd:pfam20517   2 VTNEIVLLMRVIIALCFMAIIFSLFGFLLDLFGPNQRALKVIRRNAVGSILTVIWCVAIVGFCYWVTELILDLQRETKLY 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2246031128  81 HGSQVYVTFAVSFYLVAGAGGASILATAANLL 112
Cdd:pfam20517  82 PGSKVQVSFDVGFYLITAAGALSVLATACNLL 113
 
Name Accession Description Interval E-value
TMEM127 pfam20517
Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its ...
 1-112 3.10e-43

Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its interaction with early endosomal GTPase Rab5 to inhibit mTOR signalling seems to be related with its tumour-suppressing properties.


Pssm-ID: 466666  Cd Length: 113  Bit Score: 138.55  E-value: 3.10e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2246031128   1 MNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKY 80
Cdd:pfam20517   2 VTNEIVLLMRVIIALCFMAIIFSLFGFLLDLFGPNQRALKVIRRNAVGSILTVIWCVAIVGFCYWVTELILDLQRETKLY 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2246031128  81 HGSQVYVTFAVSFYLVAGAGGASILATAANLL 112
Cdd:pfam20517  82 PGSKVQVSFDVGFYLITAAGALSVLATACNLL 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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