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Conserved domains on  [gi|2277652563|ref|NP_001396955|]
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hippocampus abundant transcript 1 protein isoform 14 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 37-314 1.51e-146

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17387:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 410  Bit Score: 419.90  E-value: 1.51e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  37 VYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 116
Cdd:cd17387     1 VYHAVVVIFLEFFAWGLLTTPMITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 117 PLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGL---------------------------------- 162
Cdd:cd17387    81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLvsatfaaslvtspalgaylsesygdnlvvlvati 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563     --------------------------------------------------------------------------------
Cdd:cd17387   161 valldicfillavpeslpekmrpaswgapisweqadpfaslrkvgkdktvllicitvflsylpeagqyssffvylkqvmg 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 163 ---------------------TIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSA 221
Cdd:cd17387   241 feyeevaafiavvgilsitaqTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 222 LVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELKELPITGTDLGTNTSPQhhfEQNSIIPGPPFLFGAC 301
Cdd:cd17387   321 LVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIKPVQSSKQRMQNPS---LEGAIIPGPPFLFGAI 397

                         410
                  ....*....|...
gi 2277652563 302 SVLLALLVALFIP 314
Cdd:cd17387   398 SVLLAILVASFIP 410
 
Name Accession Description Interval E-value
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 37-314 1.51e-146

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 419.90  E-value: 1.51e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  37 VYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 116
Cdd:cd17387     1 VYHAVVVIFLEFFAWGLLTTPMITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 117 PLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGL---------------------------------- 162
Cdd:cd17387    81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLvsatfaaslvtspalgaylsesygdnlvvlvati 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563     --------------------------------------------------------------------------------
Cdd:cd17387   161 valldicfillavpeslpekmrpaswgapisweqadpfaslrkvgkdktvllicitvflsylpeagqyssffvylkqvmg 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 163 ---------------------TIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSA 221
Cdd:cd17387   241 feyeevaafiavvgilsitaqTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 222 LVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELKELPITGTDLGTNTSPQhhfEQNSIIPGPPFLFGAC 301
Cdd:cd17387   321 LVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIKPVQSSKQRMQNPS---LEGAIIPGPPFLFGAI 397

                         410
                  ....*....|...
gi 2277652563 302 SVLLALLVALFIP 314
Cdd:cd17387   398 SVLLAILVASFIP 410
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
34-249 4.85e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 53.82  E-value: 4.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  34 SPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTF-LMNGLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFF 111
Cdd:COG2814    95 APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRgRALGLLGAGLGLGPALGPLLGGLLADLFGwRWVFLVNAVLA 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 112 TCAPIPLMKISP--------------------WWYFAVISVSGVFAVTFSVVFAYVADITQE--HERSMAYGL------- 162
Cdd:COG2814   175 LLALLLLLRLLPesrpaararlrgslrellrrPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvlGLSASAAGLllalfgl 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 163 -----TIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQ 236
Cdd:COG2814   255 ggvlgALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAELAPPEARGRAS 334

                         250
                  ....*....|...
gi 2277652563 237 GMITGIRGLCNGL 249
Cdd:COG2814   335 GLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
32-174 6.46e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 50.49  E-value: 6.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  32 IGSPSVYHAVIVIFLEFFAWGLLTapTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVF- 110
Cdd:pfam07690 197 LLRDPVLWLLLALLLFGFAFFGLL--TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLl 274

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2277652563 111 -----FTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLTIVLSLLMRSIG 174
Cdd:pfam07690 275 lilaaLGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
 
Name Accession Description Interval E-value
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 37-314 1.51e-146

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 419.90  E-value: 1.51e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  37 VYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 116
Cdd:cd17387     1 VYHAVVVIFLEFFAWGLLTTPMITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 117 PLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGL---------------------------------- 162
Cdd:cd17387    81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLvsatfaaslvtspalgaylsesygdnlvvlvati 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563     --------------------------------------------------------------------------------
Cdd:cd17387   161 valldicfillavpeslpekmrpaswgapisweqadpfaslrkvgkdktvllicitvflsylpeagqyssffvylkqvmg 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 163 ---------------------TIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSA 221
Cdd:cd17387   241 feyeevaafiavvgilsitaqTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 222 LVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELKELPITGTDLGTNTSPQhhfEQNSIIPGPPFLFGAC 301
Cdd:cd17387   321 LVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIKPVQSSKQRMQNPS---LEGAIIPGPPFLFGAI 397

                         410
                  ....*....|...
gi 2277652563 302 SVLLALLVALFIP 314
Cdd:cd17387   398 SVLLAILVASFIP 410
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 42-261 4.10e-32

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 123.07  E-value: 4.10e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  42 IVIFLEFFAWGLLTAP-TLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMK 120
Cdd:cd17330     3 LVVFLDALGFGIVFPVlPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 121 ISP--WWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLT----------------------------------- 163
Cdd:cd17330    83 LSRnlWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIIsaafglgfilgpalggflstpygyalpflvaaala 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 164 ------------------------------------------------------------------IVLSLLMRSIGNKN 177
Cdd:cd17330   163 llnlvlvlfflpplrrlllvyflialafaglesvfslflkdrfgfspsqiglllalvgiagilaqlLLIPRLAKRLGERK 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 178 TILLGLGFQILQLAWYGFGSE-PWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGF 256
Cdd:cd17330   243 LLRLGLLLAIIGLLLLPFASSvPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGP 322


                  ....*
gi 2277652563 257 IFYIF 261
Cdd:cd17330   323 LYSFL 327
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 57-261 1.28e-11

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 64.96  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  57 PTL---VVLHETFPKHTFlmnGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVIS 131
Cdd:cd17388    23 PTLlreFVGDSADAATHY---GVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPtlWWLYLGRI 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 132 VSGVFAVTFSVVFAYVADITQEHERSMAYG-------------------------------------------------- 161
Cdd:cd17388   100 IAGITGATGAVAAAYIADVTPPEQRARNFGllgaafglgfiagpalggllgeisprapflvaaglnglnfllglfvlpes 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 162 -------------------------------LTIVLSLLM---------------------------------------- 170
Cdd:cd17388   180 lpperrrafrwrranpfgslrwltgfpgllgLLAVFFLIQligqvpattwvlftedrfdwsptmvglslavfgllhalfq 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 171 --------RSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGI 242
Cdd:cd17388   260 afvtgpiaKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSL 339

                         330
                  ....*....|....*....
gi 2277652563 243 RGLCNGLGPALYGFIFYIF 261
Cdd:cd17388   340 TSLTSIIGPLLFTGIFAAS 358
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 42-163 3.03e-10

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 60.70  E-value: 3.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  42 IVIFLEFFAWGLLTAptLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI 121
Cdd:cd17390     3 LVGFLDLFGVSMILP--LLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2277652563 122 SPWWYFAVIS--VSGVFAVTFSVVFAYVADITQEHERSMAYGLT 163
Cdd:cd17390    81 STSLALLFLSriPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRF 124
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 61-263 3.38e-08

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 54.51  E-value: 3.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  61 VLHETFPKH-TFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKS-----FLLLTVFFTCAP---IPLMKISPWW--YFAV 129
Cdd:cd17504   107 LVREEFPPErVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWifwtaAPVAVLLAALVPlidLRLLRRRNVLlaNITA 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 130 ISVSGVFAVTFSVVFAYVADITqeherSMAYGLTIVLS-------------------LLMRSIGNKNTILLGLGFQILQL 190
Cdd:cd17504   187 LLAGFGMFMVFQLLPQLLQLPT-----PTGFGLGITEAgllllpgalvmliagplagRLIARVGPRRVLLIGLVISAVGL 261

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2277652563 191 AWYGF-GSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHV 263
Cdd:cd17504   262 LLLALlHSSLWALVVALLLIGIgLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTV 336
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
34-249 4.85e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 53.82  E-value: 4.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  34 SPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTF-LMNGLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFF 111
Cdd:COG2814    95 APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRgRALGLLGAGLGLGPALGPLLGGLLADLFGwRWVFLVNAVLA 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 112 TCAPIPLMKISP--------------------WWYFAVISVSGVFAVTFSVVFAYVADITQE--HERSMAYGL------- 162
Cdd:COG2814   175 LLALLLLLRLLPesrpaararlrgslrellrrPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvlGLSASAAGLllalfgl 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 163 -----TIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQ 236
Cdd:COG2814   255 ggvlgALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAELAPPEARGRAS 334

                         250
                  ....*....|...
gi 2277652563 237 GMITGIRGLCNGL 249
Cdd:COG2814   335 GLYNSAFFLGGPL 347
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 40-261 3.44e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 51.66  E-value: 3.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  40 AVIVIFLEFFAWGLLTAptLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM 119
Cdd:cd06174     1 LLLGFFLTGLARGLISP--LLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 120 KISP--WWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLTivlsLLMRSIGnkNTILLGLGFQILQLAWYGFg 196
Cdd:cd06174    79 AFAPsfWLLLLGRFLLGLGsGLIDPAVLALIADLFPERERGRALGLL----QAFGSVG--GILGPLLGGILASSLGFGW- 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2277652563 197 sePWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 261
Cdd:cd06174   152 --RAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFL 214
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 42-157 4.12e-07

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 51.12  E-value: 4.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  42 IVIFLEFFAWGLLTAptlVVLHETFPKHTFLMNGLIQGVKGLLSflsAPLIGALSDVWGRKSFLLLTV--FFTCAPIPLM 119
Cdd:cd17386     6 PIVFLYMFASVLSGP---VTQNFVYAANFYLYMNLMGSIPPLFS---SLFLGSWSDRYGRKPPLLMSLvgLLLSSLILVL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2277652563 120 K------ISPWWYF---AVISVSGVFAVTFSVVFAYVADITQEHERS 157
Cdd:cd17386    80 IvyfttvPSVWWFYlsaIPLALFGGFTAFLSASFAYISDISSEKKRT 126
MFS_1 pfam07690
Major Facilitator Superfamily;
32-174 6.46e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 50.49  E-value: 6.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  32 IGSPSVYHAVIVIFLEFFAWGLLTapTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVF- 110
Cdd:pfam07690 197 LLRDPVLWLLLALLLFGFAFFGLL--TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLl 274

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2277652563 111 -----FTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLTIVLSLLMRSIG 174
Cdd:pfam07690 275 lilaaLGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 42-162 6.81e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 50.65  E-value: 6.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  42 IVIFLEFFAWGLLtAPTLVVLHETFPKHTFLMnGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLL-TVFFTCAPIPLMK 120
Cdd:cd17325     3 LALFLDMLGYGII-IPILPLYAESLGASVAQI-GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLgLLLLAVSTLLFAF 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2277652563 121 ISPWWYFAVISV-SGVF-AVTFSVVFAYVADITQEHERSMAYGL 162
Cdd:cd17325    81 ATSYWQLLLARFlQGLAsAAVWPAAMALIADIAPPEERGRAMGI 124
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 34-262 8.43e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 50.27  E-value: 8.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  34 SPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTF-LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKS-------FL 105
Cdd:cd17325    81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERgRAMGIFSSAIGLGFLIGPLLGGLLADALGYRApflvcaaLA 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 106 LLTVFFTCAPIP--------------------LMKISPWWYFAVISVSGVFAVTFSVVFA----YVADITQ--EHERSMA 159
Cdd:cd17325   161 LLALVLALLLLPeprpppnkravsaarlrsglRLLLRDRRLLALFLAIFVLAFAFGALEPflplYAAELGGlsPAQIGLL 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 160 YGLTIVLSLLMR--------SIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVA-AMSSITFPAVSALVSRTADAD 230
Cdd:cd17325   241 FGAQGLASALSQppagklsdRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLgLGLGLVFPATLALLADIVPPE 320

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2277652563 231 QQGVVQGMITGIRGLCNGLGPALYGFIFYIFH 262
Cdd:cd17325   321 GRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
MFS_1 pfam07690
Major Facilitator Superfamily;
42-162 1.47e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.34  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  42 IVIFLEFFAWGLLTAPTLVVLHETFpKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAP--IPLM 119
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLLLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGllLLLF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2277652563 120 KISPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGL 162
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGL 125
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
41-261 1.65e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 49.20  E-value: 1.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  41 VIVIFLEFFAWGLLTaPTLVVLHETFPkHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMK 120
Cdd:COG2814    16 ALGAFLSGLGIGIVL-PALPLIAADLG-ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 121 ISP--WWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLTIVLSLLMRSIGnkntilLGLGFQILQLAWYgfgs 197
Cdd:COG2814    94 LAPslWLLLAARFLQGLGaGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALG------PLLGGLLADLFGW---- 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2277652563 198 ePWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 261
Cdd:COG2814   164 -RWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFAL 226
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
32-162 1.74e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 49.20  E-value: 1.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  32 IGSPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFpKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFF 111
Cdd:COG2814   204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL-GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL 282

