|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC22A16_CT2 |
cd17375 |
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ... |
118-528 |
1.48e-175 |
|
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340933 [Multi-domain] Cd Length: 341 Bit Score: 509.68 E-value: 1.48e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 118 GYKRDSPCSDGYIYDQSKWRSSVVGSFNLVCDQKWYANMIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGI 197
Cdd:cd17375 1 GNKTRFSCSDGFVYDQSKWESSIVTDWDLVCDREWLAKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 198 GSIFIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTWWLYQIILWTV 277
Cdd:cd17375 81 AVAFTFDYYSFVIVRFLLAMVSSGYLVVVFVYVTEFTGIKARTWASMHVHAFFAVGIMVVALVGYLVRTWWIYQIILSLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 278 TAPFILCCWMLPetpfwllsegrykeaqgvvdamavwnkssscdliellsldvtrshdkshkgagkpslgdlfrnpdiaK 357
Cdd:cd17375 161 TIPFILCCWMLP-------------------------------------------------------------------K 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 358 MTLIVWLDWFTVNLGYYVFAMEAVRRKEHEHLYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIPS 437
Cdd:cd17375 174 RTITVWLIWFTGSLGYYVFSLGSVNLGGNEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQ 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 438 DSDTAKEakgAVALFVKVAVGSVFAFIYLYTAELYPTIMRCLAVGSSNMVSHVASMVIPLSQHFSKVWIFLPQILFGTLA 517
Cdd:cd17375 254 DYEVLTI---VLSMTGKFAIAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQLLVGIMA 330
|
410
....*....|.
gi 2780227945 518 ILSGLLSLNLP 528
Cdd:cd17375 331 FLSGILTLMLP 341
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
14-538 |
7.86e-95 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 306.56 E-value: 7.86e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 14 GHFGRFQIALYLICAYQSISCGIHFLSSVFMSIIPEHACKPPGTVrkavfrNVS-AWRLEDILAL---RSPEHKDHIMVE 89
Cdd:TIGR00898 1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRLPDAA------NLSsRCELNLTLPRlpdGRPESCLRFMVD 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 90 LHDGEIWELTRCSRTWRENTSHLgyeysgykrdSPCSDGYIYDQSKWRSSVVGSFNLVCDQKWYANMIQPLFIFAMLLGA 169
Cdd:TIGR00898 75 QWANPSLLGCEPLKLSDLGLAAT----------EPCLDGWEYSYDTFSSTIVTEWDLVCEDAWKVDLTQSCFFVGVLLGS 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 170 ITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESRTWASMHLNTF 249
Cdd:TIGR00898 145 FVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 250 FAIGTMLVALVSYLVKTWwlyQIILWTVTAPFILC---CWMLPETPFWLLSEGRYKEAQGVVDAMAVWNKSSSCDLIELL 326
Cdd:TIGR00898 225 FSLGLVLLPLVAYFIPDW---RWLQLAVSLPTFLFfllSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLSL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 327 SLDVTRSHDKshkgaGKPSLGDLFRNPDIAKMTLIVWLDWFTVNLGYY--VFAMEAVrrkeHEHLYYLLV--GAVEIPAY 402
Cdd:TIGR00898 302 SLEKDLSSSK-----KQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYglVLDLGNL----GGNIYLDLFisGLVELPAK 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 403 VFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIPSDSdtaKEAKGAVALFVKVAVGSVFAFIYLYTAELYPTIMRCLAVG 482
Cdd:TIGR00898 373 LITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDL---YFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVG 449
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 2780227945 483 SSNMVSHVASMVIPLSQHFSKVWIFLPQILFGTLAILSGLLSLNLPETQNRPMIST 538
Cdd:TIGR00898 450 VCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
128-528 |
2.33e-90 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 288.71 E-value: 2.33e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 128 GYIYDQSKWRSSVVGSFNLVCDQKWYANMIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIFDYFS 207
Cdd:cd17317 1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 208 FMAARFFLVMTSSGYFVVVFVYVMEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTWWLYQIILWTVTAPFILCCWM 287
Cdd:cd17317 81 FLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWW 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 288 LPetpfwllsegrykeaqgvvdamavwnkssscdliellsldvtrshdkshkgagkpslgdlfrnpdiaKMTLIVWLDWF 367
Cdd:cd17317 161 LP-------------------------------------------------------------------RRTIIVGLIWF 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 368 TVNLGYYVFAMEAVRRKEHEHLYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIPSDSDTAKEakg 447
Cdd:cd17317 174 VTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLAL--- 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 448 AVALFVKVAVGSVFAFIYLYTAELYPTIMRCLAVGSSNMVSHVASMVIPLSQHFSKVWIFLPQILFGTLAILSGLLSLNL 527
Cdd:cd17317 251 TLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLALLGGLLTLLL 330
|
.
gi 2780227945 528 P 528
Cdd:cd17317 331 P 331
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
124-528 |
5.21e-59 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 204.83 E-value: 5.21e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 124 PCSDGYIYDQSKWRSSVVGSFNLVCDQKWYANMIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIF 203
Cdd:cd17374 7 PCVDGWVYDRSKFTSTIVTEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 204 DYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTWWLYQIilwTVTAP--- 280
Cdd:cd17374 87 TFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQL---VVSVPffl 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 281 FILCCWMLPetpfwllsegrykeaqgvvdamavwnkssscdliellsldvtrshdkshkgagkpslgdlfrnpdiaKMTL 360
Cdd:cd17374 164 FFLYSWWLP-------------------------------------------------------------------KRTL 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 361 IVWLDWFTVNLGYYVFAMEAVRRKEHEHLYYLLVGAVEIPAYvFLCIW-MQRVGRRKTMLTFLLMSSFICVVYVVIPSDS 439
Cdd:cd17374 177 ILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPAR-CLALFlLNHMGRRISQAVLLLLAGLCILANIFVPQEM 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 440 DTAKEakgAVALFVKVAVGSVFAFIYLYTAELYPTIMRCLAVGSSNMVSHVASMVIPLSQHFSKVWIFLPQILFGTLAIL 519
Cdd:cd17374 256 QTLRT---VLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPIL 332
|
....*....
gi 2780227945 520 SGLLSLNLP 528
Cdd:cd17374 333 AGLLALLLP 341
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
124-528 |
3.13e-46 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 168.75 E-value: 3.13e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 124 PCSDGYIYDQSKWRSSVVGSFNLVCDQKWYANMIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIF 203
Cdd:cd17446 5 PCTDGWVYDKSEFPSTIITEWDLVCNHRALRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 204 DYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTWWLYQIilwTVTAPFIL 283
Cdd:cd17446 85 SFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAVVGTLLGYCYTLGQLILAGVAYAIRDWRWLQL---AVSLPFFI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 284 C---CWMLPetpfwllsegrykeaqgvvdamavwnkssscdliellsldvtrshdkshkgagkpslgdlfrnpdiaKMTL 360
Cdd:cd17446 162 FflySWWFP-------------------------------------------------------------------RITF 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 361 IVWLDWFTVNLGYYVFAMEAVRRKEHEHLYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIPSDSD 440
Cdd:cd17446 175 CLSLVWFSTSFAYYGLAMDLQKFGVSIYLIQIIFGAVDIPAKFISTLTMSYLGRRPTQAAALILAGIMILANIFVPQDLQ 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 441 TAKEAkgaVALFVKVAVGSVFAFIYLYTAELYPTIMRCLAVGSSNMVSHVASMVIPLSQHFSKVWIFLPQILFGTLAILS 520
Cdd:cd17446 255 TVRTA---LAVFGKGCLAASFNCVYLYTGELYPTVIRQTGMGLGSTMARLGGIVAPLVKMLGEYYPFLPLIIYGAAPILS 331
|
....*...
gi 2780227945 521 GLLSLNLP 528
Cdd:cd17446 332 GIAACFLP 339
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
124-528 |
5.32e-43 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 159.51 E-value: 5.32e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 124 PCSDGYIYDQSKWRSSVVGSFNLVCDQKWYANMIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIF 203
Cdd:cd17447 7 PCQNGWVYDHSTFSSTIATEWDLVCDRKGLNQATATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 204 DYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTW-WLyqiiLWTVTAPF- 281
Cdd:cd17447 87 SYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLIRDWrWL----ILAVTLPCa 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 282 --ILCCWMLPetpfwllsegrykeaqgvvdamavwnkssscdliellsldvtrshdkshkgagkpslgdlfrnpdiaKMT 359
Cdd:cd17447 163 pgIITWWWVP-------------------------------------------------------------------KIS 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 360 LIVWLDWFTVNLGYYVFAMEAVRRKEHEHLYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIPSDS 439
Cdd:cd17447 176 LCTGIVWFGVAFTYYGISFNISGFGLNVYLTQFIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINILIPSEF 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 440 DTAKEakgAVALFVKVAVGSVFAFIYLYTAELYPTIMRCLAVGSSNMVSHVASMVIPLSQHFSKVWIFLPQILFGTLAIL 519
Cdd:cd17447 256 TVVRT---VIAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYTSFIARLGGSLAPLVILLDDVWLSLPQVIFCGVALL 332
|
....*....
gi 2780227945 520 SGLLSLNLP 528
Cdd:cd17447 333 AGGVAFLLP 341
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
123-528 |
1.34e-42 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 158.67 E-value: 1.34e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 123 SPCSDGYIYDQSkwRSSVVGSFNLVCDQKWYANMIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFI 202
Cdd:cd17379 6 SPCQDGWVYNTP--RSSIVTEFNLVCEDAWKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 203 FDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTWwlyQIILWTVTAP-- 280
Cdd:cd17379 84 PNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIPHW---RWLQLAVTLPnf 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 281 -FILCCWMLPetpfwllsegrykeaqgvvdamavwnkssscdliellsldvtrshdkshkgagkpslgdlfrnpdiaKMT 359
Cdd:cd17379 161 lFLLYYWFIP-------------------------------------------------------------------KHT 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 360 LIVWLDWFTVNLGYYVFAMEAVRRKEHEHLYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIPSDs 439
Cdd:cd17379 174 FILMYAWFTSAVVYQGLIMRLGITGGNLYLDFFISALVELPAAFIILLTIDRIGRRLPFAASNIVAGAACLITAFIPPD- 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 440 dtAKEAKGAVALFVKVAVGSVFAFIYLYTAELYPTIMRCLAVGSSNMVSHVASMVIP-LSQHFSKVWIFLPQILFGTLAI 518
Cdd:cd17379 253 --LHWLKTTIACVGRLGITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIGGIIAPfLLYRLAEIWLELPLIVFGVLAL 330
|
410
....*....|
gi 2780227945 519 LSGLLSLNLP 528
Cdd:cd17379 331 VAGGLVLLLP 340
|
|
| MFS_SLC22A4_5_OCTN1_2 |
cd17376 |
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ... |
124-528 |
1.22e-41 |
|
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340934 [Multi-domain] Cd Length: 342 Bit Score: 155.70 E-value: 1.22e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 124 PCSDGYIYDQSKWRSSVVGSFNLVCDQKWYANMIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIF 203
Cdd:cd17376 7 PCLDGWEYSQDVYLSTIVTEWNLVCEDDWKVPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 204 DYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESRT-WASMHLNTFFAIGTMLVALVSYLVKTWwlyQIILWTVTAPFI 282
Cdd:cd17376 87 SWEMFTVLFVIVGMGQISNYVVAFVLGTEILGKSVRIlFSTLGVCIFYAIGYMLLPLFAYFIRDW---RMLLLALTLPGV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 283 LCcwmlpeTPFWLLsegrykeaqgvvdamavwnkssscdliellsldvtrshdkshkgagkpslgdlfrnpdIAKMTLIV 362
Cdd:cd17376 164 LC------VPLWWF----------------------------------------------------------IPITTIMS 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 363 WLDWFTVNLGYYVFAMEAVRRKEHEHLYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIPSDSDTA 442
Cdd:cd17376 180 LLLWMAISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQLVPTDLQVL 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 443 keakgAVALFV--KVAVGSVFAFIYLYTAELYPTIMRCLAVGSSNMVSHVASMVIPLSQHFSKVWIFLPQILFGTLAILS 520
Cdd:cd17376 260 -----ATALVMlgKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYLGAYDRYLPYILMGSLTVLI 334
|
....*...
gi 2780227945 521 GLLSLNLP 528
Cdd:cd17376 335 GILTLFLP 342
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
138-528 |
9.19e-36 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 139.14 E-value: 9.19e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 138 SSVVGSFNLVCDQKWYANMIQPLFIFAMLLGAITFSYLSDRFGRRvALWCTtiGVFF---FGIGSIFIFDYFSFMAARFF 214
Cdd:cd17377 25 TSIVSEWFLVGNAAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRK-PVYLT--GLALdilFAYFNALAPSYEFFAVSRFL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 215 LVMTSSGYFVVVFVYVMEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTWWLYQIILWTVTAPFILCCWMLPetpfw 294
Cdd:cd17377 102 VGVMNGGMSLVAFVLLNECVGKSYWALAGSLGGLFFAVGIAQYALLGYFIRSWRTLAVVVNLQGTLVFLLSLFIP----- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 295 llseGRykeaqgvvdamavwnkssscdliellsldvtrshdkshkgagkpslgdlfrnpdiakmTLIVWLDWFTVNLGYY 374
Cdd:cd17377 177 ----GR----------------------------------------------------------TLILMYVWFVCSLVYY 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 375 VFAMEAVRRKEHEHLYYLLVGAVEIPAYVfLCIWM---QRVGRRKTMLTFLLMSSFICVVYVVIPSDSDTAKEA---KGA 448
Cdd:cd17377 195 GLTLNAGDLGGNIYLNLALSGLVELPAYP-LCIYLinqKWSGRRRTLAGFLFLGGIACLLVMFVPEKKDSGVFAvvnSTS 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 449 VALFVKVAVGSVFAFIYLYTAELYPTIMRCLAVGSSNMVSHVASMVIPLSQHFSKVWIFLPQILFGTLAILSGLLSLNLP 528
Cdd:cd17377 274 LSLLGKLTISAAFNIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFIPSLKSVQWSLPFIVFGASGLSAGLLSLLLP 353
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
146-525 |
5.81e-27 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 113.08 E-value: 5.81e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 146 LVCDQKWYANMIQPLFIFA-----MLLGAITFSYLSDRFGRRVALwctTIGVFFFGIGSI---FIFDYFSFMAARFFLVM 217
Cdd:cd17316 25 LAAEFSLGLSLLQTGLLFAagflgRPIGALLFGYLGDRIGRKKAL---ILTLLLFGLATLligLLPTPILLLVLRFLQGI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 218 TSSGYFVVVFVYVMEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTwWLYQIILWTVtaPFILCCwmlpetpfwlls 297
Cdd:cd17316 102 GIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIP-LLSGDWGWRI--LFLIGA------------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 298 egrykeaqgvvdamavwnkssscdLIELLSLdvtrshdkshkgagkpslgdLFRnpdiaKMTLIVWLDWFTVNLGYYVFA 377
Cdd:cd17316 167 ------------------------LPALLAL--------------------LLR-----RRTLLLILLWFFISFGYYGLT 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 378 ------MEAVRRKEHEH--LYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIPSDSDTAKEAKGAV 449
Cdd:cd17316 198 tflptyLQTVLGLSPATssLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFI 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 450 ALFVkvaVGSVFAFIYLYTAELYPTIMRCLAVGSSNMVSHVASMVIP------LSQHFSkvwIFLPQILFGTLAILSGLL 523
Cdd:cd17316 278 LSFF---VGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPpliallLASTGG---TGVPALILALLAIVALIV 351
|
..
