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Conserved domains on  [gi|2260108740|ref|NP_001395713|]
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lymphocyte antigen 6 family member L precursor [Rattus norvegicus]

Protein Classification

Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6L cd23551
extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L ...
 30-114 2.85e-33

extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L (also called lymphocyte antigen 6 complex locus protein L) contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467081  Cd Length: 86  Bit Score: 112.11  E-value: 2.85e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260108740  30 NLSCFQCFKVRRASLCHPMECQPSEKVCVSNEVLLYTSTKSRTQISKRCAITCPNSNDLFEWS-VKNIQARITRRCCSWD 108
Cdd:cd23551     1 NLKCYQCFKVSSDEDCKPDQCAPSEIVCISNEVVLYVGTKVRVLISKRCAPRCPNTNSRCEWSpGTQVIGSITRTCCSQS 80


                  ....*.
gi 2260108740 109 HCNRAP 114
Cdd:cd23551    81 LCNRAP 86
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6L cd23551
extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L ...
 30-114 2.85e-33

extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L (also called lymphocyte antigen 6 complex locus protein L) contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467081  Cd Length: 86  Bit Score: 112.11  E-value: 2.85e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260108740  30 NLSCFQCFKVRRASLCHPMECQPSEKVCVSNEVLLYTSTKSRTQISKRCAITCPNSNDLFEWS-VKNIQARITRRCCSWD 108
Cdd:cd23551     1 NLKCYQCFKVSSDEDCKPDQCAPSEIVCISNEVVLYVGTKVRVLISKRCAPRCPNTNSRCEWSpGTQVIGSITRTCCSQS 80


                  ....*.
gi 2260108740 109 HCNRAP 114
Cdd:cd23551    81 LCNRAP 86
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 31-114 2.02e-03

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 35.20  E-value: 2.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260108740   31 LSCFQCFKVRRASLCHPMECQPSEKVCVSnEVLLYTSTKSRTQISKRCAIT--CPNSNDlFEWSVKNIQARItrRCCSWD 108
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEECRSPDDVCLT-VVAEVISDSRGSVVYKGCATSpiCPGSHG-YEINLTIAFLKV--SCCQTD 76


                   ....*.
gi 2260108740  109 HCNRAP 114
Cdd:smart00134  77 LCNAAG 82
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6L cd23551
extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L ...
 30-114 2.85e-33

extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L (also called lymphocyte antigen 6 complex locus protein L) contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467081  Cd Length: 86  Bit Score: 112.11  E-value: 2.85e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260108740  30 NLSCFQCFKVRRASLCHPMECQPSEKVCVSNEVLLYTSTKSRTQISKRCAITCPNSNDLFEWS-VKNIQARITRRCCSWD 108
Cdd:cd23551     1 NLKCYQCFKVSSDEDCKPDQCAPSEIVCISNEVVLYVGTKVRVLISKRCAPRCPNTNSRCEWSpGTQVIGSITRTCCSQS 80


                  ....*.
gi 2260108740 109 HCNRAP 114
Cdd:cd23551    81 LCNRAP 86
TFP_LU_ECD_Ly6H cd23549
extracellular domain (ECD) found in lymphocyte antigen 6H (Ly-6H) and similar proteins; Ly-6H ...
 31-111 3.73e-08

extracellular domain (ECD) found in lymphocyte antigen 6H (Ly-6H) and similar proteins; Ly-6H may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-3:beta-4-containing nAChRs maximum response. Ly-6H may play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. It seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. Ly-6H contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467079  Cd Length: 88  Bit Score: 47.83  E-value: 3.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260108740  31 LSCFQCFKVRRASLCHPMECQPSEKVCVSNEVLLYTSTKSRTQISKRCAITCP-----NSNDLFEWSVKNIQARITRRCC 105
Cdd:cd23549     1 LWCQDCTLTTNSSNCTPKPCQPSDTVCVSVRITDPSSSRKDHSVNKMCATSCDftkrhFFSDYLMGFINSGILIVDVRCC 80


                  ....*.
gi 2260108740 106 SWDHCN 111
Cdd:cd23549    81 NKDLCN 86
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 31-111 1.60e-06

