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Conserved domains on  [gi|2501356645|ref|NP_001407880|]
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alpha-adducin isoform 10 [Mus musculus]

Protein Classification

class II aldolase/adducin head domain-containing protein( domain architecture ID 842)

class II aldolase/adducin head domain-containing protein involved in catalyzing central steps of carbohydrate metabolism; it promotes carbon-carbon bond cleavage and stabilizes enolate intermediates using divalent cations

Gene Symbol:  ADD3
PubMed:  10581174

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Aldolase_II super family cl00214
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 145-391 2.11e-97

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


The actual alignment was detected with superfamily member PRK07044:

Pssm-ID: 469663  Cd Length: 252  Bit Score: 302.54  E-value: 2.11e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 145 LRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDrgSTNLGVNQAGFTLH 224
Cdd:PRK07044   17 ARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVD--DSPYPVNPAGFTIH 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 225 SAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL-GDVAYHDYHGILVDEEEKILIQKNLGPKsKVLILRNHG 303
Cdd:PRK07044   95 SAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGDK-PAMLLRNHG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 304 LVSVGESVEEAFYYIHNLVVACEIQVRTLaSAGGPdnLVLLDPGKYKAKSRSPGTPAGEGSgsppkwqiGEQEFEALMRM 383
Cdd:PRK07044  174 LLTVGRTVAEAFLLMYTLERACEIQVAAQ-AGGGE--LVLPPPEVAERTARQSLFDPGAGA--------GELAWPALLRK 242

                         250
                  ....*....|
gi 2501356645 384 LD--NLGYRT 391
Cdd:PRK07044  243 LDriDPGYRD 252
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 629-750 7.87e-06

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.78  E-value: 7.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645  629 GSEENLDETREQKEKSPPDQSAVPNTPPSTPV-----KLEEDLPQEPTSRDDSDATTFKPTPPDLSPDEPSE-ALAFPAV 702
Cdd:PHA03307   100 PAREGSPTPPGPSSPDPPPPTPPPASPPPSPApdlseMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQaALPLSSP 179

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2501356645  703 EEEAHASPDP-TQPPAEADPEPASAPTPGAEEVASPATEEGSPMDPGSD 750
Cdd:PHA03307   180 EETARAPSSPpAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSA 228
 
Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 145-391 2.11e-97

aldolase II superfamily protein; Provisional


Pssm-ID: 235916  Cd Length: 252  Bit Score: 302.54  E-value: 2.11e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 145 LRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDrgSTNLGVNQAGFTLH 224
Cdd:PRK07044   17 ARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVD--DSPYPVNPAGFTIH 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 225 SAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL-GDVAYHDYHGILVDEEEKILIQKNLGPKsKVLILRNHG 303
Cdd:PRK07044   95 SAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGDK-PAMLLRNHG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 304 LVSVGESVEEAFYYIHNLVVACEIQVRTLaSAGGPdnLVLLDPGKYKAKSRSPGTPAGEGSgsppkwqiGEQEFEALMRM 383
Cdd:PRK07044  174 LLTVGRTVAEAFLLMYTLERACEIQVAAQ-AGGGE--LVLPPPEVAERTARQSLFDPGAGA--------GELAWPALLRK 242

                         250
                  ....*....|
gi 2501356645 384 LD--NLGYRT 391
Cdd:PRK07044  243 LDriDPGYRD 252
Aldolase_II cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 142-352 1.47e-68

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


Pssm-ID: 238232 [Multi-domain]  Cd Length: 209  Bit Score: 224.94  E-value: 1.47e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 142 EKLLRcKLAAFYRLADLFGWSQLIYNHITTRvNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIV--DRGSTNLGvnqa 219
Cdd:cd00398     1 EKLKR-KIIAACLLLDLYGWVTGTGGNVSAR-DRDRGYFLITPSGVDYEEMTASDLVVVDAQGKVVegKKPSSETP---- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 220 gftLHSAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL---GDVAYHDYHGILvDEEEKILIQKNLG-PKSK 295
Cdd:cd00398    75 ---LHLALYRARPDIGCIVHTHSTHATAVSQLKEGLIPAGHTACAVyftGDIPCTPYMTPE-TGEDEIGTQRALGfPNSK 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2501356645 296 VLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLASAGG--PDNLVLLDPGKYKAK 352
Cdd:cd00398   151 AVLLRNHGLFAWGPTLDEAFHLAVVLEVAAEIQLKALSMGGQlpPISLELLNKEYLRKH 209
AraD COG0235
5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar ...
 145-341 1.11e-56

5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; 5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440005 [Multi-domain]  Cd Length: 208  Bit Score: 192.74  E-value: 1.11e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 145 LRCKLAAFYRLADLFGWSQLIYNHITTRVnsEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGstnlGVNQAGFTLH 224
Cdd:COG0235     6 LREELAAAGRRLARRGLVDGTAGNISVRL--DDDRFLITPSGVDFGELTPEDLVVVDLDGNVVEGD----LKPSSETPLH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 225 SAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPIS-PEAL-SLGDVAYHDYHGIlVDEEEKILIQKNLGpKSKVLILRNH 302
Cdd:COG0235    80 LAIYRARPDVGAVVHTHSPYATALSALGEPLPPLEqTEAAaFLGDVPVVPYAGP-GTEELAEAIAEALG-DRPAVLLRNH 157

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2501356645 303 GLVSVGESVEEAFYYIHNLVVACEIQVRTLAsAGGPDNL 341
Cdd:COG0235   158 GVVVWGKDLAEAFDRAEVLEEAARIQLLALA-LGGPLVL 195
Aldolase_II pfam00596
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 147-329 6.33e-55

