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Conserved domains on  [gi|2307937328|ref|NP_001399101|]
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tigger transposable element-derived protein 6 isoform 1 [Homo sapiens]

Protein Classification

tigger transposable element derived family protein( domain architecture ID 10405131)

tigger transposable element derived family protein belongs to the pogo superfamily of DNA-mediated transposons

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DDE_3 super family cl46863
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 207-372 1.76e-39

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.


The actual alignment was detected with superfamily member pfam03184:

Pssm-ID: 481203  Cd Length: 177  Bit Score: 141.37  E-value: 1.76e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307937328 207 KQRLTALFCCNASGTEKMRPLIVGRSASPHCLKNIH---SLPCDYRANQWAWMTRDLFNEWLMQV-DARMKRAE-RRILL 281
Cdd:pfam03184   1 KERLTVMLCCNAAGSEKLPPLVIGKGKNPRAFKNEKtpkPLPVEYKSNGKAWMTTSIFEEWLQKWfDPRMRESPgRKVLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307937328 282 LIDNCSAH----NMLPHLER-IQVGYLPSNCTAVLQPLNLGIIHTMKVLYQSHLLKQILLKLNS-SEDQEEVDIKQAIDM 355
Cdd:pfam03184  81 LLDGSGSHptveLIRSCGLQnIFLVFLPANSTSILQPLDQGVVSTFKANYRRQWLQYLLAGNNLlSPPWKKLTLLDALKW 160

                         170
                  ....*....|....*..
gi 2307937328 356 IAAAWWSVKPSTVVKCW 372
Cdd:pfam03184 161 IAKAWNAVSPSTITSGF 177
HTH_Tnp_Tc5 pfam03221
Tc5 transposase DNA-binding domain;
75-134 8.11e-17

Tc5 transposase DNA-binding domain;


:

Pssm-ID: 460850  Cd Length: 63  Bit Score: 74.59  E-value: 8.11e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2307937328  75 YDDIDKAVFAWFQEIHAKNILVTGSVIRKKALNLAN---MLGYDNFQASVGWLNRFRDRHGIA 134
Cdd:pfam03221   1 YPDLEKALYEWILQLRARGIPITGPMIREKALELAQlaaDLGEPDFKASKGWLDRFKKRHGIK 63
CENP-B_N super family cl47877
CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein ...
 7-54 1.08e-06

CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure.


The actual alignment was detected with superfamily member pfam04218:

Pssm-ID: 461229  Cd Length: 53  Bit Score: 45.48  E-value: 1.08e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2307937328   7 KKRRQFSLEEKMKVVGAVDSGKRKGDVAKEFGITPSTLSTFLKDRTKF 54
Cdd:pfam04218   2 RKRRSLTLREKIAIIQRYEEGESKASLARRFGVPASTLRRILKNKKKL 49
 
Name Accession Description Interval E-value
DDE_1 pfam03184
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 207-372 1.76e-39

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere.


Pssm-ID: 367380  Cd Length: 177  Bit Score: 141.37  E-value: 1.76e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307937328 207 KQRLTALFCCNASGTEKMRPLIVGRSASPHCLKNIH---SLPCDYRANQWAWMTRDLFNEWLMQV-DARMKRAE-RRILL 281
Cdd:pfam03184   1 KERLTVMLCCNAAGSEKLPPLVIGKGKNPRAFKNEKtpkPLPVEYKSNGKAWMTTSIFEEWLQKWfDPRMRESPgRKVLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307937328 282 LIDNCSAH----NMLPHLER-IQVGYLPSNCTAVLQPLNLGIIHTMKVLYQSHLLKQILLKLNS-SEDQEEVDIKQAIDM 355
Cdd:pfam03184  81 LLDGSGSHptveLIRSCGLQnIFLVFLPANSTSILQPLDQGVVSTFKANYRRQWLQYLLAGNNLlSPPWKKLTLLDALKW 160

                         170
                  ....*....|....*..
gi 2307937328 356 IAAAWWSVKPSTVVKCW 372
Cdd:pfam03184 161 IAKAWNAVSPSTITSGF 177
HTH_Tnp_Tc5 pfam03221
Tc5 transposase DNA-binding domain;
75-134 8.11e-17

Tc5 transposase DNA-binding domain;


Pssm-ID: 460850  Cd Length: 63  Bit Score: 74.59  E-value: 8.11e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2307937328  75 YDDIDKAVFAWFQEIHAKNILVTGSVIRKKALNLAN---MLGYDNFQASVGWLNRFRDRHGIA 134
Cdd:pfam03221   1 YPDLEKALYEWILQLRARGIPITGPMIREKALELAQlaaDLGEPDFKASKGWLDRFKKRHGIK 63
CENPB smart00674
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;
74-133 4.17e-14

Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;


Pssm-ID: 197828  Cd Length: 66  Bit Score: 66.93  E-value: 4.17e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307937328   74 LYDDIDKAVFAWFQEIHAKNILVTGSVIRKKALNLANMLGYDNFQASVGWLNRFRDRHGI 133
Cdd:smart00674   3 LYPLLEKALYEWILRQEALGIPISGEDIREKALEILQRLGLENFKASKGWLTRFKKRHNI 62
CENP-B_N pfam04218
CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein ...
 7-54 1.08e-06

CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure.


Pssm-ID: 461229  Cd Length: 53  Bit Score: 45.48  E-value: 1.08e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2307937328   7 KKRRQFSLEEKMKVVGAVDSGKRKGDVAKEFGITPSTLSTFLKDRTKF 54
Cdd:pfam04218   2 RKRRSLTLREKIAIIQRYEEGESKASLARRFGVPASTLRRILKNKKKL 49
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
6-68 5.03e-06

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 44.92  E-value: 5.03e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2307937328   6 NKKRRQFSLEEKMKVVGAV-DSGKRKGDVAKEFGITPSTLSTFLKdrtKFEEKVREASVGPQRK 68
Cdd:COG2963     2 SKKRRRYSPEFKAEAVRLVlEGGASVAEVARELGISPSTLYRWVR---QYREGGLGGFPGDGRT 62
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
 7-136 6.22e-03

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 38.68  E-value: 6.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307937328   7 KKRRQFSLEEKMKVVGAVDSGKRKGDVAKEFGITPSTLSTFLKdrtKFEEKVREASVGPQRKRMRSALYDDIDKAVFAWF 86
Cdd:COG3415    18 RKTKDAREARRLRAVLLLAEGLSVREIAERLGVSRSTVYRWLK---RYREGGLAGLKDRPRGGRPSKLSDEQRERLLELL 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2307937328  87 QEIHAKNI-LVTGSVIRKKalnLANMLGYdnfQASVGWLNRFRDRHGIALK 136
Cdd:COG3415    95 REKSPDQGsRWTLAELAEL---LEEEFGV---EVSPSTVRRLLKRLGLSYK 139
 
Name Accession Description Interval E-value
DDE_1 pfam03184
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 207-372 1.76e-39

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere.


Pssm-ID: 367380  Cd Length: 177  Bit Score: 141.37  E-value: 1.76e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307937328 207 KQRLTALFCCNASGTEKMRPLIVGRSASPHCLKNIH---SLPCDYRANQWAWMTRDLFNEWLMQV-DARMKRAE-RRILL 281
Cdd:pfam03184   1 KERLTVMLCCNAAGSEKLPPLVIGKGKNPRAFKNEKtpkPLPVEYKSNGKAWMTTSIFEEWLQKWfDPRMRESPgRKVLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307937328 282 LIDNCSAH----NMLPHLER-IQVGYLPSNCTAVLQPLNLGIIHTMKVLYQSHLLKQILLKLNS-SEDQEEVDIKQAIDM 355
Cdd:pfam03184  81 LLDGSGSHptveLIRSCGLQnIFLVFLPANSTSILQPLDQGVVSTFKANYRRQWLQYLLAGNNLlSPPWKKLTLLDALKW 160

                         170
                  ....*....|....*..
gi 2307937328 356 IAAAWWSVKPSTVVKCW 372
Cdd:pfam03184 161 IAKAWNAVSPSTITSGF 177
HTH_Tnp_Tc5 pfam03221
Tc5 transposase DNA-binding domain;
75-134 8.11e-17

Tc5 transposase DNA-binding domain;


Pssm-ID: 460850  Cd Length: 63  Bit Score: 74.59  E-value: 8.11e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2307937328  75 YDDIDKAVFAWFQEIHAKNILVTGSVIRKKALNLAN---MLGYDNFQASVGWLNRFRDRHGIA 134
Cdd:pfam03221   1 YPDLEKALYEWILQLRARGIPITGPMIREKALELAQlaaDLGEPDFKASKGWLDRFKKRHGIK 63
CENPB smart00674
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;
74-133 4.17e-14

Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;


Pssm-ID: 197828  Cd Length: 66  Bit Score: 66.93  E-value: 4.17e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307937328   74 LYDDIDKAVFAWFQEIHAKNILVTGSVIRKKALNLANMLGYDNFQASVGWLNRFRDRHGI 133
Cdd:smart00674   3 LYPLLEKALYEWILRQEALGIPISGEDIREKALEILQRLGLENFKASKGWLTRFKKRHNI 62
CENP-B_N pfam04218
CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein ...
 7-54 1.08e-06

CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure.


Pssm-ID: 461229  Cd Length: 53  Bit Score: 45.48  E-value: 1.08e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2307937328   7 KKRRQFSLEEKMKVVGAVDSGKRKGDVAKEFGITPSTLSTFLKDRTKF 54
Cdd:pfam04218   2 RKRRSLTLREKIAIIQRYEEGESKASLARRFGVPASTLRRILKNKKKL 49
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
6-68 5.03e-06

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 44.92  E-value: 5.03e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2307937328   6 NKKRRQFSLEEKMKVVGAV-DSGKRKGDVAKEFGITPSTLSTFLKdrtKFEEKVREASVGPQRK 68
Cdd:COG2963     2 SKKRRRYSPEFKAEAVRLVlEGGASVAEVARELGISPSTLYRWVR---QYREGGLGGFPGDGRT 62
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 16-69 4.00e-04

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 38.34  E-value: 4.00e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2307937328  16 EKMKVVGAVDSGKRKGDVAKEFGITPSTLSTFLKdrtKFEEKvREASVGPQRKR 69
Cdd:pfam13518   1 ERLKIVLLALEGESIKEAARLFGISRSTVYRWIR---RYREG-GLEGLLPRRRR 50
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
 7-136 6.22e-03

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 38.68  E-value: 6.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307937328   7 KKRRQFSLEEKMKVVGAVDSGKRKGDVAKEFGITPSTLSTFLKdrtKFEEKVREASVGPQRKRMRSALYDDIDKAVFAWF 86
Cdd:COG3415    18 RKTKDAREARRLRAVLLLAEGLSVREIAERLGVSRSTVYRWLK---RYREGGLAGLKDRPRGGRPSKLSDEQRERLLELL 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2307937328  87 QEIHAKNI-LVTGSVIRKKalnLANMLGYdnfQASVGWLNRFRDRHGIALK 136
Cdd:COG3415    95 REKSPDQGsRWTLAELAEL---LEEEFGV---EVSPSTVRRLLKRLGLSYK 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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