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Conserved domains on  [gi|2284291792|ref|NP_001397479|]
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uncharacterized protein LOC224893 isoform 4 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12142424)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  22803940|11361095|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-327 8.24e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 8.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2284291792 194 KLYKCNQCGKAFACNSYLQMHER--IHTGE--KPYKCNH--CGKAFACNSNLQKHERIHTGEKRYKCK------------ 255
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllnssskfspll 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2284291792 256 -------------------------QCGKAFAYSSNLQKHERTHTGEKP--YKCNQCGKAFTCHSSLQIHERIHTGEKPY 308
Cdd:COG5048   368 nneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 2284291792 309 KCNQCGKPFDRKRYLHIHE 327
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
127-151 1.05e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.05e-03
                          10        20
                  ....*....|....*....|....*
gi 2284291792 127 LQIHERIHTGEKPYKCNQCDKTFAC 151
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
154-179 1.35e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 2284291792 154 YLQIHEKIHTGEKPYKCNQCGKTFAC 179
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-347 4.29e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.29e-03
                          10        20
                  ....*....|....*....|..
gi 2284291792 326 HERIHTGEKPYECNQCGKSFAY 347
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-327 8.24e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 8.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2284291792 194 KLYKCNQCGKAFACNSYLQMHER--IHTGE--KPYKCNH--CGKAFACNSNLQKHERIHTGEKRYKCK------------ 255
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllnssskfspll 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2284291792 256 -------------------------QCGKAFAYSSNLQKHERTHTGEKP--YKCNQCGKAFTCHSSLQIHERIHTGEKPY 308
Cdd:COG5048   368 nneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 2284291792 309 KCNQCGKPFDRKRYLHIHE 327
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
266-291 1.14e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.14e-04
                          10        20
                  ....*....|....*....|....*.
gi 2284291792 266 NLQKHERTHTGEKPYKCNQCGKAFTC 291
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
127-151 1.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.05e-03
                          10        20
                  ....*....|....*....|....*
gi 2284291792 127 LQIHERIHTGEKPYKCNQCDKTFAC 151
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
154-179 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 2284291792 154 YLQIHEKIHTGEKPYKCNQCGKTFAC 179
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-347 4.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.29e-03
                          10        20
                  ....*....|....*....|..
gi 2284291792 326 HERIHTGEKPYECNQCGKSFAY 347
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-327 8.24e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 8.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2284291792 194 KLYKCNQCGKAFACNSYLQMHER--IHTGE--KPYKCNH--CGKAFACNSNLQKHERIHTGEKRYKCK------------ 255
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllnssskfspll 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2284291792 256 -------------------------QCGKAFAYSSNLQKHERTHTGEKP--YKCNQCGKAFTCHSSLQIHERIHTGEKPY 308
Cdd:COG5048   368 nneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 2284291792 309 KCNQCGKPFDRKRYLHIHE 327
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
266-291 1.14e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.14e-04
                          10        20
                  ....*....|....*....|....*.
gi 2284291792 266 NLQKHERTHTGEKPYKCNQCGKAFTC 291
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-235 3.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 3.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 2284291792 210 YLQMHERIHTGEKPYKCNHCGKAFAC 235
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
238-263 3.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 3.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 2284291792 238 NLQKHERIHTGEKRYKCKQCGKAFAY 263
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
127-151 1.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.05e-03
                          10        20
                  ....*....|....*....|....*
gi 2284291792 127 LQIHERIHTGEKPYKCNQCDKTFAC 151
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
154-179 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 2284291792 154 YLQIHEKIHTGEKPYKCNQCGKTFAC 179
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
110-362 2.65e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2284291792 110 KPYECSQCGRAFTCHSTLQIHERIHTGEKPYKCNQCDKTFACKRY--LQIHEKIHTGEKPYKCNQCG------------- 174
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2284291792 175 -------KTFACKRYLQVHERIH------------AAEKLYKCNQCGKAFACNSYLQM-------------------HER 216
Cdd:COG5048   112 ssssnsnDNNLLSSHSLPPSSRDpqlpdllsisnlRNNPLPGNNSSSVNTPQSNSLHPplpanslskdpssnlslliSSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2284291792 217 IHTGEKPYKCNHCGKAFACNSNLQKHERIHTGEKRYKCKQCGKAFAYSSNLQKHERTHTGEKPYKCNQCGKAFTCHSSLQ 296
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2284291792 297 IHERIHTGE-------KPYKCNQCGKPFDRKRYLHIHER--IHTGE--KPYEC--NQCGKSFAYSSSLQKHERIHTDKN 362
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-347 4.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.29e-03
                          10        20
                  ....*....|....*....|..
gi 2284291792 326 HERIHTGEKPYECNQCGKSFAY 347
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-303 6.41e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 6.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2284291792 192 AEKLYKCNQCGKAFACNSYLQMHERIHTGEKPYKCNHCGKAFACNSNLQKH---ERIHTGEKRYKCKQCGKAFAYSSNLQ 268
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSrhlRTHHNNPSDLNSKSLPLSNSKASSSS 109

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2284291792 269 KHERTHTGEKPYKCNQCGKAFTCHSSLQIHERIHT 303
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS 144
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
110-270 9.84e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 37.75  E-value: 9.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2284291792 110 KPYECSQCGRAFTCHSTLQIHER--IHTGE--KPYKC--NQCDKTFACKRYLQIHEKIHTGEKPYKC--NQCGKTF---- 177
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspll 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2284291792 178 -ACKRYLQVHERIHAAEKLYKC--NQCGKAFACNSYLQMHERIHTGEKP--YKCNHCGKAFACNSNLQKHERIHTgEKRY 252
Cdd:COG5048   368 nNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAP 446

                         170
                  ....*....|....*...
gi 2284291792 253 KCKQCGKAFAYSSNLQKH 270
Cdd:COG5048   447 LLCSILKSFRRDLDLSNH 464
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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