transcriptional repressor NF-X1 isoform 1 [Homo sapiens]
Protein Classification
transcriptional repressor NF-X1( domain architecture ID 11616333)
transcriptional repressor NF-X1 is a transcription factor that regulates the expression of class II major histocompatibility complex (MHC) genes
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| R3H_NF-X1 | cd02643 | R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a ... |
987-1060 | 1.37e-39 | ||
R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a transcription factor that regulates the expression of class II major histocompatibility complex (MHC) genes. The Drosophila homolog shuttle craft (STC) has been shown to be a DNA- or RNA-binding protein required for proper axon guidance in the central nervous system and, the yeast homolog FAP1 encodes a dosage suppressor of rapamycin toxicity. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner. : Pssm-ID: 100072 Cd Length: 74 Bit Score: 140.96 E-value: 1.37e-39
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| RING-CH-C4HC3_NFX1 | cd16696 | RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar ... |
356-409 | 3.22e-28 | ||
RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar proteins; NF-X1, also known as nuclear transcription factor, X box-binding protein 1, is a novel cysteine-rich sequence-specific DNA-binding protein that interacts with the conserved X-box motif of the human major histocompatibility complex (MHC) class II genes via a repeated Cys-His domain. It functions as a cytokine-inducible transcriptional repressor that plays an important role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by interferon gamma (IFN- gamma). NFX1 contains an N-terminal PAM2 motif, a C4HC3-type RING-CH finger, a Cys-rich region that harbors several NFX1-type zinc fingers, and a C-terminal R3H domain. : Pssm-ID: 438357 [Multi-domain] Cd Length: 55 Bit Score: 107.90 E-value: 3.22e-28
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
622-674 | 1.18e-12 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. : Pssm-ID: 100116 Cd Length: 49 Bit Score: 63.13 E-value: 1.18e-12
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
496-544 | 3.80e-10 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. : Pssm-ID: 100116 Cd Length: 49 Bit Score: 56.20 E-value: 3.80e-10
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
711-763 | 1.76e-08 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. : Pssm-ID: 100116 Cd Length: 49 Bit Score: 51.58 E-value: 1.76e-08
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
557-599 | 2.34e-08 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. : Pssm-ID: 100116 Cd Length: 49 Bit Score: 51.19 E-value: 2.34e-08
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
684-732 | 5.58e-06 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. : Pssm-ID: 100116 Cd Length: 49 Bit Score: 44.26 E-value: 5.58e-06
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
822-867 | 1.63e-05 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. : Pssm-ID: 100116 Cd Length: 49 Bit Score: 43.10 E-value: 1.63e-05
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| Name | Accession | Description | Interval | E-value | ||
| R3H_NF-X1 | cd02643 | R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a ... |
987-1060 | 1.37e-39 | ||
R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a transcription factor that regulates the expression of class II major histocompatibility complex (MHC) genes. The Drosophila homolog shuttle craft (STC) has been shown to be a DNA- or RNA-binding protein required for proper axon guidance in the central nervous system and, the yeast homolog FAP1 encodes a dosage suppressor of rapamycin toxicity. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner. Pssm-ID: 100072 Cd Length: 74 Bit Score: 140.96 E-value: 1.37e-39
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| RING-CH-C4HC3_NFX1 | cd16696 | RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar ... |
356-409 | 3.22e-28 | ||
RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar proteins; NF-X1, also known as nuclear transcription factor, X box-binding protein 1, is a novel cysteine-rich sequence-specific DNA-binding protein that interacts with the conserved X-box motif of the human major histocompatibility complex (MHC) class II genes via a repeated Cys-His domain. It functions as a cytokine-inducible transcriptional repressor that plays an important role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by interferon gamma (IFN- gamma). NFX1 contains an N-terminal PAM2 motif, a C4HC3-type RING-CH finger, a Cys-rich region that harbors several NFX1-type zinc fingers, and a C-terminal R3H domain. Pssm-ID: 438357 [Multi-domain] Cd Length: 55 Bit Score: 107.90 E-value: 3.22e-28
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| R3H | smart00393 | Putative single-stranded nucleic acids-binding domain; |
983-1060 | 2.10e-23 | ||
Putative single-stranded nucleic acids-binding domain; Pssm-ID: 214647 Cd Length: 79 Bit Score: 95.06 E-value: 2.10e-23
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| R3H | pfam01424 | R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ... |
995-1059 | 1.24e-18 | ||
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA. Pssm-ID: 460206 Cd Length: 60 Bit Score: 80.61 E-value: 1.24e-18
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
622-674 | 1.18e-12 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. Pssm-ID: 100116 Cd Length: 49 Bit Score: 63.13 E-value: 1.18e-12
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
496-544 | 3.80e-10 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. Pssm-ID: 100116 Cd Length: 49 Bit Score: 56.20 E-value: 3.80e-10
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| Jag | COG1847 | Predicted RNA-binding protein Jag (SpoIIIJ-associated), conains KH and R3H domains [General ... |
1001-1059 | 1.66e-09 | ||
Predicted RNA-binding protein Jag (SpoIIIJ-associated), conains KH and R3H domains [General function prediction only]; Pssm-ID: 441452 [Multi-domain] Cd Length: 143 Bit Score: 57.43 E-value: 1.66e-09
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
711-763 | 1.76e-08 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. Pssm-ID: 100116 Cd Length: 49 Bit Score: 51.58 E-value: 1.76e-08
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
557-599 | 2.34e-08 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. Pssm-ID: 100116 Cd Length: 49 Bit Score: 51.19 E-value: 2.34e-08
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
684-732 | 5.58e-06 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. Pssm-ID: 100116 Cd Length: 49 Bit Score: 44.26 E-value: 5.58e-06
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
822-867 | 1.63e-05 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. Pssm-ID: 100116 Cd Length: 49 Bit Score: 43.10 E-value: 1.63e-05
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| Jag_EloR | NF041568 | RNA-binding cell elongation regulator Jag/EloR; Members of this family are nucleic ... |
994-1059 | 3.72e-04 | ||
RNA-binding cell elongation regulator Jag/EloR; Members of this family are nucleic acid-binding proteins (RNA or single-stranded DNA) with a KH domain at the N-terminus, an R3H domain at the C-terminus, and additional regions of homology. The founding member of this family was JAG (spoIIIJ Associated Gene) from Bacillus subtilis, but later work in other lineages, such as Streptococcus pneumoniae, as established a role in controlling cell elongation and the operation of the elongasome. The S. pneumoniae protein, a protein that undergoes regulatory phosphorylation and dephosphorylation, is also called RNA-binding cell elongation regulator EloR, and also KhpB. Pssm-ID: 469453 [Multi-domain] Cd Length: 203 Bit Score: 42.81 E-value: 3.72e-04
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| COG5219 | COG5219 | Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]; |
357-409 | 9.61e-04 | ||
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]; Pssm-ID: 227544 [Multi-domain] Cd Length: 1525 Bit Score: 43.50 E-value: 9.61e-04
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| zf-NF-X1 | pfam01422 | NF-X1 type zinc finger; This domain is presumed to be a zinc binding domain. The following ... |
567-585 | 3.90e-03 | ||
NF-X1 type zinc finger; This domain is presumed to be a zinc binding domain. The following pattern describes the zinc finger. C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C Where X can be any amino acid, and numbers in brackets indicate the number of residues. Two position can be either his or cys. This family includes Swiss:P40798, Swiss:Q12986 and Swiss:P53971. The zinc fingers in Swiss:Q12986 bind to DNA. Pssm-ID: 460205 Cd Length: 19 Bit Score: 35.58 E-value: 3.90e-03
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| zf-NF-X1 | pfam01422 | NF-X1 type zinc finger; This domain is presumed to be a zinc binding domain. The following ... |
721-739 | 6.00e-03 | ||
NF-X1 type zinc finger; This domain is presumed to be a zinc binding domain. The following pattern describes the zinc finger. C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C Where X can be any amino acid, and numbers in brackets indicate the number of residues. Two position can be either his or cys. This family includes Swiss:P40798, Swiss:Q12986 and Swiss:P53971. The zinc fingers in Swiss:Q12986 bind to DNA. Pssm-ID: 460205 Cd Length: 19 Bit Score: 35.20 E-value: 6.00e-03
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| Name | Accession | Description | Interval | E-value | ||
| R3H_NF-X1 | cd02643 | R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a ... |
987-1060 | 1.37e-39 | ||
R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a transcription factor that regulates the expression of class II major histocompatibility complex (MHC) genes. The Drosophila homolog shuttle craft (STC) has been shown to be a DNA- or RNA-binding protein required for proper axon guidance in the central nervous system and, the yeast homolog FAP1 encodes a dosage suppressor of rapamycin toxicity. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner. Pssm-ID: 100072 Cd Length: 74 Bit Score: 140.96 E-value: 1.37e-39
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| RING-CH-C4HC3_NFX1 | cd16696 | RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar ... |
356-409 | 3.22e-28 | ||
RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar proteins; NF-X1, also known as nuclear transcription factor, X box-binding protein 1, is a novel cysteine-rich sequence-specific DNA-binding protein that interacts with the conserved X-box motif of the human major histocompatibility complex (MHC) class II genes via a repeated Cys-His domain. It functions as a cytokine-inducible transcriptional repressor that plays an important role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by interferon gamma (IFN- gamma). NFX1 contains an N-terminal PAM2 motif, a C4HC3-type RING-CH finger, a Cys-rich region that harbors several NFX1-type zinc fingers, and a C-terminal R3H domain. Pssm-ID: 438357 [Multi-domain] Cd Length: 55 Bit Score: 107.90 E-value: 3.22e-28
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| R3H | smart00393 | Putative single-stranded nucleic acids-binding domain; |
983-1060 | 2.10e-23 | ||
Putative single-stranded nucleic acids-binding domain; Pssm-ID: 214647 Cd Length: 79 Bit Score: 95.06 E-value: 2.10e-23
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| RING-CH-C4HC3_NFX1-like | cd16492 | RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1, NF-X1-type ... |
356-409 | 3.95e-19 | ||
RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1, NF-X1-type zinc finger protein NFXL1, and similar proteins; NF-X1, also known as nuclear transcription factor, X box-binding protein 1, is a novel cysteine-rich sequence-specific DNA-binding protein that interacts with the conserved X-box motif of the human major histocompatibility complex (MHC) class II genes via a repeated Cys-His domain. It functions as a cytokine-inducible transcriptional repressor that plays an important role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by interferon gamma (IFN- gamma). NFXL1, also known as NF-X1-type zinc finger protein NFXL1 or ovarian zinc finger protein (OZFP), is encoded by a novel human cytoplasm-distribution zinc finger protein (CDZFP) gene. This subfamily also includes NF-X1 homologs from insects, plants, and fungi. Drosophila melanogaster shuttle craft (STC) is a DNA- or RNA-binding protein required for proper axon guidance in the central nervous system. It functions as a putative transcription factor and plays an essential role in the completion of embryonic development. In contrast to NF-X1, STC contains an RD domain. The Arabidopsis genome encodes two NF-X1 homologs, AtNFXL1 and AtNFXL2, both of which function as regulators of salt stress responses. The AtNFXL1 protein is a nuclear factor that positively affects adaptation to salt stress. It also functions as a negative regulator of the type A trichothecene phytotoxin-induced defense response. AtNFXL2 controls abscisic acid (ABA) levels and suppresses ABA responses. It may also prevent unnecessary and costly stress adaptation under favorable conditions. FKBP12-associated protein 1 (FAP1) is a dosage suppressor of rapamycin toxicity in budding yeast. It is localized in the cytoplasm, but upon rapamycin treatment translocates to the nucleus. FAP1 interacts with FKBP12 in a rapamycin-sensitive manner. It is a proline-rich protein containing a novel cysteine-rich DNA-binding motif. Unique structural features of the NFX1 and NFXL proteins are the Cys-rich region and a specific RING-CH finger motif with an unusual arrangement of zinc-coordinating residues. The Cys-rich region is required for binding to specific promoter elements. It frequently comprises more than 500 amino acids and harbors several NFX1-type zinc finger domains, characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The RING-CH finger, also known as vRING or RINGv, may have E3 ligase activity. It is characterized by a C4HC3-type Zn ligand signature and additional conserved amino acids, rather than the C3H2C3-type cysteines and histidines arrangement in canonical RING-H2 finger. In addition to the Cys-rich region and RING-CH finger, NFX1 contains a PAM2 motif in the N-terminus and a R3H domain in the C-terminus. Pssm-ID: 438155 [Multi-domain] Cd Length: 58 Bit Score: 82.10 E-value: 3.95e-19
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| R3H | pfam01424 | R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ... |
995-1059 | 1.24e-18 | ||
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA. Pssm-ID: 460206 Cd Length: 60 Bit Score: 80.61 E-value: 1.24e-18
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| R3H | cd02325 | R3H domain. The name of the R3H domain comes from the characteristic spacing of the most ... |
997-1059 | 2.68e-17 | ||
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich repeats, ring-type zinc fingers, and KH domains. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner. Pssm-ID: 100064 Cd Length: 59 Bit Score: 76.88 E-value: 2.68e-17
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| R3H_unknown_2 | cd06006 | R3H domain of a group of fungal proteins with unknown function. The name of the R3H domain ... |
1016-1058 | 7.54e-13 | ||
R3H domain of a group of fungal proteins with unknown function. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner. Pssm-ID: 100076 Cd Length: 59 Bit Score: 64.31 E-value: 7.54e-13
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
622-674 | 1.18e-12 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. Pssm-ID: 100116 Cd Length: 49 Bit Score: 63.13 E-value: 1.18e-12
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| RING-CH-C4HC3_NFXL1 | cd16697 | RING-CH finger, H2 subclass (C4HC3-type), found in nuclear transcription factor, X-box ... |
357-408 | 9.02e-11 | ||
RING-CH finger, H2 subclass (C4HC3-type), found in nuclear transcription factor, X-box binding-like 1 (NFXL1) and similar proteins; NFXL1, also known as NF-X1-type zinc finger protein NFXL1, or ovarian zinc finger protein (OZFP), is encoded by the novel human cytoplasm-distribution zinc finger protein (CDZFP) gene. It is a putative zinc finger protein with a C4HC3-type RING-CH finger and a Cys-rich region that harbors several NFX1-type zinc fingers. Pssm-ID: 438358 Cd Length: 63 Bit Score: 58.51 E-value: 9.02e-11
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
496-544 | 3.80e-10 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. Pssm-ID: 100116 Cd Length: 49 Bit Score: 56.20 E-value: 3.80e-10
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| Jag | COG1847 | Predicted RNA-binding protein Jag (SpoIIIJ-associated), conains KH and R3H domains [General ... |
1001-1059 | 1.66e-09 | ||
Predicted RNA-binding protein Jag (SpoIIIJ-associated), conains KH and R3H domains [General function prediction only]; Pssm-ID: 441452 [Multi-domain] Cd Length: 143 Bit Score: 57.43 E-value: 1.66e-09
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| R3H_jag | cd02644 | R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with ... |
