NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4827006|ref|NP_005063|]
View 

solute carrier family 12 member 4 isoform a [Homo sapiens]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
42-1085 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1352.07  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006      42 NHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRA-AEAPSMGT 120
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPpAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     121 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGA 200
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     201 VGLCFYLGTTFAAAMYILGAIEILLTyiappaaIFYPSGaHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLF 280
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLD-------LLRENG-SKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     281 LACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDqfdicaktavvdnetvatqlwsffchspnlttdscdpyfmln 360
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEIFSEN------------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     361 nvtEIPGIPGAAAGvlqenlwsaylekgdivekhglpsadapslkeslplyvvadiatsFTVLVGIFFPSVTGIMAGSNR 440
Cdd:TIGR00930  271 ---FIPGIPGPEGG---------------------------------------------FFSLFGIFFPSVTGILAGANI 302
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     441 SGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVS---------------------RNLVVGTL 499
Cdd:TIGR00930  303 SGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMSL 382
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     500 AWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAELGILIASLDMVA 578
Cdd:TIGR00930  383 VSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYgKNGEPLRAYLLTAFIAEGFILIAELNTIA 462
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     579 PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAE 658
Cdd:TIGR00930  463 PIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPD 542
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     659 KEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDedlhVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLES 738
Cdd:TIGR00930  543 VNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLEC 618
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     739 YGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEdPRAWKTFIDTVRCT 818
Cdd:TIGR00930  619 VKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAE-PRAWETYIGIIHDA 697
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     819 TAAHLALLVPKNIAFYPSNH--------------------------------------ERYLEGHIDVWWIVHDGGMLML 860
Cdd:TIGR00930  698 FDAHLAVVVVRNSEGLPISVlqvqeelendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTLL 777
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     861 LPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMhnsDISAytYERTLMMEQRSQMLRQMR 940
Cdd:TIGR00930  778 LPYLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFR 852
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     941 LTKTEREREAqlvKDRHsalrleslysdeedesavgadkiqMTWTRDKYMTEtwdpshapdnfRELvhikpdQSNVRRMH 1020
Cdd:TIGR00930  853 LHKTEKDREA---KDPK------------------------MTWTKPWKITD-----------AEL------QSNVRKSY 888
                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4827006    1021 TAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1085
Cdd:TIGR00930  889 RQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
42-1085 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1352.07  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006      42 NHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRA-AEAPSMGT 120
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPpAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     121 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGA 200
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     201 VGLCFYLGTTFAAAMYILGAIEILLTyiappaaIFYPSGaHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLF 280
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLD-------LLRENG-SKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     281 LACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDqfdicaktavvdnetvatqlwsffchspnlttdscdpyfmln 360
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEIFSEN------------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     361 nvtEIPGIPGAAAGvlqenlwsaylekgdivekhglpsadapslkeslplyvvadiatsFTVLVGIFFPSVTGIMAGSNR 440
Cdd:TIGR00930  271 ---FIPGIPGPEGG---------------------------------------------FFSLFGIFFPSVTGILAGANI 302
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     441 SGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVS---------------------RNLVVGTL 499
Cdd:TIGR00930  303 SGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMSL 382
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     500 AWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAELGILIASLDMVA 578
Cdd:TIGR00930  383 VSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYgKNGEPLRAYLLTAFIAEGFILIAELNTIA 462
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     579 PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAE 658
Cdd:TIGR00930  463 PIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPD 542
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     659 KEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDedlhVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLES 738
Cdd:TIGR00930  543 VNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLEC 618
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     739 YGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEdPRAWKTFIDTVRCT 818
Cdd:TIGR00930  619 VKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAE-PRAWETYIGIIHDA 697
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     819 TAAHLALLVPKNIAFYPSNH--------------------------------------ERYLEGHIDVWWIVHDGGMLML 860
Cdd:TIGR00930  698 FDAHLAVVVVRNSEGLPISVlqvqeelendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTLL 777
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     861 LPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMhnsDISAytYERTLMMEQRSQMLRQMR 940
Cdd:TIGR00930  778 LPYLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFR 852
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     941 LTKTEREREAqlvKDRHsalrleslysdeedesavgadkiqMTWTRDKYMTEtwdpshapdnfRELvhikpdQSNVRRMH 1020
Cdd:TIGR00930  853 LHKTEKDREA---KDPK------------------------MTWTKPWKITD-----------AEL------QSNVRKSY 888
                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4827006    1021 TAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1085
Cdd:TIGR00930  889 RQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
123-695 4.18e-51

