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Conserved domains on  [gi|2470811466|ref|NP_001406111|]
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chromatin assembly factor 1 subunit B isoform 4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAF-1_p60_C pfam15512
Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of ...
 177-344 3.55e-66

Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family pfam12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, pfam00400.


:

Pssm-ID: 464756 [Multi-domain]  Cd Length: 171  Bit Score: 206.96  E-value: 3.55e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470811466 177 GIPLKEKPVLSIRTPDTA-KKAKNQTHQGSSPGSRSVEGTPSNRTQDPSSPCTTPSPTTQSPAPSAIKDSPSAIPAGKSP 255
Cdd:pfam15512   1 GIPLKEKPVLSVRTPDTAeKKTKSQTQQGSSPGPRPVEGTPTSRTQDPSSPSTTPLQAKQSPAPPAIKDTPSTPPGVKSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470811466 256 LPQPSEE-KTLQPAGQNMKAPQPRRVTLNTLQTWGKTAPRRINLTPLKTDTVPNPQPNSG-TAPSTEEVQPEAPGEPPEE 333
Cdd:pfam15512  81 APGPSEErKSSQPSSQNTKAPQPRRVTLNTLQAWSKTTPRRINLTPLKTDSPPNSVPSSVvSPPSTEKIQHERPGDPQCS 160

                         170
                  ....*....|.
gi 2470811466 334 PPELKRPRLEE 344
Cdd:pfam15512 161 PPESKRPRLDE 171
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 110-189 1.09e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470811466 110 PYRMVFAVASED-SVLLYDTQQSFPFgYVSNIHYHTLSDISWSSDGAFLAISSTDGYCTFVTFEKGELGIPLK--EKPVL 186
Cdd:cd00200    19 PDGKLLATGSGDgTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTghTSYVS 97


                  ...
gi 2470811466 187 SIR 189
Cdd:cd00200    98 SVA 100
 
Name Accession Description Interval E-value
CAF-1_p60_C pfam15512
Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of ...
 177-344 3.55e-66

Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family pfam12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, pfam00400.


Pssm-ID: 464756 [Multi-domain]  Cd Length: 171  Bit Score: 206.96  E-value: 3.55e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470811466 177 GIPLKEKPVLSIRTPDTA-KKAKNQTHQGSSPGSRSVEGTPSNRTQDPSSPCTTPSPTTQSPAPSAIKDSPSAIPAGKSP 255
Cdd:pfam15512   1 GIPLKEKPVLSVRTPDTAeKKTKSQTQQGSSPGPRPVEGTPTSRTQDPSSPSTTPLQAKQSPAPPAIKDTPSTPPGVKSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470811466 256 LPQPSEE-KTLQPAGQNMKAPQPRRVTLNTLQTWGKTAPRRINLTPLKTDTVPNPQPNSG-TAPSTEEVQPEAPGEPPEE 333
Cdd:pfam15512  81 APGPSEErKSSQPSSQNTKAPQPRRVTLNTLQAWSKTTPRRINLTPLKTDSPPNSVPSSVvSPPSTEKIQHERPGDPQCS 160

                         170
                  ....*....|.
gi 2470811466 334 PPELKRPRLEE 344
Cdd:pfam15512 161 PPESKRPRLDE 171
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 110-189 1.09e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470811466 110 PYRMVFAVASED-SVLLYDTQQSFPFgYVSNIHYHTLSDISWSSDGAFLAISSTDGYCTFVTFEKGELGIPLK--EKPVL 186
Cdd:cd00200    19 PDGKLLATGSGDgTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTghTSYVS 97


                  ...
gi 2470811466 187 SIR 189
Cdd:cd00200    98 SVA 100
PHA03247 PHA03247
large tegument protein UL36; Provisional
 178-318 5.55e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.77  E-value: 5.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470811466  178 IPLKEKPVLSIRTPDTAKKAKNQTHQGSSPGSRSVEGT-----PSNRTQDPSSPCTTPSPTTQSPAPSAIKDSPSAiPAG 252
Cdd:PHA03247  2818 LPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSvapggDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR-STE 2896

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2470811466  253 KSPLPQPSEEKTLQPAGQNMKAPQPRRVTLNTLQTWGKTAPRRINLTPLKTDTVPNPQPnSGTAPS 318
Cdd:PHA03247  2897 SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP-SGAVPQ 2961
 
Name Accession Description Interval E-value
CAF-1_p60_C pfam15512
Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of ...
 177-344 3.55e-66

Chromatin assembly factor complex 1 subunit p60, C-terminal; CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family pfam12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, pfam00400.


Pssm-ID: 464756 [Multi-domain]  Cd Length: 171  Bit Score: 206.96  E-value: 3.55e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470811466 177 GIPLKEKPVLSIRTPDTA-KKAKNQTHQGSSPGSRSVEGTPSNRTQDPSSPCTTPSPTTQSPAPSAIKDSPSAIPAGKSP 255
Cdd:pfam15512   1 GIPLKEKPVLSVRTPDTAeKKTKSQTQQGSSPGPRPVEGTPTSRTQDPSSPSTTPLQAKQSPAPPAIKDTPSTPPGVKSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470811466 256 LPQPSEE-KTLQPAGQNMKAPQPRRVTLNTLQTWGKTAPRRINLTPLKTDTVPNPQPNSG-TAPSTEEVQPEAPGEPPEE 333
Cdd:pfam15512  81 APGPSEErKSSQPSSQNTKAPQPRRVTLNTLQAWSKTTPRRINLTPLKTDSPPNSVPSSVvSPPSTEKIQHERPGDPQCS 160

                         170
                  ....*....|.
gi 2470811466 334 PPELKRPRLEE 344
Cdd:pfam15512 161 PPESKRPRLDE 171
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 110-189 1.09e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470811466 110 PYRMVFAVASED-SVLLYDTQQSFPFgYVSNIHYHTLSDISWSSDGAFLAISSTDGYCTFVTFEKGELGIPLK--EKPVL 186
Cdd:cd00200    19 PDGKLLATGSGDgTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTghTSYVS 97


                  ...
gi 2470811466 187 SIR 189
Cdd:cd00200    98 SVA 100
PHA03247 PHA03247
large tegument protein UL36; Provisional
 178-318 5.55e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.77  E-value: 5.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470811466  178 IPLKEKPVLSIRTPDTAKKAKNQTHQGSSPGSRSVEGT-----PSNRTQDPSSPCTTPSPTTQSPAPSAIKDSPSAiPAG 252
Cdd:PHA03247  2818 LPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSvapggDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR-STE 2896

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2470811466  253 KSPLPQPSEEKTLQPAGQNMKAPQPRRVTLNTLQTWGKTAPRRINLTPLKTDTVPNPQPnSGTAPS 318
Cdd:PHA03247  2897 SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP-SGAVPQ 2961
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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