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2277652563 112 TCAPIPLMKI--SPWWYFAVISVSGV-FAVTFSVVFAYVADITQEHERSMAYGL 162
Cdd:COG2814   283 LALGLLLLALagSLWLLLLALFLLGFgFGLLFPLLQALVAELAPPEARGRASGL 336
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
127-262 1.14e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.51  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 127 FAVISVSGVFAVTFSVVFAYVADITQEHERS--------MAYGLTIVLSL-----LMRSIGNKNTILLGLGFQILQLAWY 193
Cdd:COG2814    13 LALALGAFLSGLGIGIVLPALPLIAADLGASpaqaglvvTAYLLGAALGAplagrLADRFGRRRVLLLGLLLFALGSLLC 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 194 GFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFH 262
Cdd:COG2814    93 ALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 75-162 1.82e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 46.07  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  75 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--SPWWYFAVISVSGVF-AVTFSVVFAYVADIT 151
Cdd:cd17329    38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFahSPWLFAIALVLTGFGgGLFEPASEAMIADVT 117

                          90
                  ....*....|.
gi 2277652563 152 QEHERSMAYGL 162
Cdd:cd17329   118 TPENRTRAFSL 128
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
34-262 2.07e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.02  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  34 SPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTF-LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFT 112
Cdd:COG2271    95 ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERgRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 113 CAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAY-VADITQEhERSMAYGLTIVLSLLMRSIG----------NKNTILL 181
Cdd:COG2271   175 LLLALLRFWLLALAYFLVYFALYGFLTWLPTYLVeVRGLSLA-QAGLLLSLPFLAGIVGSLLGgwlsdrlgrrRKLVLAI 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 182 GLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSI-TFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYI 260
Cdd:COG2271   254 GLLLAALALLLLALLPSPALAIALLFLAGFGLGgAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA 333


                  ..
gi 2277652563 261 FH 262
Cdd:COG2271   334 TG 335
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 83-162 3.42e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 45.23  E-value: 3.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  83 LLSFLSAPLIGALSDVWGRKSFLLLT-VFFTCAPIPLM-KISPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMA 159
Cdd:cd17370   245 LVYALAAYPAGRLSDRIGRKKLLILGyLSLALAYLGFAlGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTA 324


                  ...
gi 2277652563 160 YGL 162
Cdd:cd17370   325 YGL 327
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 52-259 3.50e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 45.24  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  52 GLLTAPTLVVLHETFPKH----TFLMNGLIQGVkgllSFLSAPLI-GALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWY 126
Cdd:cd17321    99 AAIMPASLALIAATFPGErrgrALGLWGAVVGI----GAALGPLLgGLLLELFGWRWIFLINVPIGLVALLLARTFSGAV 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 127 FAVISVSGVFAvTFSVVFAYVADITQEHERSMAYGLTIVLSLLM-----------RSIGNKNTILLGLGFQILQLAWYGF 195
Cdd:cd17321   175 LAAFLLGAALG-GLLFLLPLYLQGVLGYSPLQAGLALLPLALAMlvaaplagrlaDRFGPRLVLVAGLLLTAVGLLLLAL 253

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2277652563 196 GSEPWMMWAAGAVAAMSSI----TFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFY 259
Cdd:cd17321   254 LGADSSVWLLLPGLVLLGLglglFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLT 321
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 72-110 3.71e-05

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 45.34  E-value: 3.71e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2277652563  72 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVF 110
Cdd:cd17389    64 LFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMI 102
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
118-257 3.71e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.28  E-value: 3.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 118 LMKISPWWYFAVISVSGVFA--VTFSVVFAYVADITQEHERSMAYGLTI----------VLSLLMRSIGNKNTILLGLGF 185
Cdd:COG2211   224 LLKNRPFLLLLLAYLLFFLAlaLVAALLLYYFKYVLGLSAALVGLLLALyflaallgapLWPRLAKRFGKKKAFIIGLLL 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 186 QILQLAWYGF--GSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQ-------GVVQGMITGIRGLCNGLGPALYG 255
Cdd:COG2211   304 AALGLLLLFFlgPGNLWLLLVLAALAGIgLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAG 383


