NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2288874261|ref|NP_001398147|]
View 

60S ribosomal export protein NMD3 isoform 6 [Mus musculus]

Protein Classification

60S ribosomal export protein NMD3( domain architecture ID 10523188)

60S ribosomal export protein NMD3 acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit

Gene Ontology:  GO:0043023|GO:0003723|GO:0030674|GO:0032092|GO:0015031

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NMD3 pfam04981
NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal ...
 1-126 9.23e-57

NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal region contains four conserved CXXC motifs that could be metal binding. NMD3 is involved in export of the 60S ribosomal subunit is mediated by the adapter protein Nmd3p in a Crm1p-dependent pathway.


:

Pssm-ID: 461505  Cd Length: 242  Bit Score: 185.58  E-value: 9.23e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2288874261   1 MNGAILQQVFVVDYVVQSQMCGDCHRVEAKdFWKAVIQVRQK-----TLHKKTFYYLEQLILKYGMHQNTLRIKEIHDGL 75
Cdd:pfam04981 113 LVGTILQQEFVVEVVVRRQQCPDCSRIAGG-YWEAIVQVRQKrelteVEHKRTFLYLEQLILKHDAHAFISKIKEVKDGL 191

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2288874261  76 DFYYSSKQHAQKMVEFLQGIVPCRYKASQRLISQDIHSNTYNYKSTFSVEI 126
Cdd:pfam04981 192 DFYFGSRNHARKIVDFLSSVVPGKVKESKKLVSHDKDSGKYNYRFTYSVRI 242
 
Name Accession Description Interval E-value
NMD3 pfam04981
NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal ...
 1-126 9.23e-57

NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal region contains four conserved CXXC motifs that could be metal binding. NMD3 is involved in export of the 60S ribosomal subunit is mediated by the adapter protein Nmd3p in a Crm1p-dependent pathway.


Pssm-ID: 461505  Cd Length: 242  Bit Score: 185.58  E-value: 9.23e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2288874261   1 MNGAILQQVFVVDYVVQSQMCGDCHRVEAKdFWKAVIQVRQK-----TLHKKTFYYLEQLILKYGMHQNTLRIKEIHDGL 75
Cdd:pfam04981 113 LVGTILQQEFVVEVVVRRQQCPDCSRIAGG-YWEAIVQVRQKrelteVEHKRTFLYLEQLILKHDAHAFISKIKEVKDGL 191

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2288874261  76 DFYYSSKQHAQKMVEFLQGIVPCRYKASQRLISQDIHSNTYNYKSTFSVEI 126
Cdd:pfam04981 192 DFYFGSRNHARKIVDFLSSVVPGKVKESKKLVSHDKDSGKYNYRFTYSVRI 242
 
Name Accession Description Interval E-value
NMD3 pfam04981
NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal ...
 1-126 9.23e-57

NMD3 family; The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal region contains four conserved CXXC motifs that could be metal binding. NMD3 is involved in export of the 60S ribosomal subunit is mediated by the adapter protein Nmd3p in a Crm1p-dependent pathway.


Pssm-ID: 461505  Cd Length: 242  Bit Score: 185.58  E-value: 9.23e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2288874261   1 MNGAILQQVFVVDYVVQSQMCGDCHRVEAKdFWKAVIQVRQK-----TLHKKTFYYLEQLILKYGMHQNTLRIKEIHDGL 75
Cdd:pfam04981 113 LVGTILQQEFVVEVVVRRQQCPDCSRIAGG-YWEAIVQVRQKrelteVEHKRTFLYLEQLILKHDAHAFISKIKEVKDGL 191

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2288874261  76 DFYYSSKQHAQKMVEFLQGIVPCRYKASQRLISQDIHSNTYNYKSTFSVEI 126
Cdd:pfam04981 192 DFYFGSRNHARKIVDFLSSVVPGKVKESKKLVSHDKDSGKYNYRFTYSVRI 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH