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Conserved domains on  [gi|2593855568|ref|NP_001411936|]
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potassium voltage-gated channel subfamily KQT member 4 isoform 6 [Mus musculus]

Protein Classification

potassium voltage-gated channel subfamily KQT member 2( domain architecture ID 10507579)

potassium voltage-gated channel subfamily KQT member 2 (KCNQ2) associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KCNQ_channel pfam03520
KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type ...
 75-254 5.22e-119

KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type potassium channels.


:

Pssm-ID: 460954  Cd Length: 190  Bit Score: 339.43  E-value: 5.22e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593855568  75 EQVGEASsPSKVQKSWSFNDRTRFRASLRLK---PRCSAEE--GPSEEVAEEKSYQCELTVDDVMPAVKTVIRSVRILKF 149
Cdd:pfam03520   5 EDSIEAS-PSKVQKSWSFNDRTRFRTSLRLKgsaSRQSSEEasGPGEEVAEDKGCHCDFLVEDLIPALKTVIRAVRIMKF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593855568 150 LVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQARVDQIVGRGP--GDRKTREKGDKGPSDTEAVDEISMMGRVV 227
Cdd:pfam03520  84 LVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQIVGRGPppTDKKKREKGPKVPAEGDLVEDLSMMGRVV 163

                         170       180
                  ....*....|....*....|....*..
gi 2593855568 228 KVEKQVQSIEHKLDLLLGFYSRCLRSG 254
Cdd:pfam03520 164 KVEKQVQSIEKKLDFLLDIYSQCLRKG 190
 
Name Accession Description Interval E-value
KCNQ_channel pfam03520
KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type ...
 75-254 5.22e-119

KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type potassium channels.


Pssm-ID: 460954  Cd Length: 190  Bit Score: 339.43  E-value: 5.22e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593855568  75 EQVGEASsPSKVQKSWSFNDRTRFRASLRLK---PRCSAEE--GPSEEVAEEKSYQCELTVDDVMPAVKTVIRSVRILKF 149
Cdd:pfam03520   5 EDSIEAS-PSKVQKSWSFNDRTRFRTSLRLKgsaSRQSSEEasGPGEEVAEDKGCHCDFLVEDLIPALKTVIRAVRIMKF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593855568 150 LVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQARVDQIVGRGP--GDRKTREKGDKGPSDTEAVDEISMMGRVV 227
Cdd:pfam03520  84 LVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQIVGRGPppTDKKKREKGPKVPAEGDLVEDLSMMGRVV 163

                         170       180
                  ....*....|....*....|....*..
gi 2593855568 228 KVEKQVQSIEHKLDLLLGFYSRCLRSG 254
Cdd:pfam03520 164 KVEKQVQSIEKKLDFLLDIYSQCLRKG 190
 
Name Accession Description Interval E-value
KCNQ_channel pfam03520
KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type ...
 75-254 5.22e-119

KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type potassium channels.


Pssm-ID: 460954  Cd Length: 190  Bit Score: 339.43  E-value: 5.22e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593855568  75 EQVGEASsPSKVQKSWSFNDRTRFRASLRLK---PRCSAEE--GPSEEVAEEKSYQCELTVDDVMPAVKTVIRSVRILKF 149
Cdd:pfam03520   5 EDSIEAS-PSKVQKSWSFNDRTRFRTSLRLKgsaSRQSSEEasGPGEEVAEDKGCHCDFLVEDLIPALKTVIRAVRIMKF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2593855568 150 LVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQARVDQIVGRGP--GDRKTREKGDKGPSDTEAVDEISMMGRVV 227
Cdd:pfam03520  84 LVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQIVGRGPppTDKKKREKGPKVPAEGDLVEDLSMMGRVV 163

                         170       180
                  ....*....|....*....|....*..
gi 2593855568 228 KVEKQVQSIEHKLDLLLGFYSRCLRSG 254
Cdd:pfam03520 164 KVEKQVQSIEKKLDFLLDIYSQCLRKG 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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