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 187.53  E-value: 4.18e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     123 GVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVpAGGSYFMISRSLGPEFGGAVG 202
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     203 L--CFYLGTTFAAAmyiLGAIEILLTYIAPPAAIFYpsgahdtsnatlnnMRVYGTIFLTFMTLVVFVGVKYVNKFASLF 280
Cdd:pfam00324   80 WnyWLSWITVLALE---LTAASILIQFWELVPDIPY--------------LWVWGAVFLVLLTIINLVGVKWYGEAEFWF 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     281 LACVIISILSIYAGGIKSIFDPpvfpvcmlgnrtlsrdqfdicaktavvdnetvatqlwsffchspnlttdscdpyfmln 360
Cdd:pfam00324  143 ALIKIIAIIGFIIVGIILLSGG---------------------------------------------------------- 164
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     361 nvteipgipGAAAGVLQENLWSAYLEKgdivekhglpsadapslkeslplYVVADIATSFTVLVGIFFPSVTGIMAGSNR 440
Cdd:pfam00324  165 ---------NPNDGAIFRYLGDNGGKN-----------------------NFPPGFGKGFISVFVIAFFAFTGIELVGIA 212
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     441 SGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVV------GTLAWPSpwVIVIGSFFS 514
Cdd:pfam00324  213 AGEVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASAASPFViffkflGISGLAP--LINAVILTA 290
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     515 TCGAGLQSLTGAPRLLQAIAKDNIIPFlrVFGHGKVNGEPTWALLLTALIAELGILIASLdmVAPILSMFFLMCYLFVNL 594
Cdd:pfam00324  291 ALSAANSSLYSGSRMLYSLARDGLAPK--FLKKVDKRGVPLRAILVSMVISLLALLLASL--NPAIVFNFLLAISGLSGL 366
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     595 ACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR 674
Cdd:pfam00324  367 IVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVL 446
                          570       580
                   ....*....|....*....|.
gi 4827006     675 YALLRLEEGPPHTKNWRPQLL 695
Cdd:pfam00324  447 LFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
131-655 1.04e-33

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 135.41  E-value: 1.04e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006   131 NIFGVILFLRLTWMVGTAGvLQALLIVLICCCCTLLTAISMSAIATNgvVP-AGGSYFMISRSLGPEFGGAVGLCFYLGT 209
Cdd:COG0531   25 AIIGAGIFVLPGLAAGLAG-PAAILAWLIAGLLALLVALSYAELASA--FPrAGGAYTYARRALGPLLGFLAGWALLLSY 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006   210 TFAAAMYILGAIEILltyiappaAIFYPSGAHDtsnatlnnmrVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISIL 289
Cdd:COG0531  102 VLAVAAVAVAFGGYL--------SSLFPAGGSV----------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006   290 SIYAGGIksifdppvfpvcmlgnrtlsrdqfdicaktavvdnetvatqlwsffchspnlttdscdPYFMLNNVTEIPGIP 369
Cdd:COG0531  164 LFIVVGL----------------------------------------------------------FAFDPANFTPFLPAG 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006   370 GAAAGVlqenlwsaylekgdivekhglpsadapslkeslplyvvadiatsFTVLVGIFFpSVTGIMAGSNRSGDLRDAQK 449
Cdd:COG0531  186 GGLSGV--------------------------------------------LAALALAFF-AFTGFEAIANLAEEAKNPKR 220
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006   450 SIPVGTILAIITTSLVYFSSVVLFGacieGVVLRDKYGDGVSRNLVVGTLAWPSP--WVIVIGSFFSTCGAGLQSLTGAP 527
Cdd:COG0531  221 NIPRAIILSLLIVGVLYILVSLALT----GVVPYDELAASGAPLADAAEAVFGPWgaILIALGALLSLLGALNASILGAS 296
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006   528 RLLQAIAKDNIIPflRVFGH-GKVNGEPTWALLLTALIAELGILI--ASLDMVAPILSMFFLMCYLFVNLACAVQtLLRT 604
Cdd:COG0531  297 RLLYAMARDGLLP--KVFAKvHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAVIVL-RRRR 373
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 4827006   605 PNWRPRFKYYHWALSFLGMSLCLALMFVS---SWYYALVAMLIAGMIYKYIEYQ 655
Cdd:COG0531  374 PDLPRPFRVPLPLIPILGILLCLFLLYLLgpgALLIGLVLLAIGLLLYLLYRRR 427
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
42-1085 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1352.07  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006      42 NHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRA-AEAPSMGT 120
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPpAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     121 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGA 200
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     201 VGLCFYLGTTFAAAMYILGAIEILLTyiappaaIFYPSGaHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLF 280
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLD-------LLRENG-SKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     281 LACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDqfdicaktavvdnetvatqlwsffchspnlttdscdpyfmln 360
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEIFSEN------------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     361 nvtEIPGIPGAAAGvlqenlwsaylekgdivekhglpsadapslkeslplyvvadiatsFTVLVGIFFPSVTGIMAGSNR 440
Cdd:TIGR00930  271 ---FIPGIPGPEGG---------------------------------------------FFSLFGIFFPSVTGILAGANI 302
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     441 SGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVS---------------------RNLVVGTL 499
Cdd:TIGR00930  303 SGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMSL 382
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     500 AWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK-VNGEPTWALLLTALIAELGILIASLDMVA 578
Cdd:TIGR00930  383 VSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYgKNGEPLRAYLLTAFIAEGFILIAELNTIA 462
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     579 PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAE 658
Cdd:TIGR00930  463 PIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPD 542
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     659 KEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDedlhVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLES 738
Cdd:TIGR00930  543 VNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLEC 618
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     739 YGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEdPRAWKTFIDTVRCT 818
Cdd:TIGR00930  619 VKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAE-PRAWETYIGIIHDA 697
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     819 TAAHLALLVPKNIAFYPSNH--------------------------------------ERYLEGHIDVWWIVHDGGMLML 860
Cdd:TIGR00930  698 FDAHLAVVVVRNSEGLPISVlqvqeelendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTLL 777
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     861 LPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMhnsDISAytYERTLMMEQRSQMLRQMR 940
Cdd:TIGR00930  778 LPYLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFR 852
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     941 LTKTEREREAqlvKDRHsalrleslysdeedesavgadkiqMTWTRDKYMTEtwdpshapdnfRELvhikpdQSNVRRMH 1020
Cdd:TIGR00930  853 LHKTEKDREA---KDPK------------------------MTWTKPWKITD-----------AEL------QSNVRKSY 888
                         1050      1060      1070      1080      1090      1100
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4827006    1021 TAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1085
Cdd:TIGR00930  889 RQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
123-695 4.18e-51

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 187.53  E-value: 4.18e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     123 GVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVpAGGSYFMISRSLGPEFGGAVG 202
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     203 L--CFYLGTTFAAAmyiLGAIEILLTYIAPPAAIFYpsgahdtsnatlnnMRVYGTIFLTFMTLVVFVGVKYVNKFASLF 280
Cdd:pfam00324   80 WnyWLSWITVLALE---LTAASILIQFWELVPDIPY--------------LWVWGAVFLVLLTIINLVGVKWYGEAEFWF 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     281 LACVIISILSIYAGGIKSIFDPpvfpvcmlgnrtlsrdqfdicaktavvdnetvatqlwsffchspnlttdscdpyfmln 360
Cdd:pfam00324  143 ALIKIIAIIGFIIVGIILLSGG---------------------------------------------------------- 164
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     361 nvteipgipGAAAGVLQENLWSAYLEKgdivekhglpsadapslkeslplYVVADIATSFTVLVGIFFPSVTGIMAGSNR 440
Cdd:pfam00324  165 ---------NPNDGAIFRYLGDNGGKN-----------------------NFPPGFGKGFISVFVIAFFAFTGIELVGIA 212
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     441 SGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVV------GTLAWPSpwVIVIGSFFS 514
Cdd:pfam00324  213 AGEVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASAASPFViffkflGISGLAP--LINAVILTA 290
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     515 TCGAGLQSLTGAPRLLQAIAKDNIIPFlrVFGHGKVNGEPTWALLLTALIAELGILIASLdmVAPILSMFFLMCYLFVNL 594
Cdd:pfam00324  291 ALSAANSSLYSGSRMLYSLARDGLAPK--FLKKVDKRGVPLRAILVSMVISLLALLLASL--NPAIVFNFLLAISGLSGL 366
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     595 ACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR 674
Cdd:pfam00324  367 IVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVL 446
                          570       580
                   ....*....|....*....|.
gi 4827006     675 YALLRLEEGPPHTKNWRPQLL 695
Cdd:pfam00324  447 LFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
131-655 1.04e-33

