NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21361571|ref|NP_001769|]
View 

CD48 antigen isoform 1 precursor [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 11566358)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 36-128 3.04e-25

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


:

Pssm-ID: 409431  Cd Length: 98  Bit Score: 95.11  E-value: 3.04e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361571  36 VSGSNVTLNISeSLPENYKQLTWFYTfDQKIVEWD-SRKSKYFESkFKGRVRLDPQSGALYISKVQKEDNSTYIMRVLKK 114
Cdd:cd05775   8 ALGGNVTLTIS-SLQDDIDEIKWKKT-KDKIVEWEnNIGPTYFGS-FKDRVLLDKESGSLTIKNLTKEDSGTYELEITST 84

                        90
                ....*....|....
gi 21361571 115 TGNEQEWKIKLQVL 128
Cdd:cd05775  85 NGKVLSSKFTLEVL 98
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 133-218 8.83e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


:

Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 34.29  E-value: 8.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361571   133 KPVIKIEKIEdMDDNCYLKLSCVIPG-ESVNYTWYGDKRPFPKELQNSVLETTLmphNYSRCYTCQVSNSvssknGTVCL 211
Cdd:pfam13895   1 KPVLTPSPTV-VTEGEPVTLTCSAPGnPPPSYTWYKDGSAISSSPNFFTLSVSA---EDSGTYTCVARNG-----RGGKV 71


                  ....*..
gi 21361571   212 SPPCTLA 218
Cdd:pfam13895  72 SNPVELT 78
 
Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 36-128 3.04e-25

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 95.11  E-value: 3.04e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361571  36 VSGSNVTLNISeSLPENYKQLTWFYTfDQKIVEWD-SRKSKYFESkFKGRVRLDPQSGALYISKVQKEDNSTYIMRVLKK 114
Cdd:cd05775   8 ALGGNVTLTIS-SLQDDIDEIKWKKT-KDKIVEWEnNIGPTYFGS-FKDRVLLDKESGSLTIKNLTKEDSGTYELEITST 84

                        90
                ....*....|....
gi 21361571 115 TGNEQEWKIKLQVL 128
Cdd:cd05775  85 NGKVLSSKFTLEVL 98
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 33-128 2.65e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 39.36  E-value: 2.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361571    33 MTVVSGSNVTLNISESLPENYKQL--TWFY-----TFDQKIVEWdsrKSKYFESKFKGRVRL----DPQSGALYISKVQK 101
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSSMSEASTsvYWYRqppgkGPTFLIAYY---SNGSEEGVKKGRFSGrgdpSNGDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....*..
gi 21361571   102 EDNSTYIMRVLKKTGNEQEWKIKLQVL 128
Cdd:pfam07686  83 SDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 32-127 3.86e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.56  E-value: 3.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361571     32 HMTVVSGSNVTLNISESLPENYkQLTWFYTFDQKIvewdsrkskyfesKFKGRVRLDPQSGA--LYISKVQKEDNSTYIM 109
Cdd:smart00410   3 SVTVKEGESVTLSCEASGSPPP-EVTWYKQGGKLL-------------AESGRFSVSRSGSTstLTISNVTPEDSGTYTC 68

                           90
                   ....*....|....*...
gi 21361571    110 RVlKKTGNEQEWKIKLQV 127
Cdd:smart00410  69 AA-TNSSGSASSGTTLTV 85
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 133-218 8.83e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 34.29  E-value: 8.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361571   133 KPVIKIEKIEdMDDNCYLKLSCVIPG-ESVNYTWYGDKRPFPKELQNSVLETTLmphNYSRCYTCQVSNSvssknGTVCL 211
Cdd:pfam13895   1 KPVLTPSPTV-VTEGEPVTLTCSAPGnPPPSYTWYKDGSAISSSPNFFTLSVSA---EDSGTYTCVARNG-----RGGKV 71


                  ....*..
gi 21361571   212 SPPCTLA 218
Cdd:pfam13895  72 SNPVELT 78
 
Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 36-128 3.04e-25

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 95.11  E-value: 3.04e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361571  36 VSGSNVTLNISeSLPENYKQLTWFYTfDQKIVEWD-SRKSKYFESkFKGRVRLDPQSGALYISKVQKEDNSTYIMRVLKK 114
Cdd:cd05775   8 ALGGNVTLTIS-SLQDDIDEIKWKKT-KDKIVEWEnNIGPTYFGS-FKDRVLLDKESGSLTIKNLTKEDSGTYELEITST 84

                        90
                ....*....|....
gi 21361571 115 TGNEQEWKIKLQVL 128
Cdd:cd05775  85 NGKVLSSKFTLEVL 98
IgV_CEACAM_like cd05741
Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 35-127 7.88e-06

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409403  Cd Length: 102  Bit Score: 43.66  E-value: 7.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361571  35 VVSGSNVTLNISeSLPENYKQLTWFYT----FDQKIVEWDSRKSKYFESK-FKGRVRLDPqSGALYISKVQKEDNSTYIM 109
Cdd:cd05741   7 GAEGKNVLLLVP-NLQTPLKSVSWYKGkqvsRNDEIAEYENSSDEFRAGSaFSGREYIYT-NGSLLIQNITLSDTGFYTL 84

                        90
                ....*....|....*...
gi 21361571 110 RVLKKTGNEQEWKIKLQV 127
Cdd:cd05741  85 ESTNIGGKTESATFQLHV 102
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 33-128 2.65e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 39.36  E-value: 2.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361571    33 MTVVSGSNVTLNISESLPENYKQL--TWFY-----TFDQKIVEWdsrKSKYFESKFKGRVRL----DPQSGALYISKVQK 101
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSSMSEASTsvYWYRqppgkGPTFLIAYY---SNGSEEGVKKGRFSGrgdpSNGDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....*..
gi 21361571   102 EDNSTYIMRVLKKTGNEQEWKIKLQVL 128
Cdd:pfam07686  83 SDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 32-127 3.86e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.56  E-value: 3.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361571     32 HMTVVSGSNVTLNISESLPENYkQLTWFYTFDQKIvewdsrkskyfesKFKGRVRLDPQSGA--LYISKVQKEDNSTYIM 109
Cdd:smart00410   3 SVTVKEGESVTLSCEASGSPPP-EVTWYKQGGKLL-------------AESGRFSVSRSGSTstLTISNVTPEDSGTYTC 68

                           90
                   ....*....|....*...
gi 21361571    110 RVlKKTGNEQEWKIKLQV 127
Cdd:smart00410  69 AA-TNSSGSASSGTTLTV 85
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 133-218 8.83e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 34.29  E-value: 8.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361571   133 KPVIKIEKIEdMDDNCYLKLSCVIPG-ESVNYTWYGDKRPFPKELQNSVLETTLmphNYSRCYTCQVSNSvssknGTVCL 211
Cdd:pfam13895   1 KPVLTPSPTV-VTEGEPVTLTCSAPGnPPPSYTWYKDGSAISSSPNFFTLSVSA---EDSGTYTCVARNG-----RGGKV 71


                  ....*..
gi 21361571   212 SPPCTLA 218
Cdd:pfam13895  72 SNPVELT 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH