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Conserved domains on  [gi|2287254612|ref|NP_001397713|]
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centrosomal protein of 97 kDa isoform 3 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 46-208 3.08e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 92.93  E-value: 3.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612  46 NQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLA--------------- 110
Cdd:cd21340    34 NKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIEnqrlppgekltfdpr 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612 111 -----GNNLKTLLLHGNIITSLRMApAYLpRSLAILSLAENEIRDLNEIS-FLASLTELEQLSIMNNPcVMATPSipgfd 184
Cdd:cd21340   114 slaalSNSLRVLNISGNNIDSLEPL-APL-RNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNP-VCKKPK----- 185

                         170       180
                  ....*....|....*....|....
gi 2287254612 185 YRPYIVSWCLNLRVLDGYVISQKE 208
Cdd:cd21340   186 YRDKIILASKSLEVLDGKEITDTE 209
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 521-541 1.91e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


:

Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 39.45  E-value: 1.91e-04
                          10        20
                  ....*....|....*....|.
gi 2287254612 521 LQKLNDAATKLQACWRGFYAR 541
Cdd:cd23767     5 LQRMNRAATLIQALWRGYKVR 25
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 46-208 3.08e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 92.93  E-value: 3.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612  46 NQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLA--------------- 110
Cdd:cd21340    34 NKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIEnqrlppgekltfdpr 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612 111 -----GNNLKTLLLHGNIITSLRMApAYLpRSLAILSLAENEIRDLNEIS-FLASLTELEQLSIMNNPcVMATPSipgfd 184
Cdd:cd21340   114 slaalSNSLRVLNISGNNIDSLEPL-APL-RNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNP-VCKKPK----- 185

                         170       180
                  ....*....|....*....|....
gi 2287254612 185 YRPYIVSWCLNLRVLDGYVISQKE 208
Cdd:cd21340   186 YRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-171 2.61e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 2.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612  36 ADIHTLILDKNQIIKL-ENLEKCKRLIQLSVANNRLVRM-MGVAKLTLLRVLNLPHNSIGCV-EGLKELVHLEWLNLAGN 112
Cdd:COG4886   113 TNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2287254612 113 -------------NLKTLLLHGNIITSLrmaPAYLPR--SLAILSLAENEIRDLNEisfLASLTELEQLSIMNN 171
Cdd:COG4886   193 qitdlpeplgnltNLEELDLSGNQLTDL---PEPLANltNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNN 260
LRR_9 pfam14580
Leucine-rich repeat;
40-222 1.10e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 52.46  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612  40 TLILDKNQIIKLENLEKCKRLIQLSVANNRLVRmmgvakltllrvlnlphnsIGcvEGLKELVhlewlnlagNNLKTLLL 119
Cdd:pfam14580  46 TIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICR-------------------IG--EGLGEAL---------PNLTELIL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612 120 HGNIITSlrmapaylprslailslaeneirdLNEISFLASLTELEQLSIMNNPcVMATPsipgfDYRPYIVSWCLNLRVL 199
Cdd:pfam14580  96 TNNNLQE------------------------LGDLDPLASLKKLTFLSLLRNP-VTNKP-----HYRLYVIYKVPQLRLL 145

                         170       180
                  ....*....|....*....|...
gi 2287254612 200 DGYVISQKESLKAEWLYSQGKGR 222
Cdd:pfam14580 146 DFRKVKQKERQAAEKMFRSKQGK 168
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
38-181 4.33e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 4.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612  38 IHTLILDKNQIIKL-ENLEkcKRLIQLSVANNRLVRM-------MGVAKLTLLRVLNLP-------------HNSIGCV- 95
Cdd:PRK15370  201 ITTLILDNNELKSLpENLQ--GNIKTLYANSNQLTSIpatlpdtIQEMELSINRITELPerlpsalqsldlfHNKISCLp 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612  96 EGLKElvHLEWLNLAGNNLKTL-------LLHGNIIT-SLRMAPAYLPRSLAILSLAENEIRDLNEisflaSL-TELEQL 166
Cdd:PRK15370  279 ENLPE--ELRYLSVYDNSIRTLpahlpsgITHLNVQSnSLTALPETLPPGLKTLEAGENALTSLPA-----SLpPELQVL 351

                         170
                  ....*....|....*
gi 2287254612 167 SIMNNPCVMATPSIP 181
Cdd:PRK15370  352 DVSKNQITVLPETLP 366
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 521-541 1.91e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 39.45  E-value: 1.91e-04
                          10        20
                  ....*....|....*....|.
gi 2287254612 521 LQKLNDAATKLQACWRGFYAR 541
Cdd:cd23767     5 LQRMNRAATLIQALWRGYKVR 25
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 46-208 3.08e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 92.93  E-value: 3.08e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612  46 NQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLA--------------- 110
Cdd:cd21340    34 NKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIEnqrlppgekltfdpr 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612 111 -----GNNLKTLLLHGNIITSLRMApAYLpRSLAILSLAENEIRDLNEIS-FLASLTELEQLSIMNNPcVMATPSipgfd 184
Cdd:cd21340   114 slaalSNSLRVLNISGNNIDSLEPL-APL-RNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNP-VCKKPK----- 185

