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Conserved domains on  [gi|2325513926|ref|NP_001400578|]
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zinc finger protein 76 isoform 3 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-310 1.24e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 1.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2325513926  94 STAYIHHPVPVPSDSAILAVQTEAGLEDLAAEDEEGFGTDTVVALEQYASKVLHDSpASHNGKGQQvgdraFRCgyKGCG 173
Cdd:COG5048   225 SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDS-SSEKGFSLP-----IKS--KQCN 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2325513926 174 RLYTTAHHLKVHERA--HTG--DRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAF------KTSGDLQ 243
Cdd:COG5048   297 ISFSRSSPLTRHLRSvnHSGesLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspllnnEPPQSLQ 376

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2325513926 244 KHVRTHTgERPFRCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHT 310
Cdd:COG5048   377 QYKDLKN-DKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-310 1.24e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 1.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2325513926  94 STAYIHHPVPVPSDSAILAVQTEAGLEDLAAEDEEGFGTDTVVALEQYASKVLHDSpASHNGKGQQvgdraFRCgyKGCG 173
Cdd:COG5048   225 SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDS-SSEKGFSLP-----IKS--KQCN 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2325513926 174 RLYTTAHHLKVHERA--HTG--DRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAF------KTSGDLQ 243
Cdd:COG5048   297 ISFSRSSPLTRHLRSvnHSGesLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspllnnEPPQSLQ 376

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2325513926 244 KHVRTHTgERPFRCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHT 310
Cdd:COG5048   377 QYKDLKN-DKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-238 1.20e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 1.20e-06
                          10        20
                  ....*....|....*....|....*..
gi 2325513926 212 LKSHVRTHTGEKPYKCPEelCSKAFKT 238
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-310 1.24e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 1.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2325513926  94 STAYIHHPVPVPSDSAILAVQTEAGLEDLAAEDEEGFGTDTVVALEQYASKVLHDSpASHNGKGQQvgdraFRCgyKGCG 173
Cdd:COG5048   225 SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDS-SSEKGFSLP-----IKS--KQCN 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2325513926 174 RLYTTAHHLKVHERA--HTG--DRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAF------KTSGDLQ 243
Cdd:COG5048   297 ISFSRSSPLTRHLRSvnHSGesLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspllnnEPPQSLQ 376

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2325513926 244 KHVRTHTgERPFRCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHT 310
Cdd:COG5048   377 QYKDLKN-DKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-238 1.20e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 1.20e-06
                          10        20
                  ....*....|....*....|....*..
gi 2325513926 212 LKSHVRTHTGEKPYKCPEelCSKAFKT 238
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-257 2.19e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.19e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2325513926 192 DRPYRCDFpsCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHTGERPFRC 257
Cdd:COG5048    31 PRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLN 94
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 191-280 6.18e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.56  E-value: 6.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2325513926 191 GDRPYRCDFPSCGKAFATGYGLKSH-VRTHTGEKPYKCPEELCSKAFKTSgdlqkhvrthtgERPFRCPFegCGRSFTTS 269
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSAK------------DKPYRCEV--CDKRYKNL 411

                          90
                  ....*....|.
gi 2325513926 270 NIRKVHvRTHT 280
Cdd:COG5189   412 NGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-268 1.15e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.15e-05
                          10        20
                  ....*....|....*....|....*...
gi 2325513926 241 DLQKHVRTHTGERPFRCPFegCGRSFTT 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 144-220 6.72e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 6.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2325513926 144 KVLHDSPASHNGKGQQ---VGDRAFRCGYKGCGRLYTTAHHLKVH---------------ERAHTG----DRPYRCDFps 201
Cdd:COG5189   326 KLAHGGERNIDTPSRMlkvKDGKPYKCPVEGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV-- 403

                          90
                  ....*....|....*....
gi 2325513926 202 CGKAFATGYGLKSHvRTHT 220
Cdd:COG5189   404 CDKRYKNLNGLKYH-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
147-292 3.65e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 3.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2325513926 147 HDSPASHNGKGQqvgdRAFRCGYKGCGRLYTTAHHLKVHERAHTGDRPYRCDFPSCGKAF--ATGYGLKSHVRTHTGEKP 224
Cdd:COG5048   308 HLRSVNHSGESL----KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspLLNNEPPQSLQQYKDLKN 383

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2325513926 225 YK---CPEELCSKAFKTSGDLQKHVRTHTGERPFRCPFEGCGRSFTTSNIRKVHVRTHTGERPYtCPEPHC 292
Cdd:COG5048   384 DKkseTLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILK 453
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-275 4.38e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 4.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2325513926 192 DRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHTGERPFRCpfEGCGRSFTTSNI 271
Cdd:COG5048   384 DKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDL 461


                  ....
gi 2325513926 272 RKVH 275
Cdd:COG5048   462 SNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
181-208 5.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.27e-04
                          10        20
                  ....*....|....*....|....*...
gi 2325513926 181 HLKVHERAHTGDRPYRCdfPSCGKAFAT 208
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
253-325 6.42e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 6.42e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2325513926 253 RPFRCPFegCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHTAASAAEESPPPKPTH 325
Cdd:COG5048    32 RPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSN 102
zf-H2C2_2 pfam13465
Zinc-finger double domain;
273-298 1.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 2325513926 273 KVHVRTHTGERPYTCPEphCGRGFTS 298
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-280 2.08e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.08e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2325513926 223 KPYKCPEelCSKAFKTSGDLQKHVRTHTGERPFRCPFEGCGRSFTTSNIRKVHVRTHT 280
Cdd:COG5048    32 RPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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