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Conserved domains on  [gi|2328705306|ref|NP_001400889|]
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cadherin-17 isoform 9 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 328-421 3.38e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 3.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306 328 VFQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGS 403
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdSGENgeVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 2328705306 404 SLSSVSEFHLILMDVNDN 421
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 104-202 9.27e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 9.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306 104 VFEVQENERLGNSIGTLTAHDRDEENtaNSFLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKqSLKKQDTPQYNLTIEVS 183
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE----DGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|..
gi 2328705306 184 DKD---FKTLCFVQINVIDIND 202
Cdd:cd11304    76 DGGgppLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 29-96 2.17e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 2.17e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2328705306   29 YSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPP 96
Cdd:smart00112  15 YSILSGN--DDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 214-320 4.11e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 4.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306 214 NLTLAEDTNIGSTILTIQATDADEPFTGssKILYHIIKGDSEGRLGVDtdphTNTGYVIIKKPLDFETAAVSNIVFKAEN 293
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*..
gi 2328705306 294 PEPLVFgvkynaSSFAKFTLIVTDVNE 320
Cdd:cd11304    77 GGGPPL------SSTATVTITVLDVND 97
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 439-523 1.11e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 38.44  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306 439 SAPGSLI--FEATDDDqhlfRGPH--FTFSLGSGSLQNDWEVSKINGTharLSTRHT-EFEER-EYVVLIRINDGGRPPL 512
Cdd:pfam00028   9 APVGTEVltVTATDPD----LGPNgrIFYSILGGGPGGNFRIDPDTGD---ISTTKPlDRESIgEYELTVEATDSGGPPL 81

                          90
                  ....*....|.
gi 2328705306 513 EGIVSLPVTFC 523
Cdd:pfam00028  82 SSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 328-421 3.38e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 3.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306 328 VFQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGS 403
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdSGENgeVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 2328705306 404 SLSSVSEFHLILMDVNDN 421
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 104-202 9.27e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 9.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306 104 VFEVQENERLGNSIGTLTAHDRDEENtaNSFLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKqSLKKQDTPQYNLTIEVS 183
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE----DGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|..
gi 2328705306 184 DKD---FKTLCFVQINVIDIND 202
Cdd:cd11304    76 DGGgppLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 29-96 2.17e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 2.17e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2328705306   29 YSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPP 96
Cdd:smart00112  15 YSILSGN--DDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 214-320 4.11e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 4.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306 214 NLTLAEDTNIGSTILTIQATDADEPFTGssKILYHIIKGDSEGRLGVDtdphTNTGYVIIKKPLDFETAAVSNIVFKAEN 293
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*..
gi 2328705306 294 PEPLVFgvkynaSSFAKFTLIVTDVNE 320
Cdd:cd11304    77 GGGPPL------SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 29-94 8.16e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 8.16e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2328705306  29 YSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDN 94
Cdd:cd11304    34 YSIVSGN--EDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
329-398 1.86e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 1.86e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2328705306 329 FQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYS-LRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVAT 398
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPdLGPNgrIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 350-423 3.99e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 3.99e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2328705306  350 DPEGLDISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPP 423
Cdd:smart00112   7 SGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
104-186 9.62e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 9.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306 104 VFEVQENERLGNSIGTLTAHDRDEenTANSFLNYRIVEQtpklPMDGLFLIQTYAGMLQLAKQsLKKQDTPQYNLTIEVS 183
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDL--GPNGRIFYSILGG----GPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEAT 74


                  ...
gi 2328705306 184 DKD 186
Cdd:pfam00028  75 DSG 77
Cadherin pfam00028
Cadherin domain;
42-88 1.13e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.38  E-value: 1.13e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2328705306  42 FSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKV 88
Cdd:pfam00028  44 FRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 121-205 1.91e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 1.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306  121 TAHDRDEEntANSFLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKQsLKKQDTPQYNLTIEVSDKDFKTL---CFVQINV 197
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGND----DGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLsstATVTITV 73


                   ....*...
gi 2328705306  198 IDINDQIP 205
Cdd:smart00112  74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 231-322 9.37e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.35  E-value: 9.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306  231 QATDADEPFtgSSKILYHIIKGDSEGRLGVDTdphtNTGYVIIKKPLDFETAAVSNIVFKAENpeplvfGVKYNASSFAK 310
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDP----ETGEITTTKPLDREEQPEYTLTVEATD------GGGPPLSSTAT 68

                           90
                   ....*....|..
gi 2328705306  311 FTLIVTDVNEAP 322
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
216-293 4.11e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.15  E-value: 4.11e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2328705306 216 TLAEDTNIGSTILTIQATDADEPftGSSKILYHIIKGDSEGRLGVDTDphtnTGYVIIKKPLDFETAAVSNIVFKAEN 293
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPD----TGDISTTKPLDRESIGEYELTVEATD 75
Cadherin pfam00028
Cadherin domain;
439-523 1.11e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.44  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306 439 SAPGSLI--FEATDDDqhlfRGPH--FTFSLGSGSLQNDWEVSKINGTharLSTRHT-EFEER-EYVVLIRINDGGRPPL 512
Cdd:pfam00028   9 APVGTEVltVTATDPD----LGPNgrIFYSILGGGPGGNFRIDPDTGD---ISTTKPlDRESIgEYELTVEATDSGGPPL 81

                          90
                  ....*....|.
gi 2328705306 513 EGIVSLPVTFC 523
Cdd:pfam00028  82 SSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 328-421 3.38e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 3.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306 328 VFQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGS 403
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdSGENgeVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 2328705306 404 SLSSVSEFHLILMDVNDN 421
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 104-202 9.27e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 9.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306 104 VFEVQENERLGNSIGTLTAHDRDEENtaNSFLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKqSLKKQDTPQYNLTIEVS 183
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE----DGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|..
gi 2328705306 184 DKD---FKTLCFVQINVIDIND 202
Cdd:cd11304    76 DGGgppLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 29-96 2.17e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 2.17e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2328705306   29 YSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPP 96
Cdd:smart00112  15 YSILSGN--DDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 214-320 4.11e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 4.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306 214 NLTLAEDTNIGSTILTIQATDADEPFTGssKILYHIIKGDSEGRLGVDtdphTNTGYVIIKKPLDFETAAVSNIVFKAEN 293
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*..
gi 2328705306 294 PEPLVFgvkynaSSFAKFTLIVTDVNE 320
Cdd:cd11304    77 GGGPPL------SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 29-94 8.16e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 8.16e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2328705306  29 YSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDN 94
Cdd:cd11304    34 YSIVSGN--EDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
329-398 1.86e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 1.86e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2328705306 329 FQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYS-LRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVAT 398
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPdLGPNgrIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 350-423 3.99e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 3.99e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2328705306  350 DPEGLDISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPP 423
Cdd:smart00112   7 SGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
104-186 9.62e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 9.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306 104 VFEVQENERLGNSIGTLTAHDRDEenTANSFLNYRIVEQtpklPMDGLFLIQTYAGMLQLAKQsLKKQDTPQYNLTIEVS 183
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDL--GPNGRIFYSILGG----GPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEAT 74


                  ...
gi 2328705306 184 DKD 186
Cdd:pfam00028  75 DSG 77
Cadherin pfam00028
Cadherin domain;
42-88 1.13e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.38  E-value: 1.13e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2328705306  42 FSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKV 88
Cdd:pfam00028  44 FRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 121-205 1.91e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 1.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306  121 TAHDRDEEntANSFLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKQsLKKQDTPQYNLTIEVSDKDFKTL---CFVQINV 197
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGND----DGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLsstATVTITV 73


                   ....*...
gi 2328705306  198 IDINDQIP 205
Cdd:smart00112  74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 231-322 9.37e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.35  E-value: 9.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306  231 QATDADEPFtgSSKILYHIIKGDSEGRLGVDTdphtNTGYVIIKKPLDFETAAVSNIVFKAENpeplvfGVKYNASSFAK 310
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDP----ETGEITTTKPLDREEQPEYTLTVEATD------GGGPPLSSTAT 68

                           90
                   ....*....|..
gi 2328705306  311 FTLIVTDVNEAP 322
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
216-293 4.11e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.15  E-value: 4.11e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2328705306 216 TLAEDTNIGSTILTIQATDADEPftGSSKILYHIIKGDSEGRLGVDTDphtnTGYVIIKKPLDFETAAVSNIVFKAEN 293
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPD----TGDISTTKPLDRESIGEYELTVEATD 75
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 26-94 6.46e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 45.03  E-value: 6.46e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306  26 GAQYSLVDKEKLPRFpFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDN 94
Cdd:cd00031    30 IIKISAAGKEALPSW-LHWEPHsGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
439-523 1.11e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.44  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705306 439 SAPGSLI--FEATDDDqhlfRGPH--FTFSLGSGSLQNDWEVSKINGTharLSTRHT-EFEER-EYVVLIRINDGGRPPL 512
Cdd:pfam00028   9 APVGTEVltVTATDPD----LGPNgrIFYSILGGGPGGNFRIDPDTGD---ISTTKPlDRESIgEYELTVEATDSGGPPL 81

                          90
                  ....*....|.
gi 2328705306 513 EGIVSLPVTFC 523
Cdd:pfam00028  82 SSTATVTITVL 92
Cadherin_3 pfam16184
Cadherin-like;
193-264 3.24e-03

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 37.58  E-value: 3.24e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2328705306 193 VQINVIDINDQIPIFEKSdyGNLTLAEDtniGSTILT---IQATDADEPftgSSKILYHIIKGDSEGRLGVDTDP 264
Cdd:pfam16184   7 FNITIIPVNDEAPVLTTN--TGLRLWEG---SSRPITpdlLQAEDPDTP---PEDLTYTVVQGPSHGHLALKGAP 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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