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Conserved domains on  [gi|2274795710|ref|NP_001396678|]
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zinc finger protein 157 isoform 2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-59 4.48e-31

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.84  E-value: 4.48e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2274795710    4 VSFEDVAVDFTWEEWQALDAAQRTLYRDVMLETYSSLVSLGHCMAKPELIFNLEQG 59
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQG 56
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-373 7.56e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 7.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2274795710 199 KSHLTVHQRTHTG-EKPYDCKECRKAFYSKSQLNVHLR--IHTGE--KPYEC--KDCRKAFYRNSDLTVHQRTHTGEKPY 271
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2274795710 272 ECKVCR-------KAFYCNSQLTVHHRTHTGEKPYECQV--CNKAFYCKSQLAVHHRTHTGEKPYQCK--ECRKAFQCRS 340
Cdd:COG5048   353 KEKLLNssskfspLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHY 432

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2274795710 341 DLTRHQRTHTGERPYeCPECRKaFYRKSDLTVH 373
Cdd:COG5048   433 NLIPHKKIHTNHAPL-LCSILK-SFRRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 1.78e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 2274795710 369 DLTVHQRTHTGEKPYECKECRKAFYC 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
398-420 4.61e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.61e-03
                          10        20
                  ....*....|....*....|...
gi 2274795710 398 LTVHQRQHTGEKPYECKDCGKAF 420
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-59 4.48e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.84  E-value: 4.48e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2274795710    4 VSFEDVAVDFTWEEWQALDAAQRTLYRDVMLETYSSLVSLGHCMAKPELIFNLEQG 59
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQG 56
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 5.29e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.99  E-value: 5.29e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2274795710   3 LVSFEDVAVDFTWEEWQALDAAQRTLYRDVMLETYSSLVSLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 2.66e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 80.67  E-value: 2.66e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2274795710   4 VSFEDVAVDFTWEEWQALDAAQRTLYRDVMLETYSSLVSL 43
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-373 7.56e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 7.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2274795710 199 KSHLTVHQRTHTG-EKPYDCKECRKAFYSKSQLNVHLR--IHTGE--KPYEC--KDCRKAFYRNSDLTVHQRTHTGEKPY 271
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2274795710 272 ECKVCR-------KAFYCNSQLTVHHRTHTGEKPYECQV--CNKAFYCKSQLAVHHRTHTGEKPYQCK--ECRKAFQCRS 340
Cdd:COG5048   353 KEKLLNssskfspLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHY 432

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2274795710 341 DLTRHQRTHTGERPYeCPECRKaFYRKSDLTVH 373
Cdd:COG5048   433 NLIPHKKIHTNHAPL-LCSILK-SFRRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 3.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.16e-04
                          10        20
                  ....*....|....*....|....*.
gi 2274795710 341 DLTRHQRTHTGERPYECPECRKAFYR 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 1.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 2274795710 369 DLTVHQRTHTGEKPYECKECRKAFYC 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
398-420 4.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.61e-03
                          10        20
                  ....*....|....*....|...
gi 2274795710 398 LTVHQRQHTGEKPYECKDCGKAF 420
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-59 4.48e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.84  E-value: 4.48e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2274795710    4 VSFEDVAVDFTWEEWQALDAAQRTLYRDVMLETYSSLVSLGHCMAKPELIFNLEQG 59
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQG 56
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 5.29e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.99  E-value: 5.29e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2274795710   3 LVSFEDVAVDFTWEEWQALDAAQRTLYRDVMLETYSSLVSLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 2.66e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 80.67  E-value: 2.66e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2274795710   4 VSFEDVAVDFTWEEWQALDAAQRTLYRDVMLETYSSLVSL 43
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-373 7.56e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 7.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2274795710 199 KSHLTVHQRTHTG-EKPYDCKECRKAFYSKSQLNVHLR--IHTGE--KPYEC--KDCRKAFYRNSDLTVHQRTHTGEKPY 271
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2274795710 272 ECKVCR-------KAFYCNSQLTVHHRTHTGEKPYECQV--CNKAFYCKSQLAVHHRTHTGEKPYQCK--ECRKAFQCRS 340
Cdd:COG5048   353 KEKLLNssskfspLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHY 432