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 459862 [Multi-domain]  Cd Length: 178  Bit Score: 186.60  E-value: 6.33e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 147 CKLAAFYRLADLFGWSQLIYNHITTRVnsEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGstnLGVNqAGFTLHSA 226
Cdd:pfam00596   1 EELAAAGRLLARRGLVEGTGGNISVRL--PGDGFLITPSGVDFGELTPEDLVVVDLDGNVVEGG---LKPS-SETPLHLA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 227 VYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL--GDVAYHDYHGiLVDEEEKILIQKNLGPKSKVLILRNHGL 304
Cdd:pfam00596  75 IYRARPDAGAVVHTHSPYATALSLAKEGLPPITQEAADFlgGDIPIIPYYT-PGTEELGERIAEALGGDRKAVLLRNHGL 153

                         170       180
                  ....*....|....*....|....*
gi 2501356645 305 VSVGESVEEAFYYIHNLVVACEIQV 329
Cdd:pfam00596 154 LVWGKTLEEAFYLAEELERAAEIQL 178
Aldolase_II smart01007
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 149-329 3.14e-53

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 214970 [Multi-domain]  Cd Length: 185  Bit Score: 182.45  E-value: 3.14e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645  149 LAAFYRLADLFGWSQLIYNHITTRVNsEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGSTnlGVNQAGFTLHSAVY 228
Cdd:smart01007   1 LAAACRLLARRGLVEGTGGNISARVG-EEDLFLITPSGVDFGELTASDLVVVDLDGNVVEGGGG--PKPSSETPLHLAIY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645  229 AARPDAKCIVHIHTPAGAAVSAM--KCGLLPIS-PEALSLGDVAYHDYHGILVDEEEKI-LIQKNLGPK---SKVLILRN 301
Cdd:smart01007  78 RARPDVGAVVHTHSPYATALAALgkPLPLLPTEqAAAFLGGEIPYAPYAGPGTELAEEGaELAEALAEAlpdRPAVLLRN 157

                          170       180
                   ....*....|....*....|....*...
gi 2501356645  302 HGLVSVGESVEEAFYYIHNLVVACEIQV 329
Cdd:smart01007 158 HGLLVWGKTLEEAFDLAEELEEAAEIQL 185
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 629-750 7.87e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.78  E-value: 7.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645  629 GSEENLDETREQKEKSPPDQSAVPNTPPSTPV-----KLEEDLPQEPTSRDDSDATTFKPTPPDLSPDEPSE-ALAFPAV 702
Cdd:PHA03307   100 PAREGSPTPPGPSSPDPPPPTPPPASPPPSPApdlseMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQaALPLSSP 179

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2501356645  703 EEEAHASPDP-TQPPAEADPEPASAPTPGAEEVASPATEEGSPMDPGSD 750
Cdd:PHA03307   180 EETARAPSSPpAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSA 228
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 607-725 1.29e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 41.97  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 607 PFNTLTDRELEEYRREVERKQKGSEENLDETREQKEKSPPDQSAVPNTPPSTPVKLEEDLP--QEPTSRDDSDATTFKPT 684
Cdd:COG5180   188 PRDALKDSPEKLDRPKVEVKDEAQEEPPDLTGGADHPRPEAASSPKVDPPSTSEARSRPATvdAQPEMRPPADAKERRRA 267

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2501356645 685 PpdlspdepsealafpavEEEAHASPDPTQPPAEADPEPAS 725
Cdd:COG5180   268 A-----------------IGDTPAAEPPGLPVLEAGSEPQS 291
Androgen_recep pfam02166
Androgen receptor;
619-750 1.35e-03

Androgen receptor;


Pssm-ID: 426632 [Multi-domain]  Cd Length: 501  Bit Score: 42.22  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 619 YRREVERKQKGSEENLDETREQKEKSPP---DQSAVPNTPPSTPVKLEEDLP---------QEPTSRDDSDATTFKPTPP 686
Cdd:pfam02166   6 YPRPPAKTFRGAFQNLFQSVREVIQNPGprhPEAAGGAAPPGARLQHQQQQQqqvpqqpqqQESSPRQPQASVQPQQAGD 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2501356645 687 DLSPDEPSEALA-FPAVEEEAHASPDPTQPPAEADPEPASAPTPGAEEVASPATEEGS--PMDPGSD 750
Cdd:pfam02166  86 DGSPPAHNRGPAgYLALEDDEQPQPSQAQPAAECCPENGCVPEPGAAAAAGKGLPQQAvaPAAPDDD 152
 
Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 145-391 2.11e-97

aldolase II superfamily protein; Provisional


Pssm-ID: 235916  Cd Length: 252  Bit Score: 302.54  E-value: 2.11e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 145 LRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDrgSTNLGVNQAGFTLH 224
Cdd:PRK07044   17 ARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVD--DSPYPVNPAGFTIH 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 225 SAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL-GDVAYHDYHGILVDEEEKILIQKNLGPKsKVLILRNHG 303
Cdd:PRK07044   95 SAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGDK-PAMLLRNHG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 304 LVSVGESVEEAFYYIHNLVVACEIQVRTLaSAGGPdnLVLLDPGKYKAKSRSPGTPAGEGSgsppkwqiGEQEFEALMRM 383
Cdd:PRK07044  174 LLTVGRTVAEAFLLMYTLERACEIQVAAQ-AGGGE--LVLPPPEVAERTARQSLFDPGAGA--------GELAWPALLRK 242

                         250
                  ....*....|
gi 2501356645 384 LD--NLGYRT 391
Cdd:PRK07044  243 LDriDPGYRD 252
Aldolase_II cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 142-352 1.47e-68

