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Conserved domains on  [gi|4502403|ref|NP_001702|]
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biglycan preproprotein [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-313 2.93e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 2.93e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   92 TTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKiskihekAFSPLRKLQKLYISKNHLVEIPPNLPS--SLVELRIHDN 169
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNN 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403  170 RIRKVPKgVFSGLRNMNCIEMGGNPLENsgfEPGAFDGLK-LNYLRISEAKLTGIPKDL--PETLNELHLDHNKIQAIEl 246
Cdd:COG4886 147 QLTDLPE-PLGNLTNLKSLDLSNNQLTD---LPEELGNLTnLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLP- 221

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4502403  247 EDLLRYSKLYRLGLGHNQIRMIEngSLSFLPTLRELHLDNNKLARVPSgLPDLKLLQVVYLHSNNIT 313
Cdd:COG4886 222 EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLT 285
LRRNT smart00013
Leucine rich repeat N-terminal domain;
62-94 6.98e-12

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 59.25  E-value: 6.98e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 4502403      62 MCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTL 94
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-313 2.93e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 2.93e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   92 TTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKiskihekAFSPLRKLQKLYISKNHLVEIPPNLPS--SLVELRIHDN 169
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNN 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403  170 RIRKVPKgVFSGLRNMNCIEMGGNPLENsgfEPGAFDGLK-LNYLRISEAKLTGIPKDL--PETLNELHLDHNKIQAIEl 246
Cdd:COG4886 147 QLTDLPE-PLGNLTNLKSLDLSNNQLTD---LPEELGNLTnLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLP- 221

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4502403  247 EDLLRYSKLYRLGLGHNQIRMIEngSLSFLPTLRELHLDNNKLARVPSgLPDLKLLQVVYLHSNNIT 313
Cdd:COG4886 222 EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLT 285
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
64-297 2.54e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.43  E-value: 2.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403    64 PFGCHCHLRVVQCSDLGLKSVPKEIsPDTT-LLDLQNNDISELRKDDFKGLQhlyALVLVNNKISKIHEKAfsPlRKLQK 142
Cdd:PRK15370 215 PENLQGNIKTLYANSNQLTSIPATL-PDTIqEMELSINRITELPERLPSALQ---SLDLFHNKISCLPENL--P-EELRY 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   143 LYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMnciEMGGNPLEN--SGFEPgafdglKLNYLRISEAKL 220
Cdd:PRK15370 288 LSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKTL---EAGENALTSlpASLPP------ELQVLDVSKNQI 358

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502403   221 TGIPKDLPETLNELHLDHNKIqaieledllrysklyrlglghnqIRMIENgslsfLP-TLRELHLDNNKLARVPSGLP 297
Cdd:PRK15370 359 TVLPETLPPTITTLDVSRNAL-----------------------TNLPEN-----LPaALQIMQASRNNLVRLPESLP 408
LRRNT smart00013
Leucine rich repeat N-terminal domain;
62-94 6.98e-12

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 59.25  E-value: 6.98e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 4502403      62 MCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTL 94
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 70-293 9.61e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.96  E-value: 9.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   70 HLRvvqCSDLGLKSVPKEIS-PDTTLLDLQNNDISELRK-DDFKGLQHLYalvLVNNKISKIheKAFSPLRKLQKLYISK 147
Cdd:cd21340   6 HLY---LNDKNITKIDNLSLcKNLKVLYLYDNKITKIENlEFLTNLTHLY---LQNNQIEKI--ENLENLVNLKKLYLGG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403  148 NHL--VEippNL--PSSLVELRIHDNRIRKvpkgvfsglrnmnciemgGNPLEnsgFEPGAFDGLKlnylriseakltgi 223
Cdd:cd21340  78 NRIsvVE---GLenLTNLEELHIENQRLPP------------------GEKLT---FDPRSLAALS-------------- 119

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4502403  224 pkdlpETLNELHLDHNKIQaiELEDLLRYSKLYRLGLGHNQIRMIEN--GSLSFLPTLRELHLDNNKLARVP 293
Cdd:cd21340 120 -----NSLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
93-150 6.06e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 6.06e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 4502403     93 TLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHL 150
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 62-89 6.33e-10

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 53.79  E-value: 6.33e-10
                          10        20
                  ....*....|....*....|....*...
gi 4502403     62 MCPFGCHCHLRVVQCSDLGLKSVPKEIS 89
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-313 2.93e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 2.93e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   92 TTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKiskihekAFSPLRKLQKLYISKNHLVEIPPNLPS--SLVELRIHDN 169
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNN 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403  170 RIRKVPKgVFSGLRNMNCIEMGGNPLENsgfEPGAFDGLK-LNYLRISEAKLTGIPKDL--PETLNELHLDHNKIQAIEl 246
Cdd:COG4886 147 QLTDLPE-PLGNLTNLKSLDLSNNQLTD---LPEELGNLTnLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLP- 221