                  ..
gi 2277652563 256 FI 257
Cdd:COG2211   384 LL 385
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
34-258 4.54e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 44.86  E-value: 4.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  34 SPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVF-- 110
Cdd:COG2807   103 APSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGwRGALAVWALLal 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 111 ----------------FTCAPIPLMKISPW-----WYFAVISvsGVFAVTFSVVFAYVADITQEHERSMAYG-------- 161
Cdd:COG2807   183 lalllwlpllrrrpaaAAAAPAAASLRSLWrsplaWLLTLFF--GLQSLLYYAVVAWLPPILRDAGLSAATAglllslfq 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 162 -----LTIVLSLLMRSIGNKNTILLGLG-FQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVS-RTADADQQGV 234
Cdd:COG2807   261 lagipGSLLVPLLADRLGDRRPLLLLLGlLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGlRARTPAEAAA 340

                         250       260
                  ....*....|....*....|....
gi 2277652563 235 VQGMITGIRGLCNGLGPALYGFIF 258
Cdd:COG2807   341 LSGMAQSVGYLLAALGPLLVGALH 364
MFS_YxiO_like cd17482
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ...
 75-195 4.97e-05

Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341035 [Multi-domain]  Cd Length: 362  Bit Score: 44.90  E-value: 4.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  75 GLIQGVKGLLSFLSAPLIGALSDVWGRK-----SFLLLTVFFTCApipLMKISP--WWYFAVISVSGVFAVTFSVVF--A 145
Cdd:cd17482    42 GYANSIASLVIALLAPILGAIADYSGRKkrflaFFCLIGVVSTAL---LFFVTPgqWLLALLLFILANIGFSGANVFydA 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2277652563 146 YVADITQEHER--------SMAY---GLTIVLSLLM----RSIGNKNTILLGLGFQILQLAWYGF 195
Cdd:cd17482   119 FLPDVASPERMdrvsslgyALGYiggGLLFAVNLVLilgpDAFGLDTAEAVRLSFLSVALWWALF 183
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
34-158 8.52e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.07  E-value: 8.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  34 SPSVYHAVIVIFLEFFAWGLLTA---PTLVVLHETFPKHTFLMnGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVF 110
Cdd:COG0738     3 KKNYRRALIAIYLLFFLWGFATAlwgPLIPALKDAFGLSDAQA-GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2277652563 111 FTCAPIPLMKISPWWYFAVIS--VSGV-FAVTFSVVFAYVADITQEHERSM 158
Cdd:COG0738    82 LMALGLLLFALAPSYPLLLLAlfLLGLgLGLLDVAANPYVAALGPETAASR 132
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 32-262 8.89e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 43.95  E-value: 8.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  32 IGSPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTFlmngliQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFF 111
Cdd:cd06174   139 LGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPE------SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAI 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 112 TCAPIPLMKISPWW--YFAVISVSGVFAVTFSVVFAYVADITqehersmayGLTIVLSLLMRSIGNKNTILLGLGFQILQ 189
Cdd:cd06174   213 FLVNLAYYSFSTLLplFLLDLGGLSVAVAGLLLSLFGLAGAL---------GSLLLGLLSDRLIGRKPLLLIGLLLMALG 283

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2277652563 190 LAWYGFGSEPWMMWAAGA-VAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFH 262
Cdd:cd06174   284 LALLLLAPSLLLLLLLLLlLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
MFS_1 pfam07690
Major Facilitator Superfamily;
34-251 1.94e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.79  E-value: 1.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  34 SPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTF-LMNGLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFF 111
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERgRALGLVSAGFGLGAALGPLLGGLLASLFGwRAAFLILAILS 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 112 TCAPIPLM-----------------------------KISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAY-- 160
Cdd:pfam07690 162 LLAAVLLLlprpppeskrpkpaeearlslivawkallRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLll 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 161 --------GLTIVLSLLMRSIGNKNTILLGLGFQIL---QLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTAD 228
Cdd:pfam07690 242 glggllgaIGRLLLGRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGfGLVFPALNALVSDLAP 321

                         250       260
                  ....*....|....*....|...
gi 2277652563 229 ADQQGVVQGMITGIRGLCNGLGP 251
Cdd:pfam07690 322 KEERGTASGLYNTAGSLGGALGP 344
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
75-224 2.23e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.97  E-value: 2.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  75 GLIQGVKGLLSFLSAPLIGALSDVWGRK-SFLLLTVFFTCAPIPLMKISP---WWYFAVISVSGVF-AVTFSVVFAYVAD 149
Cdd:COG2211   267 GLLLALYFLAALLGAPLWPRLAKRFGKKkAFIIGLLLAALGLLLLFFLGPgnlWLLLVLAALAGIGlGAILVLPWAMLAD 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 150 ITQEHE-------RSMAYGLTIVLSLLMRSIGNkntillGLGFQILQLAWYGFGSEPwmmwAAGAVAAMSSITF--PAVS 220
Cdd:COG2211   347 VVDYDEwktgrrrEGLYFGIFTFAIKLGQALAG------ALAGLLLALFGYVAGAAQ----SPSALTGIRLLFFllPAVL 416


                  ....
gi 2277652563 221 ALVS 224
Cdd:COG2211   417 LLLA 420
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 36-162 2.26e-04

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 42.83  E-value: 2.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  36 SVYHAVIVIFL------EFFAWGLLTAPTLVVlhetfpkhtflmnGLIQGVKGLLSFLSAPLIGALSDVWGRK-----SF 104
Cdd:COG2270    23 SAFSTVITTFVfppyftSVAALGDPAAATALW-------------GYALAIAGLLVALLAPVLGAIADRSGRKkpflaFF 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 105 LLLTVFFTCApIPLMKISPWWYFAVISVSGVFAVTFSVVF--AYVADITQEHERSMAYGL 162
Cdd:COG2270    90 TLLGVLATAA-LFFVAPGGLWLGLLLFVLANIGFEGSLVFynAFLPDIATPEEIGRVSGL 148
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 118-258 2.52e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 42.59  E-value: 2.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 118 LMKISPWWYFAVISV--SGVFAVTFSVVFAYVADITQEHERSMAYGLTIVLSLLM---------RSIGNKNTILLGLGFQ 186
Cdd:cd17332   217 LLKNRPFLILLLAYLlyFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLallpwpplkKRFGKKKAFFIGLLLA 296

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2277652563 187 ILQLAWYGFGSEP--WMMWAAGAVAAM-SSITFPAVSALVSRTADADQ--QGV-VQGMITGIRGLCNGLGPALYGFIF 258
Cdd:cd17332   297 ILGLLLLFFLPPGnlVLILVLAVLAGIgYGGANLLPWAMLADVIDYGElkTGKrREGIFYSVMTFFRKLGLALAGALV 374
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
75-216 7.00e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.43  E-value: 7.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  75 GLIQGVKGLLSFLSAPLIGALSD----VWG-RKSFLL-------LTVFFTCAPIPLMKISPWWYFAVISVsgVFAVTFSV 142
Cdd:COG2211    49 GLILLVARLWDAITDPLIGALSDrtrtRWGrRRPWILigaiplaLSFVLLFTAPDLSPTGKLIYALVTYL--LLGLAYTL 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2277652563 143 VF----AYVADITQE-HERSMAYGLTIVLSLLMrsignknTILLGLGFQILqLAWYGFGSEPWMMWAAGAVAAMSSITF 216
Cdd:COG2211   127 VNipysALGAELTPDyEERTRLSSWRFAFAGLG-------GLLASVLPPPL-VAAFGGDAALGYRLTALIFAVLGLLAF 197
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 75-164 7.25e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.00  E-value: 7.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  75 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVIS--VSGVF-AVTFSVVFAYVADIT 151
Cdd:cd17324    37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLAraLAGLAhGGFWAIAAAYAADLV 116

                          90
                  ....*....|...
gi 2277652563 152 QEHERSMAYGLTI 164
Cdd:cd17324   117 PPEKRGRAIGLVF 129
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 29-262 7.49e-04

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 41.29  E-value: 7.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  29 PQGIGSPSVYHAVIVIFLefFA---WGLLTAPTLVVLHETFPKHT-FLMNGLIQGVKGLlsflsaplIGALSDVWGRKS- 103
Cdd:COG2270   171 PEAFGLPDAGEAVRISFL--LTalwWLLFALPLFLFLPERPRPGPaPPRGAVRAGFREL--------RRTLRELRRYRDl 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 104 --FLLLTVFFTCApiplmkispwwYFAVISVSGVFAVT---FS----VVFAYVADITqehersmAYGLTIVLSLLMRSIG 174
Cdd:COG2270   241 lrFLLAYFFYRDG-----------VQTVIAFAGIYAAGvlgFSttelIVFGLLVQIV-------AALGALLFGRLDDRIG 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 175 NKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVS-ALVSRTADADQQGV------VQGMITGIrglcn 247
Cdd:COG2270   303 PKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSrSLLARLIPPGREAEffglyaLSGKAASF----- 377