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


Pssm-ID: 238232 [Multi-domain]  Cd Length: 209  Bit Score: 224.94  E-value: 1.47e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 142 EKLLRcKLAAFYRLADLFGWSQLIYNHITTRvNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIV--DRGSTNLGvnqa 219
Cdd:cd00398     1 EKLKR-KIIAACLLLDLYGWVTGTGGNVSAR-DRDRGYFLITPSGVDYEEMTASDLVVVDAQGKVVegKKPSSETP---- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 220 gftLHSAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL---GDVAYHDYHGILvDEEEKILIQKNLG-PKSK 295
Cdd:cd00398    75 ---LHLALYRARPDIGCIVHTHSTHATAVSQLKEGLIPAGHTACAVyftGDIPCTPYMTPE-TGEDEIGTQRALGfPNSK 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2501356645 296 VLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLASAGG--PDNLVLLDPGKYKAK 352
Cdd:cd00398   151 AVLLRNHGLFAWGPTLDEAFHLAVVLEVAAEIQLKALSMGGQlpPISLELLNKEYLRKH 209
AraD COG0235
5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar ...
 145-341 1.11e-56

5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; 5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440005 [Multi-domain]  Cd Length: 208  Bit Score: 192.74  E-value: 1.11e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 145 LRCKLAAFYRLADLFGWSQLIYNHITTRVnsEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGstnlGVNQAGFTLH 224
Cdd:COG0235     6 LREELAAAGRRLARRGLVDGTAGNISVRL--DDDRFLITPSGVDFGELTPEDLVVVDLDGNVVEGD----LKPSSETPLH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 225 SAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPIS-PEAL-SLGDVAYHDYHGIlVDEEEKILIQKNLGpKSKVLILRNH 302
Cdd:COG0235    80 LAIYRARPDVGAVVHTHSPYATALSALGEPLPPLEqTEAAaFLGDVPVVPYAGP-GTEELAEAIAEALG-DRPAVLLRNH 157

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2501356645 303 GLVSVGESVEEAFYYIHNLVVACEIQVRTLAsAGGPDNL 341
Cdd:COG0235   158 GVVVWGKDLAEAFDRAEVLEEAARIQLLALA-LGGPLVL 195
Aldolase_II pfam00596
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 147-329 6.33e-55

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 459862 [Multi-domain]  Cd Length: 178  Bit Score: 186.60  E-value: 6.33e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 147 CKLAAFYRLADLFGWSQLIYNHITTRVnsEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGstnLGVNqAGFTLHSA 226
Cdd:pfam00596   1 EELAAAGRLLARRGLVEGTGGNISVRL--PGDGFLITPSGVDFGELTPEDLVVVDLDGNVVEGG---LKPS-SETPLHLA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 227 VYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL--GDVAYHDYHGiLVDEEEKILIQKNLGPKSKVLILRNHGL 304
Cdd:pfam00596  75 IYRARPDAGAVVHTHSPYATALSLAKEGLPPITQEAADFlgGDIPIIPYYT-PGTEELGERIAEALGGDRKAVLLRNHGL 153

                         170       180
                  ....*....|....*....|....*
gi 2501356645 305 VSVGESVEEAFYYIHNLVVACEIQV 329
Cdd:pfam00596 154 LVWGKTLEEAFYLAEELERAAEIQL 178
Aldolase_II smart01007
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 149-329 3.14e-53

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 214970 [Multi-domain]  Cd Length: 185  Bit Score: 182.45  E-value: 3.14e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645  149 LAAFYRLADLFGWSQLIYNHITTRVNsEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGSTnlGVNQAGFTLHSAVY 228
Cdd:smart01007   1 LAAACRLLARRGLVEGTGGNISARVG-EEDLFLITPSGVDFGELTASDLVVVDLDGNVVEGGGG--PKPSSETPLHLAIY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645  229 AARPDAKCIVHIHTPAGAAVSAM--KCGLLPIS-PEALSLGDVAYHDYHGILVDEEEKI-LIQKNLGPK---SKVLILRN 301
Cdd:smart01007  78 RARPDVGAVVHTHSPYATALAALgkPLPLLPTEqAAAFLGGEIPYAPYAGPGTELAEEGaELAEALAEAlpdRPAVLLRN 157

                          170       180
                   ....*....|....*....|....*...
gi 2501356645  302 HGLVSVGESVEEAFYYIHNLVVACEIQV 329
Cdd:smart01007 158 HGLLVWGKTLEEAFDLAEELEEAAEIQL 185
PRK06661 PRK06661
hypothetical protein; Provisional
 149-334 5.07e-43

hypothetical protein; Provisional


Pssm-ID: 168637  Cd Length: 231  Bit Score: 155.76  E-value: 5.07e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 149 LAAFYRLADLFGWSQLIYNHITTRvNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDrgSTNLGVNQAGFTLHSAVY 228
Cdd:PRK06661    7 LAAAYRIMAYLSLDDHTYTHLSAR-PKNADFYYIYPFGLRFEEVTTENLLKVSLDGQILE--GEEYQYNKTGYFIHGSIY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 229 AARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSLGD-VAYHDYHGILVDE--EEKILIQkNLGpKSKVLILRNHGLV 305
Cdd:PRK06661   84 KTRPDISAIFHYHTPASIAVSALKCGLLPISQWALHFYDrISYHNYNSLALDAdkQSSRLVN-DLK-QNYVMLLRNHGAI 161

