|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
37-367 |
0e+00 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 590.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 37 VYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 116
Cdd:cd17387 1 VYHAVVVIFLEFFAWGLLTTPMITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 117 PLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATA 196
Cdd:cd17387 81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 197 IALLDICFILVAVPESLPEKMRPASWGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMK 276
Cdd:cd17387 161 VALLDICFILLAVPESLPEKMRPASWGAPISWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 277 FSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSA 356
Cdd:cd17387 241 FEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320
|
330
....*....|.
gi 2277728961 357 LVSRTADADQQ 367
Cdd:cd17387 321 LVSRYADPDQQ 331
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
42-367 |
4.32e-51 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 174.69 E-value: 4.32e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 42 IVIFLEFFAWGLLTAP-TLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMK 120
Cdd:cd17330 3 LVVFLDALGFGIVFPVlPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 121 ISP--WWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIA 198
Cdd:cd17330 83 LSRnlWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 199 LLDICFILVAVPeslpekmrpaswgapisweqadpfaslkkvgqdsIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFS 278
Cdd:cd17330 163 LLNLVLVLFFLP----------------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFS 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 279 PESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSE-PWMMWAAGAVAAMSSITFPAVSAL 357
Cdd:cd17330 209 PSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSvPLLVLAAAILAFGTGIVFPALSAL 288
|
330
....*....|
gi 2277728961 358 VSRTADADQQ 367
Cdd:cd17330 289 LSKSVPSKEQ 298
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
57-367 |
8.60e-36 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 135.07 E-value: 8.60e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 57 PTL---VVLHETFPKHTFlmnGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVIS 131
Cdd:cd17388 23 PTLlreFVGDSADAATHY---GVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPtlWWLYLGRI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 132 VSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGrVYGDSLVVVLATAIALLDICFILVAVPE 211
Cdd:cd17388 100 IAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLG-EISPRAPFLVAAGLNGLNFLLGLFVLPE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 212 SLPEKMRPASwgapiSWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGI 291
Cdd:cd17388 179 SLPPERRRAF-----RWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGL 253
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2277728961 292 LSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQ 367
Cdd:cd17388 254 LHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQ 329
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
72-367 |
7.76e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 98.80 E-value: 7.76e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 72 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLL-TVFFTCAPIPLMKISPWWYFAVISV-SGVF-AVTFSVVFAYVA 148
Cdd:cd17325 31 AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLgLLLLAVSTLLFAFATSYWQLLLARFlQGLAsAAVWPAAMALIA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 149 DITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKmrpaswgAPISW 228
Cdd:cd17325 111 DIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPP-------NKRAV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 229 EQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRsI 308
Cdd:cd17325 184 SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR-I 262
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 309 GNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVA-AMSSITFPAVSALVSRTADADQQ 367
Cdd:cd17325 263 GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLgLGLGLVFPATLALLADIVPPEGR 322
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
41-367 |
1.42e-22 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 97.74 E-value: 1.42e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 41 VIVIFLEFFAWGLLTaPTLVVLHETFPkHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMK 120
Cdd:COG2814 16 ALGAFLSGLGIGIVL-PALPLIAADLG-ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 121 ISP--WWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAI 197
Cdd:COG2814 94 LAPslWLLLAARFLQGLGaGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 198 ALLDICFILVAVPESLPEKMRPASwgapisweqadpfASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKF 277
Cdd:COG2814 174 ALLALLLLLRLLPESRPAARARLR-------------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 278 SPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSA 356
Cdd:COG2814 241 SASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQA 319
|
330
....*....|.
gi 2277728961 357 LVSRTADADQQ 367
Cdd:COG2814 320 LVAELAPPEAR 330
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
75-366 |
1.37e-21 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 94.99 E-value: 1.37e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 75 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--SPWWYFAVISVSGVF-AVTFSVVFAYVADIT 151
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFahSPWLFAIALVLTGFGgGLFEPASEAMIADVT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 152 QEHERSMAYGLVSATFAASLVTSPAIGAYLGrVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPaswgapiswEQA 231
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA---------EKT 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 232 DPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVlSLLMRSIGNK 311
Cdd:cd17329 188 EILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPV-ARLVERFRLR 266
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 2277728961 312 NTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQ 366
Cdd:cd17329 267 KILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLgEMLVFPAVQTLVAALAPPDK 322
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
42-367 |
2.33e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 79.38 E-value: 2.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 42 IVIFLEFFAWGLLTAPTLVVLHETFpKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAP--IPLM 119
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGllLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 120 KISPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIA 198
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 199 LldICFILVAVPESLPEKMRPASWGApISWEQADPFASLKKVGQDSIVLLICITVFLSYLpeagqYSSFFLYLRQIMKFS 278
Cdd:pfam07690 162 L--LAAVLLLLPRPPPESKRPKPAEE-ARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG-----LLTYLPLYQEVLGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 279 PESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQIL---QLAWYGFGSEPWMMWAAGAVAAMS-SITFPAV 354
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGR-LLLGRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGfGLVFPAL 312
|
330
....*....|...
gi 2277728961 355 SALVSRTADADQQ 367
Cdd:pfam07690 313 NALVSDLAPKEER 325
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
40-358 |
3.05e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 79.39 E-value: 3.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 40 AVIVIFLEFFAWGLLTAptLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM 119
Cdd:cd06174 1 LLLGFFLTGLARGLISP--LLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 120 KISP--WWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATA 196
Cdd:cd06174 79 AFAPsfWLLLLGRFLLGLGsGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 197 IALLDICFIL-VAVPESLPEKMRPaswgAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIM 275
Cdd:cd06174 159 AALALLAAILlLLVVPDPPESARA----KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 276 KFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVS 355
Cdd:cd06174 235 GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLS 314
|
...
gi 2277728961 356 ALV 358
Cdd:cd06174 315 FAL 317
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
34-360 |
2.15e-15 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 77.20 E-value: 2.15e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 34 SPSVYHAVIVIFLEFFAWGLLTA---PTLVVLHETFPKHTFLMnGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVF 110
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATAlwgPLIPALKDAFGLSDAQA-GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 111 FTCAPIPLMKISPWWYFAVIS---VSGVFAVTFSVVFAYVADITQEHERSMaYGLVSATFAASLVTSPAIGAYLGRVYGD 187
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLAlflLGLGLGLLDVAANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 188 SLVVVLATAIALLDICFILVAVPESLPEKMRPASwgapiswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSF 267
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEE-------EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 268 FLYLRQIMKFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWM-MWAAGAVAAM 346
Cdd:COG0738 234 PLYLKDVLGLSEATAALGLSLFWGGMTIGR-FLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLaLIGLALVGLG 312
|
330
....*....|....
gi 2277728961 347 SSITFPAVSALVSR 360
Cdd:COG0738 313 LSLMFPTIFSLALD 326
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
42-348 |
7.99e-15 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 74.96 E-value: 7.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 42 IVIFLEFFAWGLLTAptLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI 121
Cdd:cd17390 3 LVGFLDLFGVSMILP--LLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 122 SPWWYFAVIS--VSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIAL 199
Cdd:cd17390 81 STSLALLFLSriPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 200 LdICFILVAVpeslpekMRPASWgapisweqaDPFaslkkvgqdSIVLLICITVFLSylpeagqYSSFFLYLRQIMKFSP 279
Cdd:cd17390 161 I-LNAGLVWF-------LLSKLW---------DLL---------LVRFLMGFSVLLF-------RSNFSLYLEERFDLSP 207
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 280 ESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQI-LQLAWYGFGSEPWMMWAAGAVAAMSS 348
Cdd:cd17390 208 KTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLaLSLLGLALAPSIWLLVLCLTPLSISS 277
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
42-367 |
3.43e-14 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 73.08 E-value: 3.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 42 IVIFLEFFAWGLLTAptlVVLHETFPKHTFLMNGLIQGVKGLLSflsAPLIGALSDVWGRKSFLLLTV--FFTCAPIPLM 119
Cdd:cd17386 6 PIVFLYMFASVLSGP---VTQNFVYAANFYLYMNLMGSIPPLFS---SLFLGSWSDRYGRKPPLLMSLvgLLLSSLILVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 120 K------ISPWWYF---AVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLV 190
Cdd:cd17386 80 IvyfttvPSVWWFYlsaIPLALFGGFTAFLSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 191 VVLATAIALLDICFILVAVpeslpekmrpaswgapisweqadpfaslkkvgqdSIVLLICITVFLSYLPEAGQYSSFFLY 270
Cdd:cd17386 160 FSISAALLLIALLYILFFL----------------------------------TLLILLLLAAFLTIFVLSGESDVLYLF 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 271 LRQIMKFSPESVAAFIAvLGILSIIAQTIVLSLLMRSIGNKN---TILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS 347
Cdd:cd17386 206 VLEKFAWNVKDFSYFST-LGSLIYLTGMLGGVLLLRCLLKMSdstLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFN 284
|
330 340
....*....|....*....|
gi 2277728961 348 SITFPAVSALVSRTADADQQ 367
Cdd:cd17386 285 GIVGPMIRSILSKLVPKSEQ 304
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
73-367 |
4.14e-14 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 73.02 E-value: 4.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 73 MNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--SPWWYFavIS-VSGVFAVTFSVVFAYVAD 149
Cdd:cd17331 36 VFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFasSVPMLF--LSrLPSVFMHAMQAAQMVVTD 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 150 ITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICfILVAVPESLPEKMRPASWGAPISWE 229
Cdd:cd17331 114 LTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIV-LVILLIPSNTKSKREKEAKESASPP 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 230 QADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIG 309
Cdd:cd17331 193 SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFG 272
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 2277728961 310 NKNTILLGLGFQILQLAWYGF-GSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQ 367
Cdd:cd17331 273 ERSLLKLSVALLAIGYLLLAFvTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDT 331
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
75-362 |
4.17e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 72.97 E-value: 4.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 75 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVIS--VSGVF-AVTFSVVFAYVADIT 151
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLAraLAGLAhGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 152 QEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPASwgapisweqa 231
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLG---------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 232 dPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRsIGNK 311
Cdd:cd17324 187 -LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADR-GGRR 264
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 2277728961 312 NTILLGLGFQILQLAWYGFGSEPWMMWAAGAV-AAMSSITFPAVSALVSRTA 362
Cdd:cd17324 265 ALLIALLLLAAALLLLTLLGPSPLLLLVGLVLwGLGFFAAHSALQTRVLRLA 316
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
75-371 |
6.81e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 72.63 E-value: 6.81e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 75 GLIQGVKGLLSFLSAPLIGALSD----VWG-RKSFLL-------LTVFFTCAPIPLMKISPWWYFAVISVsgVFAVTFSV 142
Cdd:COG2211 49 GLILLVARLWDAITDPLIGALSDrtrtRWGrRRPWILigaiplaLSFVLLFTAPDLSPTGKLIYALVTYL--LLGLAYTL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 143 VF----AYVADITQE-HERSMAYGLVS-----ATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLdICFILVAVpeS 212
Cdd:COG2211 127 VNipysALGAELTPDyEERTRLSSWRFafaglGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGL-LAFLLTFF--G 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 213 LPEKMRPASwgapiswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGIL 292
Cdd:COG2211 204 TKERPVPEE-------EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 293 SIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGF--GSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQEF 369
Cdd:COG2211 277 ALLG-APLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIgLGAILVLPWAMLADVVDYDEWKT 355
|
..
gi 2277728961 370 HH 371
Cdd:COG2211 356 GR 357
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
72-223 |
3.24e-13 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 70.38 E-value: 3.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 72 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVIS--VSGVFAVTFSVVFAYVAD 149
Cdd:cd17389 64 LFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSriVGGISKGNVSLSTAIVAD 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 150 ITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVV------LATAIALLDICFILVAVPESLPEKMRPASWG 223
Cdd:cd17389 144 VTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSLGEVFfsmpalFALVLALADLLFIFFFLPETLPSNLRRLGLV 223
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
75-367 |
2.30e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 64.56 E-value: 2.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 75 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLT-------VFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVF-AY 146
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllrallAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARqAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 147 VADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATaialldICFILVAVPESLPEKMRPASWGAPI 226
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA------LSFLLSALLLLFIRRPPPAAPGESS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 227 SWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAqTIVLSLLMR 306
Cdd:cd06173 191 SLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLG-ALLLGRLSK 269
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2277728961 307 SIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITF-PAVSALVSRTADADQQ 367
Cdd:cd06173 270 RRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELR 331
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
42-209 |
6.33e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 63.36 E-value: 6.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 42 IVIFLEFFAWGLLTAPTLVVLHETFpKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI 121
Cdd:cd17325 206 LAIFVLAFAFGALEPFLPLYAAELG-GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 122 SP--WWYFAVISVSGV-FAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIA 198
Cdd:cd17325 285 ATsfWLLLLLLALLGLgLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALL 364
|
170
....*....|.
gi 2277728961 199 LLDICFILVAV 209
Cdd:cd17325 365 LLAAVLFLLLR 375
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
52-366 |
2.21e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 58.74 E-value: 2.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 52 GLLTAPTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLL--LTVFFTCAPIPLMKISPWWYFAV 129
Cdd:cd17473 15 GAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIagLLLYGIGGVAGLFLDSLYALLAS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 130 ISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGR--------VYGDSLVVVLATAIAll 200
Cdd:cd17473 95 RALLGIGvAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEigwrapflVYLLALPVLILVLLF-- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 201 dicfilvavpesLPEKMRPASwgapiswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPE 280
Cdd:cd17473 173 ------------LPEPARKSK-------SAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 281 SVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVS 359
Cdd:cd17473 234 LIGLALAIASLAGAIG-ALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLgFGLLLPTLNSWAM 312
|
....*..
gi 2277728961 360 RTADADQ 366
Cdd:cd17473 313 SLVPPEL 319
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
75-387 |
8.44e-09 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 57.08 E-value: 8.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 75 GLIQGVKGLLSFLSAPLIGALSDVWGRK-----SFLLLTVFFTCApIPLMKISPWWYFAVISVSGVFAVTFSVVF--AYV 147
Cdd:COG2270 55 GYALAIAGLLVALLAPVLGAIADRSGRKkpflaFFTLLGVLATAA-LFFVAPGGLWLGLLLFVLANIGFEGSLVFynAFL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 148 ADITQEHER--------SMAY--GLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKM 217
Cdd:COG2270 134 PDIATPEEIgrvsglgwALGYlgGVLLLLINLALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPGP 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 218 RPASWGAPISWEQAdpFASLKKVGQDSIVL--LICITVFLSYLpeAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSII 295
Cdd:COG2270 214 APPRGAVRAGFREL--RRTLRELRRYRDLLrfLLAYFFYRDGV--QTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAAL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 296 AqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVS-ALVSRTADADQQ-EFhhpw 373
Cdd:COG2270 290 G-ALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSrSLLARLIPPGREaEF---- 364
|
330
....*....|....
gi 2277728961 374 spFPLWSLFGTAGS 387
Cdd:COG2270 365 --FGLYALSGKAAS 376
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
91-357 |
1.53e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 56.04 E-value: 1.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 91 LIGALSDVWGRKSFLL--LTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVV-FAYVADITQEHERSMAYGLVSATF 167
Cdd:cd17320 53 LYGPLSDRFGRRPVLLagLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVaRAIVRDLYSGAELAKIFSLLMMIL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 168 AASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPASWGApisweqadPFASLKKVGQDSIVL 247
Cdd:cd17320 133 AIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSS--------LLRAYKRVLKNRRFL 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 248 LICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQI----- 322
Cdd:cd17320 205 GYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILG-SLLNGRLVRRFGPRRLLRLGLLLLLaaalv 283
|
250 260 270
....*....|....*....|....*....|....*.
gi 2277728961 323 -LQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSAL 357
Cdd:cd17320 284 lLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSL 319
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
75-366 |
3.35e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.91 E-value: 3.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 75 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--SPWWYFAVISVSGV-FAVTFSVVFAYVADIT 151
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLatSVALLLVLRLIHGIgWGAFTTAAATLVADII 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 152 QEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDI--CFILVAVPESLPEKMRPASWGapiswe 229
Cdd:cd17489 114 PPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALllVFLVKDPPPVAAEEAEAGTRA------ 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 230 qadPFASLKKVgqdsiVLLICITVFLSYLPEAGQYSSFFLYLRQImkfSPESVAAFIAVLGILSIIAQTIVLSLLMRsIG 309
Cdd:cd17489 188 ---FRRLVEKK-----VLPPALILFLASIAYGAISTFLPLYAAER---GISNAGLFFTVYAIALLLSRPFSGKLSDR-KG 255
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 2277728961 310 NKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQ 366
Cdd:cd17489 256 PKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQALAVDLVPPHR 313
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
80-360 |
2.65e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 52.27 E-value: 2.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 80 VKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--SPWWYFAVISVSGVF--AVTFSVVFAYVADITQEHE 155
Cdd:cd17355 46 VGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALatSLWQLYLLWGLLGGGgaGTLAAVAFATVAAWWFERR 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 156 RSMAYGLVSATFAASLVTSPAIGAYLGRVYG-DSLVVVLATAIALLDICFILVAVPESLPEKMRPASWGAPisweqADPF 234
Cdd:cd17355 126 RGLALGILTAGGGLGSLVFLPLGAALIEAFGwRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASP-----ASPG 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 235 ASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQImKFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTI 314
Cdd:cd17355 201 STLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR-GISPAAAAVALALIGLFNIVG-RLLSGWLGDRYSPRRLL 278
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2277728961 315 LLGLGFQILQLAWYGFGSEP-WMMWAAGAVAAMSSI-TFPAVSALVSR 360
Cdd:cd17355 279 AASYALRALGLALLLLLPFPpLALLLFAALFGLGWGaTVPLTAALAAR 326
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
75-354 |
3.77e-07 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 51.82 E-value: 3.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 75 GLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCA---PIPLMKISPWWYFAVISVSGVF-AVTFSVVFAYVAD 149
Cdd:cd17335 35 GILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLfflSLFFVAQIFWLLLLLVILGAFFsAPVVPLVDSITLQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 150 ITQEHERSmaYGLV----SATFAAslvTSPAIGAYLGRVYGD-SLVVVLATAIALLDICFILVAvpeslpeKMRPASWGA 224
Cdd:cd17335 115 YLGEERER--YGKQrlwgSIGFGI---AALLVGILIDRSSTYkNYTIAFYVFAVLMLLALLLAL-------KFPFRPKHP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 225 PISWEQADPFASLKKVGqdsiVLLICITVFLSYLPEAGQYSSFFLYLRQIMkfSPESVAAFIAVLGILSIIAQTIVLSLL 304
Cdd:cd17335 183 EPNENTGGLLALLRNPR----VLAFLLVAFLMGFGHGLIYSFLFWHLQDLG--GSKTLIGLLWTVGVVSEIPFFFFSSRL 256
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2277728961 305 MRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMwaaGAVAAMSSITFPAV 354
Cdd:cd17335 257 IQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLV---LPIELLHGLTFALV 303
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
54-309 |
5.50e-07 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 51.06 E-value: 5.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 54 LTAPTLVVLHETFPKHTFLMNGLIQGVKGLL-SFLSAPLiGALSDVWGRKSFLL--LTVFFTCAPIPLMKISPWWYFAVI 130
Cdd:cd17472 14 LVLPVLSVYAKSLPGATPTLIGLALGIYGLTqAIFQIPF-GLLSDRIGRKPVILfgLLLFIAGSLLAAYATSIYGLILGR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 131 SVSGVFAVTfSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVP 210
Cdd:cd17472 93 ALQGSGAIS-SVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 211 ESLPEKMRPASWGapisweqadpfASLKKVGQDSIVLLICITVFLSYLpeagQYSSFFLYLRQIMK------------FS 278
Cdd:cd17472 172 DPPKIVQISEKEK-----------KKLKKLLKNKRLLRLDFSIFILHF----VLMAFFYILPLLLTqlgggkgqlwkvYL 236
|
250 260 270
....*....|....*....|....*....|....*...
gi 2277728961 279 PESVAAFIAVlGILSIIA-------QTIVLSLLMRSIG 309
Cdd:cd17472 237 PAILIGFILM-VPFVIYAekkgkmkQVFVSSILLIAVG 273
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
87-366 |
1.29e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 49.88 E-value: 1.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 87 LSAPLIGALSDVWGRKSFLL--LTVFFTCAPIPLMKISPWWYFAVISVSGV-FAVTFSVVFAYVADITQEHERSMAYGLV 163
Cdd:cd17474 49 VLMPVAGVLADRFGRKKVLLpgLLLFGIGGLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLY 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 164 SATFAASLVTSPAIGAYLGRV--YGDSLVVVLATAIALLDICFILvavpESLPEKMRPASWGAPISWEQADPFASLKKVG 241
Cdd:cd17474 129 EAALGLGIAVGPLLGGLLAAIswRYPFFLLAALIPVAFLAILFLL----PEPKEKAKSSSATKLRDLKKALRGRGLLTFL 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 242 QDSIVLLICITVFLSYLPeagqyssffLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQ 321
Cdd:cd17474 205 VSAFLYFFLYFAFLTYLP---------FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLY 275
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2277728961 322 ILQLAWYGFGSEPWMMWAAGAVAAMSS-ITFPAVSALVSRTADADQ 366
Cdd:cd17474 276 ALSLLLLGFVPSLALLLIAIVLFGLGLgLNLPLLTTLVTELAPEEE 321
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
83-200 |
1.47e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 49.85 E-value: 1.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 83 LLSFLSAPLIGALSDVWGRKSFLLLT-VFFTCAPIPLM-KISPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMA 159
Cdd:cd17370 245 LVYALAAYPAGRLSDRIGRKKLLILGyLSLALAYLGFAlGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTA 324
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 2277728961 160 YGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALL 200
Cdd:cd17370 325 YGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALI 365
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
40-366 |
2.21e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 49.49 E-value: 2.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 40 AVIVIFLEFFAWGLLtAPTLVVLHETFpKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM 119
Cdd:COG2223 10 ATLAFFLAFGVWYLW-SVLAPPLAEEF-GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 120 --KISPWWYFAVISVSGVFA-VTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATA 196
Cdd:COG2223 88 alAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 197 IALLDICFILVAVPEsLPEKMRPASwgapisweqADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMK 276
Cdd:COG2223 168 LLLVVAVLAWLFLRD-PPAGAAAAA---------KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 277 FSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLAW--YGFGSEPWMMWAAGAVAAMSSITFPAV 354
Cdd:COG2223 238 LSAATAGLLAALFALLGALG-RPLGGWLSDRIGGRRVLLIVFALMALGLLLlaLALGSLWLFLVLFLLLGLALGGGNGAV 316
|
330
....*....|..
gi 2277728961 355 SALVSRTADADQ 366
Cdd:COG2223 317 FALVPDIFPTKN 328
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
36-211 |
2.19e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.02 E-value: 2.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 36 SVYHAVIVIFLEFFAWGLLTAPTLVVLHETFpKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAP 115
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVR-GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 116 IPLMKI----SPWWYFAVISVSGVFA-VTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLV 190
Cdd:COG2271 260 LALLLLallpSPALAIALLFLAGFGLgGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|.
gi 2277728961 191 VVLATAIALLDICFILVAVPE 211
Cdd:COG2271 340 FLLLAALALLAALLALLLLRE 360
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
75-209 |
2.20e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.03 E-value: 2.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 75 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLT---VFFTCAPIPLMKISPWWYFAVISVSGVFA-VTFSVVFAYVADI 150
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVfalMALGLLLLALALGSLWLFLVLFLLLGLALgGGNGAVFALVPDI 323
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2277728961 151 TQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGdSLVVVLATAIALLDICFILVAV 209
Cdd:COG2223 324 FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG-SYTAAFLVFAVLALVALVLTLL 381
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
75-362 |
2.85e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.63 E-value: 2.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 75 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--SPWWYFAVISVSGVF-AVTFSVVFAYVADIT 151
Cdd:COG2271 48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFatSFWQLLLLRFLLGLGeAGFFPAALKLIAEWF 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 152 QEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLdicfilvavpeslpekmrpasWGAPISWeqa 231
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLL---------------------LALLRFW--- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 232 dpfaslkkvgqdsivlLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIG-- 309
Cdd:COG2271 184 ----------------LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVG-SLLGGWLSDRLGrr 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2277728961 310 NKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSI-TFPAVSALVSRTA 362
Cdd:COG2271 247 RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGgAFGLLWALAAELF 300
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
87-367 |
4.06e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 45.26 E-value: 4.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 87 LSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVIS--VSGVFAVTFSVVFAYVADITQEHERSMAYGLVS 164
Cdd:cd17504 46 VSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGraLQGIGGAVFPLAFALVREEFPPERVPVAQGILS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 165 ATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLdicfILVAVPESLPEKMRPASWGAPIsweqadpfaslkkvgqdS 244
Cdd:cd17504 126 ATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL----LAALVPLIDLRLLRRRNVLLAN-----------------I 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 245 IVLLICITVFLSY--LPEAGQYSSFFLYLRQIMkfspesVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQI 322
Cdd:cd17504 185 TALLAGFGMFMVFqlLPQLLQLPTPTGFGLGIT------EAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISA 258
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2277728961 323 LQLAWYGF-GSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQ 367
Cdd:cd17504 259 VGLLLLALlHSSLWALVVALLLIGIgLGLAFASLPNIVVESVPPDRT 305
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
75-309 |
5.14e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.80 E-value: 5.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 75 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVISVSGVF-AVTFSVVFAYVADIT 151
Cdd:COG0477 52 GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPspELLIAARALQGIGaGGLMPGALALIAELF 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 152 QEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDIcFILVAVPESLPEKMRPASWGAPISWEQA 231
Cdd:COG0477 132 PARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLAL-VLRLRLPESRGLLLALLALALAALLLAA 210
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2277728961 232 DPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIG 309
Cdd:COG0477 211 LALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLL 288
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
32-167 |
1.00e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.81 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 32 IGSPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFpKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFF 111
Cdd:COG2814 204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL-GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL 282
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2277728961 112 TCAPIPLMKI--SPWWYFAVISVSGV-FAVTFSVVFAYVADITQEHERSMAYGLVSATF 167
Cdd:COG2814 283 LALGLLLLALagSLWLLLLALFLLGFgFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
72-351 |
2.36e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.93 E-value: 2.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 72 LMNGLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPLM-KISPWWYFAVISVSGVFAVTFSVVF-AYVA 148
Cdd:cd17477 31 ALIGLVASAYYLGILLGSPLVPRLIRRVGhIRAFAAGAAITAVSVLLLAlTDSPWVWFLLRFVMGIGLAGLFVVSeSWLN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 149 DITQEHERSMAYGLVSATFAASLVTSPAIGAYLGrVYGDS--LVVVLATAIALLDICFILVAVPESlpekmrpaswgapi 226
Cdd:cd17477 111 ALATNENRGRVLGLYSTVLGLGFALGPLLLALVG-TAGALpfLIAAVLLLLALVPLLLTRRAAPEI-------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 227 swEQADPFASLKKVgqdSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMkFSPESVAAFIAVLGILSIIAQTIVLSLLMR 306
Cdd:cd17477 176 --EEAESISLRRLL---RIAPLALLGAFVAGFLEGAFYSLLPLYGLRLG-LSVAQAALLLAAFVLGGLLLQWPLGWLADR 249
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2277728961 307 SIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITF 351
Cdd:cd17477 250 FDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPL 294
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
91-337 |
2.45e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 2.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 91 LIGALSDVWG-RKSFLLLTVFF---TCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEH---ERSMAYGLV 163
Cdd:cd17471 51 WLGRLSDRGGdRKPLILLALLAgalGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYADRSsgrDATLFNSVL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 164 SATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLdicfILVAVPESLPEKMRPAswgapiswEQADPFASLKKVGQD 243
Cdd:cd17471 131 RAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLV----VALLVLFLLPSVKPPA--------QKATPASSLVKAPVN 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 244 SIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFsPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQIL 323
Cdd:cd17471 199 RRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGG-SESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVL 277
|
250
....*....|....
gi 2277728961 324 QLAWYGFGSEPWMM 337
Cdd:cd17471 278 FYLGLALATSLWQL 291
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
87-366 |
2.55e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 42.98 E-value: 2.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 87 LSAPLIGALSD-------------VWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVF-AYVADITQ 152
Cdd:cd17332 50 INDPLMGYLIDrtrsrwgrfrpwlLWGAIPLALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYtALIPELTD 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 153 E-HERS--MAYGLVSATFAASLVTS--PAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESlpEKMRPASWGAPIS 227
Cdd:cd17332 130 DpEERTslTSWRMFFATIGGLLVTVlpPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGT--RERVVPPEEEKSK 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 228 WEQADPFASLKKvgQDSIVLLICITVFLSYLPEAGQySSFFLYLRQIMKFSPESVAAFIAVLGILSIIaqTIVLSLLMRS 307
Cdd:cd17332 208 LPLLKSLKALLK--NRPFLILLLAYLLYFLAFNIVN-TVLVYYFKYVLGGRAELVLLLLLILSGALLA--LLPWPPLKKR 282
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2277728961 308 IGNKNTILLGLGFQILQLAWYGFGSEP--WMMWAAGAVAAM-SSITFPAVSALVSRTADADQ 366
Cdd:cd17332 283 FGKKKAFFIGLLLAILGLLLLFFLPPGnlVLILVLAVLAGIgYGGANLLPWAMLADVIDYGE 344
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
75-367 |
3.11e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.53 E-value: 3.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 75 GLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPLMKISPWWYFAVISVS------GVFAvtfSVVFAYV 147
Cdd:cd17370 37 GLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRIlerlgkGIRT---PPRDALL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 148 ADITQEHERSMAYGLVSA--TFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESlPEKMRPaswgap 225
Cdd:cd17370 114 ADATPPSGRGKAFGLHRAldTLGAVLGPLLAALLLYLLGGNYRTIFLLAAIPALLALLILLFVVKEY-PRPPKL------ 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 226 iswEQADPFASLKKVGQDSIVLLICITVFlsylpEAGQYS-SFFLYLRQIMKFSPESVAAFIAVLGILSIIAqTIVLSLL 304
Cdd:cd17370 187 ---RKKSKKTSLKKLPKAFWLYLLAVALF-----ALGNFSfAFLILRAQELGLSAALIPLLYALFNLVYALA-AYPAGRL 257
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2277728961 305 MRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQ 367
Cdd:cd17370 258 SDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELR 321
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
32-175 |
3.80e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.02 E-value: 3.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 32 IGSPSVYHAVIVIFLEFFAWGLLTapTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVF- 110
Cdd:pfam07690 197 LLRDPVLWLLLALLLFGFAFFGLL--TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLl 274
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 111 -----FTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSP 175
Cdd:pfam07690 275 lilaaLGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
75-351 |
4.22e-04 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 42.23 E-value: 4.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 75 GLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFF-TCAPIPLMKISP----WWYFAVISV-----SGVFAVTFSVV 143
Cdd:pfam12832 37 GLITAILPLTRILAPPIWGWLADRTGkRKAVVRLASILaAVLFLSVLFIPIsltfWWLALLVVLfsffwNAILPQFEVAT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 144 FAYVADITQEHERSMAYGLVSatFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDicfilVAVPESLPEKMRPASWG 223
Cdd:pfam12832 117 LQHLGEKRKDYGRQRLWGSVG--FALSVFGLGALFDHYSVGLLPSVLFYLFAALMLLS-----LLLPLAPPEMEYESKGG 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 224 apisweqadPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQiMKFSPESVAAFIAVlGILSIIAQTIVLSL 303
Cdd:pfam12832 190 ---------SKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLEN-LGASNTLLGALWAL-GVVAEIPLFFYAHR 258
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2277728961 304 LMRSIGNKNTILLGLGFQILQLAWYGFGSEPWmmWAAGAVAAMSSITF 351
Cdd:pfam12832 259 LLRRFGHRNLLIIALLLTALRWLLYAFFVENP--WLVLPIQFLHAISF 304
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
56-358 |
1.13e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.62 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 56 APTLVVLHETFpKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVISVS 133
Cdd:cd17478 16 PALLPLLIAKL-GLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPnyWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 134 GVFAVTFSVVFAYVADITQEHERSMAYGLVSA-----TFAASLVTSPAIGAYLGRVYgdSLVVVLATAIALLDICFILVA 208
Cdd:cd17478 95 GIGSAAFHPEGARLASQAAGGRRGLAMSIFSVggnlgFALGPLIAAALVALFGGLGL--LILLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 209 VPESLPEKMRPASWGAPisweqadpfaslkKVGQDSIVLLICITVFLSYLPEAGqYSSFF-LYLRQiMKFSPESVAAFIA 287
Cdd:cd17478 173 KKPEAKKAAAKSSARST-------------LKGVWRALLLLLIIVFLRSWVLSS-LTTFLpFYLVQ-RGYSLVFAGLLLS 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2277728961 288 VLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALV 358
Cdd:cd17478 238 LFLFAGAIG-TLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLA 307
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
40-200 |
1.63e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.28 E-value: 1.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 40 AVIVIFLEFFAWGLLT-APTLVVLHETFPKHTFLMNGLIQGvkgLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPL 118
Cdd:cd17316 183 ILLWFFISFGYYGLTTfLPTYLQTVLGLSPATSSLYLLLIS---LGALVGALIAGLLSDRIGRKKTLVIGLILSGILALP 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 119 M----KISPWWYFAVISVSGVFAVTFSVVF-AYVADITQEHERSMAYGLVSAT-FAASLVTSPAIGAYLGRVYGDSLVVV 192
Cdd:cd17316 260 LfyllSGSPTLLLLLLFILSFFVGGVWGALyAYLAELFPTEVRATGVGLSYNLgRLGGGGAPPLIALLLASTGGTGVPAL 339
|
....*...
gi 2277728961 193 LATAIALL 200
Cdd:cd17316 340 ILALLAIV 347
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
75-360 |
2.88e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.56 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 75 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVISVSGVFAVTFSVVFAYVADITQ 152
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTnvWQLLILRLLQGVFSGYVPNATALIASQTP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 153 EHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATaiALLDICFILVAVpeSLPEKMRPASWGAPISWEQAd 232
Cdd:cd17391 119 KEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITG--GLLFLAFLLTLF--FVKEDFKPVEKKKMVSTKEV- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 233 pfasLKKVGQDSIVLLICITVFLSylpeagQYSSFF------LYLRQIMkfSPESVAAFIA-----VLGILSIIAqTIVL 301
Cdd:cd17391 194 ----WNSVPNPSLLISLFVTTFII------QLANQSiepiltLYIRQLM--GDASNLAFISglvfsATGVSSLLS-APRL 260
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 302 SLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPW-MMWAAGAVAAMSSITFPAVSALVSR 360
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWqLGILRFLLGLATGGLLPAINSLLAK 320
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
75-156 |
3.69e-03 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 39.13 E-value: 3.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 75 GLIQGVKGLLSFLSAPLIGALSDVWGRK-----SFLLLTVFFTCApipLMKISP--WWYFAVISVSGVFAVTFSVVF--A 145
Cdd:cd17482 42 GYANSIASLVIALLAPILGAIADYSGRKkrflaFFCLIGVVSTAL---LFFVTPgqWLLALLLFILANIGFSGANVFydA 118
|
90
....*....|.
gi 2277728961 146 YVADITQEHER 156
Cdd:cd17482 119 FLPDVASPERM 129
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
82-200 |
4.61e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 38.82 E-value: 4.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 82 GLLSFLSAPLIGALSDVWGRKSFLLLT-VFFTCAPIPLMKI-----SPWWYFAVISVSGVFAVTFSVVFAYV-ADITQEH 154
Cdd:cd17367 269 LLVFMLLQPLGGRLSDRIGRRPLLLFFgIGGTLATVPLLSAldhtdSPYTAFALVLVGLVFLSGYTSINAVVkAELFPTH 348
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2277728961 155 ER----SMAYGLVSATFAAslvTSPAIGAYLGRVYGDSLVVVLATAIALL 200
Cdd:cd17367 349 VRalgvGLPYALAVAIFGG---TAPYVALWLKSIGHEWVFFWYVAGLIAI 395
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
83-350 |
4.63e-03 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 39.02 E-value: 4.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 83 LLSFLSaPLIGALSDVWGRKSF----------LLLTVFFTCAP--IPLMKISPWW--YFAVISVSGVFAVTFSVV----F 144
Cdd:cd06176 47 LVAPLR-VWIGHRSDTHPLRGYrrtpyiwlgmLLLALGLALAPfaALLLAGAAFWlgLALAVLAFLLYGIGVGAAgtafL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 145 AYVADITQEHERSMAYGLV-SATFAASLVTSPAIGAYLGRVYGDSL--VVVLATAIALLDICFILVAVpeslpEKMRPAS 221
Cdd:cd06176 126 ALLADLTPEERRPRAVTVVwTMLILGIIVTAIVFGRLLDPYSPERLiqVFQIVALVALLLALLALWGV-----ERRRSRA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 222 WGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLpeagqysSFFL-------YLRQIMKFSPESVAAFIAVLGILSI 294
Cdd:cd06176 201 ALAAEEAPPETFREALRLLWASPQARRFFIFLFLSTL-------ALFMqdvilepFGGEVFGMSVGETTRLTAIWGGGTL 273
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2277728961 295 IAQTIVLSLLMRSIGNKNTILLGLGFQILQ---LAWYGFGSEPWM-------------MWAAGAVAAMSSIT 350
Cdd:cd06176 274 LGMLLAGFLLSRRLGKKRTAALGCLLSALGfllLALAGLLGNPWLfrpgvfllglgngLFTVGALTLMMDLT 345
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
75-209 |
4.64e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.12 E-value: 4.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 75 GLIQGVKGLLSFLSAPLIGALSDVWGRK-SFLLLTVFFTCAPIPLMKISP---WWYFAVISVSGVF-AVTFSVVFAYVAD 149
Cdd:COG2211 267 GLLLALYFLAALLGAPLWPRLAKRFGKKkAFIIGLLLAALGLLLLFFLGPgnlWLLLVLAALAGIGlGAILVLPWAMLAD 346
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2277728961 150 ITQEHE-------RSMAYGLVSATFAASLVTSPAIGAYL--------GRVYGDSLVVVLATAIALLDICFILVAV 209
Cdd:COG2211 347 VVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLlalfgyvaGAAQSPSALTGIRLLFFLLPAVLLLLAA 421
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
90-367 |
5.49e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.69 E-value: 5.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 90 PLIGALSDVWGRKSFLL--LTVFFTCAPIPLMKISPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSAT 166
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLigLALFGLASLLCALAPSLAFLIAARALQGIGaAAIMPASLALIAATFPGERRGRALGLWGAV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 167 FAASLVTSPAIGAYLGRVYGDSLVVVLATAIALldICFILVavpeslpekmrPASWGApisweqadpfaslkkvgqdsiv 246
Cdd:cd17321 129 VGIGAALGPLLGGLLLELFGWRWIFLINVPIGL--VALLLA-----------RTFSGA---------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 247 lliCITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLA 326
Cdd:cd17321 174 ---VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVA-APLAGRLADRFGPRLVLVAGLLLTAVGLL 249
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2277728961 327 WYGFGSEPWMMWAAGAVAAMSSI----TFPAVSALVSRTADADQQ 367
Cdd:cd17321 250 LLALLGADSSVWLLLPGLVLLGLglglFATPLTNAALSSVPKEKA 294
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
40-359 |
5.51e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.74 E-value: 5.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 40 AVIVIFLEFFAWGLLTAPTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM 119
Cdd:cd17316 4 AGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 120 KISP--WWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSATFAASLVTSpaigaylgrvygdSLVVVLATA 196
Cdd:cd17316 84 GLLPtpILLLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA-------------ALVASLLIP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 197 IALLD----ICFILVAVPESLPEKMRPASWGAPISWeqadpfaslkkvgqdsIVLLICITVFLSYLPEagqyssfflYLR 272
Cdd:cd17316 151 LLSGDwgwrILFLIGALPALLALLLRRRTLLLILLW----------------FFISFGYYGLTTFLPT---------YLQ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 273 QIMKFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGF---GSEPWMMWAAGAVAAMSSI 349
Cdd:cd17316 206 TVLGLSPATSSLYLLLISLGALVG-ALIAGLLSDRIGRKKTLVIGLILSGILALPLFYllsGSPTLLLLLLFILSFFVGG 284
|
330
....*....|
gi 2277728961 350 TFPAVSALVS 359
Cdd:cd17316 285 VWGALYAYLA 294
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
79-206 |
7.02e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.36 E-value: 7.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 79 GVKGLLSFLSAPLIGALSDVWGRK---SFLLLTVFFTCAPIPLMKISPWWYFAVISVSGV-FAVTFSVVFAYVADITQEH 154
Cdd:cd17353 256 SILSIFNGGGRPFWGWLSDKIGRKntlSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFcYGGGFALFPALTADFFGTK 335
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2277728961 155 ERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFIL 206
Cdd:cd17353 336 NAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALAL 387
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
72-366 |
9.40e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 38.06 E-value: 9.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 72 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPlmkispwwYFAVISVSGVFAVTFSVVFAYVADIt 151
Cdd:pfam13347 72 LLSAIILAVSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIP--------YWSLGPELTRDYDERTSLTSYRSFF- 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 152 qeherSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPASWGAPISWEQa 231
Cdd:pfam13347 143 -----SVGGGLLAAALAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQKEAGSLLDM- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277728961 232 dpfasLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFspESVAAFIAVLGILSIIAQTIVLSLLMRSIGNK 311
Cdd:pfam13347 217 -----LKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGN--GFAASAFPLVFTIGALLGIPLWPPLAKRIGKK 289
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 2277728961 312 NTILLGLGFQI--LQLAWYGFGSEPWMMWAAGAVAAMSSIT-FPAVSALVSRTADADQ 366
Cdd:pfam13347 290 NTYILGALITIagFALALLLGPNNTLLFLVLYIIIGFGYGSsFFLPWSMLADVVDYGE 347
|
|
| |
