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Conserved domains on  [gi|2329567277|ref|NP_001401184|]
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low-density lipoprotein receptor-related protein 6 isoform j [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 402-600 2.59e-15

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14952:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 247  Bit Score: 77.25  E-value: 2.59e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  402 IAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPmVGYMYWTDWGEIPKIERAAlDGSDR 481
Cdd:cd14952      9 LDGPGGVAVD-AAGNVYVADSGNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDA-AGTVYVTDFGNNRVLKLAA-GSTTQ 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  482 VVLVNTSLGWPNGLALDyDEGKIY---WGDAKTDKIETisrafmnGSALEHVVEF-GLDYPEGMAVDWLGkNLYWADTGT 557
Cdd:cd14952     86 TVLPFTGLNDPTGVAVD-AAGNVYvadTGNNRVLKLAA-------GSNTQTVLPFtGLSNPDGVAVDGAG-NVYVTDTGN 156

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 2329567277  558 NRieVSKLD-GQHRQ-VLVWKDLDSPRALALDPAeGFMYWTEWGG 600
Cdd:cd14952    157 NR--VLKLAaGSTTQtVLPFTGLNSPSGVAVDTA-GNVYVTDHGN 198
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 150-191 1.13e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 63.33  E-value: 1.13e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567277  150 GFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDY 191
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1157-1191 2.19e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 62.61  E-value: 2.19e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2329567277 1157 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1191
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1119-1153 3.71e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 3.71e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2329567277 1119 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1153
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 286-323 3.13e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 59.18  E-value: 3.13e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2329567277  286 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLENGKTC 323
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 724-760 3.80e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.79  E-value: 3.80e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2329567277  724 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 760
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1080-1116 1.99e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.83  E-value: 1.99e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2329567277 1080 CSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDELNC 1116
Cdd:cd00112      1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 175-216 7.89e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 7.89e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2329567277   175 IIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNR 216
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 89-127 9.02e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 9.02e-09
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2329567277    89 VVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGS 127
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1038-1074 1.42e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.86  E-value: 1.42e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2329567277 1038 CAQDNGGCSHICLVKGDGTTrCSCPMHLVLLQDELSC 1074
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 614-656 7.19e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 7.19e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2329567277   614 RTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNR 656
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 353-393 2.42e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.37  E-value: 2.42e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567277   353 VLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSG 393
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 925-967 4.32e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 4.32e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2329567277   925 EVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR 967
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1-204 5.78e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.31  E-value: 5.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277    1 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGL----IYWSDVSEEAIK 76
Cdd:COG3391     14 AVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRVS 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277   77 RTEFNKTESVQNVVVSGllSPDGLACDWLGEKLYWTDSETNRIEVsnLDGSLRKVL-FWQELDQPRAIALDPSSGFMYWT 155
Cdd:COG3391     94 VIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVA 169

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2329567277  156 DWG--EVPKIERAgMDGSSRFII--INSEIYwPNGLTLDYEEQKLYWADAKLN 204
Cdd:COG3391    170 NSGsnTVSVIVSV-IDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANRGSN 220
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 658-697 6.26e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 6.26e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2329567277   658 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 697
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 789-829 2.02e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 2.02e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567277   789 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 829
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
799-906 5.62e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 5.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  799 RAIDYDPLDKQLYWIDSRQNMIRKAqeDGSQGftVVVSSVPsqnLEIQPYDLSIDIYSRYIYWTCEATN---VInVTRLD 875
Cdd:COG3391    113 RGLAVDPDGGRLYVADSGNGRVSVI--DTATG--KVVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsVI-VSVID 184

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2329567277  876 GRSvGVVLK--GEQDRPRAVVVNPEKGYMYFTN 906
Cdd:COG3391    185 TAT-GKVVAtiPVGGGPVGVAVSPDGRRLYVAN 216
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 217-251 7.32e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.74  E-value: 7.32e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2329567277   217 QAVVKGSLPHP--FALTLFEDILYWTDWSTHSILACN 251
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37
 
Name Accession Description Interval E-value
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 402-600 2.59e-15

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 77.25  E-value: 2.59e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  402 IAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPmVGYMYWTDWGEIPKIERAAlDGSDR 481
Cdd:cd14952      9 LDGPGGVAVD-AAGNVYVADSGNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDA-AGTVYVTDFGNNRVLKLAA-GSTTQ 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  482 VVLVNTSLGWPNGLALDyDEGKIY---WGDAKTDKIETisrafmnGSALEHVVEF-GLDYPEGMAVDWLGkNLYWADTGT 557
Cdd:cd14952     86 TVLPFTGLNDPTGVAVD-AAGNVYvadTGNNRVLKLAA-------GSNTQTVLPFtGLSNPDGVAVDGAG-NVYVTDTGN 156

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 2329567277  558 NRieVSKLD-GQHRQ-VLVWKDLDSPRALALDPAeGFMYWTEWGG 600
Cdd:cd14952    157 NR--VLKLAaGSTTQtVLPFTGLNSPSGVAVDTA-GNVYVTDHGN 198
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
339-560 2.81e-15

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 77.75  E-value: 2.81e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  339 LRRISLDTPDFTDIVLQLEDIRHAIAIDYDpveGYIYWTDDEVRAIRR-SFIDGSGSQFVVTAQIAHPDGIAVDwVARNL 417
Cdd:COG4257     40 IGRLDPATGEFTEYPLGGGSGPHGIAVDPD---GNLWFTDNGNNRIGRiDPKTGEITTFALPGGGSNPHGIAFD-PDGNL 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  418 YWTDTGTDRI-EVTRLNGTMRKILISEDLEEPRAIVLDPMvGYMYWTDWG--EIPKIERAalDGSDRVVLVNTSLGWPNG 494
Cdd:COG4257    116 WFTDQGGNRIgRLDPATGEVTEFPLPTGGAGPYGIAVDPD-GNLWVTDFGanAIGRIDPD--TGTLTEYALPTPGAGPRG 192

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2329567277  495 LALDyDEGKIYWGDAKTDKIETISRAfmNGSALEHVVEFGLDYPEGMAVDWLGkNLYWADTGTNRI 560
Cdd:COG4257    193 LAVD-PDGNLWVADTGSGRIGRFDPK--TGTVTEYPLPGGGARPYGVAVDGDG-RVWFAESGANRI 254
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 150-191 1.13e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 63.33  E-value: 1.13e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567277  150 GFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDY 191
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1157-1191 2.19e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 62.61  E-value: 2.19e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2329567277 1157 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1191
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1119-1153 3.71e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 3.71e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2329567277 1119 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1153
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 397-437 5.39e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.46  E-value: 5.39e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567277   397 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 437
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 458-499 1.10e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.64  E-value: 1.10e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567277  458 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 499
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 286-323 3.13e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 59.18  E-value: 3.13e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2329567277  286 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLENGKTC 323
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 724-760 3.80e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.79  E-value: 3.80e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2329567277  724 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 760
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1119-1153 8.44e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 8.44e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2329567277 1119 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1153
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1080-1116 1.99e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.83  E-value: 1.99e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2329567277 1080 CSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDELNC 1116
Cdd:cd00112      1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1119-1150 4.04e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.10  E-value: 4.04e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2329567277  1119 CSESQFQCASGQCIDGALRCNGDANCQDKSDE 1150
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1157-1188 5.48e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 5.48e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2329567277  1157 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1188
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 175-216 7.89e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 7.89e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2329567277   175 IIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNR 216
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1079-1113 1.32e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 1.32e-09
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 2329567277  1079 TCSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDE 1113
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 130-173 1.58e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 1.58e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2329567277   130 KVLFWQELDQPRAIALDPSSGFMYWTDWGEvPKIERAGMDGSSR 173
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1079-1116 5.28e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 5.28e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2329567277 1079 TCSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDELNC 1116
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 89-127 9.02e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 9.02e-09
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2329567277    89 VVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGS 127
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1157-1191 1.11e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 1.11e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2329567277 1157 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1191
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1038-1074 1.42e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.86  E-value: 1.42e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2329567277 1038 CAQDNGGCSHICLVKGDGTTrCSCPMHLVLLQDELSC 1074
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 614-656 7.19e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 7.19e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2329567277   614 RTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNR 656
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 107-147 1.14e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 1.14e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567277  107 EKLYWTDSET-NRIEVSNLDGSLRKVLFWQELDQPRAIALDP 147
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 353-393 2.42e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.37  E-value: 2.42e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567277   353 VLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSG 393
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 925-967 4.32e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 4.32e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2329567277   925 EVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR 967
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1-204 5.78e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.31  E-value: 5.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277    1 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGL----IYWSDVSEEAIK 76
Cdd:COG3391     14 AVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRVS 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277   77 RTEFNKTESVQNVVVSGllSPDGLACDWLGEKLYWTDSETNRIEVsnLDGSLRKVL-FWQELDQPRAIALDPSSGFMYWT 155
Cdd:COG3391     94 VIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVA 169

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2329567277  156 DWG--EVPKIERAgMDGSSRFII--INSEIYwPNGLTLDYEEQKLYWADAKLN 204
Cdd:COG3391    170 NSGsnTVSVIVSV-IDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANRGSN 220
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 658-697 6.26e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 6.26e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2329567277   658 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 697
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 789-829 2.02e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 2.02e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567277   789 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 829
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 55-272 2.16e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.62  E-value: 2.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277   55 AVDfvfSHGLIYWSDVSEEAIKRteFNK-TESVQNVVVSG-----LLSPDGLACDWLGEkLYWTDSETNRIEVSNLDGSL 128
Cdd:cd05819     14 AVD---SSGNIYVADTGNNRIQV--FDPdGNFITSFGSFGsgdgqFNEPAGVAVDSDGN-LYVADTGNHRIQKFDPDGNF 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  129 RKV-----LFWQELDQPRAIALDpSSGFMYWTDWGEVpKIERAGMDGSSRFII-----INSEIYWPNGLTLDyEEQKLYW 198
Cdd:cd05819     88 LASfggsgDGDGEFNGPRGIAVD-SSGNIYVADTGNH-RIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVD-SDGNIYV 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  199 ADAKLNFIHKSNLDGT-----NRQAVVKGSLPHPFALTLFED-ILYWTDWSTHSILacnKYTGEGLREI--------HSD 264
Cdd:cd05819    165 ADTGNHRIQVFDPDGNflttfGSTGTGPGQFNYPTGIAVDSDgNIYVADSGNNRVQ---VFDPDGAGFGgngnflgsDGQ 241


                   ....*...
gi 2329567277  265 IFSPMDIH 272
Cdd:cd05819    242 FNRPSGLA 249
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 372-412 3.52e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.45  E-value: 3.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567277  372 GYIYWTDDEVRA-IRRSFIDGSGSQFVVTAQIAHPDGIAVDW 412
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
799-906 5.62e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 5.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  799 RAIDYDPLDKQLYWIDSRQNMIRKAqeDGSQGftVVVSSVPsqnLEIQPYDLSIDIYSRYIYWTCEATN---VInVTRLD 875
Cdd:COG3391    113 RGLAVDPDGGRLYVADSGNGRVSVI--DTATG--KVVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsVI-VSVID 184

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2329567277  876 GRSvGVVLK--GEQDRPRAVVVNPEKGYMYFTN 906
Cdd:COG3391    185 TAT-GKVVAtiPVGGGPVGVAVSPDGRRLYVAN 216
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 217-251 7.32e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.74  E-value: 7.32e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2329567277   217 QAVVKGSLPHP--FALTLFEDILYWTDWSTHSILACN 251
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 945-985 1.15e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.91  E-value: 1.15e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567277  945 GKLFWADSDLR-RIESSDLSGANRIVLEDSNILQPVGLTVFE 985
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 846-879 8.02e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 8.02e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 2329567277   846 QPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSV 879
Cdd:smart00135   10 HPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
 
Name Accession Description Interval E-value
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 402-600 2.59e-15

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 77.25  E-value: 2.59e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  402 IAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPmVGYMYWTDWGEIPKIERAAlDGSDR 481
Cdd:cd14952      9 LDGPGGVAVD-AAGNVYVADSGNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDA-AGTVYVTDFGNNRVLKLAA-GSTTQ 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  482 VVLVNTSLGWPNGLALDyDEGKIY---WGDAKTDKIETisrafmnGSALEHVVEF-GLDYPEGMAVDWLGkNLYWADTGT 557
Cdd:cd14952     86 TVLPFTGLNDPTGVAVD-AAGNVYvadTGNNRVLKLAA-------GSNTQTVLPFtGLSNPDGVAVDGAG-NVYVTDTGN 156

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 2329567277  558 NRieVSKLD-GQHRQ-VLVWKDLDSPRALALDPAeGFMYWTEWGG 600
Cdd:cd14952    157 NR--VLKLAaGSTTQtVLPFTGLNSPSGVAVDTA-GNVYVTDHGN 198
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
339-560 2.81e-15

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 77.75  E-value: 2.81e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  339 LRRISLDTPDFTDIVLQLEDIRHAIAIDYDpveGYIYWTDDEVRAIRR-SFIDGSGSQFVVTAQIAHPDGIAVDwVARNL 417
Cdd:COG4257     40 IGRLDPATGEFTEYPLGGGSGPHGIAVDPD---GNLWFTDNGNNRIGRiDPKTGEITTFALPGGGSNPHGIAFD-PDGNL 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  418 YWTDTGTDRI-EVTRLNGTMRKILISEDLEEPRAIVLDPMvGYMYWTDWG--EIPKIERAalDGSDRVVLVNTSLGWPNG 494
Cdd:COG4257    116 WFTDQGGNRIgRLDPATGEVTEFPLPTGGAGPYGIAVDPD-GNLWVTDFGanAIGRIDPD--TGTLTEYALPTPGAGPRG 192

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2329567277  495 LALDyDEGKIYWGDAKTDKIETISRAfmNGSALEHVVEFGLDYPEGMAVDWLGkNLYWADTGTNRI 560
Cdd:COG4257    193 LAVD-PDGNLWVADTGSGRIGRFDPK--TGTVTEYPLPGGGARPYGVAVDGDG-RVWFAESGANRI 254
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 150-191 1.13e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 63.33  E-value: 1.13e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567277  150 GFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDY 191
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1157-1191 2.19e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 62.61  E-value: 2.19e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2329567277 1157 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1191
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1119-1153 3.71e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 3.71e-12
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2329567277 1119 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1153
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 397-437 5.39e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.46  E-value: 5.39e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567277   397 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 437
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 458-499 1.10e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 60.64  E-value: 1.10e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567277  458 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 499
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 401-646 2.15e-11

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 66.19  E-value: 2.15e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  401 QIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTmRKILISED------LEEPRAIVLDPMvGYMYWTDWG--EIPKIe 472
Cdd:cd05819      6 ELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGN-FITSFGSFgsgdgqFNEPAGVAVDSD-GNLYVADTGnhRIQKF- 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  473 raalDGSDRVVLVNTSLGW-------PNGLALDyDEGKIYWGDAKTDKIETISRafmNGSALEHVVEFG-----LDYPEG 540
Cdd:cd05819     82 ----DPDGNFLASFGGSGDgdgefngPRGIAVD-SSGNIYVADTGNHRIQKFDP---DGEFLTTFGSGGsgpgqFNGPTG 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  541 MAVDWLGkNLYWADTGTNRIEVSKLDGQhrQVLVWKD-------LDSPRALALDPaEGFMYWTEWGGKpKIDRAAMDGSE 613
Cdd:cd05819    154 VAVDSDG-NIYVADTGNHRIQVFDPDGN--FLTTFGStgtgpgqFNYPTGIAVDS-DGNIYVADSGNN-RVQVFDPDGAG 228

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 2329567277  614 RTTLVPNVGRAN------GLTIDyAKRRLYWTDLDTNLI 646
Cdd:cd05819    229 FGGNGNFLGSDGqfnrpsGLAVD-SDGNLYVADTGNNRI 266
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 528-570 2.89e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.54  E-value: 2.89e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2329567277   528 EHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHR 570
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 286-323 3.13e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 59.18  E-value: 3.13e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2329567277  286 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLENGKTC 323
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 724-760 3.80e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.79  E-value: 3.80e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2329567277  724 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 760
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
361-559 4.16e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 64.72  E-value: 4.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  361 HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV--TRLNGTMRK 438
Cdd:COG3391     26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVidLATGKVVAT 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  439 ILISEDleePRAIVLDPMVGYMYWTDWGEiPKIerAALDGSDRVVLVNTSLG-WPNGLALDYDEGKIYWGDAKTDKIETI 517
Cdd:COG3391    106 IPVGGG---PRGLAVDPDGGRLYVADSGN-GRV--SVIDTATGKVVATIPVGaGPHGIAVDPDGKRLYVANSGSNTVSVI 179

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 2329567277  518 SRAF-MNGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNR 559
Cdd:COG3391    180 VSVIdTATGKVVATIPVG-GGPVGVAVSPDGRRLYVANRGSNT 221
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 401-647 4.28e-11

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 65.38  E-value: 4.28e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  401 QIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRKILIS-----EDLEEPRAIVLDP----MVG-YMYWtdwgeipK 470
Cdd:cd14956     11 QFKDPRGIAVD-ADDNVYVADARNGRIQVFDKDGTFLRRFGTtgdgpGQFGRPRGLAVDKdgwlYVAdYWGD-------R 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  471 IERAALDGSDRVVL-----VNTSLGWPNGLALDYDeGKIYWGDAKTDKIETIS--RAFMN--GSALEHVVEFglDYPEGM 541
Cdd:cd14956     83 IQVFTLTGELQTIGgssgsGPGQFNAPRGVAVDAD-GNLYVADFGNQRIQKFDpdGSFLRqwGGTGIEPGSF--NYPRGV 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  542 AVDWLGkNLYWADTGTNRIEVSKLDGqhRQVLVW-------KDLDSPRALALDPAeGFMYWTEWGGKpKIDRAAMDGSER 614
Cdd:cd14956    160 AVDPDG-TLYVADTYNDRIQVFDNDG--AFLRKWggrgtgpGQFNYPYGIAIDPD-GNVFVADFGNN-RIQKFTADGTFL 234

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 2329567277  615 TTlVPNVGRANG-------LTIDyAKRRLYWTDLDTNLIE 647
Cdd:cd14956    235 TS-WGSPGTGPGqfknpwgVVVD-ADGTVYVADSNNNRVQ 272
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
433-644 6.70e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 63.94  E-value: 6.70e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  433 NGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGK-IYWGDAKT 511
Cdd:COG3391     10 AVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRrLYVANSGS 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  512 DKIETISRAfmnGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNRieVSKLDGQHRQVL-VWKDLDSPRALALDPAE 590
Cdd:COG3391     90 GRVSVIDLA---TGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKVVaTIPVGAGPHGIAVDPDG 163

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  591 GFMYWTEWGGKP------KIDRAAMdgsERTTLVPNVGRANGLTIDYAKRRLYWTDLDTN 644
Cdd:COG3391    164 KRLYVANSGSNTvsvivsVIDTATG---KVVATIPVGGGPVGVAVSPDGRRLYVANRGSN 220
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 405-560 6.95e-11

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 64.15  E-value: 6.95e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  405 PDGIAVDwVARNLYWTDTGTDRieVTRLNG--TMRKILISEDLEEPRAIVLDPmVGYMYWTDWGEiPKIERAALDGSDRV 482
Cdd:cd14952     96 PTGVAVD-AAGNVYVADTGNNR--VLKLAAgsNTQTVLPFTGLSNPDGVAVDG-AGNVYVTDTGN-NRVLKLAAGSTTQT 170

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2329567277  483 VLVNTSLGWPNGLALDyDEGKIYWGDAKTDKIetisRAFMNGSALEHVVEF-GLDYPEGMAVDWLGkNLYWADTGTNRI 560
Cdd:cd14952    171 VLPFTGLNSPSGVAVD-TAGNVYVTDHGNNRV----LKLAAGSTTPTVLPFtGLNGPLGVAVDAAG-NVYVADRGNDRV 243
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1119-1153 8.44e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 8.44e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2329567277 1119 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1153
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 438-481 9.45e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 9.45e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2329567277   438 KILISEDLEEPRAIVLDPMVGYMYWTDWGEiPKIERAALDGSDR 481
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1080-1116 1.99e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.83  E-value: 1.99e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2329567277 1080 CSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDELNC 1116
Cdd:cd00112      1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1119-1150 4.04e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.10  E-value: 4.04e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2329567277  1119 CSESQFQCASGQCIDGALRCNGDANCQDKSDE 1150
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 483-525 4.74e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 4.74e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2329567277   483 VLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEtisRAFMNGS 525
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIE---VANLDGT 41
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1157-1188 5.48e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 5.48e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2329567277  1157 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1188
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 175-216 7.89e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 7.89e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2329567277   175 IIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNR 216
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1079-1113 1.32e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 1.32e-09
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 2329567277  1079 TCSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDE 1113
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 130-173 1.58e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 1.58e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2329567277   130 KVLFWQELDQPRAIALDPSSGFMYWTDWGEvPKIERAGMDGSSR 173
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1079-1116 5.28e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 5.28e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2329567277 1079 TCSPQQFTCFTGEidCIPVAWRCDGFTECEDHSDELNC 1116
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 89-127 9.02e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 9.02e-09
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2329567277    89 VVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGS 127
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1157-1191 1.11e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 1.11e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2329567277 1157 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1191
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1038-1074 1.42e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.86  E-value: 1.42e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2329567277 1038 CAQDNGGCSHICLVKGDGTTrCSCPMHLVLLQDELSC 1074
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT-CSCPEGYELQDDGRTC 36
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 405-588 1.54e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 57.30  E-value: 1.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  405 PDGIAVDWvaRNLYWTDTGTDRIEVTRLNGTMRKILISEDLEE-----PRAIVLDPMvGYMYWTDW--GEIPKIERaalD 477
Cdd:cd14963     12 PMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPGTGPgefkyPYGIAVDSD-GNIYVADLynGRIQVFDP---D 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  478 GSDRVVLVNTS--LGWPNGLALDYDEGKIYWGDAKTDKIETISRafmNGsalEHVVEFG--------LDYPEGMAVDWLG 547
Cdd:cd14963     86 GKFLKYFPEKKdrVKLISPAGLAIDDGKLYVSDVKKHKVIVFDL---EG---KLLLEFGkpgsepgeLSYPNGIAVDEDG 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2329567277  548 kNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDS-----PRALALDP 588
Cdd:cd14963    160 -NIYVADSGNGRIQVFDKNGKFIKELNGSPDGKsgfvnPRGIAVDP 204
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 361-560 1.85e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 57.33  E-value: 1.85e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  361 HAIAIDYDpveGYIYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 435
Cdd:cd05819    105 RGIAVDSS---GNIYVADTGNHRIQKfdpdgEFLTTFGSGGSGPGQFNGPTGVAVD-SDGNIYVADTGNHRIQVFDPDGN 180

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  436 mrkilisedleepraivldpmvgymYWTDWGEIpkieraaldgsdrvVLVNTSLGWPNGLALDyDEGKIYWGDAKTDKIE 515
Cdd:cd05819    181 -------------------------FLTTFGST--------------GTGPGQFNYPTGIAVD-SDGNIYVADSGNNRVQ 220

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2329567277  516 TISRAFM----NGSALehVVEFGLDYPEGMAVDwLGKNLYWADTGTNRI 560
Cdd:cd05819    221 VFDPDGAgfggNGNFL--GSDGQFNRPSGLAVD-SDGNLYVADTGNNRI 266
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 571-614 1.88e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 1.88e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2329567277   571 QVLVWKDLDSPRALALDPAEGFMYWTEWgGKPKIDRAAMDGSER 614
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 614-656 7.19e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 7.19e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2329567277   614 RTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNR 656
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 363-562 7.34e-08

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 55.74  E-value: 7.34e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  363 IAIDYDpveGYIYWTDDEVRAIR-----RSFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMR 437
Cdd:cd14957     70 IAVDSN---GNIYVADTDNNRIQvfnssGVYQYSIGTGGSGDGQFNGPYGIAVD-SNGNIYVADTGNHRIQVFTSSGTFS 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  438 -----KILISEDLEEPRAIVLDPmVGYMYWTDwgeipkieraalDGSDRVVLVNTS----------------LGWPNGLA 496
Cdd:cd14957    146 ysigsGGTGPGQFNGPQGIAVDS-DGNIYVAD------------TGNHRIQVFTSSgtfqytfgssgsgpgqFSDPYGIA 212

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  497 LDYDeGKIYWGDAKTDKIE--TISRAF--MNGSALEHVVEFglDYPEGMAVDWLGkNLYWADTGTNRIEV 562
Cdd:cd14957    213 VDSD-GNIYVADTGNHRIQvfTSSGAYqySIGTSGSGNGQF--NYPYGIAVDNDG-KIYVADSNNNRIQV 278
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 362-560 8.24e-08

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 56.00  E-value: 8.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  362 AIAIDydpVEGYIYWTDDEVRAIRR-------SFIDGSGSQF------VVTAQIAHPDGIAVDwVARNLYWTDTGTDRI- 427
Cdd:cd14953     81 GVAVD---AAGNLYVADTGNHRIRKitpdgvvSTLAGTGTAGfsddggATAAQFNYPTGVAVD-AAGNLYVADTGNHRIr 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  428 ------EVTRLNGTMR------KILISEDLEEPRAIVLDPMvGYMYWTDWGE--IPKIeraALDG-------------SD 480
Cdd:cd14953    157 kitpdgVVTTVAGTGGagyagdGPATAAQFNNPTGVAVDAA-GNLYVADRGNhrIRKI---TPDGvvttvagtgtagfSG 232

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  481 RVVLVNTSLGWPNGLALDyDEGKIYWGDAKTDKIETISRA-----FMNGSA-----LEHVVEFGLDYPEGMAVDWLGkNL 550
Cdd:cd14953    233 DGGATAAQLNNPTGVAVD-AAGNLYVADSGNHRIRKITPAgvvttVAGGGAgfsgdGGPATSAQFNNPTGVAVDAAG-NL 310

                          250
                   ....*....|
gi 2329567277  551 YWADTGTNRI 560
Cdd:cd14953    311 YVADTGNNRI 320
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 415-455 8.98e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 8.98e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567277  415 RNLYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPRAIVLDP 455
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 361-562 1.07e-07

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 54.96  E-value: 1.07e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  361 HAIAIDYDpveGYIYWTDDEVRAIR-----RSFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEV-TRLNG 434
Cdd:cd14957     21 RGIAVDSA---GNIYVADTGNNRIQvftssGVYSYSIGSGGTGSGQFNSPYGIAVD-SNGNIYVADTDNNRIQVfNSSGV 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  435 TMRKI----LISEDLEEPRAIVLDPMvGYMYWTDwgeipkieraalDGSDRVVLVNTS----------------LGWPNG 494
Cdd:cd14957     97 YQYSIgtggSGDGQFNGPYGIAVDSN-GNIYVAD------------TGNHRIQVFTSSgtfsysigsggtgpgqFNGPQG 163

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2329567277  495 LALDYDeGKIYWGDAKTDKIETISRA----FMNGSALEHVVEFglDYPEGMAVDWLGkNLYWADTGTNRIEV 562
Cdd:cd14957    164 IAVDSD-GNIYVADTGNHRIQVFTSSgtfqYTFGSSGSGPGQF--SDPYGIAVDSDG-NIYVADTGNHRIQV 231
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 107-147 1.14e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 1.14e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567277  107 EKLYWTDSET-NRIEVSNLDGSLRKVLFWQELDQPRAIALDP 147
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 405-600 1.89e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 54.22  E-value: 1.89e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  405 PDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRKIL----ISEDLEEPRAIVLDPmvGYMYWTDWGEiPKIerAALDGSD 480
Cdd:cd14963     58 PYGIAVD-SDGNIYVADLYNGRIQVFDPDGKFLKYFpekkDRVKLISPAGLAIDD--GKLYVSDVKK-HKV--IVFDLEG 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  481 RVVLVNTSLG-------WPNGLALDyDEGKIYWGDAKTDKIETISrafMNGS-----ALEHVVEFGLDYPEGMAVDWLGk 548
Cdd:cd14963    132 KLLLEFGKPGsepgelsYPNGIAVD-EDGNIYVADSGNGRIQVFD---KNGKfikelNGSPDGKSGFVNPRGIAVDPDG- 206

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2329567277  549 NLYWADTGTNRIEVSKLDGQHRQVLVWKDLDS-----PRALALDPaEGFMYWTEWGG 600
Cdd:cd14963    207 NLYVVDNLSHRVYVFDEQGKELFTFGGRGKDDgqfnlPNGLFIDD-DGRLYVTDREN 262
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 353-393 2.42e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.37  E-value: 2.42e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567277   353 VLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSG 393
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 362-567 2.85e-07

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 53.73  E-value: 2.85e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  362 AIAIDydpVEGYIYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTM 436
Cdd:cd14955     20 GIAVD---SAGNVYVADTGNNRIQKfdstgTFLTKWGSSGSGDGQFYSPTGIAVD-SDGNVYVADTGNHRIQKFDSTGTF 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  437 RKILISEDLEE-----PRAIVLDPMvGYMYWTDWGEiPKIERAALDGSdrvvlVNTSLG----------WPNGLALDyDE 501
Cdd:cd14955     96 LTKWGSSGSGDgqfnsPSGIAVDSA-GNVYVTDSGN-NRIQKFDSSGT-----FITKWGsfgsgdgqfnSPTGIAVD-SA 167

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2329567277  502 GKIYWGDAKTDKIetisRAFMN--------GSALEHVVEFglDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDG 567
Cdd:cd14955    168 GNVYVADTGNNRI----QKFTStgtfltkwGSEGSGDGQF--NAPYGIAVDSAG-NVYVADTGNNRIQKFDSSG 234
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 482-644 3.63e-07

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 52.98  E-value: 3.63e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  482 VVLVNTSLGWPNGLALDYDeGKIYWGDAKTDKIETISrafmNGSALEHVVEF-GLDYPEGMAVDWLGkNLYWADTGTNRi 560
Cdd:cd14952      2 TVLPFTGLDGPGGVAVDAA-GNVYVADSGNNRVLKLA----AGSTTQTVLPFtGLYQPQGVAVDAAG-TVYVTDFGNNR- 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  561 eVSKLD-GQHRQ-VLVWKDLDSPRALALDPAeGFMYWTEWGGKPKIDRAAmdGSERTTLVPNVG--RANGLTIDYAKrRL 636
Cdd:cd14952     75 -VLKLAaGSTTQtVLPFTGLNDPTGVAVDAA-GNVYVADTGNNRVLKLAA--GSNTQTVLPFTGlsNPDGVAVDGAG-NV 149


                   ....*...
gi 2329567277  637 YWTDLDTN 644
Cdd:cd14952    150 YVTDTGNN 157
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 925-967 4.32e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 4.32e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2329567277   925 EVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR 967
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 367-560 5.78e-07

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 52.59  E-value: 5.78e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  367 YDPvEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQiAHPDGIAVD-----WVARN---LYWTDTGTDRIEVtrlngtmrk 438
Cdd:COG3386     15 WDP-DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDpdgrlLVADHgrgLVRFDPADGEVTV--------- 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  439 ilISEDLEEPRA----IVLDPMvGYMYWTDwgeiPKIERAA-----LDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDA 509
Cdd:COG3386     84 --LADEYGKPLNrpndGVVDPD-GRLYFTD----MGEYLPTgalyrVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADT 156

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2329567277  510 KTDKIetisRAF---MNG--SALEHVVEFGLD--YPEGMAVDWLGkNLYWADTGTNRI 560
Cdd:COG3386    157 GAGRI----YRFdldADGtlGNRRVFADLPDGpgGPDGLAVDADG-NLWVALWGGGGV 209
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 387-562 7.24e-07

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 52.65  E-value: 7.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  387 SFIDGS-GSQfvvTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRKILISEDL-----EEPRAIVLDPmVGYM 460
Cdd:cd14957      4 SYAFGSnGSG---NGQFNTPRGIAVD-SAGNIYVADTGNNRIQVFTSSGVYSYSIGSGGTgsgqfNSPYGIAVDS-NGNI 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  461 YWTDwgeipkieraalDGSDRVVLVNTS----------------LGWPNGLALDyDEGKIYWGDAKTDKIE------TIS 518
Cdd:cd14957     79 YVAD------------TDNNRIQVFNSSgvyqysigtggsgdgqFNGPYGIAVD-SNGNIYVADTGNHRIQvftssgTFS 145

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2329567277  519 RAFmnGSALEHVVEFGldYPEGMAVDWLGkNLYWADTGTNRIEV 562
Cdd:cd14957    146 YSI--GSGGTGPGQFN--GPQGIAVDSDG-NIYVADTGNHRIQV 184
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 55-208 9.68e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 51.94  E-value: 9.68e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277   55 AVDfvfSHGLIYWSDVSEEAIKRteFNKTESVQNVVVSG------LLSPDGLACDWLGeKLYWTDSETNRIEVSNLDGSL 128
Cdd:cd05819    108 AVD---SSGNIYVADTGNHRIQK--FDPDGEFLTTFGSGgsgpgqFNGPTGVAVDSDG-NIYVADTGNHRIQVFDPDGNF 181

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  129 rkVLFW-------QELDQPRAIALDpSSGFMYWTDWG--EVPKIERAGM--DGSSRFIIINSEIYWPNGLTLDyEEQKLY 197
Cdd:cd05819    182 --LTTFgstgtgpGQFNYPTGIAVD-SDGNIYVADSGnnRVQVFDPDGAgfGGNGNFLGSDGQFNRPSGLAVD-SDGNLY 257

                          170
                   ....*....|.
gi 2329567277  198 WADAKLNFIHK 208
Cdd:cd05819    258 VADTGNNRIQV 268
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 591-631 1.38e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.38  E-value: 1.38e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567277  591 GFMYWTEWGGKPKIDRAAMDGSER-TTLVPNVGRANGLTIDY 631
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1-204 5.78e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.31  E-value: 5.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277    1 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGL----IYWSDVSEEAIK 76
Cdd:COG3391     14 AVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRVS 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277   77 RTEFNKTESVQNVVVSGllSPDGLACDWLGEKLYWTDSETNRIEVsnLDGSLRKVL-FWQELDQPRAIALDPSSGFMYWT 155
Cdd:COG3391     94 VIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVA 169

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2329567277  156 DWG--EVPKIERAgMDGSSRFII--INSEIYwPNGLTLDYEEQKLYWADAKLN 204
Cdd:COG3391    170 NSGsnTVSVIVSV-IDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANRGSN 220
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
106-246 6.22e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.31  E-value: 6.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  106 GEKLYWTDSETNRIEVSNLDgSLRKVLFWQELDQPRAIALDPSSGFMYWTDW--GEVPKIeragmDGSSRFIIinSEI-- 181
Cdd:COG3391     79 GRRLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSgnGRVSVI-----DTATGKVV--ATIpv 150

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2329567277  182 -YWPNGLTLDYEEQKLYWADAKLNFIHK--SNLDGTNRQaVVK----GSLPHPFALTLFEDILYWTDWSTHS 246
Cdd:COG3391    151 gAGPHGIAVDPDGKRLYVANSGSNTVSVivSVIDTATGK-VVAtipvGGGPVGVAVSPDGRRLYVANRGSNT 221
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 401-562 1.15e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 48.83  E-value: 1.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  401 QIAHPDGIAVDwvARNLYWTDTGTDRIEVTRLNGTMRKILISE-----DLEEPRAIVLDPMvGYMYWTDWG--------- 466
Cdd:cd14963    100 KLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLEFGKPgsepgELSYPNGIAVDED-GNIYVADSGngriqvfdk 176

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  467 EIPKIERAALDGSDRVVLVNtslgwPNGLALDyDEGKIYWGDAKTDKIETISRafmNGSALEHVVEFGLD-----YPEGM 541
Cdd:cd14963    177 NGKFIKELNGSPDGKSGFVN-----PRGIAVD-PDGNLYVVDNLSHRVYVFDE---QGKELFTFGGRGKDdgqfnLPNGL 247

                          170       180
                   ....*....|....*....|.
gi 2329567277  542 AVDWLGkNLYWADTGTNRIEV 562
Cdd:cd14963    248 FIDDDG-RLYVTDRENNRVAV 267
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 549-588 4.21e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.15  E-value: 4.21e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2329567277  549 NLYWADTGT-NRIEVSKLDGQHRQVLVWKDLDSPRALALDP 588
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 658-697 6.26e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 6.26e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2329567277   658 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 697
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 401-563 1.17e-04

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 45.62  E-value: 1.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  401 QIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT-MRKI----LISEDLEEPRAIVLDPmVGYMYWTDWgeipkieraa 475
Cdd:cd14954    116 QFNYPWGVAVD-SEGRIYVSDTRNHRVQVFDSDGQfIRKFgfegAGPGQLDSPRGVAVNP-DGNIVVSDF---------- 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  476 ldGSDRVVLVNT---------SLG-------WPNGLALDyDEGKIYWGDAKTDKIETISrafmngSALEHVVEFG----- 534
Cdd:cd14954    184 --NNHRLQVFDPdgqflrffgSEGsgngqfkRPRGVAVD-DEGNIIVADSGNHRVQVFS------PDGEFLCSFGtegng 254

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2329567277  535 ---LDYPEGMAVDWLGkNLYWADTGTNRIEVS 563
Cdd:cd14954    255 egqFDRPSGVAVTPDG-RIVVVDRGNHRIQVF 285
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 405-571 1.25e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 45.66  E-value: 1.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  405 PDGIAVDWVARnLYWTDTGTDRIEVTRL-NGTMRKILISED--LEEPRAIVLDPMvGYMYWTDwGEIPKIERaaLDGSDR 481
Cdd:cd14962     14 PYGVAADGRGR-IYVADTGRGAVFVFDLpNGKVFVIGNAGPnrFVSPIGVAIDAN-GNLYVSD-AELGKVFV--FDRDGK 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  482 VV-LVNTSLGW--PNGLALDYDEGKIYWGDAKTDKIETISrafMNGsalEHVVEFG--------LDYPEGMAVDWLGkNL 550
Cdd:cd14962     89 FLrAIGAGALFkrPTGIAVDPAGKRLYVVDTLAHKVKVFD---LDG---RLLFDIGkrgsgpgeFNLPTDLAVDRDG-NL 161

                          170       180
                   ....*....|....*....|.
gi 2329567277  551 YWADTGTNRIEVSKLDGQHRQ 571
Cdd:cd14962    162 YVTDTMNFRVQIFDADGKFLR 182
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 789-829 2.02e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 2.02e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567277   789 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 829
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 367-572 2.07e-04

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 44.56  E-value: 2.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  367 YDPVEGYIYWTDDEVRAIRR-SFIDGSGSQFVVTAQIA----HPDGIAVDWVARNLYWTDTGTdrievtrlnGTMRKILI 441
Cdd:pfam08450    7 WDEEEGALYWVDILGGRIHRlDPATGKETVWDTPGPVGaiapRDDGGLIVALKDGVALLDLAT---------GELTPLAD 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  442 SEDLEEPRAI----VLDP----MVGYMywtDWGEIPKIERAAL---DGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAK 510
Cdd:pfam08450   78 PEDDDWPLNRfndgKVDPdgrfWFGTM---GDDEAPGGDPGALyrlDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSP 154

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2329567277  511 TDKIETISRAFMNG--SALEHVVEF--GLDYPEGMAVDwLGKNLYWADTGTNRIEVSKLDGQHRQV 572
Cdd:pfam08450  155 ARKIWAYDYDLDGGliSNRRVFADFkpGLGRPDGMAVD-AEGNVWVARWGGGKVVRFDPDGKLLRE 219
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 55-272 2.16e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.62  E-value: 2.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277   55 AVDfvfSHGLIYWSDVSEEAIKRteFNK-TESVQNVVVSG-----LLSPDGLACDWLGEkLYWTDSETNRIEVSNLDGSL 128
Cdd:cd05819     14 AVD---SSGNIYVADTGNNRIQV--FDPdGNFITSFGSFGsgdgqFNEPAGVAVDSDGN-LYVADTGNHRIQKFDPDGNF 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  129 RKV-----LFWQELDQPRAIALDpSSGFMYWTDWGEVpKIERAGMDGSSRFII-----INSEIYWPNGLTLDyEEQKLYW 198
Cdd:cd05819     88 LASfggsgDGDGEFNGPRGIAVD-SSGNIYVADTGNH-RIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVD-SDGNIYV 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  199 ADAKLNFIHKSNLDGT-----NRQAVVKGSLPHPFALTLFED-ILYWTDWSTHSILacnKYTGEGLREI--------HSD 264
Cdd:cd05819    165 ADTGNHRIQVFDPDGNflttfGSTGTGPGQFNYPTGIAVDSDgNIYVADSGNNRVQ---VFDPDGAGFGgngnflgsDGQ 241


                   ....*...
gi 2329567277  265 IFSPMDIH 272
Cdd:cd05819    242 FNRPSGLA 249
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 372-412 3.52e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.45  E-value: 3.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567277  372 GYIYWTDDEVRA-IRRSFIDGSGSQFVVTAQIAHPDGIAVDW 412
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
799-906 5.62e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 5.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  799 RAIDYDPLDKQLYWIDSRQNMIRKAqeDGSQGftVVVSSVPsqnLEIQPYDLSIDIYSRYIYWTCEATN---VInVTRLD 875
Cdd:COG3391    113 RGLAVDPDGGRLYVADSGNGRVSVI--DTATG--KVVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsVI-VSVID 184

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2329567277  876 GRSvGVVLK--GEQDRPRAVVVNPEKGYMYFTN 906
Cdd:COG3391    185 TAT-GKVVAtiPVGGGPVGVAVSPDGRRLYVAN 216
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 217-251 7.32e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.74  E-value: 7.32e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2329567277   217 QAVVKGSLPHP--FALTLFEDILYWTDWSTHSILACN 251
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 900-941 8.79e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.29  E-value: 8.79e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567277  900 GYMYFTNLQERsPKIERAALDGTEREVLFFSGLSKPIALALD 941
Cdd:pfam00058    1 GRLYWTDSSLR-ASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 945-985 1.15e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.91  E-value: 1.15e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567277  945 GKLFWADSDLR-RIESSDLSGANRIVLEDSNILQPVGLTVFE 985
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 483-688 1.40e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.19  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  483 VLVNTSLGWPNGLALDyDEGKIYWGDAKTDKIetiSRAFMNGSALEHVVEFGlDYPEGMAVDWLGkNLYWADTGtNRIEV 562
Cdd:COG3386      1 KLADAGFRLGEGPVWD-PDGRLYWVDIPGGRI---HRYDPDGGAVEVFAEPS-GRPNGLAFDPDG-RLLVADHG-RGLVR 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  563 SKLDGQHRQVLV---WKDLDSPRALALDPAeGFMYWT---EWGGKPKIDRAAMDGsERTTLVPNVGRANGLTIDYAKRRL 636
Cdd:COG3386     74 FDPADGEVTVLAdeyGKPLNRPNDGVVDPD-GRLYFTdmgEYLPTGALYRVDPDG-SLRVLADGLTFPNGIAFSPDGRTL 151

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2329567277  637 YWTDLDTNLI-----ESSNMLGlNREVIADDLPHPF---GLTQYQD-YIYWTDWSRRSIER 688
Cdd:COG3386    152 YVADTGAGRIyrfdlDADGTLG-NRRVFADLPDGPGgpdGLAVDADgNLWVALWGGGGVVR 211
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 346-562 1.85e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 41.88  E-value: 1.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  346 TPDFTDivlQLEDIRhAIAIDYDpveGYIYWTDDEVRAIRRSFIDGS-----GSQFVVTAQIAHPDGIAVDwVARNLYWT 420
Cdd:cd14956     52 TGDGPG---QFGRPR-GLAVDKD---GWLYVADYWGDRIQVFTLTGElqtigGSSGSGPGQFNAPRGVAVD-ADGNLYVA 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  421 DTGTDRIEVTRLNGTMRKILISEDLEE-----PRAIVLDPmVGYMYWTDwGEIPKIERAALDGsdRVVLV----NTSLGW 491
Cdd:cd14956    124 DFGNQRIQKFDPDGSFLRQWGGTGIEPgsfnyPRGVAVDP-DGTLYVAD-TYNDRIQVFDNDG--AFLRKwggrGTGPGQ 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  492 ---PNGLALDYDeGKIYWGDAKTDKIE------TISRAFmnGSALEHVVEFGldYPEGMAVDWLGkNLYWADTGTNRIEV 562
Cdd:cd14956    200 fnyPYGIAIDPD-GNVFVADFGNNRIQkftadgTFLTSW--GSPGTGPGQFK--NPWGVVVDADG-TVYVADSNNNRVQR 273
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 502-545 5.60e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.98  E-value: 5.60e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2329567277  502 GKIYWGDAKTDkiETISRAFMNGSALEHVVEFGLDYPEGMAVDW 545
Cdd:pfam00058    1 GRLYWTDSSLR--ASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 535-588 5.88e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 40.22  E-value: 5.88e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2329567277  535 LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQH-----RQVLVWKDLDSPRALALDP 588
Cdd:cd14954    117 FNYPWGVAVDSEG-RIYVSDTRNHRVQVFDSDGQFirkfgFEGAGPGQLDSPRGVAVNP 174
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 846-879 8.02e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 8.02e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 2329567277   846 QPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSV 879
Cdd:smart00135   10 HPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 881-924 8.18e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 8.18e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2329567277   881 VVLKGEQDRPRAVVVNPEKGYMYFTNLqeRSPKIERAALDGTER 924
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 489-587 9.46e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 39.58  E-value: 9.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567277  489 LGWPNGLALDydEGKIYWGDAKTDKIetisRAFMNGSalEHVVEFG--------LDYPEGMAVDWLGkNLYWADTGTNRI 560
Cdd:cd14963      9 LNKPMGVAVS--DGRIYVADTNNHRV----QVFDYEG--KFKKSFGgpgtgpgeFKYPYGIAVDSDG-NIYVADLYNGRI 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2329567277  561 EVSKLDGQHRQVLVWKD----LDSPRALALD 587
Cdd:cd14963     80 QVFDPDGKFLKYFPEKKdrvkLISPAGLAID 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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