                         170       180
                  ....*....|....*....|....*....
gi 2501356645 306 SVGESVEEAFYYIHNLVVACEIQVRTLAS 334
Cdd:PRK06661  162 TCGKTIHEAMFYTYHLEQACKTQCLLNST 190
PRK06208 PRK06208
class II aldolase/adducin family protein;
148-371 1.78e-39

class II aldolase/adducin family protein;


Pssm-ID: 235743  Cd Length: 274  Bit Score: 147.06  E-value: 1.78e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 148 KLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDrgsTNLGVNQAGFTLHSAV 227
Cdd:PRK06208   46 RLAAAFRLFARFGFDEGLAGHITARDPELPDHFWVNPLGVHFSQIKVSDLLLVDHDGEVVE---GDRPLNRAAFAIHSAI 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 228 YAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL-GDVA-YHDYHGILVDEEEKILIQKNLGPKsKVLILRNHGLV 305
Cdd:PRK06208  123 HEARPDVVAAAHTHSTYGKAWSTLGRPLDPITQDACAFyEDHAlFDDFTGVVVDTSEGRRIAAALGTH-KAVILQNHGLL 201

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2501356645 306 SVGESVEEA-FYYIhNLVVACEIQVrtLASAGGPdnLVLLDPGKYKAKSRSPGTPAGEGSGSPPKWQ 371
Cdd:PRK06208  202 TVGPSVDAAaWWFI-ALERACQTQL--LAEAAGP--PQPIDHETARHTRSQVGSEYGGWFNFQPLYQ 263
PRK06486 PRK06486
aldolase;
114-385 1.80e-25

aldolase;


Pssm-ID: 235814  Cd Length: 262  Bit Score: 106.33  E-value: 1.80e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 114 MA-ALNMSLGMVTPVNDLRGSDSIAYdkgeklLRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEV 192
Cdd:PRK06486    1 MAhSLTTDSAPPAGNRPLLDSDAVAQ------ARVDLAACFRAAARHGLEEGICNHFSAVLPGHDDLFLVNPYGYAFSEI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 193 TASSLVKVNLQGDIVD-RGStnlgVNQAGFTLHSAVYAARPDAKCIVHIHTPAGAAVSAMK-CGLLPISPEALSL-GDVA 269
Cdd:PRK06486   75 TASDLLICDFDGNVLAgRGE----PEATAFFIHARIHRAIPRAKAAFHTHMPYATALSLTEgRPLTTLGQTALKFyGRTA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 270 Y-HDYHGILVDEEEKILIQKNLGPKSkVLILRNHGLVSVGESVEEAF---YYihnLVVACEIQVRTLaSAGGPdnLVLLD 345
Cdd:PRK06486  151 VdEDYNGLALDAAEGDRIARAMGDAD-IVFLKNHGVMVCGPRIAEAWddlYY---LERACEVQVLAM-STGRP--LVPVD 223

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2501356645 346 PGKYKAKSRspgtpagegsgsppKWQIGEQE-----FEALMRMLD 385
Cdd:PRK06486  224 PAIAAAVAR--------------QMREGDREsarlhLEALRRTLD 254
PRK07090 PRK07090
class II aldolase/adducin domain protein; Provisional
 145-338 9.04e-20

class II aldolase/adducin domain protein; Provisional


Pssm-ID: 180832  Cd Length: 260  Bit Score: 89.70  E-value: 9.04e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 145 LRCKLAAFYRLADLFGWSQLIYNHITTRvnSEQEH-FLIVPFGLLYSEVTASSLVKVNLQGDIVD-RGSTNlGVNQagft 222
Cdd:PRK07090   31 LRQKLALTCRILFDAGHDSGLAGQITAR--AEAPGtYYTQRLGLGFDEITASNLLLVDEDLNVLDgEGMPN-PANR---- 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 223 LHSAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSL-GDVAY-HDYHGILVDEEEKILIQKNLGPKSKVLiLR 300
Cdd:PRK07090  104 FHSWIYRARPDVNCIIHTHPPHVAALSMLEVPLVVSHMDTCPLyDDCAFlKDWPGVPVGNEEGEIISAALGDKRAIL-LS 182

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2501356645 301 NHGLVSVGESVEEAFYYIHNLVVACEIQVrtLASAGGP 338
Cdd:PRK07090  183 HHGQLVAGKSIEEACVLALLIERAARLQL--LAMAAGP 218
PRK07490 PRK07490
hypothetical protein; Provisional
 135-334 1.88e-18

hypothetical protein; Provisional


Pssm-ID: 236031 [Multi-domain]  Cd Length: 245  Bit Score: 85.54  E-value: 1.88e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 135 SIAYDKGEKLLRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNlqGDIVDRGSTNL 214
Cdd:PRK07490    1 MTMALSDEEQIRVDLAAAFRWIARLGMHEAVANHFSAAVSADGKQFLLNPKWKHFSRIRASDLLLLD--ADDPSTAERPD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 215 GVNQAGFTLHSAVYAARPDAKCIVHIHTPAGAAVSAMKCG-LLPISPE-ALSLGDVAYHDYHGILVDEEEKILIQKNLGP 292
Cdd:PRK07490   79 VPDATAWAIHGQIHRRLPHARCVMHVHSVYATALACLADPtLPPIDQNtARFFNRVAVDTLYGGMALEEEGERLAGLLGD 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2501356645 293 KSkVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLAS 334
Cdd:PRK07490  159 KR-RLLMGNHGVLVTGDTVAEAFDDLYYFERACQTYITALST 199
PRK08333 PRK08333
aldolase;
143-316 1.79e-12

aldolase;


