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Conserved domains on  [gi|2277651424|ref|NP_001396956|]
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hippocampus abundant transcript 1 protein isoform 15 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 37-313 6.41e-145

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17387:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 410  Bit Score: 415.66  E-value: 6.41e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  37 VYHAVIVIFLEFFAWGLLTAPTL-VLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 115
Cdd:cd17387     1 VYHAVVVIFLEFFAWGLLTTPMItVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 116 PLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGL---------------------------------- 161
Cdd:cd17387    81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLvsatfaaslvtspalgaylsesygdnlvvlvati 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424     --------------------------------------------------------------------------------
Cdd:cd17387   161 valldicfillavpeslpekmrpaswgapisweqadpfaslrkvgkdktvllicitvflsylpeagqyssffvylkqvmg 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 162 ---------------------TIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSA 220
Cdd:cd17387   241 feyeevaafiavvgilsitaqTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 221 LVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELKELPITGTDLGTNTSPQhhfEQNSIIPGPPFLFGAC 300
Cdd:cd17387   321 LVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIKPVQSSKQRMQNPS---LEGAIIPGPPFLFGAI 397

                         410
                  ....*....|...
gi 2277651424 301 SVLLALLVALFIP 313
Cdd:cd17387   398 SVLLAILVASFIP 410
 
Name Accession Description Interval E-value
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 37-313 6.41e-145

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 415.66  E-value: 6.41e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  37 VYHAVIVIFLEFFAWGLLTAPTL-VLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 115
Cdd:cd17387     1 VYHAVVVIFLEFFAWGLLTTPMItVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 116 PLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGL---------------------------------- 161
Cdd:cd17387    81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLvsatfaaslvtspalgaylsesygdnlvvlvati 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424     --------------------------------------------------------------------------------
Cdd:cd17387   161 valldicfillavpeslpekmrpaswgapisweqadpfaslrkvgkdktvllicitvflsylpeagqyssffvylkqvmg 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 162 ---------------------TIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSA 220
Cdd:cd17387   241 feyeevaafiavvgilsitaqTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 221 LVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELKELPITGTDLGTNTSPQhhfEQNSIIPGPPFLFGAC 300
Cdd:cd17387   321 LVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIKPVQSSKQRMQNPS---LEGAIIPGPPFLFGAI 397

                         410
                  ....*....|...
gi 2277651424 301 SVLLALLVALFIP 313
Cdd:cd17387   398 SVLLAILVASFIP 410
MFS_1 pfam07690
Major Facilitator Superfamily;
32-173 1.73e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.42  E-value: 1.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  32 IGSPSVYHAVIVIFLEFFAWGLLTAPTLVLHETFpKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVF-- 109
Cdd:pfam07690 197 LLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLll 275

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2277651424 110 ----FTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLTIVLSLLMRSIG 173
Cdd:pfam07690 276 ilaaLGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
88-248 7.54e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 50.36  E-value: 7.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  88 APLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVAditqeherSMAYGLTIVLSL 167
Cdd:COG2814   194 ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFG--------LGGVLGALLAGR 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 168 LMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQGMITGIRGLCN 246
Cdd:COG2814   266 LADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345


                  ..
gi 2277651424 247 GL 248
Cdd:COG2814   346 PL 347
 
Name Accession Description Interval E-value
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 37-313 6.41e-145

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 415.66  E-value: 6.41e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  37 VYHAVIVIFLEFFAWGLLTAPTL-VLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 115
Cdd:cd17387     1 VYHAVVVIFLEFFAWGLLTTPMItVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 116 PLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGL---------------------------------- 161
Cdd:cd17387    81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLvsatfaaslvtspalgaylsesygdnlvvlvati 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424     --------------------------------------------------------------------------------
Cdd:cd17387   161 valldicfillavpeslpekmrpaswgapisweqadpfaslrkvgkdktvllicitvflsylpeagqyssffvylkqvmg 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 162 ---------------------TIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSA 220
Cdd:cd17387   241 feyeevaafiavvgilsitaqTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 221 LVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELKELPITGTDLGTNTSPQhhfEQNSIIPGPPFLFGAC 300
Cdd:cd17387   321 LVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIKPVQSSKQRMQNPS---LEGAIIPGPPFLFGAI 397

                         410
                  ....*....|...
gi 2277651424 301 SVLLALLVALFIP 313
Cdd:cd17387   398 SVLLAILVASFIP 410
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 42-260 6.27e-33

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 125.38  E-value: 6.27e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  42 IVIFLEFFAWGLLTA--PTLVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMK 119
Cdd:cd17330     3 LVVFLDALGFGIVFPvlPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 120 ISP--WWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLT----------------------------------- 162
Cdd:cd17330    83 LSRnlWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIIsaafglgfilgpalggflstpygyalpflvaaala 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 163 ------------------------------------------------------------------IVLSLLMRSIGNKN 176
Cdd:cd17330   163 llnlvlvlfflpplrrlllvyflialafaglesvfslflkdrfgfspsqiglllalvgiagilaqlLLIPRLAKRLGERK 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 177 TILLGLGFQILQLAWYGFGSE-PWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGF 255
Cdd:cd17330   243 LLRLGLLLAIIGLLLLPFASSvPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGP 322


                  ....*
gi 2277651424 256 IFYIF 260
Cdd:cd17330   323 LYSFL 327
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 157-260 1.33e-11

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 64.96  E-value: 1.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 157 MAYGLT------IVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQ 230
Cdd:cd17388   249 AVFGLLhalfqaFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENE 328

                          90       100       110
                  ....*....|....*....|....*....|
gi 2277651424 231 QGVVQGMITGIRGLCNGLGPALYGFIFYIF 260
Cdd:cd17388   329 QGELQGVLTSLTSLTSIIGPLLFTGIFAAS 358
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 42-162 4.64e-11

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 63.40  E-value: 4.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  42 IVIFLEFFAWGLLTaPTLVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKIS 121
Cdd:cd17390     3 LVGFLDLFGVSMIL-PLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFS 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2277651424 122 PWWYFAVIS--VSGVFAVTFSVVFAYVADITQEHERSMAYGLT 162
Cdd:cd17390    82 TSLALLFLSriPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRF 124
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 60-262 2.83e-08

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 54.89  E-value: 2.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  60 VLHETFPKH-TFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKS-----FLLLTVFFTCAP---IPLMKISPWW--YFAV 128
Cdd:cd17504   107 LVREEFPPErVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWifwtaAPVAVLLAALVPlidLRLLRRRNVLlaNITA 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 129 ISVSGVFAVTFSVVFAYVADITqeherSMAYGLTIVLS-------------------LLMRSIGNKNTILLGLGFQILQL 189
Cdd:cd17504   187 LLAGFGMFMVFQLLPQLLQLPT-----PTGFGLGITEAgllllpgalvmliagplagRLIARVGPRRVLLIGLVISAVGL 261

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2277651424 190 AWYGF-GSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHV 262
Cdd:cd17504   262 LLLALlHSSLWALVVALLLIGIgLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTV 336
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 40-260 6.88e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 53.58  E-value: 6.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  40 AVIVIFLEFFAWGLLTaPTLVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMK 119
Cdd:cd06174     1 LLLGFFLTGLARGLIS-PLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 120 ISP--WWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLTivlsLLMRSIGnkNTILLGLGFQILQLAWYGFgs 196
Cdd:cd06174    80 FAPsfWLLLLGRFLLGLGsGLIDPAVLALIADLFPERERGRALGLL----QAFGSVG--GILGPLLGGILASSLGFGW-- 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2277651424 197 ePWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 260
Cdd:cd06174   152 -RAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFL 214
MFS_1 pfam07690
Major Facilitator Superfamily;
32-173 1.73e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.42  E-value: 1.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  32 IGSPSVYHAVIVIFLEFFAWGLLTAPTLVLHETFpKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVF-- 109
Cdd:pfam07690 197 LLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLll 275

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2277651424 110 ----FTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLTIVLSLLMRSIG 173
Cdd:pfam07690 276 ilaaLGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 42-156 3.49e-07

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 51.51  E-value: 3.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  42 IVIFLEFFAWGLLTapTLVLHETFPKHTFLMNGLIQGVKGLLSflsAPLIGALSDVWGRKSFLLLTV--FFTCAPIPLMK 119
Cdd:cd17386     6 PIVFLYMFASVLSG--PVTQNFVYAANFYLYMNLMGSIPPLFS---SLFLGSWSDRYGRKPPLLMSLvgLLLSSLILVLI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2277651424 120 ------ISPWWYF---AVISVSGVFAVTFSVVFAYVADITQEHERS 156
Cdd:cd17386    81 vyfttvPSVWWFYlsaIPLALFGGFTAFLSASFAYISDISSEKKRT 126
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 71-161 7.20e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 50.65  E-value: 7.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  71 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLL-TVFFTCAPIPLMKISPWWYFAVISV-SGVF-AVTFSVVFAYVA 147
Cdd:cd17325    31 AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLgLLLLAVSTLLFAFATSYWQLLLARFlQGLAsAAVWPAAMALIA 110

                          90
                  ....*....|....
gi 2277651424 148 DITQEHERSMAYGL 161
Cdd:cd17325   111 DIAPPEERGRAMGI 124
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
88-248 7.54e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 50.36  E-value: 7.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  88 APLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVAditqeherSMAYGLTIVLSL 167
Cdd:COG2814   194 ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFG--------LGGVLGALLAGR 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 168 LMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQGMITGIRGLCN 246
Cdd:COG2814   266 LADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345


                  ..
gi 2277651424 247 GL 248
Cdd:COG2814   346 PL 347
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
32-161 3.85e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 48.05  E-value: 3.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  32 IGSPSVYHAVIVIFLEFFAWGLLTAPTLVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFT 111
Cdd:COG2814   204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2277651424 112 CAPIPLMKI--SPWWYFAVISVSGV-FAVTFSVVFAYVADITQEHERSMAYGL 161
Cdd:COG2814   284 ALGLLLLALagSLWLLLLALFLLGFgFGLLFPLLQALVAELAPPEARGRASGL 336
MFS_1 pfam07690
Major Facilitator Superfamily;
42-213 4.69e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.80  E-value: 4.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  42 IVIFLEFFAWGLL--TAPTLVLHETfpKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAP--IPL 117
Cdd:pfam07690   3 LAAFLAALGRSLLgpALPLLLAEDL--GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGllLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 118 MKISPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGltivLSLLMRSIGnkntILLGLGFQILQLAWYGFgs 196
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALG----LVSAGFGLG----AALGPLLGGLLASLFGW-- 150

                         170
                  ....*....|....*..
gi 2277651424 197 ePWMMWAAGAVAAMSSI 213
Cdd:pfam07690 151 -RAAFLILAILSLLAAV 166
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 117-261 4.78e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.96  E-value: 4.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 117 LMKISPWWYFAVISVSGVFAVTFSVVFAYVADitqehersmaygltivlsllmrSIGNKNTILLGLGFQILQLAWYGFGS 196
Cdd:cd17325   229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSD----------------------RIGRKPLILIGLLLSAVALLLLPLAT 286

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2277651424 197 EPWMMWAAGAVA-AMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFH 261
Cdd:cd17325   287 SFWLLLLLLALLgLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 18-161 7.91e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 47.15  E-value: 7.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  18 AKKIIIKDGGTPQGIGSPSVYHAVIVIFLefFAWGLLTAPTLVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDV 97
Cdd:cd17370   183 PPKLRKKSKKTSLKKLPKAFWLYLLAVAL--FALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDR 260

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2277651424  98 WGRKSFLLLT-VFFTCAPIPLM-KISPWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGL 161
Cdd:cd17370   261 IGRKKLLILGyLSLALAYLGFAlGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGL 327
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 32-261 9.02e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.04  E-value: 9.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  32 IGSPSVYHAVIVIFLEFFAWGLLTAPTLVLHETFPKHTflmngLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFT 111
Cdd:cd06174   139 LGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDP-----PESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIF 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 112 CAPIPLMKISPWW--YFAVISVSGVFAVTFSVVFAYVADITqehersmayGLTIVLSLLMRSIGNKNTILLGLGFQILQL 189
Cdd:cd06174   214 LVNLAYYSFSTLLplFLLDLGGLSVAVAGLLLSLFGLAGAL---------GSLLLGLLSDRLIGRKPLLLIGLLLMALGL 284

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2277651424 190 AWYGFGSEPWMMWAAGA-VAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFH 261
Cdd:cd06174   285 ALLLLAPSLLLLLLLLLlLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
126-261 1.06e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.89  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 126 FAVISVSGVFAVTFSVVFAYVADITQEHERS--------MAYGLTIVLSL-----LMRSIGNKNTILLGLGFQILQLAWY 192
Cdd:COG2814    13 LALALGAFLSGLGIGIVLPALPLIAADLGASpaqaglvvTAYLLGAALGAplagrLADRFGRRRVLLLGLLLFALGSLLC 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 193 GFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFH 261
Cdd:COG2814    93 ALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
74-260 1.23e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.51  E-value: 1.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  74 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVISVSGVF-AVTFSVVFAYVADIT 150
Cdd:COG2814    48 GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPslWLLLAARFLQGLGaGALFPAALALIADLV 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 151 QEHERSMAYGLTIVLSLLMRSIGnkntilLGLGFQILQLAWYgfgsePWMMWAAGAVAAMSSITFPAVSALVSRTADADQ 230
Cdd:COG2814   128 PPERRGRALGLLGAGLGLGPALG------PLLGGLLADLFGW-----RWVFLVNAVLALLALLLLLRLLPESRPAARARL 196

                         170       180       190
                  ....*....|....*....|....*....|
gi 2277651424 231 QGVVQGMITGIRGLCNGLGPALYGFIFYIF 260
Cdd:COG2814   197 RGSLRELLRRPRLLLLLLLAFLLGFGFFAL 226
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 74-161 1.77e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 46.07  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  74 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--SPWWYFAVISVSGVF-AVTFSVVFAYVADIT 150
Cdd:cd17329    38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFahSPWLFAIALVLTGFGgGLFEPASEAMIADVT 117

                          90
                  ....*....|.
gi 2277651424 151 QEHERSMAYGL 161
Cdd:cd17329   118 TPENRTRAFSL 128
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
117-256 3.50e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.28  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 117 LMKISPWWYFAVISVSGVFA--VTFSVVFAYVADITQEHERSMAYGLTI----------VLSLLMRSIGNKNTILLGLGF 184
Cdd:COG2211   224 LLKNRPFLLLLLAYLLFFLAlaLVAALLLYYFKYVLGLSAALVGLLLALyflaallgapLWPRLAKRFGKKKAFIIGLLL 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 185 QILQLAWYGF--GSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQ-------GVVQGMITGIRGLCNGLGPALYG 254
Cdd:COG2211   304 AALGLLLLFFlgPGNLWLLLVLAALAGIgLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAG 383


                  ..
gi 2277651424 255 FI 256
Cdd:COG2211   384 LL 385
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 71-158 3.62e-05

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 45.34  E-value: 3.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  71 LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVIS--VSGVFAVTFSVVFAYVAD 148
Cdd:cd17389    64 LFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSriVGGISKGNVSLSTAIVAD 143

                          90
                  ....*....|..
gi 2277651424 149 ITQEHERS--MA 158
Cdd:cd17389   144 VTSPKKRSkgMA 155
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 36-161 4.87e-05