                         170       180
                  ....*....|....*....|....
gi 2287254612 185 YRPYIVSWCLNLRVLDGYVISQKE 208
Cdd:cd21340   186 YRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-171 2.61e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 2.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612  36 ADIHTLILDKNQIIKL-ENLEKCKRLIQLSVANNRLVRM-MGVAKLTLLRVLNLPHNSIGCV-EGLKELVHLEWLNLAGN 112
Cdd:COG4886   113 TNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2287254612 113 -------------NLKTLLLHGNIITSLrmaPAYLPR--SLAILSLAENEIRDLNEisfLASLTELEQLSIMNN 171
Cdd:COG4886   193 qitdlpeplgnltNLEELDLSGNQLTDL---PEPLANltNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-172 2.67e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.50  E-value: 2.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612  40 TLILDKNQIIKL-ENLEKCKRLIQLSVANNRLVRM-MGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGN----- 112
Cdd:COG4886   186 ELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNqltdl 265

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2287254612 113 -------NLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNNP 172
Cdd:COG4886   266 pplanltNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-172 1.77e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 1.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612  40 TLILDKNQIIKLENLEKCKRLIQLSVANNRlvrmmGVAKLTLLRVLNLPHNSIGCV-EGLKELVHLEWLNLAGNNLKTLl 118
Cdd:COG4886    78 SLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDL- 151

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2287254612 119 lhgniitslrmaPAYLPR--SLAILSLAENEIRDLNEisFLASLTELEQLSIMNNP 172
Cdd:COG4886   152 ------------PEPLGNltNLKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQ 193
LRR_9 pfam14580
Leucine-rich repeat;
40-222 1.10e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 52.46  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612  40 TLILDKNQIIKLENLEKCKRLIQLSVANNRLVRmmgvakltllrvlnlphnsIGcvEGLKELVhlewlnlagNNLKTLLL 119
Cdd:pfam14580  46 TIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICR-------------------IG--EGLGEAL---------PNLTELIL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612 120 HGNIITSlrmapaylprslailslaeneirdLNEISFLASLTELEQLSIMNNPcVMATPsipgfDYRPYIVSWCLNLRVL 199
Cdd:pfam14580  96 TNNNLQE------------------------LGDLDPLASLKKLTFLSLLRNP-VTNKP-----HYRLYVIYKVPQLRLL 145

                         170       180
                  ....*....|....*....|...
gi 2287254612 200 DGYVISQKESLKAEWLYSQGKGR 222
Cdd:pfam14580 146 DFRKVKQKERQAAEKMFRSKQGK 168
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
38-181 4.33e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 4.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612  38 IHTLILDKNQIIKL-ENLEkcKRLIQLSVANNRLVRM-------MGVAKLTLLRVLNLP-------------HNSIGCV- 95
Cdd:PRK15370  201 ITTLILDNNELKSLpENLQ--GNIKTLYANSNQLTSIpatlpdtIQEMELSINRITELPerlpsalqsldlfHNKISCLp 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612  96 EGLKElvHLEWLNLAGNNLKTL-------LLHGNIIT-SLRMAPAYLPRSLAILSLAENEIRDLNEisflaSL-TELEQL 166
Cdd:PRK15370  279 ENLPE--ELRYLSVYDNSIRTLpahlpsgITHLNVQSnSLTALPETLPPGLKTLEAGENALTSLPA-----SLpPELQVL 351

                         170
                  ....*....|....*
gi 2287254612 167 SIMNNPCVMATPSIP 181
Cdd:PRK15370  352 DVSKNQITVLPETLP 366
LRR_8 pfam13855
Leucine rich repeat;
113-172 1.70e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.70e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612 113 NLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFlASLTELEQLSIMNNP 172
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF-SGLPSLRYLDLSGNR 60
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 521-541 1.91e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 39.45  E-value: 1.91e-04
                          10        20
                  ....*....|....*....|.
gi 2287254612 521 LQKLNDAATKLQACWRGFYAR 541
Cdd:cd23767     5 LQRMNRAATLIQALWRGYKVR 25
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-171 4.56e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 4.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612  38 IHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEgLKELVHLEWLNLAGNNLKTL 117
Cdd:COG4886   230 LETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK-LKELELLLGLNSLLLLLLLL 308

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2287254612 118 LLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNN 171
Cdd:COG4886   309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362
LRR_8 pfam13855
Leucine rich repeat;
63-114 1.19e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.19e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2287254612  63 LSVANNRLVRMMGVA--KLTLLRVLNLPHNSIGCVEG--LKELVHLEWLNLAGNNL 114
Cdd:pfam13855   6 LDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 23-172 1.84e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612  23 QGLQKLGPNLPCEADIHTLILDKNQI------IKLENLEKCKRLIQLSVANNRLVR--MMGVAKL----TLLRVLNLPHN 90
Cdd:COG5238   195 EGIEELAEALTQNTTVTTLWLKRNPIgdegaeILAEALKGNKSLTTLDLSNNQIGDegVIALAEAlknnTTVETLYLSGN 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287254612  91 SIGCvEGLKELVHLewlnLAGN-NLKTLLLHGNIIT---SLRMAPAyLPRS--LAILSLAENEIRDLNEISFLASL---T 161
Cdd:COG5238   275 QIGA-EGAIALAKA----LQGNtTLTSLDLSVNRIGdegAIALAEG-LQGNktLHTLNLAYNGIGAQGAIALAKALqenT 348

                         170
                  ....*....|.
gi 2287254612 162 ELEQLSIMNNP 172
Cdd:COG5238   349 TLHSLDLSDNQ 359
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 82-114 8.36e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 8.36e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2287254612  82 LRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNL 114
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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