1001-1059 | 1.93e-09 | ||
R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner. Pssm-ID: 100073 Cd Length: 67 Bit Score: 54.79 E-value: 1.93e-09
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
711-763 | 1.76e-08 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. Pssm-ID: 100116 Cd Length: 49 Bit Score: 51.58 E-value: 1.76e-08
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
557-599 | 2.34e-08 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. Pssm-ID: 100116 Cd Length: 49 Bit Score: 51.19 E-value: 2.34e-08
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
684-732 | 5.58e-06 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. Pssm-ID: 100116 Cd Length: 49 Bit Score: 44.26 E-value: 5.58e-06
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| NF-X1-zinc-finger | cd06008 | Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ... |
822-867 | 1.63e-05 | ||
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms. Pssm-ID: 100116 Cd Length: 49 Bit Score: 43.10 E-value: 1.63e-05
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| R3H_G-patch | cd02646 | R3H domain of a group of fungal and plant proteins with unknown function, who also contain a ... |
999-1059 | 4.49e-05 | ||
R3H domain of a group of fungal and plant proteins with unknown function, who also contain a G-patch domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the R3H domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner. Pssm-ID: 100075 Cd Length: 58 Bit Score: 42.17 E-value: 4.49e-05
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| R3H_encore_like | cd02642 | R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ... |
993-1059 | 8.17e-05 | ||
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner. Pssm-ID: 100071 Cd Length: 63 Bit Score: 41.43 E-value: 8.17e-05
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| RING-H2 | cd16448 | H2 subclass of RING (RING-H2) fingers and its variants; The RING finger is a specialized type ... |
358-409 | 2.00e-04 | ||
H2 subclass of RING (RING-H2) fingers and its variants; The RING finger is a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc. It is defined by the "cross-brace" motif that chelates zinc atoms by eight amino acid residues, typically Cys or His, arranged in a characteristic spacing. Canonical RING motifs have been categorized into two major subclasses, RING-HC (C3HC4-type) and RING-H2 (C3H2C3-type), according to their Cys/His content. There are also many variants of RING fingers: some have different Cys/His patterns while some lack a single Cys or His residue at typical Zn ligand positions (the fourth or eighth zinc ligand is prevalently exchanged for an Asp, which can indeed chelate Zn in a RING finger as well). This family corresponds to the H2 subclass of RING (RING-H2) finger proteins that are characterized by containing C3H2C3-type canonical RING-H2 fingers or noncanonical RING-H2 finger variants, including C4HC3- (RING-CH alias RINGv), C3H3C2-, C3H2C2D-, C3DHC3-, and C4HC2H-type modified RING-H2 fingers. The canonical RING-H2 finger has been defined as C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, X is any amino acid and the number of X residues varies in different fingers. It binds two Zn ions in a unique "cross-brace" arrangement, which distinguishes it from tandem zinc fingers and other similar motifs. RING-H2 finger can be found in a group of diverse proteins with a variety of cellular functions, including oncogenesis, development, viral replication, signal transduction, the cell cycle and apoptosis. Many of them are ubiquitin-protein ligases (E3s) that serves as a scaffold for binding to ubiquitin-conjugating enzymes (E2s, also referred to as ubiquitin carrier proteins or UBCs) in close proximity to substrate proteins, which enables efficient transfer of ubiquitin from E2 to the substrates. Pssm-ID: 438112 [Multi-domain] Cd Length: 43 Bit Score: 39.69 E-value: 2.00e-04
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| Jag_EloR | NF041568 | RNA-binding cell elongation regulator Jag/EloR; Members of this family are nucleic ... |
994-1059 | 3.72e-04 | ||
RNA-binding cell elongation regulator Jag/EloR; Members of this family are nucleic acid-binding proteins (RNA or single-stranded DNA) with a KH domain at the N-terminus, an R3H domain at the C-terminus, and additional regions of homology. The founding member of this family was JAG (spoIIIJ Associated Gene) from Bacillus subtilis, but later work in other lineages, such as Streptococcus pneumoniae, as established a role in controlling cell elongation and the operation of the elongasome. The S. pneumoniae protein, a protein that undergoes regulatory phosphorylation and dephosphorylation, is also called RNA-binding cell elongation regulator EloR, and also KhpB. Pssm-ID: 469453 [Multi-domain] Cd Length: 203 Bit Score: 42.81 E-value: 3.72e-04
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| COG5219 | COG5219 | Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]; |
357-409 | 9.61e-04 | ||
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]; Pssm-ID: 227544 [Multi-domain] Cd Length: 1525 Bit Score: 43.50 E-value: 9.61e-04
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| R3H_NRF | cd02640 | R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB ... |
1022-1059 | 1.44e-03 | ||
R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB proteins that can silence the IFNbeta promoter via binding to a negative regulatory element (NRE). Beside R3H NRF also contains a G-patch domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner. Pssm-ID: 100069 Cd Length: 60 Bit Score: 38.15 E-value: 1.44e-03
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| mRING-H2-C3DHC3_ZFPL1 | cd16487 | Modified RING finger, H2 subclass (C3DHC3-type), found in zinc finger protein-like 1 (ZFPL1) ... |
377-410 | 1.56e-03 | ||
Modified RING finger, H2 subclass (C3DHC3-type), found in zinc finger protein-like 1 (ZFPL1) and similar proteins; ZFPL1, also known as zinc finger protein MCG4, is a novel mitotic Golgi phosphoprotein required for cis-Golgi integrity and efficient endoplasmic reticulum (ER)-to-Golgi transport via directly interacting with the cis-Golgi matrix protein GM130. ZFPL1 is a widely expressed integral membrane protein with two predicted zinc fingers at its N-terminus. One is a novel type of zinc finger, and the other is a modified RING-H2 finger that lacks the fourth zinc-binding residue of the consensus C3H2C3-type RING-H2 finger. It also contains a bipartite nuclear localization signal (NLS), and a leucine zipper at the C-terminus. Pssm-ID: 438150 [Multi-domain] Cd Length: 57 Bit Score: 37.66 E-value: 1.56e-03
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| zf-NF-X1 | pfam01422 | NF-X1 type zinc finger; This domain is presumed to be a zinc binding domain. The following ... |
567-585 | 3.90e-03 | ||
NF-X1 type zinc finger; This domain is presumed to be a zinc binding domain. The following pattern describes the zinc finger. C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C Where X can be any amino acid, and numbers in brackets indicate the number of residues. Two position can be either his or cys. This family includes Swiss:P40798, Swiss:Q12986 and Swiss:P53971. The zinc fingers in Swiss:Q12986 bind to DNA. Pssm-ID: 460205 Cd Length: 19 Bit Score: 35.58 E-value: 3.90e-03
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| R3H_sperm-antigen | cd02636 | R3H domain of a group of metazoan proteins that is related to the sperm-associated antigen 7. ... |
1023-1058 | 5.45e-03 | ||
R3H domain of a group of metazoan proteins that is related to the sperm-associated antigen 7. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner. Pssm-ID: 100065 Cd Length: 61 Bit Score: 36.54 E-value: 5.45e-03
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| zf-NF-X1 | pfam01422 | NF-X1 type zinc finger; This domain is presumed to be a zinc binding domain. The following ... |
721-739 | 6.00e-03 | ||
NF-X1 type zinc finger; This domain is presumed to be a zinc binding domain. The following pattern describes the zinc finger. C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C Where X can be any amino acid, and numbers in brackets indicate the number of residues. Two position can be either his or cys. This family includes Swiss:P40798, Swiss:Q12986 and Swiss:P53971. The zinc fingers in Swiss:Q12986 bind to DNA. Pssm-ID: 460205 Cd Length: 19 Bit Score: 35.20 E-value: 6.00e-03
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