                         250
                  ....*....|....*
gi 2277652563 248 gLGPALYGFIFYIFH 262
Cdd:COG2270   378 -LGPLLFGLVTQLTG 391
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 129-261 7.98e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.02  E-value: 7.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 129 VISVSGVFAVTFSVVFAYVADItqehersmaygltivlsllmrsIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAV 208
Cdd:cd17325    36 IVAAYALAQLLFSPPAGRLSDR----------------------FGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFL 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2277652563 209 A-AMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 261
Cdd:cd17325    94 QgLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL 147
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 75-214 1.62e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.88  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  75 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--SPWWYFAVISVSGV-FAVTFSVVFAYVADIT 151
Cdd:cd17489    34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLatSVALLLVLRLIHGIgWGAFTTAAATLVADII 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2277652563 152 QEHERSMA---YGLTIVLSLlmrsignkntiLLGLGFQILQLAWYGFgsePWMMWAAGAVAAMSSI 214
Cdd:cd17489   114 PPSRRGEGigyYGLATTLAM-----------ALGPALGLFLYQHLGF---AVLFIVAAVLALLALL 165
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 169-257 2.40e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 39.49  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 169 LMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMwaaGAVAAMSSITFPAV----SALVSRTADADQQGVVQGMITgirG 244
Cdd:cd17335   256 LIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLV---LPIELLHGLTFALVwaaaVSYASAAAPPGLRATAQGLLQ---G 329

                          90
                  ....*....|...
gi 2277652563 245 LCNGLGPALYGFI 257
Cdd:cd17335   330 LYFGLGGGLGSLI 342
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 40-216 3.31e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.12  E-value: 3.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  40 AVIVIFLEFFAWGLLT-APTLVVLHETFPKHTFLMNGLIQGvkgLLSFLSAPLIGALSDVWGRKSFLLLT-VFFTCAPIP 117
Cdd:cd17316   183 ILLWFFISFGYYGLTTfLPTYLQTVLGLSPATSSLYLLLIS---LGALVGALIAGLLSDRIGRKKTLVIGlILSGILALP 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 118 LMKI---SPWWYFAVISVSGVFAVTFSVVF-AYVADITQEHERSMAYGLTIVLSllmRSIGNKNTILLGlgfqilQLAWY 193
Cdd:cd17316   260 LFYLlsgSPTLLLLLLFILSFFVGGVWGALyAYLAELFPTEVRATGVGLSYNLG---RLGGGGAPPLIA------LLLAS 330

                         170       180
                  ....*....|....*....|...
gi 2277652563 194 GFGSEPWMMWAAGAVAAMSSITF 216
Cdd:cd17316   331 TGGTGVPALILALLAIVALIVAL 353
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 82-216 6.06e-03

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 38.43  E-value: 6.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  82 GLLSFLSAPLIGALSDVWGRKSFLLLT-VFFTCAPIPLMKI-----SPWWYFAVISVSGVFAVTFSVVFAYV-ADITQEH 154
Cdd:cd17367   269 LLVFMLLQPLGGRLSDRIGRRPLLLFFgIGGTLATVPLLSAldhtdSPYTAFALVLVGLVFLSGYTSINAVVkAELFPTH 348

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2277652563 155 ER----SMAYGLTIVlsllmrsignkntiLLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITF 216
Cdd:cd17367   349 VRalgvGLPYALAVA--------------IFGGTAPYVALWLKSIGHEWVFFWYVAGLIAISLVVY 400
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 56-135 8.15e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 37.92  E-value: 8.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563  56 APTLVVLHETFpKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVISVS 133
Cdd:cd17478    16 PALLPLLIAKL-GLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPnyWLLLLLVALA 94


                  ..
gi 2277652563 134 GV 135
Cdd:cd17478    95 GI 96
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 104-261 8.93e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 37.55  E-value: 8.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 104 FLLLTVFFTCAPIPL---MKISPWWYFAVISVSGVFAVTFSVVFAYvaditqehersmaygltivlsLLMRSIGNKNTIL 180
Cdd:cd17474   211 FFLYFAFLTYLPFLLellYGISPIIIGLLFAGWSVLLALGSLFVGR---------------------LLKKRFGARRILV 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277652563 181 LGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSS-ITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFY 259
Cdd:cd17474   270 IGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLgLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLE 349


                  ..
gi 2277652563 260 IF 261
Cdd:cd17474   350 IF 351
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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