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Conserved domains on  [gi|2462858778|ref|NP_001405365|]
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interleukin-3 receptor subunit alpha isoform 3 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 122-232 3.85e-31

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


:

Pssm-ID: 401252  Cd Length: 96  Bit Score: 114.04  E-value: 3.85e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462858778 122 DLRCWVHE-GQLSCQWERGPKATGDVHYRMFWRDVRLGPAHnrECPHYHSLDvntagpaphGGHEGCTLDLDTVLGSTPN 200
Cdd:pfam09240   1 DLTCFIHNpSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVL--QCQYYIRDD---------GTRIGCQFDDLEGLSSSFH 69

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462858778 201 spdlvpQVTITVNGSGRAGPVPCMDNTVDLQR 232
Cdd:pfam09240  70 ------QVYICVNGSSSAGPIRSSDQTFQLQN 95
IL3Ra_N super family cl39930
IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell ...
 34-94 2.61e-03

IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Structure of IL-3 receptor alpha chain (IL3Ra) in complex with the anti-leukemia antibody CSL362 reveals that the N-terminal domain (NTD), a domain also present in the granulocyte-macrophage colony-stimulating factor (GM-CSF), contains the CSL362 binding epitope. Furthermore, NTD of IL3Ra adopts a typical fibronectin type III (FnIII) fold.


The actual alignment was detected with superfamily member pfam18611:

Pssm-ID: 436618  Cd Length: 76  Bit Score: 36.56  E-value: 2.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462858778  34 IQNLHIDPAHYTLSWDpAPGAdiTTGAFCRKGRDIFVWADPGLAR----CSFQSLSLCHVTNFTV 94
Cdd:pfam18611   1 ILNLRVDPRKRRLTWD-CHGN--VTEIECFLNSKENSPIEKKVAEkncyCTFPDLSLHEGANLTV 62
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 122-232 3.85e-31

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 114.04  E-value: 3.85e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462858778 122 DLRCWVHE-GQLSCQWERGPKATGDVHYRMFWRDVRLGPAHnrECPHYHSLDvntagpaphGGHEGCTLDLDTVLGSTPN 200
Cdd:pfam09240   1 DLTCFIHNpSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVL--QCQYYIRDD---------GTRIGCQFDDLEGLSSSFH 69

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462858778 201 spdlvpQVTITVNGSGRAGPVPCMDNTVDLQR 232
Cdd:pfam09240  70 ------QVYICVNGSSSAGPIRSSDQTFQLQN 95
IL3Ra_N pfam18611
IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell ...
 34-94 2.61e-03

IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Structure of IL-3 receptor alpha chain (IL3Ra) in complex with the anti-leukemia antibody CSL362 reveals that the N-terminal domain (NTD), a domain also present in the granulocyte-macrophage colony-stimulating factor (GM-CSF), contains the CSL362 binding epitope. Furthermore, NTD of IL3Ra adopts a typical fibronectin type III (FnIII) fold.


Pssm-ID: 436618  Cd Length: 76  Bit Score: 36.56  E-value: 2.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462858778  34 IQNLHIDPAHYTLSWDpAPGAdiTTGAFCRKGRDIFVWADPGLAR----CSFQSLSLCHVTNFTV 94
Cdd:pfam18611   1 ILNLRVDPRKRRLTWD-CHGN--VTEIECFLNSKENSPIEKKVAEkncyCTFPDLSLHEGANLTV 62
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 122-232 3.85e-31

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 114.04  E-value: 3.85e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462858778 122 DLRCWVHE-GQLSCQWERGPKATGDVHYRMFWRDVRLGPAHnrECPHYHSLDvntagpaphGGHEGCTLDLDTVLGSTPN 200
Cdd:pfam09240   1 DLTCFIHNpSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVL--QCQYYIRDD---------GTRIGCQFDDLEGLSSSFH 69

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462858778 201 spdlvpQVTITVNGSGRAGPVPCMDNTVDLQR 232
Cdd:pfam09240  70 ------QVYICVNGSSSAGPIRSSDQTFQLQN 95
IL3Ra_N pfam18611
IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell ...
 34-94 2.61e-03

IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Structure of IL-3 receptor alpha chain (IL3Ra) in complex with the anti-leukemia antibody CSL362 reveals that the N-terminal domain (NTD), a domain also present in the granulocyte-macrophage colony-stimulating factor (GM-CSF), contains the CSL362 binding epitope. Furthermore, NTD of IL3Ra adopts a typical fibronectin type III (FnIII) fold.


Pssm-ID: 436618  Cd Length: 76  Bit Score: 36.56  E-value: 2.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462858778  34 IQNLHIDPAHYTLSWDpAPGAdiTTGAFCRKGRDIFVWADPGLAR----CSFQSLSLCHVTNFTV 94
Cdd:pfam18611   1 ILNLRVDPRKRRLTWD-CHGN--VTEIECFLNSKENSPIEKKVAEkncyCTFPDLSLHEGANLTV 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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