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 135.41  E-value: 1.04e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006   131 NIFGVILFLRLTWMVGTAGvLQALLIVLICCCCTLLTAISMSAIATNgvVP-AGGSYFMISRSLGPEFGGAVGLCFYLGT 209
Cdd:COG0531   25 AIIGAGIFVLPGLAAGLAG-PAAILAWLIAGLLALLVALSYAELASA--FPrAGGAYTYARRALGPLLGFLAGWALLLSY 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006   210 TFAAAMYILGAIEILltyiappaAIFYPSGAHDtsnatlnnmrVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISIL 289
Cdd:COG0531  102 VLAVAAVAVAFGGYL--------SSLFPAGGSV----------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006   290 SIYAGGIksifdppvfpvcmlgnrtlsrdqfdicaktavvdnetvatqlwsffchspnlttdscdPYFMLNNVTEIPGIP 369
Cdd:COG0531  164 LFIVVGL----------------------------------------------------------FAFDPANFTPFLPAG 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006   370 GAAAGVlqenlwsaylekgdivekhglpsadapslkeslplyvvadiatsFTVLVGIFFpSVTGIMAGSNRSGDLRDAQK 449
Cdd:COG0531  186 GGLSGV--------------------------------------------LAALALAFF-AFTGFEAIANLAEEAKNPKR 220
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006   450 SIPVGTILAIITTSLVYFSSVVLFGacieGVVLRDKYGDGVSRNLVVGTLAWPSP--WVIVIGSFFSTCGAGLQSLTGAP 527
Cdd:COG0531  221 NIPRAIILSLLIVGVLYILVSLALT----GVVPYDELAASGAPLADAAEAVFGPWgaILIALGALLSLLGALNASILGAS 296
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006   528 RLLQAIAKDNIIPflRVFGH-GKVNGEPTWALLLTALIAELGILI--ASLDMVAPILSMFFLMCYLFVNLACAVQtLLRT 604
Cdd:COG0531  297 RLLYAMARDGLLP--KVFAKvHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAVIVL-RRRR 373
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 4827006   605 PNWRPRFKYYHWALSFLGMSLCLALMFVS---SWYYALVAMLIAGMIYKYIEYQ 655
Cdd:COG0531  374 PDLPRPFRVPLPLIPILGILLCLFLLYLLgpgALLIGLVLLAIGLLLYLLYRRR 427
SLC12 pfam03522
Solute carrier family 12;
709-1085 1.87e-23

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 104.24  E-value: 1.87e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     709 PRLLTFASQLKAGKGLTIVGSVIQGSFleSYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRH 788
Cdd:pfam03522    2 PALVDFAHLITKNVSLMICGHVVKGRL--SQKLRSELQKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLKP 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     789 NSVVLGWPYGWRQSE----------------------------------------------------------------- 803
Cdd:pfam03522   80 NILLMGYKSDWRTCDkeeleeyfnvihdafdlqyavailrlpegldvshllqdqdteelglgdetnssyaeqsseeqsts 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     804 DPRAWKTFIDTVRCTTAAHLALLV--------------------PKNIAFYPSNHERYLE-----------GHIDVWWIV 852
Cdd:pfam03522  160 NSKQDDDKSKLSKKDSNLSLSPDKstknpsgkdssksdklkkksPSIILRTASNEKEILNnitqfqkkqkkGTIDVWWLY 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     853 HDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLE-AEVEVVemhnSDISAYTYERTLmmeq 931
Cdd:pfam03522  240 DDGGLTLLLPYILSTRSKWSDCKLRVFALGNRKDELEEEQRNMASLLSKFRIDySDLTVI----PDITKKPKKETK---- 311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     932 rsQMLRQMrltkterereaqlvkdrhsalrLESLYSDEEDESAVGADKIqmtwtrdkymTETwdpshapdnfrELVHIKp 1011
Cdd:pfam03522  312 --KFFDEL----------------------IEPFRLHEDDKEEESAEKI----------TDS-----------ELEALK- 345
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4827006    1012 DQSNvrRMhtaVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1085
Cdd:pfam03522  346 EKTN--RQ---LRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLETLTKDLPPFLLVRGNQTSVLTFYS 414
AA_permease_2 pfam13520
Amino acid permease;
395-652 1.58e-13

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 73.88  E-value: 1.58e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     395 GLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGdlRDAQKSIPVGTILAIITTSLVYFSSVVLFG 474
Cdd:pfam13520  165 VTADGGGFNLLSGEWHTFFPDGWPGVFAGFLGVLWSFTGFESAANVSE--EVKKRNVPKAIFIGVIIVGVLYILVNIAFF 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     475 ACI--EGVVLRDKYGDGVS---RNLVVGTLAWpspwVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK 549
Cdd:pfam13520  243 GVVpdDEIALSSGLGQVAAllfQAVGGKWGAI----IVVILLALSLLGAVNTAIVGASRLLYALARDGVLPFSRFFAKVN 318
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827006     550 VNGEPTWALLLTALIAELGILIASLDMVAPI----LSMFFLMCYLFVNLACAVqtLLRTPNWRPRFKYYHWALSFLGMsL 625
Cdd:pfam13520  319 KFGSPIRAIILTAILSLILLLLFLLSPAAYNallsLSAYGYLLSYLLPIIGLL--ILRKKRPDLGRIPGRWPVAIFGI-L 395
                          250       260
                   ....*....|....*....|....*..
gi 4827006     626 CLALMFVSSWYYALVAMLIAGMIYKYI 652
Cdd:pfam13520  396 FSLFLIVALFFPPVGPATGSSLNYAII 422
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH