NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2512276227|ref|NP_001408905|]
View 

calcium and integrin-binding protein 1 isoform 7 [Mus musculus]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 10040236)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494
SCOP:  3001983

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 108-175 2.93e-11

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


:

Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 56.40  E-value: 2.93e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2512276227 108 AFRIFDFDDDGTLDREDLSQLVNcltgegedtRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVIS 175
Cdd:cd00051     5 AFRLFDKDGDGTISADELKAALK---------SLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLELMA 63
 
Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 108-175 2.93e-11

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 56.40  E-value: 2.93e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2512276227 108 AFRIFDFDDDGTLDREDLSQLVNcltgegedtRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVIS 175
Cdd:cd00051     5 AFRLFDKDGDGTISADELKAALK---------SLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLELMA 63
EF-hand_7 pfam13499
EF-hand domain pair;
106-175 5.03e-08

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 48.02  E-value: 5.03e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2512276227 106 HYAFRIFDFDDDGTLDREDLSQLVNCLtGEGEDTRlsasemKQLIDNILEESDIDRDGTINLSEFQHVIS 175
Cdd:pfam13499   5 KEAFKLLDSDGDGYLDVEELKKLLRKL-EEGEPLS------DEEVEELFKEFDLDKDGRISFEEFLELYS 67
PTZ00183 PTZ00183
centrin; Provisional
 80-178 4.21e-05

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 41.98  E-value: 4.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2512276227  80 RDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLtgeGEDtrLSASEMKQLIDnileESDI 159
Cdd:PTZ00183   67 SGKIDFEEFLDIMTKKLGERDPREEILKAFRLFDDDKTGKISLKNLKRVAKEL---GET--ITDEELQEMID----EADR 137

                          90
                  ....*....|....*....
gi 2512276227 160 DRDGTINLSEFQHVISRSP 178
Cdd:PTZ00183  138 NGDGEISEEEFYRIMKKTN 156
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
81-172 8.04e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 40.93  E-value: 8.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2512276227  81 DSLSFEDFL-DLLSVFSDTATPDIKShyAFRIFDFDDDGTLDREDLSQLVncltgegEDTRLSASEMKQLIDNIleesDI 159
Cdd:COG5126    48 GRISREEFVaGMESLFEATVEPFARA--AFDLLDTDGDGKISADEFRRLL-------TALGVSEEEADELFARL----DT 114

                          90
                  ....*....|...
gi 2512276227 160 DRDGTINLSEFQH 172
Cdd:COG5126   115 DGDGKISFEEFVA 127
 
Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 108-175 2.93e-11

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 56.40  E-value: 2.93e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2512276227 108 AFRIFDFDDDGTLDREDLSQLVNcltgegedtRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVIS 175
Cdd:cd00051     5 AFRLFDKDGDGTISADELKAALK---------SLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLELMA 63
EF-hand_7 pfam13499
EF-hand domain pair;
106-175 5.03e-08

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 48.02  E-value: 5.03e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2512276227 106 HYAFRIFDFDDDGTLDREDLSQLVNCLtGEGEDTRlsasemKQLIDNILEESDIDRDGTINLSEFQHVIS 175
Cdd:pfam13499   5 KEAFKLLDSDGDGYLDVEELKKLLRKL-EEGEPLS------DEEVEELFKEFDLDKDGRISFEEFLELYS 67
PTZ00183 PTZ00183
centrin; Provisional
 80-178 4.21e-05

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 41.98  E-value: 4.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2512276227  80 RDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLtgeGEDtrLSASEMKQLIDnileESDI 159
Cdd:PTZ00183   67 SGKIDFEEFLDIMTKKLGERDPREEILKAFRLFDDDKTGKISLKNLKRVAKEL---GET--ITDEELQEMID----EADR 137