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4502403  247 EDLLRYSKLYRLGLGHNQIRMIEngSLSFLPTLRELHLDNNKLARVPSgLPDLKLLQVVYLHSNNIT 313
Cdd:COG4886 222 EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-311 1.80e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 1.80e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   70 HLRVVQCSDLGLKSVPKEISPDTTL--LDLQNNDISELRkDDFKGLQHLYALVLVNNKISKIhEKAFSPLRKLQKLYISK 147
Cdd:COG4886 114 NLESLDLSGNQLTDLPEELANLTNLkeLDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSN 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403  148 NHLVEIPPNL--PSSLVELRIHDNRIRKVPKGvFSGLRNMNCIEMGGNPLEnsgfEPGAFDGL-KLNYLRISEAKLTGIP 224
Cdd:COG4886 192 NQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT----DLPELGNLtNLEELDLSNNQLTDLP 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403  225 KDLP-ETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIE-NGSLSFLPTLRELHLDNNKLARVPSGLPDLKLL 302
Cdd:COG4886 267 PLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLElLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346


                ....*....
gi 4502403  303 QVVYLHSNN 311
Cdd:COG4886 347 LALLTLLLL 355
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
64-297 2.54e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.43  E-value: 2.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403    64 PFGCHCHLRVVQCSDLGLKSVPKEIsPDTT-LLDLQNNDISELRKDDFKGLQhlyALVLVNNKISKIHEKAfsPlRKLQK 142
Cdd:PRK15370 215 PENLQGNIKTLYANSNQLTSIPATL-PDTIqEMELSINRITELPERLPSALQ---SLDLFHNKISCLPENL--P-EELRY 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   143 LYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMnciEMGGNPLEN--SGFEPgafdglKLNYLRISEAKL 220
Cdd:PRK15370 288 LSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKTL---EAGENALTSlpASLPP------ELQVLDVSKNQI 358

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502403   221 TGIPKDLPETLNELHLDHNKIqaieledllrysklyrlglghnqIRMIENgslsfLP-TLRELHLDNNKLARVPSGLP 297
Cdd:PRK15370 359 TVLPETLPPTITTLDVSRNAL-----------------------TNLPEN-----LPaALQIMQASRNNLVRLPESLP 408
LRRNT smart00013
Leucine rich repeat N-terminal domain;
62-94 6.98e-12

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 59.25  E-value: 6.98e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 4502403      62 MCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTL 94
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 70-293 9.61e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.96  E-value: 9.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   70 HLRvvqCSDLGLKSVPKEIS-PDTTLLDLQNNDISELRK-DDFKGLQHLYalvLVNNKISKIheKAFSPLRKLQKLYISK 147
Cdd:cd21340   6 HLY---LNDKNITKIDNLSLcKNLKVLYLYDNKITKIENlEFLTNLTHLY---LQNNQIEKI--ENLENLVNLKKLYLGG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403  148 NHL--VEippNL--PSSLVELRIHDNRIRKvpkgvfsglrnmnciemgGNPLEnsgFEPGAFDGLKlnylriseakltgi 223
Cdd:cd21340  78 NRIsvVE---GLenLTNLEELHIENQRLPP------------------GEKLT---FDPRSLAALS-------------- 119

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4502403  224 pkdlpETLNELHLDHNKIQaiELEDLLRYSKLYRLGLGHNQIRMIEN--GSLSFLPTLRELHLDNNKLARVP 293
Cdd:cd21340 120 -----NSLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
93-150 6.06e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 6.06e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 4502403     93 TLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHL 150
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 62-89 6.33e-10

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 53.79  E-value: 6.33e-10
                          10        20
                  ....*....|....*....|....*...
gi 4502403     62 MCPFGCHCHLRVVQCSDLGLKSVPKEIS 89
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 231-313 1.99e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 1.99e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403  231 LNELHLDHNKIQAIE-LEDLLRYSKLYrlgLGHNQIRMIENgsLSFLPTLRELHLDNNKLArvpsglPDLKL-------- 301
Cdd:cd21340  48 LTHLYLQNNQIEKIEnLENLVNLKKLY---LGGNRISVVEG--LENLTNLEELHIENQRLP------PGEKLtfdprsla 116