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467071  Cd Length: 83  Bit Score: 43.47  E-value: 1.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260108740  31 LSCFQCFKVRRASLCHPMECQPSEKVCVSNEVLLYTSTKSRTQISKRCAITCP-NSNDLFEWSVKNIQARITrrCCSWDH 109
Cdd:cd23541     3 LRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSQRVKLKNKFCLPFCPkNLYFLEEILGTTVNVKTS--CCKEDL 80


                  ..
gi 2260108740 110 CN 111
Cdd:cd23541    81 CN 82
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 31-111 2.84e-06

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 42.73  E-value: 2.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260108740  31 LSCFQCFKVRRASLC-HPMECQPSEKVCVSNEVLLYTSTKSRTQISKRCAITCPNSNDLFEwsvkniQARITRRCCSWDH 109
Cdd:cd23543     3 LYCYTCENQSSNWNClKPTKCSDNDKYCVTTVASGGTGSSSGVRITKKCSPKCPETNVNIG------IASVSTSCCQSSL 76


                  ..
gi 2260108740 110 CN 111
Cdd:cd23543    77 CN 78
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 27-113 1.39e-04

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 38.16  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260108740  27 PARNLSCFQCFKvrrASLC-HPMECQPSEKVCVSNevllyTSTKSRTQIS-KRCAITCPNSNDLFEWSvkNIQARITrrC 104
Cdd:cd23542     2 PANALQCHVCNS---SSNCtNPVNCEGSERYCKTT-----TVVQPSGNLVkKGCAETCPPSTSRQQVG--SGISSVT--C 69


                  ....*....
gi 2260108740 105 CSWDHCNRA 113
Cdd:cd23542    70 CQGDLCNSK 78
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 31-114 5.93e-04

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 36.54  E-value: 5.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260108740  31 LSCFQCFKVRRASLC-HPMECQPSEKVCVSNEVLLYTSTKSRTQISKRCAITCPNSNdlfewsVKNIQARITRRCCSWDH 109
Cdd:cd23575     3 LKCYTCVSAHSNSDClTETNCSSSDTYCKTLVASASGGSGSLTTITKWCASSCTPST------RTVEGTKVTVSCCQTDL 76


                  ....*
gi 2260108740 110 CNRAP 114
Cdd:cd23575    77 CNVSG 81
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 31-114 2.02e-03

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 35.20  E-value: 2.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260108740   31 LSCFQCFKVRRASLCHPMECQPSEKVCVSnEVLLYTSTKSRTQISKRCAIT--CPNSNDlFEWSVKNIQARItrRCCSWD 108
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEECRSPDDVCLT-VVAEVISDSRGSVVYKGCATSpiCPGSHG-YEINLTIAFLKV--SCCQTD 76


                   ....*.
gi 2260108740  109 HCNRAP 114
Cdd:smart00134  77 LCNAAG 82
TFP_LU_ECD_Ly6M cd23552
extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar ...
 27-113 4.45e-03

extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar proteins; Ly-6M is a novel member of the Ly-6 family of hematopoietic proteins. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467082  Cd Length: 80  Bit Score: 34.06  E-value: 4.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260108740  27 PARNLSCFQCFKVrrASLCHPMECQPSEKVCVSNevlLYTSTKSRTQISKRCAITCPNSNDlfewsvknIQARITRRCCS 106
Cdd:cd23552     3 SAQALKCHECKGI--EDCYNPTSCNNQSRYCLTT---WYTPPGEKTTVTKSCAYTCPDAPE--------SLANSKASCCN 69


                  ....*..
gi 2260108740 107 WDHCNRA 113
Cdd:cd23552    70 TDLCNSA 76
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 31-111 6.59e-03

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 33.61  E-value: 6.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2260108740  31 LSCFQCFKVRRASLC----HPMECQPSEKVCVsneVLLYTSTKSRTQISKRCAITCPNSNDLFEWSVKNiQARITRRCCS 106
Cdd:cd00117     1 LKCYQCNSSNDPNCCnsspTLVTCSSPETFCR---KIVGKVGGGETLVIRGCATECECGCTECCSGTGT-SGTTCTSCCD 76


                  ....*
gi 2260108740 107 WDHCN 111
Cdd:cd00117    77 TDLCN 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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