                          90
                  ....*....|....*....
gi 2512276227 160 DRDGTINLSEFQHVISRSP 178
Cdd:PTZ00183  138 NGDGEISEEEFYRIMKKTN 156
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
81-172 8.04e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 40.93  E-value: 8.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2512276227  81 DSLSFEDFL-DLLSVFSDTATPDIKShyAFRIFDFDDDGTLDREDLSQLVncltgegEDTRLSASEMKQLIDNIleesDI 159
Cdd:COG5126    48 GRISREEFVaGMESLFEATVEPFARA--AFDLLDTDGDGKISADEFRRLL-------TALGVSEEEADELFARL----DT 114

                          90
                  ....*....|...
gi 2512276227 160 DRDGTINLSEFQH 172
Cdd:COG5126   115 DGDGKISFEEFVA 127
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
108-175 1.92e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 39.78  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2512276227 108 AFRIFDFDDDGTLDREDLSQLVNCLTGE-------GEDTRLSASEMKQLIDNILEES------------DIDRDGTINLS 168
Cdd:COG5126    10 RFDLLDADGDGVLERDDFEALFRRLWATlfseadtDGDGRISREEFVAGMESLFEATvepfaraafdllDTDGDGKISAD 89


                  ....*..
gi 2512276227 169 EFQHVIS 175
Cdd:COG5126    90 EFRRLLT 96
PTZ00184 PTZ00184
calmodulin; Provisional
 82-170 3.60e-04

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 38.97  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2512276227  82 SLSFEDFLDLLSV-FSDTATPD-IKShyAFRIFDFDDDGTLDREDLSQLvncLTGEGEdtRLSASEmkqlIDNILEESDI 159
Cdd:PTZ00184   63 TIDFPEFLTLMARkMKDTDSEEeIKE--AFKVFDRDGNGFISAAELRHV---MTNLGE--KLTDEE----VDEMIREADV 131

                          90
                  ....*....|.
gi 2512276227 160 DRDGTINLSEF 170
Cdd:PTZ00184  132 DGDGQINYEEF 142
EFh_parvalbumin_like cd16251
EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family; The family includes ...
 81-171 5.36e-03

EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family; The family includes alpha- and beta-parvalbumins, and a group of uncharacterized calglandulin-like proteins. Parvalbumins are small, acidic, cytosolic EF-hand-containing Ca2+-buffer and Ca2+ transporter/shuttle proteins belonging to EF-hand superfamily. They are expressed by vertebrates in fast-twitch muscle cells, specific neurons of the central and peripheral nervous system, sensory cells of the mammalian auditory organ (Corti's cell), and some other cells, and characterized by the presence of three consecutive EF-hand motifs (helix-loop-helix) called AB, CD, and EF, but only CD and EF can chelate metal ions, such as Ca2+ and Mg2+. Thus, they may play an additional role in Mg2+ handling. Moreover, parvalbumins represent one of the major animal allergens. In metal-bound states, parvalbumins possess a rigid and stable tertiary structure and display strong allergenicity. In contrast, the metal-free parvalbumins are intrinsically disordered, and the loss of metal ions results in a conformational change that decreases their IgE binding capacity. Furthermore, parvalbumins have been widely used as a neuronal marker for a variety of functional brain systems. They also function as a Ca2+ shuttle transporting Ca2+ from troponin-C (TnC) to the sarcoplasmic reticulum (SR) Ca2+ pump during muscle relaxation. Thus they may facilitate myocardial relaxation and play important roles in cardiac diastolic dysfunction. Parvalbumins consists of alpha- and beta- sublineages, which can be distinguished on the basis of isoelectric point (pI > 5 for alpha; pI


Pssm-ID: 319994 [Multi-domain]  Cd Length: 101  Bit Score: 35.20  E-value: 5.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2512276227  81 DSLSFEDFLDLLSVFSDTATpDIKShyAFRIFDFDDDGTLDREDLSQLVNCLTGEGEDtrLSASEMKQLidniLEESDID 160
Cdd:cd16251    15 GSFNYKKFFEHVGLKQKSED-QIKK--VFQILDKDKSGFIEEEELKYILKGFSIAGRD--LTDEETKAL----LAAGDTD 85

                          90
                  ....*....|.
gi 2512276227 161 RDGTINLSEFQ 171
Cdd:cd16251    86 GDGKIGVEEFA 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH