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Conserved domains on  [gi|2500286970|ref|NP_001407580|]
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zinc finger protein 628 isoform 1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
41-221 6.22e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 6.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970   41 KSFRWSSRLLHHQRTHTGER-PYKCPDCPKAFKGSSALLYHQRG--HTGE--RPYQCP--DCPKAFKRSSLLQIHRSVHT 113
Cdd:COG5048    268 ASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHT 347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  114 GLRAFTC--GQC---------GLAFKWSSHYQYHLRQHTGERPYPCpdCPKAFKNSSSLRRHRHVHTGERP--YTCGICG 180
Cdd:COG5048    348 SISPAKEklLNSsskfspllnNEPPQSLQQYKDLKNDKKSETLSNS--CIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 2500286970  181 KSFTQSTNLRQHQRVHTGERPFRCplCPKTFTHSSNLLLHH 221
Cdd:COG5048    426 KSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
445-634 1.03e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 1.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  445 PYKCAECGKAFKGSSGLRYHLR--DHTGE--RPYQCGE--CGKAFKRSSLLAIHQRVHTGLRAFTC---------GQCGL 509
Cdd:COG5048    289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEkllnssskfSPLLN 368

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  510 TFKWSSHYQYHLRLHSgeRPYACT--ECGKAFRNTSCLRRHRHVHTGERPHSCsvcgksfaqtsnlrqhqrvhtgerpfR 587
Cdd:COG5048    369 NEPPQSLQQYKDLKND--KKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNC--------------------------K 420

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2500286970  588 CPLCPKTFTHSSNLLLHQRTHSAERPFACPICGRgFVMAAYLQRHLR 634
Cdd:COG5048    421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
41-221 6.22e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 6.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970   41 KSFRWSSRLLHHQRTHTGER-PYKCPDCPKAFKGSSALLYHQRG--HTGE--RPYQCP--DCPKAFKRSSLLQIHRSVHT 113
Cdd:COG5048    268 ASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHT 347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  114 GLRAFTC--GQC---------GLAFKWSSHYQYHLRQHTGERPYPCpdCPKAFKNSSSLRRHRHVHTGERP--YTCGICG 180
Cdd:COG5048    348 SISPAKEklLNSsskfspllnNEPPQSLQQYKDLKNDKKSETLSNS--CIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 2500286970  181 KSFTQSTNLRQHQRVHTGERPFRCplCPKTFTHSSNLLLHH 221
Cdd:COG5048    426 KSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
445-634 1.03e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 1.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  445 PYKCAECGKAFKGSSGLRYHLR--DHTGE--RPYQCGE--CGKAFKRSSLLAIHQRVHTGLRAFTC---------GQCGL 509
Cdd:COG5048    289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEkllnssskfSPLLN 368

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  510 TFKWSSHYQYHLRLHSgeRPYACT--ECGKAFRNTSCLRRHRHVHTGERPHSCsvcgksfaqtsnlrqhqrvhtgerpfR 587
Cdd:COG5048    369 NEPPQSLQQYKDLKND--KKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNC--------------------------K 420

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2500286970  588 CPLCPKTFTHSSNLLLHQRTHSAERPFACPICGRgFVMAAYLQRHLR 634
Cdd:COG5048    421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
572-597 1.46e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.44  E-value: 1.46e-06
                           10        20
                   ....*....|....*....|....*.
gi 2500286970  572 NLRQHQRVHTGERPFRCPLCPKTFTH 597
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
188-213 1.46e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.44  E-value: 1.46e-06
                           10        20
                   ....*....|....*....|....*.
gi 2500286970  188 NLRQHQRVHTGERPFRCPLCPKTFTH 213
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 173-220 3.00e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 41.78  E-value: 3.00e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2500286970  173 PYTCGICGKSFTQSTNLRQHQRVhtGERPFRCPLCPKTFTHSSNLLLH 220
Cdd:PHA00733    73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
41-221 6.22e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 6.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970   41 KSFRWSSRLLHHQRTHTGER-PYKCPDCPKAFKGSSALLYHQRG--HTGE--RPYQCP--DCPKAFKRSSLLQIHRSVHT 113
Cdd:COG5048    268 ASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHT 347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  114 GLRAFTC--GQC---------GLAFKWSSHYQYHLRQHTGERPYPCpdCPKAFKNSSSLRRHRHVHTGERP--YTCGICG 180
Cdd:COG5048    348 SISPAKEklLNSsskfspllnNEPPQSLQQYKDLKNDKKSETLSNS--CIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 2500286970  181 KSFTQSTNLRQHQRVHTGERPFRCplCPKTFTHSSNLLLHH 221
Cdd:COG5048    426 KSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
445-634 1.03e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 1.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  445 PYKCAECGKAFKGSSGLRYHLR--DHTGE--RPYQCGE--CGKAFKRSSLLAIHQRVHTGLRAFTC---------GQCGL 509
Cdd:COG5048    289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEkllnssskfSPLLN 368