Pssm-ID: 181393 [Multi-domain]  Cd Length: 184  Bit Score: 66.38  E-value: 1.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 143 KLLRCKLAAFYRLADLFGWSQLIYNHITTRVNseqEHFLIVPFGLLYSEVTASSLVKVNLQGDIVD--RGSTNlgvnqag 220
Cdd:PRK08333    2 RNVKAQLVKYSKLAHERGLTAAFGGNLSIRVG---NLVFIKATGSVMDELTREQVAVIDLNGNQLSsvRPSSE------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 221 FTLHSAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLP-ISPEA-LSLGDVAYHDYHGI----LVDEEEKILIQKNlgpks 294
Cdd:PRK08333   72 YRLHLAVYRNRPDVRAIAHLHPPYSIVASTLLEEELPiITPEAeLYLKKIPILPFRPAgsveLAEQVAEAMKEYD----- 146

                         170       180
                  ....*....|....*....|..
gi 2501356645 295 kVLILRNHGLVSVGESVEEAFY 316
Cdd:PRK08333  147 -AVIMERHGIVTVGRSLREAFY 167
PRK06557 PRK06557
L-ribulose-5-phosphate 4-epimerase; Validated
 176-314 1.20e-11

L-ribulose-5-phosphate 4-epimerase; Validated


Pssm-ID: 235829 [Multi-domain]  Cd Length: 221  Bit Score: 65.03  E-value: 1.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 176 EQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDrGSTNLGVNQAGftlHSAVYAARPDAKCIVHIHTPAGAAVSA----M 251
Cdd:PRK06557   41 GTDLVVIKPSGVSYDDLTPEDMVVVDLDGNVVE-GDLKPSSDTAS---HLYVYRHMPDVGGVVHTHSTYATAWAArgepI 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2501356645 252 KCGLLPISPEAlsLGDVAYHDYHGILVDEEEKILIQKNLGPKSKVLILRNHGLVSVGESVEEA 314
Cdd:PRK06557  117 PCVLTAMADEF--GGPIPVGPFALIGDEAIGKGIVETLKGGRSPAVLMQNHGVFTIGKDAEDA 177
PRK08130 PRK08130
putative aldolase; Validated
 179-316 2.33e-08

putative aldolase; Validated


Pssm-ID: 181241 [Multi-domain]  Cd Length: 213  Bit Score: 55.27  E-value: 2.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 179 HFLIVPFGLLYSEVTASSLVKVNLQGDIV--DRGSTNLgvnqagfTLHSAVYAARPDAKCIVHIHTPAGAAVS------- 249
Cdd:PRK08130   38 GWLVTPTGSCLGRLDPARLSKVDADGNWLsgDKPSKEV-------PLHRAIYRNNPECGAVVHLHSTHLTALSclggldp 110

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2501356645 250 -----------AMKCGLLPISPEALSlGDVAyhdyhgiLVDEEEKiliqknLGPKSKVLILRNHGLVSVGESVEEAFY 316
Cdd:PRK08130  111 tnvlppftpyyVMRVGHVPLIPYYRP-GDPA-------IAEALAG------LAARYRAVLLANHGPVVWGSSLEAAVN 174
PRK08087 PRK08087
L-fuculose-phosphate aldolase;
177-333 7.03e-07

L-fuculose-phosphate aldolase;


Pssm-ID: 181226 [Multi-domain]  Cd Length: 215  Bit Score: 50.89  E-value: 7.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 177 QEHFLIVPFGLLYSEVTASSLVKVNlqgdivDRGSTNLG-VNQAGFTLHSAVYAARPDAKCIVHIHTPAGAAVSAMKCGL 255
Cdd:PRK08087   35 QDGMLITPTGIPYEKLTESHIVFVD------GNGKHEEGkLPSSEWRFHMAAYQTRPDANAVVHNHAVHCTAVSILNRPI 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 256 LPISPE-ALSLGD----VAYHDYHGILVDEEEKILIQknlgpKSKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVR 330
Cdd:PRK08087  109 PAIHYMiAAAGGNsipcAPYATFGTRELSEHVALALK-----NRKATLLQHHGLIACEVNLEKALWLAHEVEVLAQLYLK 183


                  ...
gi 2501356645 331 TLA 333
Cdd:PRK08087  184 TLA 186
PRK06833 PRK06833
L-fuculose-phosphate aldolase;
174-338 9.04e-07

L-fuculose-phosphate aldolase;


Pssm-ID: 180717 [Multi-domain]  Cd Length: 214  Bit Score: 50.52  E-value: 9.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 174 NSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDrGSTnlgVNQAGFTLHSAVYAARPDAKCIVHIHTPAGAAVSAMKC 253
Cdd:PRK06833   34 NREQGLMAITPSGIDYFEIKPEDIVIMDLDGKVVE-GER---KPSSELDMHLIFYRNREDINAIVHTHSPYATTLACLGW 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 254 GLLPISPE-ALSLGDVAYHDYHGI----LVDEEEKILIQKnlgpksKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQ 328
Cdd:PRK06833  110 ELPAVHYLiAVAGPNVRCAEYATFgtkeLAENAFEAMEDR------RAVLLANHGLLAGANNLKNAFNIAEEIEFCAEIY 183

                         170
                  ....*....|
gi 2501356645 329 VRTlASAGGP 338
Cdd:PRK06833  184 YQT-KSIGEP 192
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 629-750 7.87e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.78  E-value: 7.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645  629 GSEENLDETREQKEKSPPDQSAVPNTPPSTPV-----KLEEDLPQEPTSRDDSDATTFKPTPPDLSPDEPSE-ALAFPAV 702
Cdd:PHA03307   100 PAREGSPTPPGPSSPDPPPPTPPPASPPPSPApdlseMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQaALPLSSP 179