                        90
                ....*....|....*..
gi 4502403  302 -----LQVVYLHSNNIT 313
Cdd:cd21340 117 alsnsLRVLNISGNNID 133
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 78-313 6.82e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 6.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403    78 DLGLKSVPKEIsPDTtLLDLQNNDISELRKDDFKG--------LQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNH 149
Cdd:PLN00113 290 DLSDNSLSGEI-PEL-VIQLQNLEILHLFSNNFTGkipvaltsLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNN 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   150 LV-EIPPNLPSS--LVELRIHDNRIR-KVPKGVfSGLRNMNCIEMGGNPLenSGFEPGAFDGLKL-NYLRISEAKLTG-- 222
Cdd:PLN00113 368 LTgEIPEGLCSSgnLFKLILFSNSLEgEIPKSL-GACRSLRRVRLQDNSF--SGELPSEFTKLPLvYFLDISNNNLQGri 444

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   223 --IPKDLPeTLNELHLDHNKIQAiELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLA-RVPSGLPDL 299
Cdd:PLN00113 445 nsRKWDMP-SLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSC 522

                        250
                 ....*....|....
gi 4502403   300 KLLQVVYLHSNNIT 313
Cdd:PLN00113 523 KKLVSLDLSHNQLS 536
LRR_8 pfam13855
Leucine rich repeat;
230-289 2.20e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.20e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403    230 TLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKL 289
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 234-315 2.75e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 2.75e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403  234 LHLDHNKIQAIEleDLLRYSKLYRLGLGHNQIRMIENgsLSFLPTLRELHLDNNKLARVPsGLPDLKLLQVVYLHSNNIT 313
Cdd:cd21340   7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRIS 81


                ..
gi 4502403  314 KV 315
Cdd:cd21340  82 VV 83
LRR_8 pfam13855
Leucine rich repeat;
114-171 3.29e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 3.29e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4502403    114 QHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPN----LPsSLVELRIHDNRI 171
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGafsgLP-SLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 95-321 4.58e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.74  E-value: 4.58e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   95 LDLQNNDISELRKDD-FKGLQHLYALVLVNNKISKIHEKAFS----PLRKLQKLYISKNHLVEIPPNLPS---------S 160
Cdd:cd00116   3 LSLKGELLKTERATElLPKLLCLQVLRLEGNTLGEEAAKALAsalrPQPSLKELCLSLNETGRIPRGLQSllqgltkgcG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403  161 LVELRIHDNRIRKVPKGVF-SGLRNMNCIEMggnPLENSGFEPGAF----DGLK----------LNYLRISEAKLTGIPK 225
Cdd:cd00116  83 LQELDLSDNALGPDGCGVLeSLLRSSSLQEL---KLNNNGLGDRGLrllaKGLKdlppaleklvLGRNRLEGASCEALAK 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403  226 DLPE--TLNELHLDHNKI--QAIEL--EDLLRYSKLYRLGLGHNQIRMIE----NGSLSFLPTLRELHLDNNKLARVP-- 293
Cdd:cd00116 160 ALRAnrDLKELNLANNGIgdAGIRAlaEGLKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTDAGaa 239

                       250       260       270
                ....*....|....*....|....*....|..
gi 4502403  294 ---SGLPDL-KLLQVVYLHSNNITKVGVNDFC 321
Cdd:cd00116 240 alaSALLSPnISLLTLSLSCNDITDDGAKDLA 271
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 84-313 8.14e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 8.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403    84 VPKEISPDTTL--LDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLV-EIPpnlpss 160
Cdd:PLN00113 228 IPYEIGGLTSLnhLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIP------ 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   161 lvELRIHdnrirkvpkgvfsgLRNMNCIEMGGNPLenSGFEPGAFDGL-KLNYLRISEAKLTG-IPKDLPE--TLNELHL 236
Cdd:PLN00113 302 --ELVIQ--------------LQNLEILHLFSNNF--TGKIPVALTSLpRLQVLQLWSNKFSGeIPKNLGKhnNLTVLDL 363

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502403   237 DHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLA-RVPSGLPDLKLLQVVYLHSNNIT 313
Cdd:PLN00113 364 STNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQ 441
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
206-343 9.24e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 9.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   206 DGLKLN--YLRISEAKLTGIPKDLPETLNELHLDHNKIQAIElEDLlrYSKLYRLGLGHNQIRMIEngslSFLP-TLREL 282
Cdd:PRK15370 174 DCLKNNktELRLKILGLTTIPACIPEQITTLILDNNELKSLP-ENL--QGNIKTLYANSNQLTSIP----ATLPdTIQEM 246

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4502403   283 HLDNNKLARVPSGLPdlKLLQVVYLHSNNITkvGVNDFCPMGFGVKRAYYNGISLFNNPVP 343
Cdd:PRK15370 247 ELSINRITELPERLP--SALQSLDLFHNKIS--CLPENLPEELRYLSVYDNSIRTLPAHLP 303
LRR_8 pfam13855
Leucine rich repeat;
253-312 1.12e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.12e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4502403    253 SKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLARV-PSGLPDLKLLQVVYLHSNNI 312
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
159-241 9.47e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 9.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403    159 SSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLenSGFEPGAFDGLKLnylriseakltgipkdlpetLNELHLDH 238
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPS--------------------LRYLDLSG 58


                  ...
gi 4502403    239 NKI 241
Cdd:pfam13855  59 NRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-251 1.10e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 1.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   71 LRVVQCSDLGLKSVPKEISPDTTL--LDLQNNDISELrkDDFKGLQHLYALVLVNNKISKIHEkaFSPLRKLQKLYISKN 148
Cdd:COG4886 207 LEELDLSGNQLTDLPEPLANLTNLetLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNN 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403  149 HLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLP 228
Cdd:COG4886 283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362

                       170       180
                ....*....|....*....|...
gi 4502403  229 ETLNELHLDHNKIQAIELEDLLR 251
Cdd:COG4886 363 LTLLLTLGLLGLLEATLLTLALL 385
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 95-313 1.21e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403    95 LDLQNNDISELRKDDFKGLQHLYALVLVNNKIS-KIHEKAFSPLRKLQKLYISKNHLV-EIPPNLPSSLVELRIHDNRIR 172
Cdd:PLN00113  74 IDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   173 -KVPK--GVFSGLRnmnCIEMGGNPLenSGFEPGAFDGL-KLNYLRISEAKLTG-IPKDLPETLNelhldhnkiqaiele 247
Cdd:PLN00113 154 gEIPNdiGSFSSLK---VLDLGGNVL--VGKIPNSLTNLtSLEFLTLASNQLVGqIPRELGQMKS--------------- 213

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4502403   248 dllryskLYRLGLGHNQIR---MIENGSLSFLPtlrelHLD---NNKLARVPSGLPDLKLLQVVYLHSNNIT 313
Cdd:PLN00113 214 -------LKWIYLGYNNLSgeiPYEIGGLTSLN-----HLDlvyNNLTGPIPSSLGNLKNLQYLFLYQNKLS 273
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
140-282 9.40e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.30  E-value: 9.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   140 LQKLYISKNHLVEIPpNLPSSLVELRIHDNRIRKVPkGVFSGLRNMnciEMGGNPLENSGFEPGafdglKLNYLRISEAK 219
Cdd:PRK15387 344 LQELSVSDNQLASLP-TLPSELYKLWAYNNRLTSLP-ALPSGLKEL---IVSGNRLTSLPVLPS-----ELKELMVSGNR 413

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4502403   220 LTGIPKdLPETLNELHLDHNKIQAIElEDLLRYSKLYRLGLGHNQIrmiengSLSFLPTLREL 282
Cdd:PRK15387 414 LTSLPM-LPSGLLSLSVYRNQLTRLP-ESLIHLSSETTVNLEGNPL------SERTLQALREI 468
LRR_9 pfam14580
Leucine-rich repeat;
95-175 9.97e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.75  E-value: 9.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403     95 LDLQNNDISELrkDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLP----SSLVELRIHDNR 170
Cdd:pfam14580  47 IDFSDNEIRKL--DGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDPlaslKKLTFLSLLRNP 124


                  ....*
gi 4502403    171 IRKVP 175
Cdd:pfam14580 125 VTNKP 129
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 75-266 8.46e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 37.85  E-value: 8.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403   75 QCSDLGLKSVPKEISPDTTL--LDLQNNDISELRKDDF----KGLQHLYALVLVNNKISK--IHE--KAFSPLRKLQKLY 144
Cdd:COG5238 191 QIGDEGIEELAEALTQNTTVttLWLKRNPIGDEGAEILaealKGNKSLTTLDLSNNQIGDegVIAlaEALKNNTTVETLY 270

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502403  145 ISKNHLVE-----IPPNL--PSSLVELRIHDNRIRKvpKGVFS---GLRNMNCIE---MGGNPLENSGFEPGAfDGLKLN 211
Cdd:COG5238 271 LSGNQIGAegaiaLAKALqgNTTLTSLDLSVNRIGD--EGAIAlaeGLQGNKTLHtlnLAYNGIGAQGAIALA-KALQEN 347

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502403  212 YL---------RISEAKLTGIPKDLPE--TLNELHLDHNKI---QAIELEDLLRYSKLYRLGLGHNQIR 266
Cdd:COG5238 348 TTlhsldlsdnQIGDEGAIALAKYLEGntTLRELNLGKNNIgkqGAEALIDALQTNRLHTLILDGNLIG 416
LRR_8 pfam13855
Leucine rich repeat;
277-323 9.21e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 9.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 4502403    277 PTLRELHLDNNKLARVPSG-LPDLKLLQVVYLHSNNITKVGVNDFCPM 323
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSGL 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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