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  510 TFKWSSHYQYHLRLHSgeRPYACT--ECGKAFRNTSCLRRHRHVHTGERPHSCsvcgksfaqtsnlrqhqrvhtgerpfR 587
Cdd:COG5048    369 NEPPQSLQQYKDLKND--KKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNC--------------------------K 420

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2500286970  588 CPLCPKTFTHSSNLLLHQRTHSAERPFACPICGRgFVMAAYLQRHLR 634
Cdd:COG5048    421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
481-637 8.23e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 8.23e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  481 KAFKRSSLLAIHQRVHTGLRA-FTCGQCGLTFKWSSHYQYHLR--LHSGE--RPYACTE--CGKAFRNTSCLRRHRHVHT 553
Cdd:COG5048    268 ASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  554 GERPHSC--SVCGKSFAQTSNLRQHQRVH-----TGERPFRCPL--CPKTFTHSSNLLLHQRTHSAERP--FACPICGRG 622
Cdd:COG5048    348 SISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                          170
                   ....*....|....*
gi 2500286970  623 FVMAAYLQRHLRTHT 637
Cdd:COG5048    428 FNRHYNLIPHKKIHT 442
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 142-224 2.70e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 54.34  E-value: 2.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  142 GERPYPCP--DCPKAFKNSSSLRRHR-HVHtgerpytcgiCGKSFTQSTNLRQHQRVHTGERPFRCPLCPKTFThSSNLL 218
Cdd:COG5189    346 DGKPYKCPveGCNKKYKNQNGLKYHMlHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK-NLNGL 414


                   ....*.
gi 2500286970  219 LHHRTH 224
Cdd:COG5189    415 KYHRKH 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
572-597 1.46e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.44  E-value: 1.46e-06
                           10        20
                   ....*....|....*....|....*.
gi 2500286970  572 NLRQHQRVHTGERPFRCPLCPKTFTH 597
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
188-213 1.46e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.44  E-value: 1.46e-06
                           10        20
                   ....*....|....*....|....*.
gi 2500286970  188 NLRQHQRVHTGERPFRCPLCPKTFTH 213
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
39-183 6.32e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 6.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970   39 CGKSFRWSSRLLHHQRTHTGERPYKCP--DCPKAFKGSS-----ALLYHQRGHTGERPYQC--PDCPKAFKRSSLLqihr 109
Cdd:COG5048    329 CGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNL---- 404

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2500286970  110 svhtglraftcgqcglafkwSSHYQYHLRQhtGERPYPCPDCPKAFKNSSSLRRHRHVHTGERPYTCGICGKSF 183
Cdd:COG5048    405 --------------------SLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
461-485 8.50e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 8.50e-06
                           10        20
                   ....*....|....*....|....*
gi 2500286970  461 LRYHLRDHTGERPYQCGECGKAFKR 485
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
132-157 9.84e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 9.84e-06
                           10        20
                   ....*....|....*....|....*.
gi 2500286970  132 HYQYHLRQHTGERPYPCPDCPKAFKN 157
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 58-109 1.36e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.95  E-value: 1.36e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2500286970   58 GERPYKCP--DCPKAFKGSSALLYHQR-GHTG------------------ERPYQCPDCPKAFKRSSLLQIHR 109
Cdd:COG5189    346 DGKPYKCPveGCNKKYKNQNGLKYHMLhGHQNqklhenpspekmnifsakDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
52-72 2.11e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 2.11e-05
                           10        20
                   ....*....|....*....|.
gi 2500286970   52 HQRTHTGERPYKCPDCPKAFK 72
Cdd:pfam13465    5 HMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
76-101 2.47e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 2.47e-05
                           10        20
                   ....*....|....*....|....*.
gi 2500286970   76 ALLYHQRGHTGERPYQCPDCPKAFKR 101
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
491-638 3.20e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 3.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  491 IHQRVHTGLRAFTCGQCGLTFKWSSHYQYHLRLHSGERPYACTECGKAFRNTSCLRRHRHVHTGERPHSCSVCGKSFAQT 570
Cdd:COG5048    188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  571 SNLRQHQRVHTGER-------PFRCPLCPKTFTHSSNLLLHQRT--HSAE--RPFACPI--CGRGFVMAAYLQRHLRTHT 637
Cdd:COG5048    268 ASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347


                   .
gi 2500286970  638 P 638
Cdd:COG5048    348 S 348
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 526-609 3.98e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 3.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  526 GERPYAC--TECGKAFRNTSCLRRHR-HVHTGERPHscsvcgksfaQTSNLRQHQRVHTGERPFRCPLCPKTFTHSSNLL 602
Cdd:COG5189    346 DGKPYKCpvEGCNKKYKNQNGLKYHMlHGHQNQKLH----------ENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                   ....*..
gi 2500286970  603 LHqRTHS 609
Cdd:COG5189    416 YH-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 174-196 5.57e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.75  E-value: 5.57e-05
                           10        20
                   ....*....|....*....|...
gi 2500286970  174 YTCGICGKSFTQSTNLRQHQRVH 196
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
147-224 7.06e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 7.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  147 PCPDCPKAFKNSSSLRRHRHVHTGER-------PYTCGICGKSFTQSTNLRQHQR--VHTGE--RPFRCP--LCPKTFTH 213
Cdd:COG5048    256 SASESPRSSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSR 335

                           90
                   ....*....|.
gi 2500286970  214 SSNLLLHHRTH 224
Cdd:COG5048    336 NDALKRHILLH 346
zf-H2C2_2 pfam13465
Zinc-finger double domain;
545-569 8.10e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 8.10e-05
                           10        20
                   ....*....|....*....|....*
gi 2500286970  545 LRRHRHVHTGERPHSCSVCGKSFAQ 569
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 586-608 8.24e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.36  E-value: 8.24e-05
                           10        20
                   ....*....|....*....|...
gi 2500286970  586 FRCPLCPKTFTHSSNLLLHQRTH 608
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
160-185 1.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.36e-04
                           10        20
                   ....*....|....*....|....*.
gi 2500286970  160 SLRRHRHVHTGERPYTCGICGKSFTQ 185
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 202-224 1.62e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 1.62e-04
                           10        20
                   ....*....|....*....|...
gi 2500286970  202 FRCPLCPKTFTHSSNLLLHHRTH 224
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
516-541 1.71e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.71e-04
                           10        20
                   ....*....|....*....|....*.
gi 2500286970  516 HYQYHLRLHSGERPYACTECGKAFRN 541
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
584-638 2.11e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 2.11e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2500286970  584 RPFRCPLCPKTFTHSSNLLLHQRTHSAERPFACPICGRG--FVMAAYLQRHLRTHTP 638
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHN 88
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 474-496 2.20e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 2.20e-04
                           10        20
                   ....*....|....*....|...
gi 2500286970  474 YQCGECGKAFKRSSLLAIHQRVH 496
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 173-220 3.00e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 41.78  E-value: 3.00e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2500286970  173 PYTCGICGKSFTQSTNLRQHQRVhtGERPFRCPLCPKTFTHSSNLLLH 220
Cdd:PHA00733    73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDH 118
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 146-168 3.48e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 3.48e-04
                           10        20
                   ....*....|....*....|...
gi 2500286970  146 YPCPDCPKAFKNSSSLRRHRHVH 168
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
441-607 3.56e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 3.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  441 SAERPYKCAECGKAFKGSSGLRYHLRDHTGERPYQCG--ECGKAFKRSSLLAIHQR-VHTGLRAFTCGQCGLTFKWSSHY 517
Cdd:COG5048     29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRtHHNNPSDLNSKSLPLSNSKASSS 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2500286970  518 QYHLRLHSGERPYACTECGKAFRNTSCLRRHRHVHTGERPHSCSVCGKSFAQTSN-------LRQHQRVHTGERPFRCPL 590
Cdd:COG5048    109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhppLPANSLSKDPSSNLSLLI 188

                          170       180
                   ....*....|....*....|.
gi 2500286970  591 C----PKTFTHSSNLLLHQRT 607
Cdd:COG5048    189 SsnvsTSIPSSSENSPLSSSY 209
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 558-580 4.03e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 4.03e-04
                           10        20
                   ....*....|....*....|...
gi 2500286970  558 HSCSVCGKSFAQTSNLRQHQRVH 580
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 90-112 5.15e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 5.15e-04
                           10        20
                   ....*....|....*....|...
gi 2500286970   90 YQCPDCPKAFKRSSLLQIHRSVH 112
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 131-192 5.72e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 41.01  E-value: 5.72e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2500286970  131 SHYQYHLRQHTGERPYPCPDCPKAFKNSSSLRrhRHVHTGERPYTCGICGKSFTQSTNLRQH 192
Cdd:PHA00733    59 SSYLYKLLTSKAVSPYVCPLCLMPFSSSVSLK--QHIRYTEHSKVCPVCGKEFRNTDSTLDH 118
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 443-497 9.73e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 9.73e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2500286970  443 ERPYKCA--ECGKAFKGSSGLRYH-LRDHTG------------------ERPYQCGECGKAFKRSSLLAIHqRVHT 497
Cdd:COG5189    347 GKPYKCPveGCNKKYKNQNGLKYHmLHGHQNqklhenpspekmnifsakDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 530-552 4.46e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.46e-03
                           10        20
                   ....*....|....*....|...
gi 2500286970  530 YACTECGKAFRNTSCLRRHRHVH 552
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 614-636 4.46e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.46e-03
                           10        20
                   ....*....|....*....|...
gi 2500286970  614 FACPICGRGFVMAAYLQRHLRTH 636
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 62-84 5.76e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 5.76e-03
                           10        20
                   ....*....|....*....|...
gi 2500286970   62 YKCPDCPKAFKGSSALLYHQRGH 84
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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