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 44.76  E-value: 4.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  36 SVYHAVIVIFL------EFFAWGLLTAPTLVLhetfpkhtflmnGLIQGVKGLLSFLSAPLIGALSDVWGRK-----SFL 104
Cdd:COG2270    23 SAFSTVITTFVfppyftSVAALGDPAAATALW------------GYALAIAGLLVALLAPVLGAIADRSGRKkpflaFFT 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2277651424 105 LLTVFFTCApIPLMKISPWWYFAVISVSGVFAVTFSVVF--AYVADITQEHERSMAYGL 161
Cdd:COG2270    91 LLGVLATAA-LFFVAPGGLWLGLLLFVLANIGFEGSLVFynAFLPDIATPEEIGRVSGL 148
MFS_YxiO_like cd17482
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ...
 74-194 4.90e-05

Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341035 [Multi-domain]  Cd Length: 362  Bit Score: 44.90  E-value: 4.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  74 GLIQGVKGLLSFLSAPLIGALSDVWGRK-----SFLLLTVFFTCApipLMKISP--WWYFAVISVSGVFAVTFSVVF--A 144
Cdd:cd17482    42 GYANSIASLVIALLAPILGAIADYSGRKkrflaFFCLIGVVSTAL---LFFVTPgqWLLALLLFILANIGFSGANVFydA 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2277651424 145 YVADITQEHER--------SMAY---GLTIVLSLLM----RSIGNKNTILLGLGFQILQLAWYGF 194
Cdd:cd17482   119 FLPDVASPERMdrvsslgyALGYiggGLLFAVNLVLilgpDAFGLDTAEAVRLSFLSVALWWALF 183
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
41-223 1.41e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 43.35  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  41 VIVIFLEFFAWGLLTAPTLVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPLMK 119
Cdd:COG2211   234 LLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGkKKAFIIGLLLAALGLLLLFF 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 120 ISP---WWYFAVISVSGVF-AVTFSVVFAYVADITQEHE-------RSMAYGLTIVLSLLMRSIGNkntillGLGFQILQ 188
Cdd:COG2211   314 LGPgnlWLLLVLAALAGIGlGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAG------ALAGLLLA 387

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2277651424 189 LAWYGFGSEPwmmwAAGAVAAMSSITF--PAVSALVS 223
Cdd:COG2211   388 LFGYVAGAAQ----SPSALTGIRLLFFllPAVLLLLA 420
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
34-157 1.82e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.92  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  34 SPSVYHAVIVIFLEFFAWGLLTAPTLVLHETFpKHTFLMN----GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVF 109
Cdd:COG0738     3 KKNYRRALIAIYLLFFLWGFATALWGPLIPAL-KDAFGLSdaqaGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2277651424 110 FTCAPIPLMKISPWWYFAVIS--VSGV-FAVTFSVVFAYVADITQEHERSM 157
Cdd:COG0738    82 LMALGLLLFALAPSYPLLLLAlfLLGLgLGLLDVAANPYVAALGPETAASR 132
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 117-257 2.36e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 42.59  E-value: 2.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 117 LMKISPWWYFAVISV--SGVFAVTFSVVFAYVADITQEHERSMAYGLTIVLSLLM---------RSIGNKNTILLGLGFQ 185
Cdd:cd17332   217 LLKNRPFLILLLAYLlyFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLallpwpplkKRFGKKKAFFIGLLLA 296

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2277651424 186 ILQLAWYGFGSEP--WMMWAAGAVAAM-SSITFPAVSALVSRTADADQ--QGV-VQGMITGIRGLCNGLGPALYGFIF 257
Cdd:cd17332   297 ILGLLLLFFLPPGnlVLILVLAVLAGIgYGGANLLPWAMLADVIDYGElkTGKrREGIFYSVMTFFRKLGLALAGALV 374
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
65-257 2.95e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 42.55  E-value: 2.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  65 FPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVF------------------FTCAPIPLMKISPW-- 123
Cdd:COG2807   135 FPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGwRGALAVWALLallalllwlpllrrrpaaAAAAPAAASLRSLWrs 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 124 ---WYFAVISvsGVFAVTFSVVFAYVADITQEHERSMAYG-------------LTIVLSLLMRSIGNKNTILLGLG-FQI 186
Cdd:COG2807   215 plaWLLTLFF--GLQSLLYYAVVAWLPPILRDAGLSAATAglllslfqlagipGSLLVPLLADRLGDRRPLLLLLGlLGL 292

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2277651424 187 LQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVS-RTADADQQGVVQGMITGIRGLCNGLGPALYGFIF 257
Cdd:COG2807   293 AGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGlRARTPAEAAALSGMAQSVGYLLAALGPLLVGALH 364
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 74-258 4.33e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 41.77  E-value: 4.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  74 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVISVSGVFAvTFSVVFAYVADITQEH 153
Cdd:cd17321   123 GLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLARTFSGAVLAAFLLGAALG-GLLFLLPLYLQGVLGY 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 154 ERSMAYGLTIVLSLLM-----------RSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSI----TFPAV 218
Cdd:cd17321   202 SPLQAGLALLPLALAMlvaaplagrlaDRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLglglFATPL 281

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2277651424 219 SALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFY 258
Cdd:cd17321   282 TNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLT 321
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
34-261 5.37e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.39  E-value: 5.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  34 SPSVYHAVIVIFLEFFAWGLLTAPTL-VLHETFPKHTF-LMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFT 111
Cdd:COG2271    95 ATSFWQLLLLRFLLGLGEAGFFPAALkLIAEWFPPKERgRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 112 CAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAY-VADITQEhERSMAYGLTIVLSLLMRSIG----------NKNTILL 180
Cdd:COG2271   175 LLLALLRFWLLALAYFLVYFALYGFLTWLPTYLVeVRGLSLA-QAGLLLSLPFLAGIVGSLLGgwlsdrlgrrRKLVLAI 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 181 GLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSI-TFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYI 259
Cdd:COG2271   254 GLLLAALALLLLALLPSPALAIALLFLAGFGLGgAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA 333


                  ..
gi 2277651424 260 FH 261
Cdd:COG2271   334 TG 335
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
74-215 6.21e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.43  E-value: 6.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  74 GLIQGVKGLLSFLSAPLIGALSD----VWG-RKSFLL-------LTVFFTCAPIPLMKISPWWYFAVISVsgVFAVTFSV 141
Cdd:COG2211    49 GLILLVARLWDAITDPLIGALSDrtrtRWGrRRPWILigaiplaLSFVLLFTAPDLSPTGKLIYALVTYL--LLGLAYTL 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2277651424 142 VF----AYVADITQE-HERSMAYGLTIVLSLLMrsignknTILLGLGFQILqLAWYGFGSEPWMMWAAGAVAAMSSITF 215
Cdd:COG2211   127 VNipysALGAELTPDyEERTRLSSWRFAFAGLG-------GLLASVLPPPL-VAAFGGDAALGYRLTALIFAVLGLLAF 197
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 74-163 6.97e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.00  E-value: 6.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  74 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVIS--VSGVF-AVTFSVVFAYVADIT 150
Cdd:cd17324    37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLAraLAGLAhGGFWAIAAAYAADLV 116

                          90
                  ....*....|...
gi 2277651424 151 QEHERSMAYGLTI 163
Cdd:cd17324   117 PPEKRGRAIGLVF 129
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 128-260 7.81e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.02  E-value: 7.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 128 VISVSGVFAVTFSVVFAYVADItqehersmaygltivlsllmrsIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAV 207
Cdd:cd17325    36 IVAAYALAQLLFSPPAGRLSDR----------------------FGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFL 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2277651424 208 A-AMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 260
Cdd:cd17325    94 QgLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL 147
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 74-213 1.52e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 40.27  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  74 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--SPWWYFAVISVSGV-FAVTFSVVFAYVADIT 150
Cdd:cd17489    34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLatSVALLLVLRLIHGIgWGAFTTAAATLVADII 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2277651424 151 QEHERSMA---YGLTIVLSLlmrsignkntiLLGLGFQILQLAWYGFgsePWMMWAAGAVAAMSSI 213
Cdd:cd17489   114 PPSRRGEGigyYGLATTLAM-----------ALGPALGLFLYQHLGF---AVLFIVAAVLALLALL 165
MFS_1 pfam07690
Major Facilitator Superfamily;
88-250 2.03e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.71  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  88 APLIGALSDVWGRKSFLLLTVFFtCAPIPLMKISPW--WYFAVISVSGVFAVTFSVVFAYVADITQehersmaygltIVL 165
Cdd:pfam07690 188 LSLIVAWKALLRDPVLWLLLALL-LFGFAFFGLLTYlpLYQEVLGLSALLAGLLLGLGGLLGAIGR-----------LLL 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 166 SLLMRSIGNKNTILLGLGFQIL---QLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQGMITGI 241
Cdd:pfam07690 256 GRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGfGLVFPALNALVSDLAPKEERGTASGLYNTA 335


                  ....*....
gi 2277651424 242 RGLCNGLGP 250
Cdd:pfam07690 336 GSLGGALGP 344
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 168-256 2.35e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 39.49  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 168 LMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMwaaGAVAAMSSITFPAV----SALVSRTADADQQGVVQGMITgirG 243
Cdd:cd17335   256 LIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLV---LPIELLHGLTFALVwaaaVSYASAAAPPGLRATAQGLLQ---G 329

                          90
                  ....*....|...
gi 2277651424 244 LCNGLGPALYGFI 256
Cdd:cd17335   330 LYFGLGGGLGSLI 342
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 52-134 3.60e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.08  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  52 GLLTAPTLVLHETFpKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISP--WWYFAVI 129
Cdd:cd17478    13 GFLPALLPLLIAKL-GLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPnyWLLLLLV 91


                  ....*
gi 2277651424 130 SVSGV 134
Cdd:cd17478    92 ALAGI 96
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 81-215 5.63e-03

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 38.43  E-value: 5.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424  81 GLLSFLSAPLIGALSDVWGRKSFLLLT-VFFTCAPIPLMKI-----SPWWYFAVISVSGVFAVTFSVVFAYV-ADITQEH 153
Cdd:cd17367   269 LLVFMLLQPLGGRLSDRIGRRPLLLFFgIGGTLATVPLLSAldhtdSPYTAFALVLVGLVFLSGYTSINAVVkAELFPTH 348

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2277651424 154 ER----SMAYGLTIVlsllmrsignkntiLLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITF 215
Cdd:cd17367   349 VRalgvGLPYALAVA--------------IFGGTAPYVALWLKSIGHEWVFFWYVAGLIAISLVVY 400
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 126-261 6.97e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 38.21  E-value: 6.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 126 FAVISVSGVFAVT---FS----VVFAYVADITqehersmAYGLTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEP 198
Cdd:COG2270   255 QTVIAFAGIYAAGvlgFSttelIVFGLLVQIV-------AALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTA 327

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 199 WMMWAAGAVAAMSSITFPAVS-ALVSRTADADQQGV------VQGMITGIrglcngLGPALYGFIFYIFH 261
Cdd:COG2270   328 LAFWILGLLIGLVMGGIQALSrSLLARLIPPGREAEffglyaLSGKAASF------LGPLLFGLVTQLTG 391
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 103-260 8.43e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 37.94  E-value: 8.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 103 FLLLTVFFTCAPIPL---MKISPWWYFAVISVSGVFAVTFSVVFAYvaditqehersmaygltivlsLLMRSIGNKNTIL 179
Cdd:cd17474   211 FFLYFAFLTYLPFLLellYGISPIIIGLLFAGWSVLLALGSLFVGR---------------------LLKKRFGARRILV 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2277651424 180 LGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSS-ITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFY 258
Cdd:cd17474   270 IGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLgLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLE 349


                  ..
gi 2277651424 259 IF 260
Cdd:cd17474   350 IF 351
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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