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2274795710 341 DLTRHQRTHTGERPYeCPECRKaFYRKSDLTVH 373
Cdd:COG5048   433 NLIPHKKIHTNHAPL-LCSILK-SFRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-466 5.58e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 5.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2274795710 185 KPHACLECGKSFYCKSHLTVHQRTHTGEKPYDC--KECRKAFYSKSQLNVHLRIHTGEKPYECKDCRKafYRNSDLTVHQ 262
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2274795710 263 RTHTGEKPYECKVCRKAFYCNSQ---LTVHHRTHTGEKPYECQVCNKaFYCKSQLAVHHRtHTGEKPYQCKEcrkAFQCR 339
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHSLPPSSrdpQLPDLLSISNLRNNPLPGNNS-SSVNTPQSNSLH-PPLPANSLSKD---PSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2274795710 340 SDLTRHQRTHTGERPYECPECRKA------------FYRKSDLTVHQRTHTGEKPY---------------ECKECRKAF 392
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLlsqspsslsssdsssSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2274795710 393 YCNSQLTVHQRQHTGE-------KPYECKDCGKAFQCKYELTRHQRT--HTGE--KPYGCRE--CKKAFYTKSDLTRHLK 459
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344


                  ....*..
gi 2274795710 460 THAGDKP 466
Cdd:COG5048   345 LHTSISP 351
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-459 1.20e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2274795710 225 YSKSQLNVHLRIHTGEKPYECKDCRKAFYRNSDLTVHQRTHTGEKPYEC----KVCRKAFYCNSQLTVHHRTHTGEKP-- 298
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttnsQLSPKSLLSQSPSSLSSSDSSSSASes 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2274795710 299 YECQVCNKAFYCKSQLAVHHRTHTG-EKPYQCKECRKAFQCRSDLTRHQRT--HTGE--RPYECPE--CRKAFYRKSDLT 371
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALK 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2274795710 372 VHQRTHTGEKPYECKECR--------------------------KAFYCNSQ-----------LTVHQRQHTGEKPYECK 414
Cdd:COG5048   341 RHILLHTSISPAKEKLLNssskfspllnneppqslqqykdlkndKKSETLSNscirnfkrdsnLSLHIITHLSFRPYNCK 420

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2274795710 415 D--CGKAFQCKYELTRHQRTHTgEKPYGCRECKKAFYTKSDLTRHLK 459
Cdd:COG5048   421 NppCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 3.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.16e-04
                          10        20
                  ....*....|....*....|....*.
gi 2274795710 341 DLTRHQRTHTGERPYECPECRKAFYR 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 211-294 1.30e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2274795710 211 GEKPYDCK--ECRKAFYSKSQLNVHlRIHtgekpyecKDCRKAFYRNSDLTVHQRTHTGEKPYECKVCRKAFYCNSQLTv 288
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK- 415


                  ....*.
gi 2274795710 289 HHRTHT 294
Cdd:COG5189   416 YHRKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 246-378 1.72e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2274795710 246 KDCRKAFYRNSDLTVHQRTHTGEKPyeckvcRKAFYCNSQLTVHHRTH----TGEKPYECQV--CNKAFycKSQLAV-HH 318
Cdd:COG5189   299 KEIRGGISTGEMIDVRKLPCTNSSS------NGKLAHGGERNIDTPSRmlkvKDGKPYKCPVegCNKKY--KNQNGLkYH 370

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2274795710 319 RTHtgekpyqcKECRKAFQCRSDLTRHQRTHTGERPYECPECRKAFYRKSDLTVHqRTHT 378
Cdd:COG5189   371 MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 1.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 2274795710 369 DLTVHQRTHTGEKPYECKECRKAFYC 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-254 2.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.10e-03
                          10        20
                  ....*....|....*....|....*
gi 2274795710 230 LNVHLRIHTGEKPYECKDCRKAFYR 254
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-282 2.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.27e-03
                          10        20
                  ....*....|....*....|....*.
gi 2274795710 257 DLTVHQRTHTGEKPYECKVCRKAFYC 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-224 3.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.54e-03
                          10        20
                  ....*....|....*....|....
gi 2274795710 201 HLTVHQRTHTGEKPYDCKECRKAF 224
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-336 4.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.61e-03
                          10        20
                  ....*....|....*....|...
gi 2274795710 314 LAVHHRTHTGEKPYQCKECRKAF 336
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
398-420 4.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.61e-03
                          10        20
                  ....*....|....*....|...
gi 2274795710 398 LTVHQRQHTGEKPYECKDCGKAF 420
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 355-377 8.96e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.96e-03
                          10        20
                  ....*....|....*....|...
gi 2274795710 355 YECPECRKAFYRKSDLTVHQRTH 377
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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