gi 2780227945 524 SL 525
Cdd:cd17316 352 AL 353
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
138-528 |
6.71e-24 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 103.98 E-value: 6.71e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 138 SSVVGSFNLVCDQKWYANMIQPLFIFAMLLGAITFSYLSD-RFGRRVALWCTTIGVFFFGIGSIFIFDYFSFMAARFFLV 216
Cdd:cd17378 19 VSIVSEWGLICAGSFLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 217 MTSSGYFVVVFVYVMEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTWW--LYqiiLWTVTAPFILCCWMLPetpfw 294
Cdd:cd17378 99 FGRSGIGTCALVLATEPVGPKWRGQVGMSTFFFFVLGFMSLPGIAYLNGSSWrvLY---FWTSIPALIYCILVYL----- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 295 llsegrykeaqgvvdamavwnkssscdliellsldvtrshdkshkgagkpslgdlfrnpdIAKMTLIVWLDWFTVNLGYY 374
Cdd:cd17378 171 ------------------------------------------------------------FARRLLAVMVIGFGIGMVYY 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 375 VFAMEAVRRKEHEHLYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIPSDSDTakEAKGAVALFVK 454
Cdd:cd17378 191 GIPLAVGNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIGGTT--SLQIALELVGF 268
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2780227945 455 VAVGSVFAFIYLYTAELYPTIMRCLAVGSSNMVSHVASMVIPLSQHFSKVWIFLPQILFGTLAILSGLLSLNLP 528
Cdd:cd17378 269 FGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALSFGVFGVAILLLGLFALGLP 342
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
156-525 |
1.26e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 103.66 E-value: 1.26e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 156 MIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIG 235
Cdd:cd06174 35 LLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 236 RESRTWASMHLNTFFAIGTMLVALVSYLVKTW--WLYQIILWTVTAPFILCCwmlpeTPFWLLSEGRYKEAQgvvdamav 313
Cdd:cd06174 115 ERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAA-----ILLLLVVPDPPESAR-------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 314 wnkssscdliellsldvtRSHDKSHKGAGKPSLGDLFRNPDIAKMTLIvwldWFTVNLGYYVFAMEAVRRKEHEH----- 388
Cdd:cd06174 182 ------------------AKNEEASSKSVLKLLKRVLKNPGLWLLLLA----IFLVNLAYYSFSTLLPLFLLDLGglsva 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 389 ---LYYLLVGAVEIPAYVFLCIWMQRV-GRRKTMLTFLLMSSFICVVYVVIPSDSDTAkeakgAVALFVKVAVGSVFAFI 464
Cdd:cd06174 240 vagLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLL-----LLLLLLGFGLGGLLPLS 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2780227945 465 YLYTAELYPTIMRCLAVGSSNMVSHVASMVIPLSQHFSKVWIFLPQILFGTLAILSGLLSL 525
Cdd:cd06174 315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
160-496 |
2.73e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 87.09 E-value: 2.73e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 160 LFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESR 239
Cdd:pfam07690 40 LFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEER 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 240 TWASMHLNTFFAIGTMLVALVSYLVKTWWLYQIILWTVTAPFILCCWMLpetpfWLLSEGRYKEAQgvvdamavwnksss 319
Cdd:pfam07690 120 GRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLL-----LLPRPPPESKRP-------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 320 cdliellsldvtRSHDKSHKGAGKPsLGDLFRNPDIakMTLIVWLDWFTVNLGYYVFAMEAVRRKEHEHL----YYLLVG 395
Cdd:pfam07690 181 ------------KPAEEARLSLIVA-WKALLRDPVL--WLLLALLLFGFAFFGLLTYLPLYQEVLGLSALlaglLLGLGG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 396 AVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIPSDSDTAkeAKGAVALFVKVAVGSVFAFIYLYTAELYPTI 475
Cdd:pfam07690 246 LLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSL--WLLLALLLLGFGFGLVFPALNALVSDLAPKE 323
|
330 340
....*....|....*....|.
gi 2780227945 476 MRCLAVGSSNMVSHVASMVIP 496
Cdd:pfam07690 324 ERGTASGLYNTAGSLGGALGP 344
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
153-534 |
1.34e-17 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 86.62 E-value: 1.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 153 YANMIQPLFIFAMLLGAITFS----YLSDRFGRRValwCTTIGVFFFGIGSIFI------FDYFSFMAARFFLVMTSSGY 222
Cdd:TIGR00879 68 YSSSLWGLVVSIFLVGGFIGAlfagWLSDRFGRKK---SLLIIALLFVIGAILMglaafaLSVEMLIVGRVLLGIGVGIA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 223 FVVVFVYVMEFigresrtwASMHL--------NTFFAIGTMLVALVSYLVKTWW---LYQIIL---WTVTAPFILCCWML 288
Cdd:TIGR00879 145 SALVPMYLSEI--------APKALrgaltslyQLAITFGILVAYGFGSGKVSLNntlGWRIPLglqLIPAGLLFLGLFFL 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 289 PETPFWLLSEGRYKEAQGVVDAMavwNKSSSCDLIELLSLDVTRSHDKSHKGAGKPSLGDLFR-----NPDIAKMTLIVW 363
Cdd:TIGR00879 217 PESPRWLVGKGRVEEARKSLARL---RGTSGEDKELLDELELIDIKRSIEKRSVQPSWGSLFSstrriRRRLFLGVVLQW 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 364 LDWFT---VNLGY--YVFAMEAVrRKEHEHLYYLLVGAVEIpAYVFLCIWM-QRVGRRkTMLTFLLMSSFICVV---YVV 434
Cdd:TIGR00879 294 FQQFTginAIMYYspTIFENAGV-STDHAFLVSIIVGAVNF-AFTFVAIFLvDRFGRR-PLLLIGAAGMAICLFvlgILG 370
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 435 IPSDSDTAKEAKGaVALFVKVAVGSVFAF-----IYLYTAELYPTIMR----CLAVGSSNMVSHVASMVIP-LSQHFSKV 504
Cdd:TIGR00879 371 ASFVTGSSKSSGN-VAIVFILLFIAFFAMgwgpvPWVIVSEIFPLSLRpkgiSIAVAANWLANFIVGFLFPtMLESIGVG 449
|
410 420 430
....*....|....*....|....*....|.
gi 2780227945 505 WIFlpqILFGTLAILSGLL-SLNLPETQNRP 534
Cdd:TIGR00879 450 GVF---IFFGGLNVLGLIFvYFFLPETKGRT 477
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
150-528 |
1.92e-17 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 85.25 E-value: 1.92e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 150 QKWYANMIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIFDYFSFMAARFfLVMTSSGYFVVVFVY 229
Cdd:cd17441 32 PSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRG-LVGFGIGGVPQSVTL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 230 VMEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTWWLYQIILWTVTAPF----ILCcwmlpetpFWLLSEGRYKEAq 305
Cdd:cd17441 111 YAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLlifaVLC--------FWLPESARYWTT- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 306 gvVDAMAVWNKSSSCDL-IELLSLDVTRSHDKSHKGAGKPSLGDLfrnpdiakmtlivwldwftvnlgyyvfAMEAVRRK 384
Cdd:cd17441 182 --ILLWFIWFSNAFSYYgLVLLTTELFQAGDVCSGSSGKKVEGKC---------------------------SLECEYLT 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 385 EHEHLYYLLVGAVEIPAyVFLCIW-MQRVGRRKTM-LTFLLMSSFICVVYVVIPSDSDTakeakgaVALFVKVA-VGSVF 461
Cdd:cd17441 233 TSDYMDLLWTTLSEFPG-LLVTLWiIDRFGRKKTMaLCFFVFSFCTLLLFSCVGRFSLT-------VLLFIARAfISGGF 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2780227945 462 AFIYLYTAELYPTIMRCLAVGSSNMVSHVASMVIP-LSQHFSKVWIFLPQILFGTLAILSGLLSLNLP 528
Cdd:cd17441 305 QAAYVYTPEVYPTATRALGLGTCSGMARVGALITPfIAQVMLESSVYLTLSVYSGCCLLAAIASCFLP 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
160-492 |
2.02e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 84.64 E-value: 2.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 160 LFIFAMLLGAITFSYLSDRFGRRVALwctTIGVFFFGIGSI---FIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGR 236
Cdd:COG2814 53 AYLLGAALGAPLAGRLADRFGRRRVL---LLGLLLFALGSLlcaLAPSLWLLLAARFLQGLGAGALFPAALALIADLVPP 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 237 ESRTWASMHLNTFFAIGTMLVALVSYLVKTWWLYQIILWTVTAPFILCCWMLpetpFWLLSEGRykeaqgvvdamavwnk 316
Cdd:COG2814 130 ERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLL----LRLLPESR---------------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 317 ssscdliellsldvtrshdKSHKGAGKPSLGDLFRNPDIAKMTLIVWLDWFTVN--LGYYVFAMEAVRRKEHEH--LYYL 392
Cdd:COG2814 190 -------------------PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFalFTYLPLYLQEVLGLSASAagLLLA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 393 LVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIPSDSdtakeAKGAVALFVKVAVGSVFAFIYLYTAELY 472
Cdd:COG2814 251 LFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLW-----LLLLALFLLGFGFGLLFPLLQALVAELA 325
|
330 340
....*....|....*....|
gi 2780227945 473 PTIMRCLAVGSSNMVSHVAS 492
Cdd:COG2814 326 PPEARGRASGLYNSAFFLGG 345
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
160-533 |
8.43e-16 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 80.77 E-value: 8.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 160 LFIFAMLlGAITFSYLSDRFGRRVALwctTIGVFFFGIGSIFIFdyFS--------FMAARFFLVMTSSGYFVVVFVYVM 231
Cdd:cd17357 58 FFIGGAI-GSFISAFLANRFGRKNGL---LISNALLVVSSLLMF--LSksakspelLIFGRFLVGIACGLSTGFVPMYLQ 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 232 EFIGRESRTWASMHLNTFFAIGTMLVALVS--YLVKTWWLYQIILWTVTAPFILCC---WMLPETPFWLL-SEGRYKEAQ 305
Cdd:cd17357 132 EISPSELRGALGSLTQIGVTLGILLGQVFGlpSVLGTETLWPYLLFFPGIPALLQLaalPFFPESPKFLLiSKGDEEEAE 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 306 GVVDAMAVWNKSSSCDLIELlsldvtRSHDKSHKGAGKPSLGDLFRNPDIAKMTLIVWLDWFTVNL-GYYV-------FA 377
Cdd:cd17357 212 KSLKFLRGIEDDVDQELEEI------KKESEQMGDQKQVSLMQLLRDPSLRLPLLLVLVVSASQQFsGINAiffystfIF 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 378 MEAVRRKEHEHLYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVV--IPSDSDTAKEAKGAVALFV-- 453
Cdd:cd17357 286 ENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVflFLSEQNSWMSYGCIVAIFLfi 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 454 ---KVAVGSVFAFIylyTAELYPTIMRCLAVGSSNMVSHVASMVIPLS-QHFSKVWIFLPQILF-GTLAILSGLLSLNLP 528
Cdd:cd17357 366 fffAIGLGPIPWFI---GAELFPQAPRSAAQSLGSSVNWTSNFIVGMAfPPLQSIGGGFVFIIFaIPCALFLLYLYRYLP 442
|
....*
gi 2780227945 529 ETQNR 533
Cdd:cd17357 443 ETKGR 447
|
|
| MFS_SLC22A31 |
cd17443 |
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ... |
124-528 |
1.80e-15 |
|
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341001 [Multi-domain] Cd Length: 343 Bit Score: 78.66 E-value: 1.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 124 PCSDGYIYDQSKW-RSSVVGSFNLVCDQKWYANMIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFI 202
Cdd:cd17443 7 LCTGGWPFSAAAGlGSNLVTEWNLVCDDGWKVPLEKISYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 203 FDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTWWLYQIIlwtVTAPFI 282
Cdd:cd17443 87 ASPPTFLVLRLLQGGTLAGVFLSLYIARLELCDPSHRLMVSMGAGFFSVAGELLLPGLAVLCRDWRVLQGV---GTLPLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 283 LccwmlpetpfwLLSegrykeaqgvvdamaVWNKSSSCDLIELLSLDVtrshdkshkGAG-KPSlgdlfrnpdiakmtli 361
Cdd:cd17443 164 L-----------LLL---------------YWCFPSRNGLILGFTAFI---------GGGiRYC---------------- 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 362 vwldwFTVNLGYYVfameavrrkEHEHLYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIpsdsdt 441
Cdd:cd17443 193 -----FARNLAPFV---------PTFYLPYFLQAGLEALACIFLCLTVDRCGRRGVLLLGTIVTGLSSLLLLAL------ 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 442 AKEAKGAVALFVKV----AVGSVFAFIYLYTAELYPTIMRCLAVG---SSNMVSHVASmviPLSQHFSKVWIFLPQILFG 514
Cdd:cd17443 253 TQYLHGGLVLVLSVvgllASHAVSMLSMFFAAEVLPTVIRGAGLGlimGAGFLGRAAG---PLMELQNKQGYFLHHVVFA 329
|
410
....*....|....
gi 2780227945 515 TLAILSGLLSLNLP 528
Cdd:cd17443 330 SFAVLSVLCILLLP 343
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
152-527 |
1.88e-15 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 79.12 E-value: 1.88e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 152 WYANMIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIFDYFSFMAARFfLVMTSSGYFVVVFVYVM 231
Cdd:cd17372 34 WQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRC-LVGLGLGGGPQLASWYL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 232 EFIGRESRTWASMHLNTFFAIGTMLVALVSYLV--KTWWLYQIILWTVTAP-FILCCWMLPETPF--WLLSEGRYKEAQG 306
Cdd:cd17372 113 EFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVmpRLGWRWLLAFSSVPSSlLLVFYRWTPKTTLllWVIWFGNAFAYYG 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 307 VVdamavwnkssscdlieLLSLDVTRSHD----KSHKGAGKPSLGDLFRN-PDIAKMTLIvwldWFTVNlgyyvfameav 381
Cdd:cd17372 193 VV----------------LLTTELNNSHNvcgsKSDSDSGESPTEKQCRNsNDVDYRDVF----IATFA----------- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 382 rrkehehlyyllvgavEIPAyVFLCIWM-QRVGRRKTMltfllMSSFICVVYVVIPSDSDTAKEAKGAVALFVKVAVGSV 460
Cdd:cd17372 242 ----------------EFPG-LLISAAMiDRLGRKASM-----ASMLFTCCIFLLLLLICQSPFILTVLLFGGRACISAA 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2780227945 461 FAFIYLYTAELYPTIMRCLAVGSSNMVSHVASMVIPL-SQHFSKVWIFLPQILFGTLAILSGLLSLNL 527
Cdd:cd17372 300 FTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFiAQVLVHGSQTIALLLFSVVCLVSAICVCLL 367
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
160-528 |
5.92e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 77.22 E-value: 5.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 160 LFIFAMLLGAITFSYLSDRFGRRVALwctTIGVFFFGIGSI---FIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGR 236
Cdd:COG2271 53 AFFLGYALGQIPAGLLADRFGRRRVL---AIGLLLWGLATLlfgFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPP 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 237 ESRTWASMHLNTFFAIGTMLVALVSYLVKTWWLYQIILWTVTAPFILccWMLPetPFWLLsegrykeaqgvvdamavwnk 316
Cdd:COG2271 130 KERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLL--LALL--RFWLL-------------------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 317 ssscdliellsldvtrshdkshkgagkpslgdlfrnpdiakmtlivWLDWFTVNLGYYVFA------MEAVRRKEHEH-- 388
Cdd:COG2271 186 ----------------------------------------------ALAYFLVYFALYGFLtwlptyLVEVRGLSLAQag 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 389 LYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIPSDSDTAKEAKGAVALFvkvAVGSVFAFIYLYT 468
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGF---GLGGAFGLLWALA 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2780227945 469 AELYPTIMRCLAVGSSNMVSHVASMVIP-----LSQHFSKVWIFlpqILFGTLAILSGLLSLNLP 528
Cdd:COG2271 297 AELFPKKARGTASGLVNTFGFLGGALGPllvgyLLDATGYQAAF---LLLAALALLAALLALLLL 358
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
153-530 |
3.37e-14 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 75.42 E-value: 3.37e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 153 YANMIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIFDYFSFMAARFFLVMTSSGYFVVVFVYVME 232
Cdd:cd17371 35 EAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 233 FIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTW----WLYQIILWTVTAPFILCCWM---LPETPFWLLSEGRykeaq 305
Cdd:cd17371 115 YVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLlppeIAWRVLFLLGALPALLVLFIrrfVKEPPQWQAARAA----- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 306 gvvdamavwnkssscdliellsldvtRSHDKSHkgagkPSLGDLFrNPDIAKMTLIVWLDWFTVNLGYY-------VFAM 378
Cdd:cd17371 190 --------------------------RRHFADR-----PSLRELF-SPPLLRTTLLASLLATGALGGYYgittwlpSYLT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 379 EAVRRKEHEHLYYL-LVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIPSDSDTAKEAKGAVALFVKVAV 457
Cdd:cd17371 238 GERGLSFEGSAGYLvVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPF 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 458 GSVFAFIylytAELYPTIMRCLAVGSSN----MVSHVASMVIP-LSQHFSKvwiflpQILFGTLA----ILSGLLSLNLP 528
Cdd:cd17371 318 SGMGAYL----TELFPTAVRATAQGFCYnvgrIIGALFPFLVGfLATSGSL------GTAIAVFAavyyIAGLVLALLLP 387
|
..