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2501356645  703 EEEAHASPDP-TQPPAEADPEPASAPTPGAEEVASPATEEGSPMDPGSD 750
Cdd:PHA03307   180 EETARAPSSPpAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSA 228
PHA03169 PHA03169
hypothetical protein; Provisional
 612-750 2.01e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 44.58  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 612 TDRELEEYRREVERKQKGSEENlDETREQKEKSPPDQSAVP---------NTPPSTPVKLEEDLPQEPTSRDDSDATTFK 682
Cdd:PHA03169   73 TETAEESRHGEKEERGQGGPSG-SGSESVGSPTPSPSGSAEelasglspeNTSGSSPESPASHSPPPSPPSHPGPHEPAP 151

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2501356645 683 PTPPDLSPDEPSEALAFPAVEEEAHASPDPTQPPAEADPEPASAPTPG-AEEVASPATEEGSPMDPGSD 750
Cdd:PHA03169  152 PESHNPSPNQQPSSFLQPSHEDSPEEPEPPTSEPEPDSPGPPQSETPTsSPPPQSPPDEPGEPQSPTPQ 220
PHA03247 PHA03247
large tegument protein UL36; Provisional
 645-747 3.26e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645  645 PPDQSAVPNTPPSTPVKleeDLPQEPTSRDDSDATTFKPTPPDLSPDEPSEALAFPAVEEEAHASPDPTQPPAEAD-PEP 723
Cdd:PHA03247  2734 ALPAAPAPPAVPAGPAT---PGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADpPAA 2810

                           90       100
                   ....*....|....*....|....
gi 2501356645  724 ASAPTPGAEEVASPATEEGSPMDP 747
Cdd:PHA03247  2811 VLAPAAALPPAASPAGPLPPPTSA 2834
PHA03247 PHA03247
large tegument protein UL36; Provisional
 645-768 3.43e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645  645 PPDQSAVPNTPPSTPVKLEEDLPQEPTSRDDSDATTFKPTPPdlspdEPSEALAFPAVEEEAHASPDPTQPPAEADPE-- 722
Cdd:PHA03247  2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPP-----AVPAGPATPGGPARPARPPTTAGPPAPAPPAap 2775

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2501356645  723 ----PASAPTPGAEEVASPATEEGSPMDPGSDGSPGKSPSKKKKKFRTPS 768
Cdd:PHA03247  2776 aagpPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
635-744 3.88e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.07  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 635 DETREQKEKSPPDQSAVPNtpPSTPVKLEEDLPQEPTSRDDSDATTFKPTPPDL-SPDEPSEALAFPAVEEEAHASPDPT 713
Cdd:PRK07003  437 DRGDDAADGDAPVPAKANA--RASADSRCDERDAQPPADSGSASAPASDAPPDAaFEPAPRAAAPSAATPAAVPDARAPA 514

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2501356645 714 QPPAEADPEPASAPTPgaeEVASPATEEGSP 744
Cdd:PRK07003  515 AASREDAPAAAAPPAP---EARPPTPAAAAP 542
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 644-748 4.41e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 4.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 644 SPPDQSAVPNTPPSTPvkleedlPQEPTSRDDSDATTFKPTPPDLSPD--EPSEALAFPAVEEEAHASPDPTQPPAEADP 721
Cdd:PRK07764  698 PAQPAPAPAATPPAGQ-------ADDPAAQPPQAAQGASAPSPAADDPvpLPPEPDDPPDPAGAPAQPPPPPAPAPAAAP 770

                          90       100
                  ....*....|....*....|....*..
gi 2501356645 722 EPASAPTPGAEEVASPATEEGSPMDPG 748
Cdd:PRK07764  771 AAAPPPSPPSEEEEMAEDDAPSMDDED 797
PHA03247 PHA03247
large tegument protein UL36; Provisional
 643-744 6.10e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645  643 KSPPDQS--AVPNTPPSTPVKleeDLPQEPTSRddsdATTFKPTPPDLSPDEPSEALAFPAVEEEAHASPDPTQPPAEAD 720
Cdd:PHA03247  2864 RRPPSRSpaAKPAAPARPPVR---RLARPAVSR----STESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP 2936

                           90       100
                   ....*....|....*....|....
gi 2501356645  721 PEPASAPTPGAEEVASPATEEGSP 744
Cdd:PHA03247  2937 PRPQPPLAPTTDPAGAGEPSGAVP 2960
PRK08660 PRK08660
aldolase;
180-327 7.25e-04

aldolase;


Pssm-ID: 181527 [Multi-domain]  Cd Length: 181  Bit Score: 41.10  E-value: 7.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 180 FLIVPFGLLYSEVTASSLVKVNLQG-DIVDRG-STNLGVnqagftlHSAVYAaRPDAKCIVHIHTPAGAAVSAMKCGLLP 257
Cdd:PRK08660   33 LLITRTGSMLDEITEGDVIEVGIDDdGSVDPLaSSETPV-------HRAIYR-RTSAKAIVHAHPPYAVALSLLEDEIVP 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2501356645 258 ISPEALS-LGD--VAYHDYHGILVDEEEKILIQKNlgpksKVLILRNHGLVSVGESVEEAFYYIHNLVVACEI 327
Cdd:PRK08660  105 LDSEGLYfLGTipVVGGDIGSGELAENVARALSEH-----KGVVVRGHGTFAIGKTLEEAYIYTSQLEHSCKV 172
PHA03419 PHA03419
E4 protein; Provisional
 645-730 8.04e-04

E4 protein; Provisional


Pssm-ID: 223079 [Multi-domain]  Cd Length: 200  Bit Score: 41.47  E-value: 8.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 645 PPDQSAVPNTPPSTPVKLEEDLPQEPTSR----DDSDATTFKPTPPDLSPDEPSEALAFPAVEEEAHASPDPTQPPAEAD 720
Cdd:PHA03419   63 PPPCPPSPGHPPQTNDTHEKDLALQPPPGgkkkEKKKKETEKPAQGGEKPDQGPEAKGEGEGHEPEDPPPEDTPPPPGGE 142

                          90
                  ....*....|
gi 2501356645 721 PEPASAPTPG 730
Cdd:PHA03419  143 GEVEGGPSPG 152
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 640-747 9.11e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.76  E-value: 9.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645  640 QKEKSPPDQSAVPNTPPSTPVKLEEDLPQEPTSRDDSDATTFKPTPPdlSPDEPSEALAFPAVEEEAHASPDPTQPPAEA 719
Cdd:PRK10263   390 AVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAP--APEQPVAGNAWQAEEQQSTFAPQSTYQTEQT 467

                           90       100
                   ....*....|....*....|....*...
gi 2501356645  720 DPEPASAPTPgaeEVASPATEEGSPMDP 747
Cdd:PRK10263   468 YQQPAAQEPL---YQQPQPVEQQPVVEP 492
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 640-738 1.25e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 42.02  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 640 QKEKSPPDqsavPNTPPSTPVKLEEDLPQEPTSrddsdATTFKPTPPdLSPDEPSEALAFPAVEEEAHAS--PDPTQPP- 716
Cdd:PHA03269   48 QAASRAPD----PAVAPTSAASRKPDLAQAPTP-----AASEKFDPA-PAPHQAASRAPDPAVAPQLAAApkPDAAEAFt 117

                          90       100
                  ....*....|....*....|....
gi 2501356645 717 --AEADPEPASAPTPGAEEVASPA 738
Cdd:PHA03269  118 saAQAHEAPADAGTSAASKKPDPA 141
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 607-725 1.29e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 41.97  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 607 PFNTLTDRELEEYRREVERKQKGSEENLDETREQKEKSPPDQSAVPNTPPSTPVKLEEDLP--QEPTSRDDSDATTFKPT 684
Cdd:COG5180   188 PRDALKDSPEKLDRPKVEVKDEAQEEPPDLTGGADHPRPEAASSPKVDPPSTSEARSRPATvdAQPEMRPPADAKERRRA 267

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2501356645 685 PpdlspdepsealafpavEEEAHASPDPTQPPAEADPEPAS 725
Cdd:COG5180   268 A-----------------IGDTPAAEPPGLPVLEAGSEPQS 291
Androgen_recep pfam02166
Androgen receptor;
619-750 1.35e-03

Androgen receptor;


Pssm-ID: 426632 [Multi-domain]  Cd Length: 501  Bit Score: 42.22  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 619 YRREVERKQKGSEENLDETREQKEKSPP---DQSAVPNTPPSTPVKLEEDLP---------QEPTSRDDSDATTFKPTPP 686
Cdd:pfam02166   6 YPRPPAKTFRGAFQNLFQSVREVIQNPGprhPEAAGGAAPPGARLQHQQQQQqqvpqqpqqQESSPRQPQASVQPQQAGD 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2501356645 687 DLSPDEPSEALA-FPAVEEEAHASPDPTQPPAEADPEPASAPTPGAEEVASPATEEGS--PMDPGSD 750
Cdd:pfam02166  86 DGSPPAHNRGPAgYLALEDDEQPQPSQAQPAAECCPENGCVPEPGAAAAAGKGLPQQAvaPAAPDDD 152
sgaE PRK12348
L-ribulose-5-phosphate 4-epimerase; Reviewed
 173-327 1.94e-03

L-ribulose-5-phosphate 4-epimerase; Reviewed


Pssm-ID: 183460  Cd Length: 228  Bit Score: 40.55  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 173 VNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVD---RGSTNLGVnqagftlHSAVYAARPDAKCIVHIHTP------ 243
Cdd:PRK12348   31 IDRERGLVVIKPSGVAYETMKADDMVVVDMSGKVVEgeyRPSSDTAT-------HLELYRRYPSLGGIVHTHSThatawa 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 244 -AGAAVSAMKC-------GLLPISpEALSLGDVAyHDYhgilvDEEEKILIQKNLGPKSKV----LILRNHGLVSVGESV 311
Cdd:PRK12348  104 qAGLAIPALGTthadyffGDIPCT-RGLSEEEVQ-GEY-----ELNTGKVIIETLGNAEPLhtpgIVVYQHGPFAWGKDA 176

                         170
                  ....*....|....*.
gi 2501356645 312 EEAfyyIHNLVVACEI 327
Cdd:PRK12348  177 HDA---VHNAVVMEEV 189
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 644-750 1.98e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 644 SPPDQSAVPNTPPSTPVKLEEDLPQEPTSRDDSDATTFKPTPPDLSPDEPSEALAFPAVEEEAHASPDPT-QPPAEADPE 722
Cdd:PRK07764  400 SAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPApAAAPEPTAA 479

                          90       100
                  ....*....|....*....|....*...
gi 2501356645 723 PASAPTPGAEEVASPATEEGSPMDPGSD 750
Cdd:PRK07764  480 PAPAPPAAPAPAAAPAAPAAPAAPAGAD 507
PHA03247 PHA03247
large tegument protein UL36; Provisional
 630-750 2.66e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645  630 SEENLDETREQKEKSPPDQSAVPNTP-PSTPVKLEEDLPQEPTSRDDSDATTFKPTPPD-LSPDEPSEALAFPAVEEEAH 707
Cdd:PHA03247   364 SLEDLSAGRHHPKRASLPTRKRRSARhAATPFARGPGGDDQTRPAAPVPASVPTPAPTPvPASAPPPPATPLPSAEPGSD 443

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2501356645  708 ASPDPT---QPPAEADPEPASAPTPGAEEVASPATEEGSPMDPGSD 750
Cdd:PHA03247   444 DGPAPPperQPPAPATEPAPDDPDDATRKALDALRERRPPEPPGAD 489
PHA03247 PHA03247
large tegument protein UL36; Provisional
 644-750 3.29e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 3.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645  644 SPPDQSAVPN-TPPSTPVKLEEDLPQEPTSRDDSDATTFKPTPPDlsPDEPSEALAFPAVEEEAHASPDPTQPPAEAdPE 722
Cdd:PHA03247  2759 RPPTTAGPPApAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD--PADPPAAVLAPAAALPPAASPAGPLPPPTS-AQ 2835

                           90       100
                   ....*....|....*....|....*...
gi 2501356645  723 PASAPTPgAEEVASPATEEGSpMDPGSD 750
Cdd:PHA03247  2836 PTAPPPP-PGPPPPSLPLGGS-VAPGGD 2861
PRK12373 PRK12373
NADH-quinone oxidoreductase subunit E;
655-744 3.55e-03

NADH-quinone oxidoreductase subunit E;


Pssm-ID: 237082 [Multi-domain]  Cd Length: 400  Bit Score: 40.56  E-value: 3.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 655 PPSTPVKLEEDLPQEPTSRDDSDATTFKPTPPDLSPDEPSeaLAFPAVEEEAHASPDPTQPPAEADPEPASAPTPGAEEV 734
Cdd:PRK12373  190 PAGGLTSLTEEAGKARYNASKALAEDIGDTVKRIDGTEVP--LLAPWQGDAAPVPPSEAARPKSADAETNAALKTPATAP 267

                          90
                  ....*....|
gi 2501356645 735 ASPATEEGSP 744
Cdd:PRK12373  268 KAAAKNAKAP 277
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 646-739 4.08e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 40.60  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 646 PDQSAVPNTPPSTPVKLEEDLPQEPTSRDDSDATTFKPTPPDLSPDEPSEALAFPAVEEEahASPDPT-QPPAEADPEPA 724
Cdd:COG3266   258 PSQASSASAPATTSLGEQQEVSLPPAVAAQPAAAAAAQPSAVALPAAPAAAAAAAAPAEA--AAPQPTaAKPVVTETAAP 335

                          90
                  ....*....|....*.
gi 2501356645 725 SAPTPGAEEVAS-PAT 739
Cdd:COG3266   336 AAPAPEAAAAAAaPAA 351
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 645-741 4.18e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 40.32  E-value: 4.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 645 PPDQSAVPNTPPSTPVKLEEDLPQEPTSRDDSDATTF-KPTPPDLSPDEPSEAlAFPAVEEEAHASPDPTQPPAEADPEP 723
Cdd:PHA03291  181 SADGSCDPALPLSAPRLGPADVFVPATPRPTPRTTASpETTPTPSTTTSPPST-TIPAPSTTIAAPQAGTTPEAEGTPAP 259

                          90       100
                  ....*....|....*....|..
gi 2501356645 724 asaPTPGAEEV----ASPATEE 741
Cdd:PHA03291  260 ---PTPGGGEAppanATPAPEA 278
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 674-750 5.50e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 40.26  E-value: 5.50e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2501356645  674 DDSDATTFKPTPPDLSPDEPSEALAFPAVEEEAHASPDPTQPPAEADPEPASAPTPGAEEVASPATEEGSPMDPGSD 750
Cdd:PRK12270    39 GSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 645-744 8.24e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.77  E-value: 8.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645  645 PPDQSAVPNTPPSTPVKLEEDLPQEPTSRD-DSDATTFKPTPPDLSPDEPSEALAFPAVEEEAHASPDPTQPPAEADP-- 721
Cdd:PHA03307    81 ANESRSTPTWSLSTLAPASPAREGSPTPPGpSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASpa 160

                           90       100
                   ....*....|....*....|....
gi 2501356645  722 -EPASAPTPGAEEVASPATEEGSP 744
Cdd:PHA03307   161 aVASDAASSRQAALPLSSPEETAR 184
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 635-747 8.43e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 39.71  E-value: 8.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645 635 DETREQKEKSPPDQSAvPNTPPSTPVKLEEdlPQEPTSRDDSDATTFKPTPPDLSP-DEPSEALAFPAVEEEAHASPDPT 713
Cdd:PRK14949  629 LSPKEGDGKKSSADRK-PKTPPSRAPPASL--SKPASSPDASQTSASFDLDPDFELaTHQSVPEAALASGSAPAPPPVPD 705

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2501356645 714 ---QPPAEADPEPASAPTPGA--------EEVASPATEEGSPMDP 747
Cdd:PRK14949  706 pydRPPWEEAPEVASANDGPNnaaegnlsESVEDASNSELQAVEQ 750
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 609-744 8.59e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.77  E-value: 8.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501356645  609 NTLTDRELEEYRREVERKQKGSEENLDETREQKEKSPPDQSAVPNTPPSTPVKLEEDLPQEptsrDDSDATTfkptppdl 688
Cdd:PHA03307   263 ITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRE----SSSSSTS-------- 330

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2501356645  689 SPDEPSEALAFPAVEEEaHASPDPTQPPAEADPEPASAPTPGAEEVASPATEEGSP 744
Cdd:PHA03307   331 SSSESSRGAAVSPGPSP-SRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRP 385
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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