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Conserved domains on  [gi|2429181033|ref|NP_001403111|]
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zinc finger protein 7 isoform 2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
103-525 4.09e-18

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 87.06  E-value: 4.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 103 KPFKCDQCGKRFVLASVLTQHQRIHTGERPFKCA--ECGKGFHLSAKLVQHQRIHTGEKPYRCEECGKT--FGQSSSLVH 178
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 179 HQrIHTGERPFICQECGKAFCQRSQLSRHRRTHTGERPYSCQECGKAFCQR--ATLAQHQKMMHtaekSQMPRASESPSL 256
Cdd:COG5048   112 SS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPAN----SLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 257 IACQGNTTEEKPFKCEQCGKAFRWLSRLNQHQVVHSGEKPYQCNKCSKAFGCTSRLIRHQRTHTGEKPFKCDECGKRFVQ 336
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 337 SSHLIQHQRIHTGE-------KPYVCDDCGRAFTQSSSLIYHQR--IHKGE--KPYKC--SQCGKAFSMSTQLTSHQRTH 403
Cdd:COG5048   267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLH 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 404 TGERPYTC--NECGKTFRQNST-----LFQHQIIHVRVKPYEC--NECGKAFSRSSYLIEHqRIHTRAQGGHEFgdtpes 474
Cdd:COG5048   347 TSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLH-IITHLSFRPYNC------ 419

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2429181033 475 ptvlnhkkvhtvkklyQCDDCDKVFRWRSYLIIHQRIHTGERPYKCNACGK 525
Cdd:COG5048   420 ----------------KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
103-525 4.09e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 87.06  E-value: 4.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 103 KPFKCDQCGKRFVLASVLTQHQRIHTGERPFKCA--ECGKGFHLSAKLVQHQRIHTGEKPYRCEECGKT--FGQSSSLVH 178
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 179 HQrIHTGERPFICQECGKAFCQRSQLSRHRRTHTGERPYSCQECGKAFCQR--ATLAQHQKMMHtaekSQMPRASESPSL 256
Cdd:COG5048   112 SS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPAN----SLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 257 IACQGNTTEEKPFKCEQCGKAFRWLSRLNQHQVVHSGEKPYQCNKCSKAFGCTSRLIRHQRTHTGEKPFKCDECGKRFVQ 336
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 337 SSHLIQHQRIHTGE-------KPYVCDDCGRAFTQSSSLIYHQR--IHKGE--KPYKC--SQCGKAFSMSTQLTSHQRTH 403
Cdd:COG5048   267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLH 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 404 TGERPYTC--NECGKTFRQNST-----LFQHQIIHVRVKPYEC--NECGKAFSRSSYLIEHqRIHTRAQGGHEFgdtpes 474
Cdd:COG5048   347 TSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLH-IITHLSFRPYNC------ 419

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2429181033 475 ptvlnhkkvhtvkklyQCDDCDKVFRWRSYLIIHQRIHTGERPYKCNACGK 525
Cdd:COG5048   420 ----------------KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
311-336 1.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.50e-04
                          10        20
                  ....*....|....*....|....*.
gi 2429181033 311 RLIRHQRTHTGEKPFKCDECGKRFVQ 336
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 79-127 9.89e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 9.89e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2429181033  79 CNKCTKVFASSSRLIRHQRAHTgekpFKCDQCGKRFVLASVLTQH-QRIH 127
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
103-525 4.09e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 87.06  E-value: 4.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 103 KPFKCDQCGKRFVLASVLTQHQRIHTGERPFKCA--ECGKGFHLSAKLVQHQRIHTGEKPYRCEECGKT--FGQSSSLVH 178
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 179 HQrIHTGERPFICQECGKAFCQRSQLSRHRRTHTGERPYSCQECGKAFCQR--ATLAQHQKMMHtaekSQMPRASESPSL 256
Cdd:COG5048   112 SS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPAN----SLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 257 IACQGNTTEEKPFKCEQCGKAFRWLSRLNQHQVVHSGEKPYQCNKCSKAFGCTSRLIRHQRTHTGEKPFKCDECGKRFVQ 336
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 337 SSHLIQHQRIHTGE-------KPYVCDDCGRAFTQSSSLIYHQR--IHKGE--KPYKC--SQCGKAFSMSTQLTSHQRTH 403
Cdd:COG5048   267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLH 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 404 TGERPYTC--NECGKTFRQNST-----LFQHQIIHVRVKPYEC--NECGKAFSRSSYLIEHqRIHTRAQGGHEFgdtpes 474
Cdd:COG5048   347 TSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLH-IITHLSFRPYNC------ 419

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2429181033 475 ptvlnhkkvhtvkklyQCDDCDKVFRWRSYLIIHQRIHTGERPYKCNACGK 525
Cdd:COG5048   420 ----------------KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
49-451 9.05e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 9.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033  49 YPCEECGKAFRWRSRLNQHKLSHTGEKSYQCNKCTKVFASSSR--LIRHQRAHTGEKPFKCDQCGKRFVLASVLTQHqRI 126
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL-SS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 127 HTGERPFKCAECGKGFHLSAKLVQHQRIHTGEKPYRCEECGKTFGQSSSLVHHQRIHTGERPFICqecGKAFCQRSQLSR 206
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLS---KDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 207 HRRTHTGERPYSCQECGKAFCQRAtLAQHQKMMH--TAEKSQMPRASESPSLIACQGNTTEEK--PFKCEQCGKAFRWLS 282
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPS-SSSDQNLENssSSLPLTTNSQLSPKSLLSQSPSSLSSSdsSSSASESPRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 283 RLNQHQVVHSGE-------KPYQCNKCSKAFGCTSRLIRHQRT--HTGE--KPFKCDE--CGKRFVQSSHLIQHQRIHTG 349
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 350 EKPYVC--DDCGRAFTQSS-----SLIYHQRIHKGEKPYKC--SQCGKAFSMSTQLTSHQRTHTGERPYTCN--ECGKTF 418
Cdd:COG5048   349 ISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                         410       420       430
                  ....*....|....*....|....*....|...
gi 2429181033 419 RQNSTLFQHQIIHVRVKPYECNECGKAFSRSSY 451
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 213-287 6.82e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.56  E-value: 6.82e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2429181033 213 GERPYSCQ--ECGKAFCQRATLAQHQKMMHtaeksQMPRASESPSLIACQGNTTEEKPFKCEQCGKAFRWLSRLNQH 287
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHGH-----QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
25-243 1.13e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033  25 PDDQRDHLSSKLIRRQSVPTGENRY---PCEECGKAFRWRSRLNQHKLSHTGE-------KSYQCNKCTKVFASSSRLIR 94
Cdd:COG5048   228 PLTTNSQLSPKSLLSQSPSSLSSSDsssSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTR 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033  95 HQRA--HTGE--KPFKCD--QCGKRFVLASVLTQHQRIHTGERPFKCaecgkgfhlsaKLVQHQRIHTGEKPYRceecgk 168
Cdd:COG5048   308 HLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKE-----------KLLNSSSKFSPLLNNE------ 370

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2429181033 169 tfgqSSSLVHHQRIHTGERPFIC--QECGKAFCQRSQLSRHRRTHTGERPYSCQ--ECGKAFcQRATLAQHQKMMHTAE 243
Cdd:COG5048   371 ----PPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF-NRHYNLIPHKKIHTNH 444
zf-H2C2_2 pfam13465
Zinc-finger double domain;
311-336 1.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.50e-04
                          10        20
                  ....*....|....*....|....*.
gi 2429181033 311 RLIRHQRTHTGEKPFKCDECGKRFVQ 336
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 79-127 9.89e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 9.89e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2429181033  79 CNKCTKVFASSSRLIRHQRAHTgekpFKCDQCGKRFVLASVLTQH-QRIH 127
Cdd:cd20908     4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
148-170 1.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.46e-03
                          10        20
                  ....*....|....*....|...
gi 2429181033 148 LVQHQRIHTGEKPYRCEECGKTF 170
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
339-364 1.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.80e-03
                          10        20
                  ....*....|....*....|....*.
gi 2429181033 339 HLIQHQRIHTGEKPYVCDDCGRAFTQ 364
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
204-226 2.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.39e-03
                          10        20
                  ....*....|....*....|...
gi 2429181033 204 LSRHRRTHTGERPYSCQECGKAF 226
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 131-183 2.48e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.48e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2429181033 131 RPFkCAECGKGFHLSAKLVQHQRIHTgekpYRCEECGKTFGQSSSLVHH-QRIH 183
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
396-420 3.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.30e-03
                          10        20
                  ....*....|....*....|....*
gi 2429181033 396 LTSHQRTHTGERPYTCNECGKTFRQ 420
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 101-179 3.81e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 101 GEKPFKCD--QCGKRFVLASVLTQHqRIHtgerpfkcAECGKGFHLSAKLVQHQRIHTGEKPYRCEECGKTFGQSSSLVH 178
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 2429181033 179 H 179
Cdd:COG5189   417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 376-455 4.81e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 4.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2429181033 376 KGEKPYKCS--QCGKAFSMSTQLTSHqRTHtgerpytcNECGKTFRQNSTLFQHQIIHVRVKPYECNECGKAFSRSSYLI 453
Cdd:COG5189   345 KDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ..
gi 2429181033 454 EH 455
Cdd:COG5189   416 YH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
367-391 4.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.94e-03
                          10        20
                  ....*....|....*....|....*
gi 2429181033 367 SLIYHQRIHKGEKPYKCSQCGKAFS 391
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
120-142 6.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.02e-03
                          10        20
                  ....*....|....*....|...
gi 2429181033 120 LTQHQRIHTGERPFKCAECGKGF 142
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 325-347 6.11e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.11e-03
                          10        20
                  ....*....|....*....|...
gi 2429181033 325 FKCDECGKRFVQSSHLIQHQRIH 347
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
91-115 6.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.14e-03
                          10        20
                  ....*....|....*....|....*
gi 2429181033  91 RLIRHQRAHTGEKPFKCDQCGKRFV 115
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 437-459 9.88e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.88e-03
                          10        20
                  ....*....|....*....|...
gi 2429181033 437 YECNECGKAFSRSSYLIEHQRIH 459
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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