gi 2780227945 529 ET 530
Cdd:cd17371 388 ET 389
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
162-482 |
1.59e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 73.16 E-value: 1.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 162 IFAMLLGAITFSYLSDRFGR-RVALWCtTIGVFFFGIGSIFIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESRT 240
Cdd:TIGR00895 62 LIGMAFGALFFGPLADRIGRrRVLLWS-ILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 241 WASMHLNTFFAIGTMLVALVSYlvktwWLYQIILWTV------TAPFILCCWM---LPETPFWLLSEGRYKEAQGVVDAM 311
Cdd:TIGR00895 141 TAVGLMFCGYPIGAAVGGFLAG-----WLIPVFGWRSlfyvggIAPLLLLLLLmrfLPESIDFLVSKRPETVRRIVNAIA 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 312 AVWNKSSSCDLIELlsldvtrshdKSHKGAGKPSLGDLFRnPDIAKMTLIVWLDWFTVNLGYYvFAM--------EAVRR 383
Cdd:TIGR00895 216 PQMQAEAQSALPEQ----------KSTQGTKRSVFKALFQ-GKTARITVLLWLLYFMLLVGVY-FLTnwlpklmvELGFS 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 384 KEHEHLYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIPSDSDTAkeakgAVALFVKVAVGSVFAF 463
Cdd:TIGR00895 284 LSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLL-----LLGAIAGFFVNGGQSG 358
|
330
....*....|....*....
gi 2780227945 464 IYLYTAELYPTIMRCLAVG 482
Cdd:TIGR00895 359 LYALMALFYPTAIRATGVG 377
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
114-534 |
1.94e-13 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 73.46 E-value: 1.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 114 YEYSGYKRDSPCsdgyiYDQSKWRSSVVGSFNLVCdqkwyanmiqplfifamLLGAITFSYLSDRFGRRVALWCTTIGVF 193
Cdd:pfam00083 30 KNFGLSKSVSSL-----AALSVLSGLIVSIFSVGC-----------------FIGSLFAGKLGDRFGRKKSLLIANVLFV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 194 FFGIGSIFIFDYFSF---MAARFFLVMtssgyfvvvfvyvmeFIGRESRTwASMHL----------------NTFFAIGT 254
Cdd:pfam00083 88 IGAVLQGAAKGKWSVyqlIVGRVLVGI---------------GVGGASVL-APMYIseiapkklrgalgslyQLAITFGI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 255 MLVALVSYLVKT--------WWLYQIILWTVtaPFILCCWMLPETPFWLLSEGRYKEAQGVVDAMAVWNKSSSCDLIELL 326
Cdd:pfam00083 152 LLAYIFGLGLNKtsnsdgwrIPLGLQLVPAL--LLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELDEIKD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 327 SLDVTRShdkshkgAGKPSLGDLFRNP-DIAKMTLIVWLDWFTVNLGYYVFameavrrkehehLYY-------------- 391
Cdd:pfam00083 230 SLEAGQE-------AEKASWKELFSTKtRRQRLLIGVMLQIFQQLTGINAI------------FYYsttifenlglsdsf 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 392 ---LLVGAVEIpayVFLCIW---MQRVGRRKTMLT-FLLMSsfICVVYVVIPSD--SDTAKEAKGA--VALFVKVAV--- 457
Cdd:pfam00083 291 lvtIIVGVVNF---VFTFIAiflVDRFGRRPLLLLgAAGMA--ICFVILGIVALlgVSKSDWAGIVaiVFIALFIAFfam 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 458 --GSVFAFIylyTAELYPTIMRCLAVGSSNMVSHVASMVIPL--------SQHFSKVWIFLPQILFGTLAILsgllsLNL 527
Cdd:pfam00083 366 gwGPVPWVI---VSELFPLSVRSKAMALATAANWLANFLIGFlfpiitdaIGLGYTFFIFAGLLVLFIIFVF-----FFV 437
|
....*..
gi 2780227945 528 PETQNRP 534
Cdd:pfam00083 438 PETKGRT 444
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
645-852 |
5.39e-13 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 71.93 E-value: 5.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 645 DAKKWGLGRAPPDAETGgsgraPPNTETGGSDRAPPNTESGGSG-RAPPNTESR-GSGRAPPETESGGPGRVPPDAESWG 722
Cdd:PHA03169 32 QAGRRRGTAARAAKPAP-----PAPTTSGPQVRAVAEQGHRQTEsDTETAEESRhGEKEERGQGGPSGSGSESVGSPTPS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 723 LGKAPPDDEIGGS----GRASPETESGGSGQALPETESGGSGRAPPEtESGGSGRAPPETESGGSGQALPETESGGSGRA 798
Cdd:PHA03169 107 PSGSAEELASGLSpentSGSSPESPASHSPPPSPPSHPGPHEPAPPE-SHNPSPNQQPSSFLQPSHEDSPEEPEPPTSEP 185
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 2780227945 799 PPetESGGSGRAPPETESGEGGSGRVSP-KDKNEGSGRAP-PEENTEVENEIENSE 852
Cdd:PHA03169 186 EP--DSPGPPQSETPTSSPPPQSPPDEPgEPQSPTPQQAPsPNTQQAVEHEDEPTE 239
|
|
| MFS_SLC22A17_like |
cd17373 |
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ... |
134-528 |
7.15e-13 |
|
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340931 [Multi-domain] Cd Length: 348 Bit Score: 71.01 E-value: 7.15e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 134 SKWRS----SVVGSFNLVCDQKWYANMIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIFDYFSFM 209
Cdd:cd17373 3 YGIRAglvqNAVSKWDLVCDNGWKVHLEQFSLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 210 AARFFLVMTSSGYFVVVFVYVMEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTWWLYQIIlwtVTAPFILccwMLp 289
Cdd:cd17373 83 TLRFLEGFCLAGIILTLYLLRLELCDPGKRLMITMVASLVAVAGQFLMPGLAALCRDWRVLQAL---IICPFLL---ML- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 290 etPFWllsegrykeaqgvvdamavwnkssSCDLIELLSLDVTRSHDKSHKGAGKPSLGDlfrnpdiakmtlivwldwftv 369
Cdd:cd17373 156 --LYW------------------------SIFPKNILILGFNSLTGYGIRHCFARSMMG--------------------- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 370 nlgyyvfameavRRKEHEHLYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVI-------------- 435
Cdd:cd17373 189 ------------HEPENFYLDYYLTAGIAAVACVFLCVTVDFLGRRGGLLLFMILTGLASLLLLGLlnligkysqhpdsg 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 436 PSDS--DTAKEAKGAVALFVKVAVGSVFAFiylYTAELYPTIMRCLAVGSSNMVSHVASMVIPLSQHFSKVWIFLPQILF 513
Cdd:cd17373 257 MSDSvkDKFSIAFSVLGLFASHAVGSLSVL---FAAEVTPTVIRGGGLGLVLASGGLGMLTGPIIELHNQKGYFLQHVVF 333
|
410
....*....|....*
gi 2780227945 514 GTLAILSGLLSLNLP 528
Cdd:cd17373 334 ACCALLCILCILLLP 348
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
133-535 |
8.08e-13 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 71.45 E-value: 8.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 133 QSKWRSSVVGSFNLVCDQK-WYANMiqpLFIFAMLlGAITFSYLSDRFGRRVALWCTTIgvfFFGIGSI---FIFDYFSF 208
Cdd:cd17358 25 LPSLMSDNSLSLPLTVAQFsWFGSL---LTLGALI-GALLSGKLADRIGRKRTLLISAI---PCILGWLliaFAKDVWML 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 209 MAARFFLVMTSSGYFVVVFVYVMEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKtwwlYQIILWTVTAP---FILCC 285
Cdd:cd17358 98 YLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP----WRTLALIGAIPpvvFLILL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 286 WMLPETPFWLLSEGRYKEAQGVVDamavWNKSSSCDLIELLSlDVTRSHDKSHKGAGKPSLGDLF----RNPDIAKMTLI 361
Cdd:cd17358 174 FFIPESPRWLAKKGREEEAEKSLQ----FLRGKDADISKEAA-EIQEELAELEKEAKESSFSDLFqrkyLKPLVIGLGLM 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 362 VWLDWFTVN--LGYYVFAMEAVRRKEHEHLYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVipsdS 439
Cdd:cd17358 249 LFQQLSGINavIFYASSIFDEAGSGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALGL----Y 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 440 DTAKEAKGAVALFVKVAVGSVFAFIYLYT-----------AELYPTIMRCLAVGSSNMVSHVASMVIPLS-QHFSKVW-I 506
Cdd:cd17358 325 FYLQEHGALLSSVSWLPLVGLVIYIISFSiglgplpwvimSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTfPFLTLAWgA 404
|
410 420 430
....*....|....*....|....*....|
gi 2780227945 507 FLPQILFGTLAILSGLLS-LNLPETQNRPM 535
Cdd:cd17358 405 SGTFWIFAGICGLALVFVlLFVPETKGKSL 434
|
|
| MFS_SLC22A17 |
cd17445 |
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ... |
125-528 |
1.69e-12 |
|
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341003 [Multi-domain] Cd Length: 346 Bit Score: 69.80 E-value: 1.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 125 CSDGYIY-DQSKWRSSVVGSFNLVCDQKWYANMIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIF 203
Cdd:cd17445 8 CDAGWNYtGLPGLTNNIVTEWDLVCSRYWLVPLEQVCFILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 204 DYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTWwlyQIILWTVTAPFIL 283
Cdd:cd17445 88 SPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQRLLVAMAGGLTMVGGHFLLLGLALGCGSW---RVLQGTITAPLSL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 284 C-CWMLPetpfwllsegRYKeaqgvvdamavwnkssscdliELLSLDVTR--SHDKSH-----KGAGKPSLGDLFrnpdi 355
Cdd:cd17445 165 FlCYGCP----------GVK---------------------NLLILGFTTfiAHAISHcyqsfSDDVRGTPSTFY----- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 356 akmtlivwldwftvnlgyyvfameavrrkehehLYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYV-V 434
Cdd:cd17445 209 ---------------------------------LSYLLSTGTAGLACLFLCATVDRFGRRGILLLAMTLTGIASLILLgL 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 435 IPSDSDTAKEAKGAVALFVKVAVGSVFAFiylYTAELYPTIMRCLAVGSSNMVSHVASMVIPLSQHFSKVWIFLPQILFG 514
Cdd:cd17445 256 MDYLNDAAIKTFSILGLFSSQAAASLSIL---FAAEVIPTVIRGSGLGLIMALGSLGGLSSPLMRLRNQHGYFLHHVVLA 332
|
410
....*....|....
gi 2780227945 515 TLAILSGLLSLNLP 528
Cdd:cd17445 333 SLALLAILSIMLLP 346
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
629-849 |
3.09e-12 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 69.61 E-value: 3.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 629 APPDAERWGSSGRAPSDAkkwglGRAPPDAETGGSGRAPPNTETGGSDRAPpntesGGSGRAPPNTESRGSGRAPPETES 708
Cdd:PHA03169 47 APPAPTTSGPQVRAVAEQ-----GHRQTESDTETAEESRHGEKEERGQGGP-----SGSGSESVGSPTPSPSGSAEELAS 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 709 GGPgrvpPDAESwglGKAPPDDEiGGSGRASPETEsGGSGQALPETESGGSGRAPPETESGGSGRAPPETESGGSGQALP 788
Cdd:PHA03169 117 GLS----PENTS---GSSPESPA-SHSPPPSPPSH-PGPHEPAPPESHNPSPNQQPSSFLQPSHEDSPEEPEPPTSEPEP 187
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2780227945 789 ETESGGSGrapPETESGGSGRAPPET---ESGEGGSGRVSPKDKNEGSGRAPPEENTEVENEIE 849
Cdd:PHA03169 188 DSPGPPQS---ETPTSSPPPQSPPDEpgePQSPTPQQAPSPNTQQAVEHEDEPTEPEREGPPFP 248
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
615-818 |
4.05e-10 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 63.65 E-value: 4.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 615 GRDPPDTERWDSGRAPPDAERWGSSGRAP------SDAKKWGLGRAPPDAETGGSGRAPPNTETGGSDRAPPNTESGGSG 688
Cdd:PHA03307 228 AADDAGASSSDSSSSESSGCGWGPENECPlprpapITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGP 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 689 RAPPNTESRGSGRaPPETESGGPGRVPPDAESWGLGKAPPDDEIGGSGRASPETESGGSGQALPETESGGSGRAP---PE 765
Cdd:PHA03307 308 APSSPRASSSSSS-SRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASagrPT 386
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2780227945 766 TESGGSGRAPPETESGGSGQaLPETESGGSGRAPPETESGGSGRAPPETESGE 818
Cdd:PHA03307 387 RRRARAAVAGRARRRDATGR-FPAGRPRPSPLDAGAASGAFYARYPLLTPSGE 438
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
637-847 |
4.75e-10 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 63.47 E-value: 4.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 637 GSSGRAPSDAKKWGLGRAPPDAEtggsgrapPNTETGGSDRAPPNTESGGSGRAPPNTESRGSGRAPPETESGGPGRVPP 716
Cdd:PRK07764 592 PGAAGGEGPPAPASSGPPEEAAR--------PAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDAS 663
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 717 DAESWGLGKAPPDDEIGGSGRASPETESGGSGQALPETESGGSGRAPPETESGGSGRAPPETESGGSGQAlpetESGGSG 796
Cdd:PRK07764 664 DGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSP----AADDPV 739
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2780227945 797 RAPPETESGGSGRAPPETESGEGGSGRVSPKDKNEGSGRAPPEENTEVENE 847
Cdd:PRK07764 740 PLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDA 790
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
654-838 |
7.35e-10 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 62.70 E-value: 7.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 654 APPDAETGGSGRAPPNTETGGSDRAPPNTESGGSGRAPPNTESRGSGRAPPETESGGPGRVPPDAESWGLGKAPPDDEIG 733
Cdd:PRK07764 589 GPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDG 668
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 734 GSGRASPETESGGSGQALPETESGGSGRAPPETESGGSGRAPPEtesgGSGQALPETESGGSGRAPPETESGGSGRAPPE 813
Cdd:PRK07764 669 WPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAG----QADDPAAQPPQAAQGASAPSPAADDPVPLPPE 744
|
170 180
....*....|....*....|....*
gi 2780227945 814 TESGEGGSGRVSPKDKNEGSGRAPP 838
Cdd:PRK07764 745 PDDPPDPAGAPAQPPPPPAPAPAAA 769
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
626-828 |
8.87e-10 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 62.31 E-value: 8.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 626 SGRAPPDAERWGSSGRAPSDAKKWGlGRAPPDAETGGSGRAPPNTETGGSDRAPPNTESGGSGRAPPNTESRGSGRAPPE 705
Cdd:PRK07764 598 EGPPAPASSGPPEEAARPAAPAAPA-APAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGA 676
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 706 TESGGPGRVPPDAESWGLGKAPPDDEIGGSGRASPET--------ESGGSGQALPETESGGSGRAPPETESGGSGRAPPe 777
Cdd:PRK07764 677 APAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQaddpaaqpPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAP- 755
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2780227945 778 tesGGSGQALPETESGGSGRAPPETESGGSGRAPPETESGEGGSGRVSPKD 828
Cdd:PRK07764 756 ---AQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEE 803
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
156-531 |
1.68e-09 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 61.09 E-value: 1.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 156 MIQPLFIFAMLLGAITFSYLSDRFGRRVALWCT-TIGVFFFGIGSiFIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFI 234
Cdd:cd17438 38 MLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISlAINASFAFLSS-FVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 235 GRESRTWASMHLNTFFAIGTMLVALV----------------SYLVKTWWLYQIILWTVTAPFILCCWMLPETPFWLLSE 298
Cdd:cd17438 117 AREKRGEHLSWLCMFWMIGGLYASAMawsiiphygwgfsmgtNYHFHSWRVFVIICALPCIASIIALKFMPESPRFLLEM 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 299 GRYKEAqgvvdamavWnkssscdliellsLDVTRSHDKSHKGAGKPSLgdLFRNPDIAKM-TLIVWLDWFTVNLGYY--- 374
Cdd:cd17438 197 GKHDEA---------W-------------MILKNIHDTNMRAKGTPEK--VFTVSNIKRKnTLFLAVVWFTMAFSYYglt 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 375 VFAMEAVR---------------------------------------------------------------------RKE 385
Cdd:cd17438 253 VWFPDMIRylqkhvtfedslfdecyfedvtstdtyfknctiestifyntdlyehkfidcrfinstfleqkegchmdfEED 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 386 HEHLYYLL--VGAVEI-PAYVFLCIWMQRVGRRKTMLTFLLMSSFICvvYVVIPSDSDTAkeAKGAVALFVKVAVGSVFA 462
Cdd:cd17438 333 NDFLIYLVsfLGSLSVlPGNIISALLMDKIGRIKMIGGSMLISAVCC--FFLFFGNSESA--MIGWQCLFCGTSIAAWNA 408
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 463 FIYLyTAELYPTIMRCLAVGSSNMVSHVASMV-IPLSQHFSKVWIFLPQILFGTLAILSGLLSLNLPETQ 531
Cdd:cd17438 409 LDVI-TVELYPTNKRATAFGILNGLCKFAAILgNSIFASFVGITKVIPILLASTALVGGGLISLRLPETR 477
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
160-314 |
2.43e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 59.44 E-value: 2.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 160 LFIFAMLLGAITFSYLSDRFGRRVALwctTIGVFFFGIGSIFI---FDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGR 236
Cdd:COG0477 57 AYLLGRAIGLLLFGRLGDRYGRKRVL---LIGLLLFGLASLLCglaPSPELLIAARALQGIGAGGLMPGALALIAELFPA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 237 ESRTWASMHLNTFFAIGTMLVALVSYLVKTWWLYQIILWtVTAPF----ILCCWMLPETPFWLLSEGRYKEAQGVVDAMA 312
Cdd:COG0477 134 RERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL-INAPLgllaLVLRLRLPESRGLLLALLALALAALLLAALA 212
|
..
gi 2780227945 313 VW 314
Cdd:COG0477 213 LA 214
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
628-812 |
2.49e-09 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 61.34 E-value: 2.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 628 RAPPDAERWGSSGRAPSDAKKWGLGRAP---PDAETGGSGRAPPNTETGGSDRAPPNTESGGSGRAPPNTESRGSGRAPP 704
Cdd:PHA03307 267 TRIWEASGWNGPSSRPGPASSSSSPRERspsPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPS 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 705 ETESGGPGRVPPDAESWGLGKAPPDDEIGGSGRASPETESGGSGQALPetesGGSGRAPPETESGGSGRAPPetesggSG 784
Cdd:PHA03307 347 PSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAV----AGRARRRDATGRFPAGRPRP------SP 416
|
170 180 190
....*....|....*....|....*....|..
gi 2780227945 785 QALPETESGGSGRAPPETESG----GSGRAPP 812
Cdd:PHA03307 417 LDAGAASGAFYARYPLLTPSGepwpGSPPPPP 448
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
616-840 |
3.06e-09 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 60.96 E-value: 3.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 616 RDPPDTERWDSGRAPPDAERWGSSGRAPSDAKKWGLGRAPPD-AETGGSGRAPPNTETGGSDRAPPNTESGGSGRA-PPN 693
Cdd:PHA03307 197 TPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDsSSSESSGCGWGPENECPLPRPAPITLPTRIWEAsGWN 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 694 TESRGSGRAPPETESGGPGRVPPDAESWGLGKAPPddeiggsGRASPETESGGSGQALPETESG------GSGRAPPETE 767
Cdd:PHA03307 277 GPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSS-------PRASSSSSSSRESSSSSTSSSSessrgaAVSPGPSPSR 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 768 SGGSGRAPPETESGGSGQALPETESGGSGRAPPETES--------GGSGRAPPETESGEGGSGRVSPKDKNEGSGRAPPE 839
Cdd:PHA03307 350 SPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTrrraraavAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYAR 429
|
.
gi 2780227945 840 E 840
Cdd:PHA03307 430 Y 430
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
150-528 |
1.54e-08 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 57.51 E-value: 1.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 150 QKWYANMIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIFDYFSFMaarFFLVMTSSGYFVVVFVY 229
Cdd:cd17442 34 EDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFV---FLRCMVGCGVSGHSQGL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 230 VM--EFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKT---W-WLYQI-----ILWTVTAPFI----LCCWMLpetpfW 294
Cdd:cd17442 111 IIktEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPtlgWrWLIRFasipgIILIVVFKFIprttLQIWVI-----W 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 295 LLSEGRYkeaQGVVdamavwnkSSSCDLIELLSLDVTRSHDKSHKGAGKPSlgdlfRNPDIAKMtlivwldwftvnlgyy 374
Cdd:cd17442 186 LGISFAY---YGVI--------LASSELLERNLLCGSDPSDEEAGIKHIES-----ESPCYCHM---------------- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 375 vFAMEAVRRkehehlyyLLVGAV-EIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIPSDSDTAkeakgAVALFV 453
Cdd:cd17442 234 -FNPSDYQT--------MIISTLgEIALNPLNILGINFLGRRLSLVITMGLTAIFFLLLNICTSSAGLT-----IFLFML 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2780227945 454 KVAVGSVFAFIYLYTAELYPTIMRCLAVGSSNMVSHVASMVIP-LSQHFSKVWIFLPQILFGTLAILSGLLSLNLP 528
Cdd:cd17442 300 RALVSANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPfISQVLMSASVLGALCLFSSVCIVCAISAFTLP 375
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
618-839 |
1.90e-08 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 58.26 E-value: 1.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 618 PPDTERWDSGRAPPDAERWGSSGRAPSDAKKWglgrAPPDAETGGSGRAPPNTETGGSDRAPPNTESGGSGRAPPN-TES 696
Cdd:PHA03307 117 PPPTPPPASPPPSPAPDLSEMLRPVGSPGPPP----AASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSpPAE 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 697 RGSGRAPPETESGGPGRVPPDA-ESWGLGKAPPDDEIGGSGRASpeteSGGSGQALPETESGGSGRAP------------ 763
Cdd:PHA03307 193 PPPSTPPAAASPRPPRRSSPISaSASSPAPAPGRSAADDAGASS----SDSSSSESSGCGWGPENECPlprpapitlptr 268
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2780227945 764 ---PETESGGSGRAPPETESGGSGQALPETESGGSGRAPPETESGGSGRAPPETESGEGGSGRVSPKDKNEGSGRAPPE 839
Cdd:PHA03307 269 iweASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSP 347
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
629-838 |
7.08e-08 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 56.33 E-value: 7.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 629 APPDAERWGSSGRAPSDAKKWGLGRAPPDAETGGSGRAPpnteTGGSDRAPPNTESGGSGRAPPN---TESRGSGRAPpE 705
Cdd:PHA03307 178 SPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISAS----ASSPAPAPGRSAADDAGASSSDsssSESSGCGWGP-E 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 706 TESGGPGRVPPDAESWGLGKAPPDDEIGGSGRASPETESGGSGqalPETESGGSGRAPPETESGGSGRAPPETESGgsgq 785
Cdd:PHA03307 253 NECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERS---PSPSPSSPGSGPAPSSPRASSSSSSSRESS---- 325
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 2780227945 786 aLPETESGGSGRAPPetesgGSGRAPPETESGEGGSGR----VSPKDKNEGSGRAPP 838
Cdd:PHA03307 326 -SSSTSSSSESSRGA-----AVSPGPSPSRSPSPSRPPppadPSSPRKRPRPSRAPS 376
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
160-497 |
7.45e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 55.66 E-value: 7.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 160 LFIFAMLLGAIT---FSYLSDRFGRRVAlwcTTIGVFFFGIGSIFIF---DYFSFMAARFFLVMTSSGYFVVVFVYVMEF 233
Cdd:COG2223 45 LFAIPVLVGALLripLGFLVDRFGPRRV---LLIGLLLLGIGLLLLAlavSYWLLLLLGLLLGIGGGGSFAVGIALVSKW 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 234 IGRESRTWASMHLNTFFAIGTMLVALVSYLVKTWWLYQIILWtVTAPFILCCWMLpetpFWLLsegrykeaqgvvdamav 313
Cdd:COG2223 122 FPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL-ILGILLLVVAVL----AWLF----------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 314 wnkssscdliellsLDVTRSHDKSHKGAGKPSLGDLFRNPDiakmTLIVWLDWFTVNLGYYVFAMeavrrkeheHLYYLL 393
Cdd:COG2223 180 --------------LRDPPAGAAAAAKASLRDQLEALRDPR----FWLLSLLYFGTFGSFIGFSS---------WLPPYL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 394 V-----GAVEIPAYVFLCIWM------------QRVGRRKTMLTFLLMSSFICVVYVVIPSDSDTAKEAKGAVALFVKVA 456
Cdd:COG2223 233 VdqfglSAATAGLLAALFALLgalgrplggwlsDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGG 312
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2780227945 457 VGSVFAFIylytAELYPTIMRCLAVGSSNMVSHVASMVIPL 497
Cdd:COG2223 313 NGAVFALV----PDIFPTKNAGAVYGLVGAAGGLGGFLGPL 349
|
|
| PBP1 |
COG5180 |
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ... |
617-845 |
2.39e-07 |
|
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];
Pssm-ID: 444064 [Multi-domain] Cd Length: 548 Bit Score: 54.30 E-value: 2.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 617 DPPDTERWDSGRAPPDAErwgSSGRAPSDAKKwglGRAPPDAETggSGRAPPNTETGGSDRAPPNTESGGSGRAPpnTES 696
Cdd:COG5180 235 DPPSTSEARSRPATVDAQ---PEMRPPADAKE---RRRAAIGDT--PAAEPPGLPVLEAGSEPQSDAPEAETARP--IDV 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 697 RGSGRAPPeteSGGPGRVPPDAESWGLGKAPPDdeiGGSGRASPETESG----GSGQALPETE--------------SGG 758
Cdd:COG5180 305 KGVASAPP---ATRPVRPPGGARDPGTPRPGQP---TERPAGVPEAASDagqpPSAYPPAEEAvpgkpleqgaprpgSSG 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 759 SGRAPPETESGGSGRAPPETESGGSGQ---ALPETESGGSGR--APPETESGGSGRAPPETESGEGGSGRVSPKDKNEGS 833
Cdd:COG5180 379 GDGAPFQPPNGAPQPGLGRRGAPGPPMgagDLVQAALDGGGRetASLGGAAGGAGQGPKADFVPGDAESVSGPAGLADQA 458
|
250
....*....|..
gi 2780227945 834 GRAPPEENTEVE 845
Cdd:COG5180 459 GAAASTAMADFV 470
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
156-531 |
2.73e-07 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 53.88 E-value: 2.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 156 MIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIG 235
Cdd:cd17439 38 MLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 236 RESRTWASMHLNTFFAIGTMLVALVSYLV---KTWWL-----YQIILWTVtapFILCCWM-----------LPETPFWLL 296
Cdd:cd17439 118 QEKRGEHLSWLCMFWMIGGIYASAMAWAIiphYGWSFqmgsaYQFHSWRV---FVLVCAFpsvfaigalttMPESPRFFL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 297 SEGRYKEAQGVVDAMavwnkssscdliellsldvtrsHDKSHKGAGKPSlgDLFRNPDIA-KMTLIVWLDWFTVNLGYY- 374
Cdd:cd17439 195 ENGKHDEAWMVLKQV----------------------HDTNMRAKGHPE--RVFSVTHIKrRITLMMMAVWFTMSFSYYg 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 375 ----------------------------------------------------VFAMEAVRRK------------------ 384
Cdd:cd17439 251 ltvwfpdmikhlqksvvfedslfeecyfeditssntffknctfistlfyntdLFEYKFINSKlinstflhnkegclldfs 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 385 --EHEHLYYLL--VGAVEI-PAYVFLCIWMQRVGRRKTMLTFLLMSSFICvvYVVIPSDSDTAKEAkgAVALFVKVAVGS 459
Cdd:cd17439 331 deNNAYMIYFVsfLGTLAVlPGNIVSALLMDKIGRLRMLAGSSVMSCVSC--FFLSFGNSESAMIA--LLCLFGGVSIAS 406
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2780227945 460 VFAFIYLyTAELYPTIMRCLAVGSSNMVSHVASMV-IPLSQHFSKVWIFLPqILFGTLAILSG-LLSLNLPETQ 531
Cdd:cd17439 407 WNALDVL-TVELYPSDKRTTAFGFLNALCKLAAVLgISIFTSFVGITKAVP-ILLASAALAAGsSLALKLPETR 478
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
165-531 |
3.61e-07 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 53.65 E-value: 3.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 165 MLLGAITFSYLSDRFGRR-VALWCTTIGVFFFGIGSiFIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESR---- 239
Cdd:cd17363 47 MMVGAFVWGGLADKLGRKqCLLIALSVNGVFAFLSS-FVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRgehl 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 240 TWASMhlntFFAIGTMLVALVSYLV---KTWWL-----YQIILWTVtapFILCCWM-----------LPETPFWLLSEGR 300
Cdd:cd17363 126 SWLCM----FWMIGGLYASAMAWAIiphYGWGFsmgtaYQFHSWRV---FVIVCALpsvasvvaltfMPESPRFLLEVGK 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 301 YKEAqgvvdamavWnkssscdliellsLDVTRSHDKSHKGAGKPSlgDLFRNPDIAKM-TLIVWLDWFTVNLGYY---VF 376
Cdd:cd17363 199 HDEA---------W-------------MILKQVHDTNMRAKGHPE--RVFTVSHIKRMnTLFLAIVWFTMSFSYYgltVW 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 377 AMEAVR------------------------------------------------------------------RKEHEHLY 390
Cdd:cd17363 255 FPDMIKylqfedslfeecyfedvtstntffenctfintvfyntdlfeykfidsrflnstfflkekcgchlndDEENAYLI 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 391 YL--LVGAVE-IPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIPSDSDTAkeakGAVALFVKVAVGSVFAfIYLY 467
Cdd:cd17363 335 YLvsFLGSLSvLPGNIVSALLMDKIGRLKMIGGSMLLSAVCCFFLFFGNSESAMI----GLQCLFCGVSIAAWNA-LDVV 409
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2780227945 468 TAELYPTIMRCLAVGSSNMVSHVASMV-IPLSQHFSKVWIFLPQILFGTLAILSGLLSLNLPETQ 531
Cdd:cd17363 410 TVELYPTDKRATAFGFLNGLCKLAAILgNSIFGSFVGITKVIPILLASAALVCGGLLALKLPETR 474
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
615-840 |
4.21e-07 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 54.02 E-value: 4.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 615 GRDPPDTERWDSGRAPPDAERWGSSGRAPSDAKKWGLGRAPPDAETG---GSGRAPP-NTETGGSDRAPPNTESGGSGRA 690
Cdd:PHA03307 81 ANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPpspAPDLSEMlRPVGSPGPPPAASPPAAGASPA 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 691 PPNTESRGSGRA------PPETE---SGGPGRVPPDAESWGLGKAPPDDEIGGSGRASPETESGGSGQA--LPETESGGS 759
Cdd:PHA03307 161 AVASDAASSRQAalplssPEETArapSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAAddAGASSSDSS 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 760 GRAPPETESGGSGRAPPETESGGSGQALPETESGGSG---RAPPETESGG-SGRAPPETESGEGGSGRVSPKDKNEGSGR 835
Cdd:PHA03307 241 SSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGpssRPGPASSSSSpRERSPSPSPSSPGSGPAPSSPRASSSSSS 320
|
....*
gi 2780227945 836 APPEE 840
Cdd:PHA03307 321 SRESS 325
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
154-524 |
6.75e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 52.55 E-value: 6.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 154 ANMIQPLFIFAMLLGAITFSYLSDRFGRR----VALWCTTIGVFFFGIGSIFIFdyfsFMAArFFLVMTSSGYFVVVFVY 229
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKrgllLGLLLMALGLLLFALAPSYPL----LLLA-LFLLGLGLGLLDVAANP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 230 VMEFIGRESRTwasMHLNT---FFAIGTMLVALVSYLvktwwlyqIILWTVTAPfilccWMLpetPFWLLSegrykeaqG 306
Cdd:COG0738 120 YVAALGPETAA---SRLNLlhaFFSLGALLGPLLGGL--------LILLGLSLS-----WHL---PYLILA--------V 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 307 VVDAMAVWNKSSSCDLIEllsldvtrsHDKSHKGAGKPSLGDLFRNPDIAKMTLIVWL---------DWFtvnlgyYVFA 377
Cdd:COG0738 173 LLLLLALLFLRSKLPEIE---------EEEEEAAGSAASLKSLLKNPRLLLGGLAIFLyvgaegaigDWL------PLYL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 378 MEAVRRKEHEHLYYLLVGAVeipAYV---FLCIW-MQRVGRRKTMLTFLLMSSFICVVYVVIPSdsdtakeakGAVALFv 453
Cdd:COG0738 238 KDVLGLSEATAALGLSLFWG---GMTigrFLGGFlLKRFGPVRLLRLSALLAAVGLLLALLAPG---------PWLALI- 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 454 kvavgsVFAFIYLYTAELYPTIM----RCLAVGSSNMVSHVASM------VIP-----LSQHFSKVWIFL-PQILFGTLA 517
Cdd:COG0738 305 ------GLALVGLGLSLMFPTIFslalDGLGKRTAAAVSAVLIMgivggaIGPpligfLADAFGLRAAFLvPLVCYLLIL 378
|
....*..
gi 2780227945 518 ILSGLLS 524
Cdd:COG0738 379 LLALALK 385
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
160-525 |
8.27e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 52.19 E-value: 8.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 160 LFIFAMLLGAITFSYLSDRFGRRVALwctTIGVFFFGIGSI---FIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGR 236
Cdd:cd17325 39 AYALAQLLFSPPAGRLSDRFGRKRLL---LLGLLLLAVSTLlfaFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 237 ESRTWASMHLNTFFAIGTMLVALVSYLVKTWWLYQiilwtvtAPFILCcwmlpetpfwllsegrykeaqGVVDAMAVwnk 316
Cdd:cd17325 116 EERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYR-------APFLVC---------------------AALALLAL--- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 317 ssscdLIELLSLDVTRSHDKSHKGAGKP---SLGDLFRNPDIAKMTLIVWLDWFTVNLGYYVFAMEAVRR-KEHEHLYYL 392
Cdd:cd17325 165 -----VLALLLLPEPRPPPNKRAVSAARlrsGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 393 LVGAVEIPAYVFLCI---WMQRVGRRKTMLTFLLMSSFICVVYVVIPSDSDTAkeakgAVALFVKVAVGSVFAFIYLYTA 469
Cdd:cd17325 240 LFGAQGLASALSQPPagkLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLL-----LLLALLGLGLGLVFPATLALLA 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2780227945 470 ELYPTIMRCLAVGSSNMVSHVASMVIP-----LSQHFSKVWIFlpqILFGTLAILSGLLSL 525
Cdd:cd17325 315 DIVPPEGRGTAMGLFNTAFSLGMVLGPllggfLYDAFGFATPF---LAAAALLLLAAVLFL 372
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
613-794 |
8.59e-07 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 52.28 E-value: 8.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 613 GLGRDPPDTER-WDSGRAPPDAE--RWGSSGRApSDAKKWGLGRAPPDAETGGSGRAPPNTETGGSDRAPPNTESGGSGR 689
Cdd:PHA03169 94 GSGSESVGSPTpSPSGSAEELASglSPENTSGS-SPESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHE 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 690 APPNTESRGSGRAPPETESGGPGrvpPDAESWGLGKAPPDDEiggSGRASPETESGGSGQALPETESGGSGRAPPETESG 769
Cdd:PHA03169 173 DSPEEPEPPTSEPEPDSPGPPQS---ETPTSSPPPQSPPDEP---GEPQSPTPQQAPSPNTQQAVEHEDEPTEPEREGPP 246
|
170 180
....*....|....*....|....*
gi 2780227945 770 GSGRAPPETESGGSGqalPETESGG 794
Cdd:PHA03169 247 FPGHRSHSYTVVGWK---PSTRPGG 268
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
164-529 |
1.26e-06 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 51.41 E-value: 1.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 164 AMLLGAITFS----YLSDRFGRRVALwcTTIGVFFF--GIGSIFIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRE 237
Cdd:cd17359 44 SALLGAAIGAlfagRLADRFGRRKTL--LISAVLFFisALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 238 SR-TWASmhLNTFFAIGTMLVA-LVSYLVKTWWLY--------QIILWTVTAP---FILCCWMLPETPFWLLSEGRYKEA 304
Cdd:cd17359 122 IRgRLVS--LNQLMIVFGQLLAyIVNYLIANAGGAdwlgaegwRWMLGLEAIPailFLLGMLFIPESPRWLVSKGKPILI 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 305 QGVVdaMAVWNKSSSCDLIellsldvtrshdkshkgagkpslgdLFRNPDIAKmtlivwldwftvNLGyyvFAMEAVRrk 384
Cdd:cd17359 200 IGIG--LAIFQQFVGINVI-------------------------FYYGPEIFQ------------NAG---FSENAAL-- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 385 ehehLYYLLVGAVEIPAyVFLCIW-MQRVGRRKTML--------TFLLMSsficVVYVVIPSDSDTAKEAKGAVALFVKV 455
Cdd:cd17359 236 ----LQTIGIGVVNVIF-TIIAILlVDKVGRKPLLLigsigmaiSLLLIG----TAFYFAPGSQASGIVALVLILLFVAF 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 456 AVGSVFAFIYLYTAELYPTIMRCLAVGSSNMVSHVASMVI-----PLSQHFSKVWIFLpqiLFGTLAILSGLL-SLNLPE 529
Cdd:cd17359 307 FAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVsltfpILLAAFGLAFTFL---IFAVICVLAFLFvWKFVPE 383
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
618-839 |
1.48e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 52.25 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 618 PPDTERWD----SGRAPPDAERWGSSGRAPSDAKKWGL---GRAPPDAETGGSGRAPPNTET--GGSDRAPPNTESGGSG 688
Cdd:PHA03247 2618 PPDTHAPDppppSPSPAANEPDPHPPPTVPPPERPRDDpapGRVSRPRRARRLGRAAQASSPpqRPRRRAARPTVGSLTS 2697
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 689 RAPPNTESRGSGRAPPETESGGPGRVPPdAESWGLGKAPPDDEIGGSGRASPETESGGSGQALPETESGGSGRAPPETES 768
Cdd:PHA03247 2698 LADPPPPPPTPEPAPHALVSATPLPPGP-AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPA 2776
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2780227945 769 GGsgrAPPETESGGSGQALPETESGGSGRAPPETESGGSGRAPPETESGEGGSGRVSPKDKNEGSGRAPPE 839
Cdd:PHA03247 2777 AG---PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844
|
|
| SPT5 |
COG5164 |
Transcription elongation factor SPT5 [Transcription]; |
601-785 |
1.96e-06 |
|
Transcription elongation factor SPT5 [Transcription];
Pssm-ID: 444063 [Multi-domain] Cd Length: 495 Bit Score: 51.18 E-value: 1.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 601 GLGRDPYDVEKWGLGRDPPDTERWDSGRAPPDaerwGSSGRAPSDAKKWGLGRAPPDAETGGSGRAPPNTETGGSDRA-- 678
Cdd:COG5164 106 GATGPPDDGGATGPPDDGGSTTPPSGGSTTPP----GDGGSTPPGPGSTGPGGSTTPPGDGGSTTPPGPGGSTTPPDDgg 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 679 ---PPNTESGGsgrapPNTESRGSGRAPPE-----TESGGPGRVPPDAEswglGKAPPDDEIGGSGRASPETESGGSGQA 750
Cdd:COG5164 182 sttPPNKGETG-----TDIPTGGTPRQGPDgpvkkDDKNGKGNPPDDRG----GKTGPKDQRPKTNPIERRGPERPEAAA 252
|
170 180 190
....*....|....*....|....*....|....*..
gi 2780227945 751 LPETESGGSGRAPPET--ESGGSGRAPPETESGGSGQ 785
Cdd:COG5164 253 LPAELTALEAENRAANpePATKTIPETTTVKDLATVL 289
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
152-220 |
2.11e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.63 E-value: 2.11e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2780227945 152 WYANMIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIF---IFDYFSFMAARFFLVMTSS 220
Cdd:cd17478 230 VFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLtpgIWSYILLVLAGFLLFASFP 301
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
639-837 |
4.11e-06 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 50.84 E-value: 4.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 639 SGRAPSDAKKWGLGRAPPDAEtgGSGRAPPNTETGGSDRAPpnteSGGSGRAPPNTESRGSGRAPpeteSGGPGRVPPDA 718
Cdd:PHA03378 679 TGANTMLPIQWAPGTMQPPPR--APTPMRPPAAPPGRAQRP----AAATGRARPPAAAPGRARPP----AAAPGRARPPA 748
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 719 ESWGLGKAPPddeiGGSGRASPETESGGSGQALPETESGGSGRAPPEtesGGSGRAPPEtesggsgQALPeTESGGSGRA 798
Cdd:PHA03378 749 AAPGRARPPA----AAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPR---GAPTPQPPP-------QAGP-TSMQLMPRA 813
|
170 180 190
....*....|....*....|....*....|....*....
gi 2780227945 799 PPeTESGGSGRAPPETESGEGGSGRVSPKDKNEGSGRAP 837
Cdd:PHA03378 814 AP-GQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAA 851
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
358-525 |
5.28e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.34 E-value: 5.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 358 MTLIVWLDWFTVNLGYYVFAMEAVRRKEHE-HLYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVVIP 436
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEiGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 437 SDSDTAkeakgAVALFVKVAVGSVFAFIYLYTAELYPTIMRCLAVGSSNMVSHVASMVIP-----LSQHFSKVWIFlpqI 511
Cdd:pfam07690 84 SLWLLL-----VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPllgglLASLFGWRAAF---L 155
|
170
....*....|....
gi 2780227945 512 LFGTLAILSGLLSL 525
Cdd:pfam07690 156 ILAILSLLAAVLLL 169
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
618-794 |
6.85e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 49.98 E-value: 6.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 618 PPDTERWDSGRAPPDAERWGSSGRAPSDAKKWGLGRAPPDAETGGSGRAPPNTETGGSDRAPPntesGGSGRAPPNTESR 697
Cdd:PRK07764 649 APEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPA----GQADDPAAQPPQA 724
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 698 GSGRAPPETESGGPGRVPPDAESWGLGKAPPDDeigGSGRASPETESGGSGQALPETESGGSGRAPPETESGGsgrAPPE 777
Cdd:PRK07764 725 AQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQ---PPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMD---DEDR 798
|
170
....*....|....*..
gi 2780227945 778 TESGGSGQALPETESGG 794
Cdd:PRK07764 799 RDAEEVAMELLEEELGA 815
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
652-828 |
9.64e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 49.40 E-value: 9.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 652 GRAPPDAETGGSGRAPPNTETGGSDRAPPNTESGGSGRAPPNTESRGSGRAPPETESGGPGRVPPDAESWGLGKAPPDde 731
Cdd:PHA03307 762 SLVPAKLAEALALLEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPARPP-- 839
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 732 iGGSGRASPETESGGSGQALPETESGGSGRAPPETESGGSGRAPPETESGGSGQAlPETESGGSGRAPPETESGGSGRAP 811
Cdd:PHA03307 840 -GAAARPPPARSSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAA-AAPPAGAPAPRPRPAPRVKLGPMP 917
|
170
....*....|....*..
gi 2780227945 812 PETESGEGGSGRVSPKD 828
Cdd:PHA03307 918 PGGPDPRGGFRRVPPGD 934
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
166-291 |
9.98e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 46.10 E-value: 9.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 166 LLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESRTWASMH 245
Cdd:TIGR00880 12 LIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGL 91
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2780227945 246 LNTFFAIGTMLVALVSYLVKTW----WLYQIILWTVTAPFILCCWMLPET 291
Cdd:TIGR00880 92 MSAGIALGPLLGPPLGGVLAQFlgwrAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
165-374 |
1.74e-05 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 48.37 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 165 MLLGAITFSYLSDRFGRRVALW-CTTIGVFFFGIGSiFIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESR---- 239
Cdd:cd17440 47 MMVGAFFWGGLADKVGRRQSLLiCMSVNGFFAFLSS-FVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRgehl 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 240 TWASMhlntFFAIGTMLVALVSYLVKTWW--------LYQIILWTVtapFILCCWM-----------LPETPFWLLSEGR 300
Cdd:cd17440 126 SWLCM----FWMIGGIYASAMAWAIIPHYgwsfsmgsAYQFHSWRV---FVIVCALpcvssvvaltfMPESPRFLLEVGK 198
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2780227945 301 YKEAQGVVDAMavwnkssscdliellsldvtrsHDKSHKGAGKPSlgDLFRNPDIAK-MTLIVWLDWFTVNLGYY 374
Cdd:cd17440 199 HDEAWMILKQI----------------------HDTNMRARGQPE--KVFTVNRIKKdNTIKLTIVWLTLSFGYY 249
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
629-842 |
2.15e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 48.31 E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 629 APPDAERWGSSGRAPSDAKKWGLGRAPPDAETGGSGRAPPNTETGGSDRAPPNTESGGSGRAPPNTESRGSGRAP---PE 705
Cdd:PRK07003 396 VPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPpadSG 475
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 706 TESGGPGRVPPDAESwglGKAPPDDEIGGSGRASPETESGGSGQALPEtESGGSGRAPPETESGGSGRAPPETESGGSGQ 785
Cdd:PRK07003 476 SASAPASDAPPDAAF---EPAPRAAAPSAATPAAVPDARAPAAASRED-APAAAAPPAPEARPPTPAAAAPAARAGGAAA 551
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2780227945 786 ALPETESGG------SGRAPPETESGGSGRAPPETESGE--------GGSGRVSPKDKNEGSGRAPPEENT 842
Cdd:PRK07003 552 ALDVLRNAGmrvssdRGARAAAAAKPAAAPAAAPKPAAPrvavqvptPRARAATGDAPPNGAARAEQAAES 622
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
165-294 |
2.43e-05 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 47.77 E-value: 2.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 165 MLLGAItfsylSDRFGRRVALwctTIGVFFFGIGSI---FIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESRTW 241
Cdd:PRK03893 73 LLLGAM-----GDRYGRRLAM---VISIVLFSVGTLacgFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNK 144
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 242 ASMHLNTFFAIGTMLVALV-SYLVKTW---WLYQIILwtvtAPFILCCWM---LPETPFW 294
Cdd:PRK03893 145 ASGFLISGFSIGAVVAAQVySLVVPVWgwrALFFIGI----LPIIFALWLrknLPEAEDW 200
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
618-812 |
2.57e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 47.92 E-value: 2.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 618 PPDTERWDSGRAPPDAERWGSSGRAPSDAKKWGLGRAPPDAETGGSGRAPPNTETGGSDRAPPNTESGGSGRAPPNTESR 697
Cdd:PRK07003 433 PATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARA 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 698 GSGrAPPETESGGPGRVPPDAeswglgkAPPddeigGSGRASPETESGGSGQALPETESGG----SGR------------ 761
Cdd:PRK07003 513 PAA-ASREDAPAAAAPPAPEA-------RPP-----TPAAAAPAARAGGAAAALDVLRNAGmrvsSDRgaraaaaakpaa 579
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2780227945 762 APPETESGGSGRAPPETESGGSGQALPETESGGSGRAPPETESGGsgrAPP 812
Cdd:PRK07003 580 APAAAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRG---APP 627
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
623-819 |
2.72e-05 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 48.14 E-value: 2.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 623 RWDSGRAPPDAErwgSSGRAPSDAKKWGLGRAPpdaeTGGSGRAPPNTETGGSDRAPpnteSGGSGRAPPNTESRGSGRA 702
Cdd:PHA03378 688 QWAPGTMQPPPR---APTPMRPPAAPPGRAQRP----AAATGRARPPAAAPGRARPP----AAAPGRARPPAAAPGRARP 756
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 703 PpeteSGGPGRVPPDAeswglgkappddeiGGSGRASPETESGGSGQALPETESGGSGRAPPETESGGSGRAPPE--TES 780
Cdd:PHA03378 757 P----AAAPGRARPPA--------------AAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAapGQQ 818
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 2780227945 781 GGSGQALPETESGG--SGRAPPETESGGSGRAP----PETESGEG 819
Cdd:PHA03378 819 GPTKQILRQLLTGGvkRGRPSLKKPAALERQAAagptPSPGSGTS 863
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
156-374 |
3.06e-05 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 47.66 E-value: 3.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 156 MIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEFIG 235
Cdd:TIGR01299 206 MLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLA 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 236 RESR----TWASMhlntFFAIGTMLVALVSYLV---KTWWL-----YQIILWTVtapFILCCWM-----------LPETP 292
Cdd:TIGR01299 286 QEKRgehlSWLCM----FWMIGGIYAAAMAWAIiphYGWSFqmgsaYQFHSWRV---FVIVCAFpcvfaigaltfMPESP 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 293 FWLLSEGRYKEAQGVVDAMAVWNKSSSC------------------DLIELLSLDVT--RSHDKSHKGAGKPSLGDLFR- 351
Cdd:TIGR01299 359 RFFLENGKHDEAWMILKLIHDTNMRAKGhpekvfsvnhiktihqedELIEIESDTGTwyQRCFVRALSEGGGIWGNFLRc 438
|
250 260
....*....|....*....|....
gi 2780227945 352 -NPDIAKMTLIVWLDWFTVNLGYY 374
Cdd:TIGR01299 439 fNPEVREITIKLMGVWFTLSFGYY 462
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
620-852 |
3.37e-05 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 47.68 E-value: 3.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 620 DTERWDSGRAPPDAERWGSSGRAPSDAKkwglgrAPPDAETGGSGRAPPNTETGGSDRAPPNTESGGSGRAPPNTESRGS 699
Cdd:TIGR00927 629 DLSKGDVAEAEHTGERTGEEGERPTEAE------GENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAK 702
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 700 GRAPP-----------------------ETESGGPGRVPPDaESWGLGKAPPDDEIGGSgRASPETESGGSGQALP---- 752
Cdd:TIGR00927 703 EADHKgeteaeevehegeteaegtedegEIETGEEGEEVED-EGEGEAEGKHEVETEGD-RKETEHEGETEAEGKEdede 780
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 753 -ETESGGSGRAPPETESGGSGRAPPETESGGS--------GQALPETESGGSGRAPPETESGGSGRAPPETESGEGGSGR 823
Cdd:TIGR00927 781 gEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKdehegqseTQADDTEVKDETGEQELNAENQGEAKQDEKGVDGGGGSDG 860
|
250 260
....*....|....*....|....*....
gi 2780227945 824 VSPKDKNEGSGRAPPEENTEVENEIENSE 852
Cdd:TIGR00927 861 GDSEEEEEEEEEEEEEEEEEEEEEEEEEE 889
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
393-529 |
3.38e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 47.18 E-value: 3.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 393 LVGAVEIPAYVFLCIWMQRVGRRKTML-TFLLMSSFiCVVYVVIPSDSDTAKEAKGavalfvkVAVGSVFAFI------- 464
Cdd:cd17315 222 IVGVVNLLATLVAIRLVDKVGRRPLLLiGFAGMAAS-LLLLAIAFLLPALAKAAGW-------LALLGILLYIaafamga 293
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2780227945 465 ----YLYTAELYPTIMRCLAVGSSNMVSHVASMVI-----PLSQHFSKVWIFlpqILFGTLAILS-GLLSLNLPE 529
Cdd:cd17315 294 gpvpWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVgltflIMVSTIGLAGVF---IFFAAVCLLAlVFVFFFVPE 365
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
677-839 |
4.29e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 47.47 E-value: 4.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 677 RAPPNTESGGSGRAPPNTESRGSGRAPPETESGGPGRVPPdaesWGLGKAPPDDEIGGSGRASPET-ESGGSGQALPETE 755
Cdd:PHA03307 763 LVPAKLAEALALLEPAEPQRGAGSSPPVRAEAAFRRPGRL----RRSGPAADAASRTASKRKSRSHtPDGGSESSGPARP 838
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 756 SGGSGRAPPETESGGSGRAPPETESGGSGQALPETESGGSGRAPPETESGGSGRAPPETESGEGGSGRVSPKDKnegSGR 835
Cdd:PHA03307 839 PGAAARPPPARSSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVK---LGP 915
|
....
gi 2780227945 836 APPE 839
Cdd:PHA03307 916 MPPG 919
|
|
| MFS_SLC22A23 |
cd17444 |
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ... |
125-283 |
4.30e-05 |
|
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341002 [Multi-domain] Cd Length: 364 Bit Score: 46.77 E-value: 4.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 125 CSDGYIYDQSKWRSSVVGSFNLVCDQKWYANMIQPLFIFAMLLGAITFSYLSDRFGRRVALWCTTIGVFFFGIGSIFIFD 204
Cdd:cd17444 9 CTERDYRIRAGLVQNIVSKWDLVCDSSWKVHIAKFSLLVGLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVN 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2780227945 205 YFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTWwlyQIILWTVTAPFIL 283
Cdd:cd17444 89 VTMFSTLRFFEGFCLAGIILSLYALRIELCPPGHRFMITMVASFIAMAGQFLMPGLAALCRDW---QVLQAVIICPFLL 164
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
618-839 |
4.38e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 47.63 E-value: 4.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 618 PPDTERWDSGRAP-PDAERWGSSGRAPSDAkkWG--LGRAPPdAETGGSGRAPPNT-----ETGGSDRAPPNTESGGSGR 689
Cdd:PHA03247 268 APETARGATGPPPpPEAAAPNGAAAPPDGV--WGaaLAGAPL-ALPAPPDPPPPAPagdaeEEDDEDGAMEVVSPLPRPR 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 690 APPNT----ESRGSGRAPPETESGGPGRVPPDaeswglgKAPPDDEIGGSGR--ASP-ETESGGSGQALPETESGGSgrA 762
Cdd:PHA03247 345 QHYPLgfpkRRRPTWTPPSSLEDLSAGRHHPK-------RASLPTRKRRSARhaATPfARGPGGDDQTRPAAPVPAS--V 415
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2780227945 763 PPETESGGSGRAPPETESggsgqALPETESGGS-GRAPPETESggsgRAPPETESGEGGSGRVSPKDKNEGSGRAPPE 839
Cdd:PHA03247 416 PTPAPTPVPASAPPPPAT-----PLPSAEPGSDdGPAPPPERQ----PPAPATEPAPDDPDDATRKALDALRERRPPE 484
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
160-439 |
5.18e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.82 E-value: 5.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 160 LFIFAMLLGAIT---FSYLSD----RFGRR---------------VALWCT----TIGVFFFGIGSIFIFD--------- 204
Cdd:COG2211 51 ILLVARLWDAITdplIGALSDrtrtRWGRRrpwiligaiplalsfVLLFTApdlsPTGKLIYALVTYLLLGlaytlvnip 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 205 YFSFMAarfflVMTSSgyfvvvfvyvmefigRESRTWASMHLNTFFAIGTMLVALVSYLVKTWWL------YQIILWTVT 278
Cdd:COG2211 131 YSALGA-----ELTPD---------------YEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgYRLTALIFA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 279 APFILCCWMlpetPFWLLSEgrykeaqgvvdamavwnkssscdliellsldvtRSHDKSHKGAGKPSLGDLFRNPDIAKM 358
Cdd:COG2211 191 VLGLLAFLL----TFFGTKE---------------------------------RPVPEEEKVSLKESLKALLKNRPFLLL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 359 TLIVWLDWFTVNL--GYYVFAMEAVRRKEHEH--LYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLTFLLMSSFICVVYVV 434
Cdd:COG2211 234 LLAYLLFFLALALvaALLLYYFKYVLGLSAALvgLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF 313
|
....*
gi 2780227945 435 IPSDS 439
Cdd:COG2211 314 LGPGN 318
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
629-810 |
6.39e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 46.77 E-value: 6.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 629 APPDAERWGSSGRAPSDAKKWGLGRAPPDAETGGSGRAPPNTETGGSDRAPPNTesgGSGRAPPNTESRGSGRAPPETES 708
Cdd:PRK07003 375 RVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPA---APAPPATADRGDDAADGDAPVPA 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 709 GGPGRVPPDAESWGLGKAPPddeiggsgrASPETESGGSGQALPETESGGSGRAPPETESGGSGRAPPETESGGSGQALP 788
Cdd:PRK07003 452 KANARASADSRCDERDAQPP---------ADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAP 522
|
170 180
....*....|....*....|..
gi 2780227945 789 ETESGGSGRAPPETESGGSGRA 810
Cdd:PRK07003 523 AAAAPPAPEARPPTPAAAAPAA 544
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
162-528 |
6.55e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.04 E-value: 6.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 162 IFAMLLGAITFSYLSDRFGRR-VALWCttigVFFFGIGSI---FIFDYFSFMAARFF------------LVMTSsgyfvv 225
Cdd:cd17365 44 LFGMAIGALLAGPLADRFGRKrVLLVS----VALFGLFTLltaFAQSVLQLALLRFLtglglgaampnaITLVS------ 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 226 vfvyvmEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTWWLYQIILWTvtapfilccwmlpetpfwllsegrykeaq 305
Cdd:cd17365 114 ------EYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL----------------------------- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 306 gvvdamavwnkssscdliellsldvtrshdkshkGAGKPSLGDLFrnpdiAKMTLIVWLDWFTVNLGYYVF------AME 379
Cdd:cd17365 159 ----------------------------------GGVPPLILLPL-----LRGTLLLWVTFFMGLLLVYLLnswlpkLMV 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 380 AVRRKEHEHLYYLLV----GAVEIPAYVFLciwMQRVGRRKT-MLTFLLMSSFICVVyvvipsdsdtAKEAKGAVALFVK 454
Cdd:cd17365 200 EAGYSLSQALTITLLlnigGVIGSLLLGWL---ADRFGPKRVlALFFALGAVSLALL----------GVSPASLVLLYVL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 455 VAVGSVFAF-----IYLYTAELYPTIMRCLAVGSSNMVSHVASMVIP------LSQHFSKVWIFLpqiLFGTLAILSGLL 523
Cdd:cd17365 267 VFLAGACVNgaqvgLYALAARFYPTEVRATGVGWALGVGRLGAILGPllggllLAAGLGPESVFL---ALAIPAALGALA 343
|
....*
gi 2780227945 524 SLNLP 528
Cdd:cd17365 344 VLLLR 348
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
603-838 |
6.58e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.86 E-value: 6.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 603 GRDPYDVEKWGLGRDP-PDTERWDSGRAPPD------AERWGSSGRAPSDAKKWGLGRAPPD-AETGGSGRAPPNTETgg 674
Cdd:PHA03247 2630 SPSPAANEPDPHPPPTvPPPERPRDDPAPGRvsrprrARRLGRAAQASSPPQRPRRRAARPTvGSLTSLADPPPPPPT-- 2707
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 675 SDRAPPNTESGGSgrAPPNTES-RGSGRAPPETES-----------GGPGRVP-PDAESWGLGKAPPDDEIGGSGRASPE 741
Cdd:PHA03247 2708 PEPAPHALVSATP--LPPGPAAaRQASPALPAAPAppavpagpatpGGPARPArPPTTAGPPAPAPPAAPAAGPPRRLTR 2785
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 742 TesgGSGQALPETESGGSGRAPPETESGGSGRAPPETESGGSGQALPETESggSGRAPPETESGgsgraPPETESGEGGS 821
Cdd:PHA03247 2786 P---AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS--AQPTAPPPPPG-----PPPPSLPLGGS 2855
|
250
....*....|....*....
gi 2780227945 822 grVSPKD--KNEGSGRAPP 838
Cdd:PHA03247 2856 --VAPGGdvRRRPPSRSPA 2872
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
617-779 |
6.90e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 46.52 E-value: 6.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 617 DPPDTERWDSGRAPPDAERWGSSGRAPSDAKKWGLGRAPPDAETGGSGR-APPNTETGGSDRAPPNTESGGSGRAPPNTE 695
Cdd:PRK07764 623 APAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAkAGGAAPAAPPPAPAPAAPAAPAGAAPAQPA 702
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 696 SRGSGRAPPETESGGPGRVPPDAEswglGKAPPDDEIGGSGRASPETESGGSGQALPETESGGSGRAPPETESGGSGRAP 775
Cdd:PRK07764 703 PAPAATPPAGQADDPAAQPPQAAQ----GASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSP 778
|
....
gi 2780227945 776 PETE 779
Cdd:PRK07764 779 PSEE 782
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
655-845 |
7.57e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 46.70 E-value: 7.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 655 PPDAETGGSGRAPP------NTETGGSDRAP--------PNTESGGSGRAPPNTESRGSGRAPPETESGGPGRVPPDAES 720
Cdd:PHA03307 67 PPTGPPPGPGTEAPanesrsTPTWSLSTLAPasparegsPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGP 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 721 WGLGKAPPDDEIGGSGrASPETESGGSGQALPETE------SGGSGRAPPETES-GGSGRAPPETESGGSGQALPETESG 793
Cdd:PHA03307 147 PPAASPPAAGASPAAV-ASDAASSRQAALPLSSPEetarapSSPPAEPPPSTPPaAASPRPPRRSSPISASASSPAPAPG 225
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2780227945 794 GSGRAPPETESGGSGrAPPETESGEGGSGRVSpkDKNEGSGRAPPEENTEVE 845
Cdd:PHA03307 226 RSAADDAGASSSDSS-SSESSGCGWGPENECP--LPRPAPITLPTRIWEASG 274
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
167-535 |
8.02e-05 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 46.02 E-value: 8.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 167 LGAITFSYLSDRFGRRVALWCTTIGvFFFGIGSIFIF-DYFSFMAARFFLVMTSSGYFVVVFVYVMEFIGRESRTWASMH 245
Cdd:cd17433 56 AGGVLGGWIVDRAGRKLSLMLCSVP-FIAGFTVITAAqNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSC 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 246 LNTFFAIGTMLvALVSYLVKTW-WLYQIILWTVTAPFILCCWMlPETPFWLLSEGRYKEAQGVV------DAMAVWnkss 318
Cdd:cd17433 135 VQLMVVIGIMG-AYLAGLVLDWrWLAVLGSIPPTLMLLLMCFM-PETPRFLLTQHRRQEAMAALrflrgpDQGWEW---- 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 319 SCDLIEllsldvtrshDKSHKGAGKPSLGDLfRNPDIAKMTLI----VWLDWFTvNLGYYVFAMEAVRRKEH---EHLYY 391
Cdd:cd17433 209 ECIGIE----------QSFHLEEQSFSLALL-KQPGIYKPLIIgvslMAFQQLT-GINAVMFYAETIFEEAKfkdSSVAS 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 392 LLVGAVEIPAYVFLCIWMQRVGRRktmlTFLLMSSFICVVyvvipsdsdtakeakgAVALFVKVAVGSVFAFI------- 464
Cdd:cd17433 277 VIVAAIQVLFTAVAALIMDRAGRK----VLLVLSGVVMVF----------------STAAFGWLAVGSMGFFIagfavgw 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 465 ----YLYTAELYPTIMRCLAVGSSNMVSHVASMVIplSQHFSKVWIFLPQilFGTLAILSGLLSLN-------LPETQNR 533
Cdd:cd17433 337 gpipWLVMSEIFPLHVRGVASGICVLTNWLMAFLV--TKEFSSLMEVLSS--YGTFWLFSAFCAFSvlftlfcVPETKGK 412
|
..
gi 2780227945 534 PM 535
Cdd:cd17433 413 TL 414
|
|
| dermokine |
cd21118 |
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ... |
636-842 |
8.43e-05 |
|
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.
Pssm-ID: 411053 [Multi-domain] Cd Length: 495 Bit Score: 46.15 E-value: 8.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 636 WGSSGRAPSDAKKWGLGRAPPDAETGGSGRAPPNTETG-GSDRAPPN--TESGGSGRAPPNTESRGSGR-----APPETE 707
Cdd:cd21118 130 YGSQGGPGVQGHGIPGGTGGPWASGGNYGTNSLGGSVGqGGNGGPLNygTNSQGAVAQPGYGTVRGNNQnsgctNPPPSG 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 708 SGGPGRVPPDAESWGLGKAPPD---DEIGGSGRASPETESGGSGQALPETESGGSGRAPPETESGGSGRAPPETESGGSG 784
Cdd:cd21118 210 SHESFSNSGGSSSSGSSGSQGShgsNGQGSSGSSGGQGNGGNNGSSSSNSGNSGGSNGGSSGNSGSGSGGSSSGGSNGWG 289
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2780227945 785 QALPETESGGSG---RAPPETESGGSGRAPPETESGEGGSGRVSPKDKNEGSGRAPPEENT 842
Cdd:cd21118 290 GSSSSGGSGGSGggnKPECNNPGNDVRMAGGGGSQGSKESSGSHGSNGGNGQAEAVGGLNT 350
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
613-743 |
8.68e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 46.13 E-value: 8.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 613 GLGRDPPDTERWDSGRAPPDAERWGSSGRAPSDAKKWGLGRAPPDAETGGSGRAPPntetGGSDRAPPNTESGGSGRAPP 692
Cdd:PRK07764 656 HVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPA----GQADDPAAQPPQAAQGASAP 731
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2780227945 693 NTESRGSGRAPPETESGGPGRVPPDAESWGLGKAPPDDEIGGSGRASPETE 743
Cdd:PRK07764 732 SPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEE 782
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
605-839 |
9.68e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 46.32 E-value: 9.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 605 DPYD-VEKWGLGRDPPDTERWDSGRAPPDAeRWGSSGRAPSDAKKwgLGRAPPDAETGGSGRAPPNTETGGSDRAPPNtE 683
Cdd:PHA03307 6 DLYDlIEAAAEGGEFFPRPPATPGDAADDL-LSGSQGQLVSDSAE--LAAVTVVAGAAACDRFEPPTGPPPGPGTEAP-A 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 684 SGGSGRAPPNTESRGSGRAPPETESGGPGRVPPDAEswglGKAPPddeiggsgRASPETESGGSGQALPETESGGSGRAP 763
Cdd:PHA03307 82 NESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPP----PPTPP--------PASPPPSPAPDLSEMLRPVGSPGPPPA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 764 PETESGGSGRAPPETESGGSGQA------LPETE---SGGSGRAPPETES-GGSGRAPPETESGEGGSGRVSPKDKNEGS 833
Cdd:PHA03307 150 ASPPAAGASPAAVASDAASSRQAalplssPEETArapSSPPAEPPPSTPPaAASPRPPRRSSPISASASSPAPAPGRSAA 229
|
....*.
gi 2780227945 834 GRAPPE 839
Cdd:PHA03307 230 DDAGAS 235
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
654-840 |
1.17e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.08 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 654 APPDAETGGSGRaPPNTETGGSDRAPPNTES--GGSGRAPPNTESRGSGRAPPETESGGPgrvPPDAESWGlGKAPPDDE 731
Cdd:PHA03247 256 APPPVVGEGADR-APETARGATGPPPPPEAAapNGAAAPPDGVWGAALAGAPLALPAPPD---PPPPAPAG-DAEEEDDE 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 732 IGGSGRASP------ETESGGSGQALP--------ETESGG---SGRAPPETESGGSGR---APPETESGGSGQALPETE 791
Cdd:PHA03247 331 DGAMEVVSPlprprqHYPLGFPKRRRPtwtppsslEDLSAGrhhPKRASLPTRKRRSARhaaTPFARGPGGDDQTRPAAP 410
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2780227945 792 SGGSGRAPPETESGGSGRAPPET--ESGEGGS--GRVSPKDKNEGSGRAPPEE 840
Cdd:PHA03247 411 VPASVPTPAPTPVPASAPPPPATplPSAEPGSddGPAPPPERQPPAPATEPAP 463
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
617-812 |
1.37e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.08 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 617 DPPDTERWDSGRAPPdaerWGSSGRAPSDAKKWGLGRAPPDAETggsgrAPPNTETGgsdrapPNTESGGSGRAPPNTES 696
Cdd:PHA03247 2700 DPPPPPPTPEPAPHA----LVSATPLPPGPAAARQASPALPAAP-----APPAVPAG------PATPGGPARPARPPTTA 2764
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 697 RGSGRAPPETESGGPGR------VPPDAESWGLGKAPPDDeiggsgrASPETESGGSGQALPETESGGSGRAPPETesgg 770
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPRrltrpaVASLSESRESLPSPWDP-------ADPPAAVLAPAAALPPAASPAGPLPPPTS---- 2833
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 2780227945 771 SGRAPPETESGgsgqALPETESGGSGRAP--PETESGGSGRAPP 812
Cdd:PHA03247 2834 AQPTAPPPPPG----PPPPSLPLGGSVAPggDVRRRPPSRSPAA 2873
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
660-786 |
2.02e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 44.98 E-value: 2.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 660 TGGSGRAPPNTETGGSDRAPPNTESGGSGRAPPNTESRGSGRAPPETESGGPGRVPPDAESWGLGKAPPDDEiggsgRAS 739
Cdd:PRK07764 387 VAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPP-----AAA 461
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 2780227945 740 PETESGGSGQALPETESGGSGRAPPETESGGSGRAPPETESGGSGQA 786
Cdd:PRK07764 462 PSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADD 508
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
160-304 |
2.22e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 44.30 E-value: 2.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 160 LFIFAMLLGAITFSYLSDRFGRR-VALWCTTIGVfFFGIGSIFIFDYFSFMAARFFLVMTSSGYFVVVFVyvmefIGRES 238
Cdd:TIGR00710 48 LYLLGFAAGQLLWGPLSDRYGRRpVLLLGLFIFA-LSSLGLALSNNIETLLVLRFVQAFGASAGSVISQA-----LVRDI 121
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2780227945 239 rtWASMHLNTFFAIGTMLVALV--------SYLVKtWWLYQIILWTVTAPFILCCWMLpetpFWLLSEGRYKEA 304
Cdd:TIGR00710 122 --YPGEELSRIYSILMPVLALApavapllgGYILV-WLSWHAIFAFLSLAGILLSALI----FFILPETLPYEA 188
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
702-844 |
2.54e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 44.59 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 702 APPETESGGPGRVPPDAESWGLGKAPPDDeigGSGRASPETESGGSGQALPETESGGSGRAPPETESGGSGRAPPETESG 781
Cdd:PRK07764 589 GPAPGAAGGEGPPAPASSGPPEEAARPAA---PAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDG 665
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2780227945 782 GSGQALPETESGGSGRAPPETE---SGGSGRAPPETESGEGGSGRVSPKDKNEGSGRAPPEENTEV 844
Cdd:PRK07764 666 GDGWPAKAGGAAPAAPPPAPAPaapAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAP 731
|
|
| PHA03264 |
PHA03264 |
envelope glycoprotein D; Provisional |
652-740 |
3.01e-04 |
|
envelope glycoprotein D; Provisional
Pssm-ID: 223029 [Multi-domain] Cd Length: 416 Bit Score: 44.23 E-value: 3.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 652 GRAPPDAETGGSGRAPPNT------ETGGSDRAPPNTESGGSGRAPpntESRGSGRAPPETESGGPGRVPPDA---ESWG 722
Cdd:PHA03264 263 GYEPPPAPSGGSPAPPGDDrpeakpEPGPVEDGAPGRETGGEGEGP---EPAGRDGAAGGEPKPGPPRPAPDAdrpEGWP 339
|
90 100
....*....|....*....|..
gi 2780227945 723 LGKA----PPDDEIGGSGRASP 740
Cdd:PHA03264 340 SLEAitfpPPTPATPAVPRARP 361
|
|
| Mucin-like |
pfam16058 |
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ... |
704-808 |
3.40e-04 |
|
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.
Pssm-ID: 464997 [Multi-domain] Cd Length: 94 Bit Score: 40.48 E-value: 3.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 704 PETESGGPGRVPPDaeSWGlgkAPPDDEIGGSGRASPETESGGSGQALPETESGGsgrAPPETESGGSGrAPPETESGGS 783
Cdd:pfam16058 1 PSSSITEPPRDPSG--SYG---EPPRAPSSSYTEPQRDPSSSITEPPADPSSSYT---EPPRDPSGSYT-EPQRDPSSSS 71
|
90 100
....*....|....*....|....*
gi 2780227945 784 GQALPETESGGSgrAPPETESGGSG 808
Cdd:pfam16058 72 TEPQRDPSSSIT--EPPRDPSGSYT 94
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
631-826 |
3.78e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.54 E-value: 3.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 631 PDAERWGSSGRAPSDakkwglgraPPDAETGGSGRAPPNTETGGSDRAPPntesggSGRAPPNTESRGSGRAPPETE--- 707
Cdd:PHA03247 2589 PDAPPQSARPRAPVD---------DRGDPRGPAPPSPLPPDTHAPDPPPP------SPSPAANEPDPHPPPTVPPPErpr 2653
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 708 -SGGPGRVPPDAESWGLGK-----APPDdeiGGSGRASPETESGGSGQALPETESGGSGRAPPETESGGSgrAPPETESG 781
Cdd:PHA03247 2654 dDPAPGRVSRPRRARRLGRaaqasSPPQ---RPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATP--LPPGPAAA 2728
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 2780227945 782 gsGQALPETESGGSGRAPPETESGGSGRAPPETESGEGGSGRVSP 826
Cdd:PHA03247 2729 --RQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
688-838 |
3.99e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 44.39 E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 688 GRAPPNTESRGSGRAPPETESGGPGRVPPDAESWGLGKAPPDDEIGGSGRASPETESGGSGqalPETESGGSGRAPPETE 767
Cdd:PHA03307 762 SLVPAKLAEALALLEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSR---SHTPDGGSESSGPARP 838
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2780227945 768 SGGSGRAPPETESGGSG---QALPETESGGSGRAPPEtesggsgraPPETESGEGGSGrvSPKDKNEGSGRAPP 838
Cdd:PHA03307 839 PGAAARPPPARSSESSKskpAAAGGRARGKNGRRRPR---------PPEPRARPGAAA--PPKAAAAAPPAGAP 901
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
626-836 |
4.69e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 44.07 E-value: 4.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 626 SGRAPPDaerwGSSGRAPSDAKKWGLGRAPPDAETGGSGRAPPNTETGGSDRAPPNTESGGSGRAPPNtesRGSGRAPPE 705
Cdd:PRK07003 364 GGGAPGG----GVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPP---AAPAPPATA 436
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 706 TESGGPGRVPPDAESWGLGKAPPDdeiggsgraSPETESGGSGQALPETESGGSGRAPPETesggsgRAPPETESGGSGQ 785
Cdd:PRK07003 437 DRGDDAADGDAPVPAKANARASAD---------SRCDERDAQPPADSGSASAPASDAPPDA------AFEPAPRAAAPSA 501
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2780227945 786 ALPETESGGSGRAPPETESGGSGRAPPETESGEGGSGRVSPKDKNEGSGRA 836
Cdd:PRK07003 502 ATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAA 552
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
661-784 |
4.85e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 43.82 E-value: 4.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 661 GGSGRAPPNTETGGSDR-APPNTESGGSGRAPPNTESRGSGRAPPETESGGPGRVPPDAESWGLGKAPPDDEIGGSGRAS 739
Cdd:PRK07764 386 GVAGGAGAPAAAAPSAAaAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQ 465
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2780227945 740 PETESGGSGQALPETESGGSGRAPPETESGGSgrAPPETESGGSG 784
Cdd:PRK07764 466 PAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAP--AAPAAPAGADD 508
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
144-296 |
5.78e-04 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 43.01 E-value: 5.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 144 FNLVCDQKWYANMIQPLfIFAML-----LGAITFSYLSDRFGRRVALWcttIGVFFFGIGSIFIF----DYFSFMAARFF 214
Cdd:cd17356 33 FADNTGTYYPSSSRQGL-IVSIVnlgsfFGALISSFLSDRIGRKKSIQ---IGCVIYIIGAIIQVaaigKWYQLIVGRII 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 215 LVMTSSGYFVVVFVYVMEFIGRESR-TWASMHlNTFFAIGTMLVALVSYLVKT-----WWLyqiILWTVTAPFILCCWM- 287
Cdd:cd17356 109 AGLGVGFASVLVPVYQSEVAPKHIRgTLVSLY-QLAITIGILVAYCINYGTHKldgsaQWR---IPLGLQIVWGLLLLIg 184
|
170
....*....|..
gi 2780227945 288 ---LPETPFWLL 296
Cdd:cd17356 185 mffLPESPRWLY 196
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
391-530 |
7.23e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.65 E-value: 7.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 391 YLLVGAVEIPAYVFLciwMQRVGRRKTMLTFLLMSSFICVVYVVIPSdsdtakeakgAVALFV-----KVAVGSVFAFIY 465
Cdd:COG2814 54 YLLGAALGAPLAGRL---ADRFGRRRVLLLGLLLFALGSLLCALAPS----------LWLLLAarflqGLGAGALFPAAL 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 466 LYTAELYPTIMRCLAVGSSNMVSHVASMVIP-----LSQHFSKVWIFLPQILFGTLAILsgLLSLNLPET 530
Cdd:COG2814 121 ALIADLVPPERRGRALGLLGAGLGLGPALGPllgglLADLFGWRWVFLVNAVLALLALL--LLLRLLPES 188
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
658-840 |
9.19e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 42.91 E-value: 9.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 658 AETGGSGRAppntetGGSDRAPPNTESGGSGRAPPNTESRGSGRAPPEteSGGPGRVPPDAESWGLGKAPPDDEIGGSGR 737
Cdd:PRK07003 361 AVTGGGAPG------GGVPARVAGAVPAPGARAAAAVGASAVPAVTAV--TGAAGAALAPKAAAAAAATRAEAPPAAPAP 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 738 ASPETESGGSGQALPETESGGSGRAPPETESGGSGRAP---PETESGGSGQALPETESGGSGRAPPETESGGSGRAPPET 814
Cdd:PRK07003 433 PATADRGDDAADGDAPVPAKANARASADSRCDERDAQPpadSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARA 512
|
170 180
....*....|....*....|....*.
gi 2780227945 815 ESGEGGSGRVSPkdKNEGSGRAPPEE 840
Cdd:PRK07003 513 PAAASREDAPAA--AAPPAPEARPPT 536
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
129-522 |
1.02e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.21 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 129 YIYDQSKWRSSVVGSFnLVCDQkwyanmiqplfiFAMLLGAITFSYLSDRFGRR-VALWCTTIGVFFFgIGSIFIFDYFS 207
Cdd:cd17329 25 YLHQQLGLSASIVGLV-LALSA------------VAGIVASLIGGRLADRFGRKpVMLAGLLLRALGF-ALLGFAHSPWL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 208 FMAARFFLVMTSSGYFVVVFVYVMEFIGRESRTWASMHLNTFFAIGTMLVALV-SYLVKTwwLYQIILWTVTAPFILCCW 286
Cdd:cd17329 91 FAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLgGLLLLY--SFRLLFLAAAVLFLLAAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 287 MLpetpFWLLSEGRYKEAQgvvdamavwnkssscdliellsldvtrshdkSHKGAGKPSLGDLFRNPDIAKMTL---IVW 363
Cdd:cd17329 169 VL----LFLLPETRPKRRA-------------------------------AEKTEILRGYKIVLRDRAFLLFLLasfLIS 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 364 LDWFTVNLGYYVFAMEAVRRKEHEH-LYYLLVGAVEIPAYVFLCIWMQRVGRRKTMLT-FLLMS-SFICVVYvvipsdsd 440
Cdd:cd17329 214 LIYFQLESTLPVYVVEILGLGESLLgLLLALNALLIVLLQFPVARLVERFRLRKILMIgILLFAiGFAVLAF-------- 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 441 takeAKGAVALFVKVAV---GSVFAF--IYLYTAELYPTIMRCLAVGSSNMVSHVASMVIPLSQHFSkVWIFLPQILFGT 515
Cdd:cd17329 286 ----ANTLAVLILAMIVltlGEMLVFpaVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLL-LDLLGPGLPWLI 360
|
....*..
gi 2780227945 516 LAILSGL 522
Cdd:cd17329 361 LAALGLI 367
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
152-285 |
1.40e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.03 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 152 WYANMIQPLFIFAMLLGAITFSYLSDR-FGRRVALWCTTIGVFFFGIGSIFIFDYFSFMAARFFLVMTSSGYFVVVFVYV 230
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 2780227945 231 MEFIGRESRTWASMHLNTFFAIGTMLVALVSylvkTWWLYQIILWTVtaPFILCC 285
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLA----GFLLAATFGLTG--AFLVLA 367
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
154-279 |
1.41e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.77 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 154 ANMIQPLFIFAMLLGAITFSYLSDRFGRRVALwctTIGVFFFGIGSIFIF---DYFSFMAARFFLVMTSSGYFVVVFVYV 230
Cdd:cd17324 36 AGLLVSAYALGYALGALLLGPLSDRIERRRLL---LVLLLLFILGNLLAAlapSFALLLLARALAGLAHGGFWAIAAAYA 112
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2780227945 231 MEFIGRESRTWASMHLNTFFAIGTMLVALVSYLVKTWWLYQIILWTVTA 279
Cdd:cd17324 113 ADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
160-292 |
1.62e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.79 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 160 LFIFAMLLGAITFSYLSDRFGRR-VALWcttiGVFFFGIGSIFIF---DYFSFMAARFFL-VMTSSGYFVVVFVYVMEFI 234
Cdd:cd17320 42 AYLLGFALGQLLYGPLSDRFGRRpVLLA----GLLLFILASLLCAlasSIEQLLIARFLQgLGAAAGSVVARAIVRDLYS 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2780227945 235 GRESRTWASMhLNTFFAIGTMLVALVSYLVKTWWLYQIILWTVT----APFILCCWMLPETP 292
Cdd:cd17320 118 GAELAKIFSL-LMMILAIAPALAPLLGGLLLLFFGWRAIFVFLAllglLLLLLVLLFLPETL 178
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
337-476 |
1.64e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 41.82 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 337 SHKGAGKPSLGDLFRNPDIAKMTLIVWLDWFTVNL--GYYVFAMEAVRRKEHEHLyyLLVGAVEIPAYVFLCIWM---QR 411
Cdd:cd17332 205 KSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIvnTVLVYYFKYVLGGRAELV--LLLLLILSGALLALLPWPplkKR 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2780227945 412 VGRRKTMLTFLLMSSFICVVYVVIPsdsdtakeaKGAVALFVkvaVGSVFAFIYLYTAELYPTIM 476
Cdd:cd17332 283 FGKKKAFFIGLLLAILGLLLLFFLP---------PGNLVLIL---VLAVLAGIGYGGANLLPWAM 335
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
153-214 |
1.92e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 41.45 E-value: 1.92e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2780227945 153 YANMIQPLFI-FAMLLGAItFSYLSDRFGRRvalWCTTIGVFFFG---IGSIFIFDYFSFMAARFF 214
Cdd:cd17328 35 LAGLLQTVFIiSYMVLSPI-FGYLGDRYNRK---WILAVGILIWSaatLLSSFAPNFWQLLLFRAL 96
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
156-519 |
2.02e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.54 E-value: 2.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 156 MIQPLFIFAMLLGAITFSYLSDRFGRR--VALWCTTIGVFFFGIgsIFIFDYFSFMAARFFLVMTSSGYFVVVFVYVMEF 233
Cdd:cd17333 35 VIFSSQNAGYLIGSLLAGFLMKRLGRRrtLILGLLLISLALALI--FATPSIYLFVVLMFLAGLGAGILDTGANTFVGAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 234 IGRESRTWASMhLNTFFAIGTMLV-ALVSYLVKT---W-WLYQIILWTVTAPFIlcCWMLPETPfwllsegrykeaqgvv 308
Cdd:cd17333 113 FEESSATRLNV-LHGFFGLGALIGpLIATSLLTSelsWsWAYLIIGLIYLLLAI--LILLTLFP---------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 309 damavwnkssscdliellsLDVTRSHDKSHKGAGKPSLGDLFRNP------------DIAKMTLIVWLDWftvnlgyyvF 376
Cdd:cd17333 174 -------------------ELPSARNPQQSVGAFSASASRLLRNPsiilgalalflyVGAETAFSSWVPS---------Y 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 377 AMEAVRRKEHEHLYYLLVGAVEIPAYVFLCIWmqrVGRRKTMLTFLLMSSFICVVYVVIpsdsdtakeakgaVALFVKVA 456
Cdd:cd17333 226 LVEKKHVSDGLAGYLLSGFWVGITIGRLLGGP---ISRRIKPHTLLVLSGSGALLGLLI-------------LLLAPTLV 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 457 VGSV-FAFIYLYTAELYPTImrcLAVGSSN-------------MVSHVASMVIP-----LSQHFSKVWIFLPQILFGTLA 517
Cdd:cd17333 290 VGLVaTALLGLFMAALFPTI---LSLGISNlpyakgkgtsvllAAGSIGGAIIPfimgfIAEAVGIQTAMLLITILYAII 366
|
..
gi 2780227945 518 IL 519
Cdd:cd17333 367 FV 368
|
|
| Herpes_LMP1 |
pfam05297 |
Herpesvirus latent membrane protein 1 (LMP1); This family consists of several latent membrane ... |
650-806 |
2.12e-03 |
|
Herpesvirus latent membrane protein 1 (LMP1); This family consists of several latent membrane protein 1 or LMP1s mostly from Epstein-Barr virus. LMP1 of EBV is a 62-65 kDa plasma membrane protein possessing six membrane spanning regions, a short cytoplasmic N-terminus and a long cytoplasmic carboxy tail of 200 amino acids. EBV latent membrane protein 1 (LMP1) is essential for EBV-mediated transformation and has been associated with several cases of malignancies. EBV-like viruses in Cynomolgus monkeys (Macaca fascicularis) have been associated with high lymphoma rates in immunosuppressed monkeys
Pssm-ID: 283060 Cd Length: 386 Bit Score: 41.17 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 650 GLGRAPP--DAETGGSGRAPPNtetGGSDraPPNTESGGSgRAPPNTESRGSGRAPPE----TESGGPgRVPPDAESWGL 723
Cdd:pfam05297 230 GAGDGPPlcSQNLGAPGGGPDN---GPQD--PDNTDDNGP-QDPDNTDDNGPHDPLPQdpdnTDDNGP-QDPDNTADNGP 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 724 GKAPPDDEIGGSGraspetESGGSGQALPETESGGSGRAPPETESGGSGRAPPETESGGSGQaLPETESGGSGRAPPETE 803
Cdd:pfam05297 303 HDPLPHNPSDSAG------NDGGPPNLTEEVENKGGDQGPPLMTDGGGGHSHDSGHGGGDPH-LPTLLLGSSGSGGDDDD 375
|
...
gi 2780227945 804 SGG 806
Cdd:pfam05297 376 PHG 378
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
160-215 |
2.47e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.00 E-value: 2.47e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2780227945 160 LFIFAMLLGAITF----SYLSDRFGRR-VALWCTTIGVFFFGIGSIFIFDYFSFMAARFFL 215
Cdd:cd17477 227 LLLAAFVLGGLLLqwplGWLADRFDRRrVLLGCALLGALAALLLPLVPGLPLALLVLLFLW 287
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|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
611-777 |
3.08e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 41.31 E-value: 3.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 611 KWGLGRDPPDTERWDSGRAPPDAERWGSSGRAPSdakkWGLGRAPPDAETGGSGRAPPNTETGGSDRAPpntesgGSGRA 690
Cdd:PHA03307 769 AEALALLEPAEPQRGAGSSPPVRAEAAFRRPGRL----RRSGPAADAASRTASKRKSRSHTPDGGSESS------GPARP 838
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 691 PPntesrGSGRAPPETESGGPGRVPPDAESWGLGKaPPDDEIGGSGRASPETESGGSGQALPETESGGSGRAPPETESGG 770
Cdd:PHA03307 839 PG-----AAARPPPARSSESSKSKPAAAGGRARGK-NGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVK 912
|
....*..
gi 2780227945 771 SGRAPPE 777
Cdd:PHA03307 913 LGPMPPG 919
|
|
| Mucin-like |
pfam16058 |
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ... |
734-817 |
3.44e-03 |
|
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.
Pssm-ID: 464997 [Multi-domain] Cd Length: 94 Bit Score: 37.40 E-value: 3.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 734 GSGRASPETESGGSGQALPETESGGSgrAPPETESGGSGrAPPETESGGSGQAlPETESGGSGRAPPETESGGSgrAPPE 813
Cdd:pfam16058 14 GSYGEPPRAPSSSYTEPQRDPSSSIT--EPPADPSSSYT-EPPRDPSGSYTEP-QRDPSSSSTEPQRDPSSSIT--EPPR 87
|
....
gi 2780227945 814 TESG 817
Cdd:pfam16058 88 DPSG 91
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
672-798 |
3.91e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 40.74 E-value: 3.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 672 TGGSDRAPPNTESGGSGRAPPNTESRGSGRAPPETESGGPGRVPPdAESWGLGKAPPDDEIGGSGRASPETESGGSGQAL 751
Cdd:PRK07764 387 VAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQP-APAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQ 465
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 2780227945 752 PETESGGSGRAPPETESGGSGRAPPETESGGSGQalPETESGGSGRA 798
Cdd:PRK07764 466 PAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAA--PAAPAGADDAA 510
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
614-740 |
5.39e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 40.54 E-value: 5.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 614 LGRDPPDTerWDSGRAPPDAERWGSSGRAPSDAKKWGLGRAPPDAETGGSGRAPPNTETGGSDRAPPNT----------- 682
Cdd:PHA03307 795 AFRRPGRL--RRSGPAADAASRTASKRKSRSHTPDGGSESSGPARPPGAAARPPPARSSESSKSKPAAAggrargkngrr 872
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 683 ESGGSGRAPPNTESRGSGRAPPETESGGPGRVPPDAESWGLGKAPPD--DEIGGSGRASP 740
Cdd:PHA03307 873 RPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVKLGPMPPGgpDPRGGFRRVPP 932
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
685-829 |
8.41e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 39.97 E-value: 8.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2780227945 685 GGSGRAPPNTESRGSGRAPPETESGGPGRVPPDAEswglgkAPPddeiggsgRASPETESGGSGQALPETESGGSGRAPP 764
Cdd:PRK07764 386 GVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAA------AAP--------APAAAPQPAPAPAPAPAPPSPAGNAPAG 451
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2780227945 765 ETESGGSGRAPPETESGGSGQAlPETESGGSGRAPPETESGGSGRAPPETESGEGGSGRVSPKDK 829
Cdd:PRK07764 452 GAPSPPPAAAPSAQPAPAPAAA-PEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRER 515
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
154-214 |
8.93e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 39.48 E-value: 8.93e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2780227945 154 ANMIQPLFIFAMLLGAITFSYLSDRFGRR-VALWCTTIGVfFFGIGSIFIFDYFSFMAARFF 214
Cdd:cd17323 36 ANLGVSLFVLGFGLGPLIWAPLSELYGRRpVYLVSLFIFV-IFQIGCALAPNIAMLIILRFL 96
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